Turner, Claire, Dr

Dr Claire Turner

School of Biosciences

Senior Research Fellow

c.e.turner@sheffield.ac.uk
+44 114 222 2819

Profile

2017-present: Royal Society/ Wellcome Trust Sir Henry Dale Research Fellow, University of ��«Ӱҵ
2017-present: Florey Institute Research Fellow, University of ��«Ӱҵ
2013-2016: Imperial College Junior Research Fellow
2009-2013: Research Associate, National Centre for Infection Prevention & Management, Imperial College London
2005-2009: PhD, Imperial College London.

Research interests

My research focus is on trying to understand the mechanisms behind upsurges in disease caused by the human pathogen Streptococcus pyogenes (also known as group A Streptococcus). Upsurges occur frequently and can be associated with specific genotypes.

I use a combination of whole genome sequencing, epidemiology, clinical analysis and phenotypic work to try and identify what makes strains successful at causing disease and become suddenly more abundant.

One of my particular interests is recombination-related genome remodelling, which we identified to be the driving force behind a very recent shift in the population of the S. pyogenes genotype emm89. A new variant of emm89 emerged from the population having undergone six regions of recombination within the core genome.

This recombination-related genome remodelling led to substantial phenotype changes, including loss of the hyaluronic acid capsule and increase of toxin expression, altering the way this genotype interacted with the host.

The emergent variant has now become the dominant form of emm89 in the UK and globally, causing a high level of disease. Understanding how recombination occurs and what the impact of recombination is on the bacterium are part of my research aims.

Publications

Show: Featured publications All publications

Featured publications

Journal articles

Turner CE, Holden MTG, Blane B, Horner C, Peacock SJ & Sriskandan S (2019) . mBio, 10(6).
Armitage EP, Senghore E, Darboe S, Barry M, Camara J, Bah S, Marks M, Cerami C, Roca A, Antonio M , Turner CE et al (2019) . PLOS Neglected Tropical Diseases, 13(10).
Lynskey NN, Jauneikaite E, Li HK, Zhi X, Turner CE, Mosavie M, Pearson M, Asai M, Lobkowicz L, Chow JY , Parkhill J et al (2019) . The Lancet Infectious Diseases.
Reglinski M, Sriskandan S & Turner C (2019) . Journal of Infection.
Turner CE, Bedford L, Brown NM, Judge K, Török ME, Parkhill J & Peacock SJ (2017) . Scientific Reports, 7(1).
Afshar B, Turner CE, Lamagni T, Smith K, Al-Shahib A, Underwood A, Holden M, Efstratiou A & Sriskandan S (2017) . Virulence, 8(7), 1390-1400.
Turner CE, Pyzio M, Song B, Lamagni T, Meltzer M, Chow JY, Efstratiou A, Curtis S & Sriskandan S (2016) . Emerging Infectious Diseases, 22(6), 1075-1078.
Turner CE, Abbott J, Lamagni T, Holden MTG, David S, Jones MD, Game L, Efstratiou A & Sriskandan S () . mBio, 6(4).

