Fagan, Robert, Dr

Dr Robert Fagan

School of Biosciences

Senior Lecturer

r.fagan@sheffield.ac.uk
+44 114 222 4182

Firth Court

Full contact details

Dr Robert Fagan
School of Biosciences
Firth Court
Western Bank
��«Ӱҵ
S10 2TN

Profile

Career history

2018-present: Senior Lecturer, School of Biosciences, University of ��«Ӱҵ, UK
2013 - 2017: Lecturer, Dept. of Molecular Biology and Biotechnology, University of ��«Ӱҵ, UK
2008 - 2012: Senior Research Associate, Centre for Molecular Microbiology and Infection, Imperial College London, UK
2005 - 2008: Research Associate, Centre for Molecular Microbiology and Infection, Imperial College London, UK
2001 - 2005: PhD, Moyne Institute of Preventive Medicine, Trinity College, University of Dublin, Ireland

Research interests

Clostridium difficile is the most common cause of antibiotic-associated diarrhea. It’s a highly antibiotic resistant pathogen that can cause severe disease following antibiotic-mediated disruption of the protective gut microbiota.

The aim of our research is to understand the molecular basis of interactions between the bacterium and its host. We study the outermost layer of the C. difficile cell envelope, the surface- or S-layer, a 2-dimensional proteinaceous crystal that completely coats the surface of the bacterium.

The S-layer has been implicated in adhesion and induction of innate immunity. Our work combines molecular microbiology and structural biology to study S-layer biogenesis and function.

Publications

Show: Featured publications All publications

Featured publications

Journal articles

Buddle JE, Thompson LM, Williams AS, Wright RCT, Durham WM, Turner CE, Chaudhuri RR, Brockhurst MA & Fagan RP (2024) . PLOS Biology, 22(8).
Lanzoni-Mangutchi P, Banerji O, Wilson J, Barwinska-Sendra A, Kirk JA, Vaz F, O'Beirne S, Baslé A, El Omari K, Wagner A , Fairweather NF et al (2022) . Nat Commun, 13(1), 970.
Fuchs M, Lamm-Schmidt V, Sulzer J, Ponath F, Jenniches L, Kirk JA, Fagan RP, Barquist L, Vogel J & Faber F (2021) . Proceedings of the National Academy of Sciences of the United States of America, 118(25).
Kirk JA, Gebhart D, Buckley AM, Lok S, Scholl D, Douce GR, Govoni GR & Fagan RP (2017) . Science Translational Medicine, 9(406).
Dembek M, Barquist L, Boinett CJ, Cain AK, Mayho M, Lawley TD, Fairweather NF & Fagan RP (2015) . MBIO, 6(2).

