Ariza, Antonio, Dr

Dr Antonio Ariza

School of Biosciences

University Teaching Associate in Molecular Biology

a.ariza@sheffield.ac.uk
+44 114 222 2386

Alfred Denny Building

Full contact details

Dr Antonio Ariza
School of Biosciences
Alfred Denny Building
Western Bank
��«Ӱҵ
S10 2TN

Profile

2021 – present: University Teaching Associate, University of ��«Ӱҵ
2014 – 2021: Postdoctoral Researcher, University of Oxford
2011 – 2013: Postdoctoral Researcher, University of Leeds
2007 – 2010: Postdoctoral Researcher, University of York
2006 – 2007: Postdoctoral Researcher, University of Dundee
2002 – 2006: Research Assistant, University of Dundee

I started my academic career when I joined the University of Abertay to study a BSc (Hons) in Biotechnology.

I then undertook a part-time PhD in Biochemistry and specialised in Structural Biology while I worked as a research assistant at the Welcome Trust in Dundee.

After obtaining my PhD, I worked as a postdoctoral research assistant in a hybrid industrial/academic setting at the University of York, where I solved many protein structures for Novozymes, the world’s largest industrial enzyme manufacturer.

I then moved on to purely academic studies of viral RNA-binding proteins at the University of Leeds, and enzymes involved in ADP-ribosylation, an important post-translational modification of proteins, at the University of Oxford.

I currently work at the University of ��«Ӱҵ, where I teach molecular biology as a University Teaching Associate and I also branch out from studying nucleic acid-binding proteins, which have been the main focus of my research since my PhD, to also study plastic-degrading enzymes, which marks a return to where my science career first started: research in biotechnology.

Qualifications

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2002-2006: PhD Structural Biology, University of Dundee
1995-2000: BSc (Hons) Microbial Biotechnology, University of Abertay

Research interests

I specialise in structural studies of nucleic-acid binding proteins. My research has spanned viral RNA-binding proteins, bacterial DNA-binding toxin-antitoxin systems and archaeal DNA-repair enzymes involved in homologous recombination.

I recently started working on plastic degrading enzymes with of view of using a biotechnological approach to tackle one of the world’s greatest environmental problems: plastic pollution.