All publications

Journal articles

Buddle JE, Thompson LM, Williams AS, Wright RCT, Durham WM, Turner CE, Chaudhuri RR, Brockhurst MA & Fagan RP (2024) . PLOS Biology, 22(8).
Hall JN, Bah SY, Khalid H, Brailey A, Coleman S, Kirk T, Hussain N, Tovey M, Chaudhuri RR, Davies S , Tilley L et al (2024) . Microbial Genomics, 10(8).
Armitage EP, de Crombrugghe G, Keeley AJ, Senghore E, Camara FE, Jammeh M, Bittaye A, Ceesay H, Ceesay I, Samateh B , Manneh M et al (2024) . The Lancet Microbe.
Hall J, Angyal A, Armitage E, Senghore E, Darboe S, Barry M, Camara J, Bah S, Keeley A, McCarthy J , Turner C et al (2023) . Clinical Infection in Practice, 20(Supplement 1).
Li HK, Zhi X, Vieira A, Whitwell HJ, Schricker A, Jauneikaite E, Li H, Yosef A, Andrew I, Game L , Turner CE et al (2023) . Microbial Genomics, 9(4).
Catton EA, Bonsor DA, Herrera C, Stålhammar-Carlemalm M, Lyndin M, Turner CE, Soden J, van Strijp JAG, Singer BB, van Sorge NM , Lindahl G et al (2023) . Nature Communications, 14.
Turner CE (2022) . The Lancet Infectious Diseases.
Jagne I, Keeley AJ, Bojang A, Camara B, Jallow E, Senghore E, Oluwalana C, Bah SY, Turner CE, Sesay AK , D’Alessandro U et al (2022) . BMC Infectious Diseases, 22(1).
Tan LKK, Reglinski M, Teo D, Reza N, Lamb LEM, Nageshwaran V, Turner CE, Wikstrom M, Frick IM, Bjorck L & Sriskandan S (2021) . npj Vaccines, 6(1).
Remmington A, Haywood S, Edgar J, Green LR, de Silva T & Turner CE (2021) . Microbial Genomics, 7(1).
Siggins MK, Lynskey NN, Lamb LE, Johnson LA, Huse KK, Pearson M, Banerji S, Turner CE, Woollard K, Jackson DG & Sriskandan S (2020) . Nature Communications, 11(1).
Turner CE, Holden MTG, Blane B, Horner C, Peacock SJ & Sriskandan S (2019) . mBio, 10(6).
Armitage EP, Senghore E, Darboe S, Barry M, Camara J, Bah S, Marks M, Cerami C, Roca A, Antonio M , Turner CE et al (2019) . PLOS Neglected Tropical Diseases, 13(10).
Sharma H, Turner CE, Siggins MK, El-Bahrawy M, Pichon B, Kearns A & Sriskandan S (2019) . mSphere, 4(5).
Lynskey NN, Jauneikaite E, Li HK, Zhi X, Turner CE, Mosavie M, Pearson M, Asai M, Lobkowicz L, Chow JY , Parkhill J et al (2019) . The Lancet Infectious Diseases.
Turner CE, Bubba L & Efstratiou A (2019) . Microbiology Spectrum, 7(3).
Davies FJ, Olme C, Lynskey NN, Turner CE & Sriskandan S (2019) . Clinical & Experimental Immunology.
Reglinski M, Sriskandan S & Turner C (2019) . Journal of Infection.
Davies F, Olme C, Lynskey N, Turner C & Sriskandan S (2018) .
Lamb LE, Siggins MK, Scudamore C, Macdonald W, Turner CE, Lynskey NN, Tan LKK & Sriskandan S (2018) . Virulence, 9(1), 1074-1084.
Edwards RJ, Pyzio M, Gierula M, Turner CE, Abdul-Salam VB & Sriskandan S (2018) . Scientific Reports, 8(1).
Remmington A & Turner CE (2018) . Microbiology, 164(3), 242-250.
Sharma H, Smith D, Turner CE, Game L, Pichon B, Hope R, Hill R, Kearns A & Sriskandan S (2018) . Emerging Infectious Diseases, 24(2).
Turner CE, Bedford L, Brown NM, Judge K, Török ME, Parkhill J & Peacock SJ (2017) . Scientific Reports, 7(1).
Afshar B, Turner CE, Lamagni T, Smith K, Al-Shahib A, Underwood A, Holden M, Efstratiou A & Sriskandan S (2017) . Virulence, 8(7), 1390-1400.
Al-Shahib A, Underwood A, Afshar B, Turner CE, Lamagni T, Sriskandan S & Efstratiou A (2016) . Microbial Genomics, 2(11).
Al-Shahib A, Underwood A, Afshar B, Turner CE, Lamagni T, Sriskandan S & Efstratiou A (2016) . Microbial Genomics, 2(6).
Turner CE, Pyzio M, Song B, Lamagni T, Meltzer M, Chow JY, Efstratiou A, Curtis S & Sriskandan S (2016) . Emerging Infectious Diseases, 22(6), 1075-1078.
Smith DS, Siggins MK, Gierula M, Pichon B, Turner CE, Lynskey NN, Mosavie M, Kearns AM, Edwards RJ & Sriskandan S (2016) . Microbial Genomics, 2(2).