All publications

Journal articles

Buddle JE, Thompson LM, Williams AS, Wright RCT, Durham WM, Turner CE, Chaudhuri RR, Brockhurst MA & Fagan RP (2024) . PLOS Biology, 22(8).
Phothichaisri W, Phetruen T, Chankhamhaengdecha S, Janvilisri T, Ounjai P, Fagan RP & Chanarat S (2024) , 245-262.
Galley NF, Greetham D, Alamán-Zárate MG, Williamson MP, Evans CA, Spittal WD, Buddle JE, Freeman J, Davis GL, Dickman MJ , Wilcox MH et al (2023) . Journal of Biological Chemistry, 105529-105529.
Ormsby MJ, Vaz F, Kirk JA, Barwinska-Sendra A, Hallam JC, Lanzoni-Mangutchi P, Cole J, Chaudhuri RR, Salgado PS, Fagan RP & Douce GR (2023) . PLOS Pathogens, 19(6).
Royer ALM, Umansky AA, Allen M-M, Garneau JR, Ospina-Bedoya M, Kirk JA, Govoni G, Fagan RP, Soutourina O & Fortier L-C (2023) . Microbiol Spectr, 11(2), e0389422.
Buddle JE & Fagan RP (2023) . Virulence, 14(1), 2150452.
Phothichaisri W, Chankhamhaengdecha S, Janvilisri T, Nuadthaisong J, Phetruen T, Fagan RP & Chanarat S (2022) . Microbiol Spectr, 10(2), e0236121.
Lanzoni-Mangutchi P, Banerji O, Wilson J, Barwinska-Sendra A, Kirk JA, Vaz F, O'Beirne S, Baslé A, El Omari K, Wagner A , Fairweather NF et al (2022) . Nat Commun, 13(1), 970.
Alabdali YAJ, Oatley P, Kirk JA & Fagan RP (2021) . Anaerobe, 70.
Fuchs M, Lamm-Schmidt V, Sulzer J, Ponath F, Jenniches L, Kirk JA, Fagan RP, Barquist L, Vogel J & Faber F (2021) . Proceedings of the National Academy of Sciences of the United States of America, 118(25).
Oatley P, Kirk JA, Ma S, Jones S & Fagan RP (2020) . Scientific Reports, 10(1).
Janganan TK, Mullin N, Dafis-Sagarmendi A, Brunt J, Tzokov SB, Stringer S, Moir A, Chaudhuri RR, Fagan RP, Hobbs JK & Bullougha PA (2020) . mSphere, 5(4).
de Lussy-Kubisa L, Chaudhuri R & Fagan R (2019) . Access Microbiology, 1(1A).
Vaz F, Wilson G, Kirk J, Salgado P, Fagan R & Douce G (2019) . Access Microbiology, 1(1A).
O’Beirne S, Kirk JA & Fagan RP (2019) . Access Microbiology, 1(1A).
Fagan R, McBride SM & Shen A (2018) . Anaerobe, 53, 1-1.
McHale TM, Garciarena CD, Fagan RP, Smith SGJ, Martin-Loches I, Curley GF, Fitzpatrick F & Kerrigan SW (2018) . Critical care medicine, 46(8), e805-e810.
Kirk JA, Gebhart D, Buckley AM, Lok S, Scholl D, Douce GR, Govoni GR & Fagan RP (2017) . Science Translational Medicine, 9(406).
Kirk JA, Banerji O & Fagan RP (2017) . Microbial Biotechnology, 10(1), 76-90.
Kirk JA & Fagan RP (2016) . Anaerobe, 42, 1-5.
Janganan TK, Mullin N, Tzokov SB, Stringer S, Fagan RP, Hobbs JK, Moir A & Bullough PA (2016) . Food Microbiology, 59, 205-212.
Buckley AM, Jukes C, Candlish D, Irvine JJ, Spencer J, Fagan RP, Roe AJ, Christie JM, Fairweather NF & Douce GR (2016) . Scientific Reports, 6.
Willing SE, Candela T, Shaw HA, Seager Z, Mesnage S, Fagan RP & Fairweather NF (2015) . Molecular Microbiology, 96(3), 596-608.
Dembek M, Barquist L, Boinett CJ, Cain AK, Mayho M, Lawley TD, Fairweather NF & Fagan RP (2015) . MBIO, 6(2).
Pettit LJ, Browne HP, Yu L, Smits WK, Fagan RP, Barquist L, Martin MJ, Goulding D, Duncan SH, Flint HJ , Dougan G et al (2014) . BMC Genomics, 15(1).
Fagan RP & Fairweather NF (2014) . Nature Reviews Microbiology, 12(3), 211-222.
Mahon V, Fagan RP & Smith SGJ (2012) . Biochimie, 94(9), 2058-2061.
Deakin LJ, Clare S, Fagan RP, Dawson LF, Pickard DJ, West MR, Wren BW, Fairweather NF, Dougan G & Lawley TD (2012) . Infect Immun, 80(8), 2704-2711.
Tam Dang TH, Fagan RP, Fairweather NF & Tate EW (2012) . Bioorg Med Chem, 20(2), 614-621.
Fagan RP & Fairweather NF (2011) . J Biol Chem, 286(31), 27483-27493.
Fagan RP, Janoir C, Collignon A, Mastrantonio P, Poxton IR & Fairweather NF (2011) . J Med Microbiol, 60(Pt 8), 1225-1228.
Reynolds CB, Emerson JE, de la Riva L, Fagan RP & Fairweather NF (2011) . PLoS Pathog, 7(4), e1002024.
Dang THT, de la Riva L, Fagan RP, Storck EM, Heal WP, Janoir C, Fairweather NF & Tate EW (2010) . ACS Chem Biol, 5(3), 279-285.
Fagan R & Fairweather N (2010) . Methods Mol Biol, 646, 117-134.
Emerson JE, Reynolds CB, Fagan RP, Shaw HA, Goulding D & Fairweather NF (2009) . Mol Microbiol, 74(3), 541-556.
Fagan RP, Albesa-Jové D, Qazi O, Svergun DI, Brown KA & Fairweather NF (2009) . Mol Microbiol, 71(5), 1308-1322.
Fagan RP, Lambert MA & Smith SGJ (2008) . Infect Immun, 76(3), 1135-1142.
Smith SGJ, Mahon V, Lambert MA & Fagan RP (2007) . FEMS Microbiol Lett, 273(1), 1-11.
Fagan RP & Smith SGJ (2007) . FEMS Microbiol Lett, 269(2), 248-255.

Preprints

Buddle JE, Wright RCT, Turner CE, Chaudhuri RR, Brockhurst MA & Fagan RP (2023) .
Wilson JS, Fortier L-C, Fagan RP & Bullough PA (2023) .
Ormsby MJ, Vaz F, Kirk JA, Barwinska-Sendra A, Hallam JC, Lanzoni-Mangutchi P, Cole J, Chaudhuri RR, Salgado PS, Fagan RP & Douce GR (2022) , Cold Spring Harbor Laboratory.
Royer ALM, Umansky AA, Allen M-M, Garneau JR, Bedoya MO, Kirk JA, Govoni G, Fagan RP, Soutourina O & Fortier L-C (2022) , Cold Spring Harbor Laboratory.
Oatley P, Kirk J, Ma S, Jones S & Fagan R (2018) .
Banerji O, Lanzoni-Mangutchi P, Vaz F, Barwinska-Sendra A, Wilson J, Kirk J, O'Beirne S, Basle A, Omari KE, Wagner A , Fairweather N et al () .
Janganan TK, Mullin N, Dafis-Sagarmendi A, Brunt J, Tzokov SB, Stringer S, Moir A, Chaudhuri R, Fagan RP, Hobbs JK & Bullough PA () .
Alabdali YAJ, Oatley P, Kirk JA & Fagan RP () .

Teaching activities

Level 3 modules

MBB328 The Organisation of Bacterial Cells (Module Coordinator)
MBB335 Bacterial Pathogenicity (Module Coordinator)