ºù«Ӱҵ

The paper is titled: Draper/CED-1 mediates an ancient damage response to control inflammatory blood cell migration in vivo.

The work describes how Src42A>Draper>Shark signalling regulates macrophage migration to wounds in Drosophila embryos.

This pathway is very similar to the Src family kinase>immune cell receptor>Syk signalling used by vertebrate immune cells and therefore this work suggests that our ability to discriminate between self/non-self may have evolved from an ancient pathway used to regulate activation of innate immune cells in response to damage.