Lamb L, MacDonald W, Scudamore C, Tan L, Lynskey N, Turner CE & Sriskandan S (2015) . Journal of Infection, 71(6), 686-686.
Turner CE & Sriskandan S (2015) . Journal of Infection, 71(3), 338-346.
Lynskey NN, Turner CE, Heng LS & Sriskandan S (2015) . Infection and Immunity, 83(4), 1732-1733.
Turner CE, Dryden M, Holden MTG, Davies FJ, Lawrenson RA, Farzaneh L, Bentley SD, Efstratiou A & Sriskandan S (2013) . Journal of Clinical Microbiology, 51(7), 2089-2095.
Al-Shahib A, Afshar B, Underwood A, Turner C, Sriskandan S, Holden M, Parkhill J & Efstratiou A (2013) . International Journal of Antimicrobial Agents, 42, S103-S104.
Davies F, Turner C, Boyle J & Sriskandan S (2010) . Journal of Infection, 61(6), 518-518.
(2009) . The Journal of Infectious Diseases, 200(8), 1353-1353.
Turner CE, Kurupati P, Jones MD, Edwards RJ & Sriskandan S (2009) . The Journal of Infectious Diseases, 200(4), 555-563.
Turner CE, Kurupati P, Wiles S, Edwards RJ & Sriskandan S (2009) . Vaccine, 27(36), 4923-4929.
Zinkernagel AS, Timmer AM, Pence MA, Locke JB, Buchanan JT, Turner CE, Mishalian I, Sriskandan S, Hanski E & Nizet V (2008) . Cell Host & Microbe, 4(2), 170-178.
Turner C & Sriskandan S (2007) . Nature Medicine, 13(8), 909-910.
Edwards RJ, Taylor GW, Ferguson M, Murray S, Rendell N, Wrigley A, Bai Z, Boyle J, Finney SJ, Jones A , Russell HH et al (2005) . The Journal of Infectious Diseases, 192(5), 783-790.
Hall JN, Armitage EP, Senghore E, Darboe S, Barry M, Camara J, Bah S, Keeley AJ, McCarthy JS, Smeesters P , Turner CE et al () . The Journal of Infectious Diseases.
Green LR, Issa R, Albaldi F, Urwin L, Thompson R, Khalid H, Turner CE, Ciani B, Partridge LJ & Monk PN () . mBio.
Keeley AJ, Groves D, Armitage EP, Senghore E, Jagne YJ, Sallah HJ, Drammeh S, Angyal A, Hornsby H, de Crombrugghe G , Smeesters P et al () . The Journal of Infectious Diseases.
Catton EA, Bonsor DA, Herrera C, Stålhammar-Carlemalm M, Lyndin M, Turner CE, Soden J, van Strijp JAG, Singer BB, van Sorge NM , Lindahl G et al () . Nature Communications, 14(1).
Carrilero L, Urwin L, Ward E, Choudhury NR, Monk IR, Turner CE, Stinear TP & Corrigan RM () . Microbiology Spectrum.
Bah S, Keeley A, Armitage E, Khalid H, Chaudhuri R, Senghore E, Manneh J, Tilley L, Marks M, Darboe S , Sesay A et al () Genomic characterisation of skin and soft tissue Streptococcus pyogenes isolates from a low-income and a high-income setting. mSphere.
Jabang S, Erhart A, Darboe S, Baldeh A-K, Delforge V, Watson G, Foster-Nyarko E, Salaudeen R, Lawal B, Mackenzie G , Botteaux A et al () . Vaccines, 9(2), 124-124.
Turner CE, Lamagni T, Holden MTG, David S, Jones MD, Game L, Efstratiou A & Sriskandan S () . mBio, 6(6).
Lynskey NN, Goulding D, Gierula M, Turner CE, Dougan G, Edwards RJ & Sriskandan S () . PLoS Pathogens, 9(12), e1003842-e1003842.
Alam FM, Bateman C, Turner CE, Wiles S & Sriskandan S () . PLoS ONE, 8(11), e82123-e82123.
Alam FM, Turner CE, Smith K, Wiles S & Sriskandan S () . PLoS ONE, 8(9).
Alam FM, Turner CE, Smith K, Wiles S & Sriskandan S () . PLoS ONE, 8(4), e61655-e61655.
Turner CE, Sommerlad M, McGregor K, Davies FJ, Pichon B, Chong DLW, Farzaneh L, Holden MTG, Spratt BG, Efstratiou A & Sriskandan S () . PLoS ONE, 7(10), e46376-e46376.
Kurupati P, Turner CE, Tziona I, Lawrenson RA, Alam FM, Nohadani M, Stamp GW, Zinkernagel AS, Nizet V, Edwards RJ & Sriskandan S () . Molecular Microbiology, 76(6), 1387-1397.
Siggins M, Lynskey NN, Lamb LE, Johnson LA, Huse KK, Pearson M, Banerji S, Turner CE, Woollard K, Jackson DG & Sriskandan S () . SSRN Electronic Journal.
Turner CE, Abbott J, Lamagni T, Holden MTG, David S, Jones MD, Game L, Efstratiou A & Sriskandan S () . mBio, 6(4).

Chapters

Efstratiou A, Lamagni T & Turner CE (2017) , Infectious Diseases (pp. 1523-1536.e2). Elsevier
Efstratiou A, Lamagni T & Turner CE (2017) , Infectious Diseases, 2-Volume Set (pp. 1523-1536.e2).
Efstratiou A, Lamagni T & Turner CE (2016) Streptococci and Enterococci In Cohen J, Powderly W & Opal S (Ed.), Infectious Diseases 4th edition Elsevier
Turner CE, Bubba L & Efstratiou A () , Gram-Positive Pathogens (pp. 264-274). ASM Press

Conference proceedings papers

Alam F, Bateman C, Turner C, Sriskandan S & Wiles S (2010) Bioluminescence imaging of a clinical isolate of Streptococcus pyogenes. LUMINESCENCE, Vol. 25(2) (pp 179-181)

Preprints

Hall JN, Bah SY, Khalid H, Brailey A, Coleman S, Kirk T, Hussain N, Tovey M, Chaudhuri RR, Davies S , Tilley L et al (2024) , Cold Spring Harbor Laboratory.
Hall JN, Armitage EP, Senghore E, Darboe S, Barry M, Camara J, Bah S, Keeley AJ, McCarthy JS, Smeesters P , Turner CE et al (2024) , Cold Spring Harbor Laboratory.
Buddle JE, Wright RCT, Turner CE, Chaudhuri RR, Brockhurst MA & Fagan RP (2023) .
Green LR, Issa R, Albaldi F, Urwin L, Khalid H, Turner CE, Ciani B, Partridge LJ & Monk PN (2023) , Cold Spring Harbor Laboratory.
Li HK, Zhi X, Vieira A, Whitwell HJ, Schricker A, Jauneikaite E, Li H, Yosef A, Andrew I, Game L , Turner CE et al (2022) , Cold Spring Harbor Laboratory.
Keeley AJ, Groves D, Armitage EP, Senghore E, Jagne YJ, Sallah HJ, Drammeh S, Angyal A, Hornsby H, de Crombrugghe G , Smeesters P et al (2022) , Cold Spring Harbor Laboratory.
Armitage EP, Senghore E, Darboe S, Barry M, Camara J, Bah S, Marks M, Cerami C, Roca A, Antonio M , Turner CE et al (2019) , Cold Spring Harbor Laboratory.
Lynskey NN, Jauneikaite E, Li HK, Zhi X, Turner CE, Mosavie M, Pearson M, Asai M, Lobkowicz L, Chow JY , Parkhill J et al (2019) , SSRN Electronic Journal.
Bah SY, Keeley AJ, Armitage EP, Khalid H, Chaudhuri RR, Senghore E, Manneh J, Tilley L, Marks M, Darboe S , Sesay AK et al () , Cold Spring Harbor Laboratory.
Jagne I, Keeley AJ, Bojang A, Camara B, Jallow E, Senghore E, Oluwalana C, Bah SY, Turner CE, Sesay AK , D’Alessandro U et al () , Cold Spring Harbor Laboratory.
Tan LKK, Reglinski M, Teo D, Reza N, Lamb LEM, Nageshwaran V, Turner CE, Wikstrom M, Frick I-M, Bjorck L & Sriskandan S () , Cold Spring Harbor Laboratory.
Remmington A, Haywood S, Edgar J & Turner CE () .
Turner CE, Holden MTG, Blane B, Horner C, Peacock SJ & Sriskandan S () .

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School of Biosciences

School of Biosciences

Dr Claire Turner

Featured publications

Journal articles

All publications

Journal articles

Chapters

Conference proceedings papers

Preprints