Publications

Journal articles

Ariza A, Liu Q, Cowieson NP, Ahel I, Filippov DV & Rack JGM (2024) . Journal of Biological Chemistry, 300(10), 107770-107770.
Schuller M, Raggiaschi R, Mikolcevic P, Rack JGM, Ariza A, Zhang Y, Ledermann R, Tang C, Mikoc A & Ahel I (2023) . Molecular Cell.
Carnie CJ, Armstrong L, Sebesta M, Ariza A, Wang X, Graham E, Zhu K & Ahel D (2023) . Cell Reports, 42(4), 112329-112329.
Ariza A, Moroz OV, Blagova EV, Turkenburg JP, Waterman J, Roberts SM, Vind J, Sjøholm C, Lassen SF, De Maria L , Glitsoe V et al (2023) . PLoS ONE, 8(5), e65062-e65062.
Schuller M, Butler RE, Ariza A, Tromans-Coia C, Jankevicius G, Claridge TDW, Kendall SL, Goh S, Stewart GR & Ahel I (2021) . Nature, 596(7873), 597-602.
Rack JGM, Liu Q, Zorzini V, Voorneveld J, Ariza A, Honarmand Ebrahimi K, Reber JM, Krassnig SC, Ahel D, van der Marel GA , Mangerich A et al (2021) . Nature Communications, 12(1).
Suskiewicz MJ, Zobel F, Ogden TEH, Fontana P, Ariza A, Yang J-C, Zhu K, Bracken L, Hawthorne WJ, Ahel D , Neuhaus D et al (2020) . Nature, 579(7800), 598-602.
Suskiewicz MJ, Zobel F, Ogden TEH, Fontana P, Ariza A & Yang JC (2020) . Cancer Discovery, 10(4), 486.
Roth C, Moroz OV, Turkenburg JP, Blagova E, Waterman J, Ariza A, Ming L, Tianqi S, Andersen C, Davies GJ & Wilson KS (2019) . International Journal of Molecular Sciences, 20(19), 4902-4902.
Rack JGM, Ariza A, Drown BS, Henfrey C, Bartlett E, Shirai T, Hergenrother PJ & Ahel I (2018) . Cell Chemical Biology, 25(12), 1533-1546.e12.
Roth C, Moroz OV, Ariza A, Skov LK, Ayabe K, Davies GJ & Wilson KS (2018) . Acta Crystallographica Section D Structural Biology, 74(5), 463-470.
Sebesta M, Cooper CDO, Ariza A, Carnie CJ & Ahel D (2017) . Nature Communications, 8(1).
Jankevicius G, Ariza A, Ahel M & Ahel I (2016) . Molecular Cell, 64(6), 1109-1116.
Agirre J, Ariza A, Offen WA, Turkenburg JP, Roberts SM, McNicholas S, Harris PV, McBrayer B, Dohnalek J, Cowtan KD , Davies GJ et al (2016) . Acta Crystallographica Section D Structural Biology, 72(2), 254-265.
Gunn AR, Banos-Pinero B, Paschke P, Sanchez-Pulido L, Ariza A, Day J, Emrich M, Leys D, Ponting CP, Ahel I & Lakin ND (2016) . Journal of Cell Science.
Surtees R, Ariza A, Punch EK, Trinh CH, Dowall SD, Hewson R, Hiscox JA, Barr JN & Edwards TA (2015) . BMC Structural Biology, 15(1).
Rack JGM, Morra R, Barkauskaite E, Kraehenbuehl R, Ariza A, Qu Y, Ortmayer M, Leidecker O, Cameron DR, Matic I , Peleg AY et al (2015) . Molecular Cell, 59(2), 309-320.
Lambrecht MJ, Brichacek M, Barkauskaite E, Ariza A, Ahel I & Hergenrother PJ (2015) . Journal of the American Chemical Society, 137(10), 3558-3564.
Shepherd DA, Ariza A, Edwards TA, Barr JN, Stonehouse NJ & Ashcroft AE (2014) . Rapid Communications in Mass Spectrometry, 28(7), 793-800.
Tanner SJ, Ariza A, Richard C-A, Kyle HF, Dods RL, Blondot M-L, Wu W, Trincão J, Trinh CH, Hiscox JA , Carroll MW et al (2014) . Proceedings of the National Academy of Sciences, 111(4), 1580-1585.
Sanchez-Romero I, Ariza A, Wilson KS, Skjøt M, Vind J, De Maria L, Skov LK & Sanchez-Ruiz JM (2013) . PLoS ONE, 8(7), e70013-e70013.
Ariza A, Tanner SJ, Walter CT, Dent KC, Shepherd DA, Wu W, Matthews SV, Hiscox JA, Green TJ, Luo M , Elliott RM et al (2013) . Nucleic Acids Research, 41(11), 5912-5926.
Carter SD, Surtees R, Walter CT, Ariza A, Bergeron É, Nichol ST, Hiscox JA, Edwards TA & Barr JN (2012) . Journal of Virology, 86(20), 10914-10923.
Ariza A, Eklöf JM, Spadiut O, Offen WA, Roberts SM, Besenmatter W, Friis EP, Skjøt M, Wilson KS, Brumer H & Davies G (2011) . Journal of Biological Chemistry, 286(39), 33890-33900.
Vévodová J, Gamble M, Künze G, Ariza A, Dodson E, Jones DD & Wilson KS (2010) . Structure, 18(6), 744-755.
Jones DC, Ariza A, Chow W-HA, Oza SL & Fairlamb AH (2010) . Molecular and Biochemical Parasitology, 169(1), 12-19.
Ariza A, Vickers TJ, Greig N, Armour KA, Dixon MJ, Eggleston IM, Fairlamb AH & Bond CS (2006) . Molecular Microbiology, 59(4), 1239-1248.
Ariza A, Vickers TJ, Greig N, Fairlamb AH & Bond CS (2005) . Acta Crystallographica Section F Structural Biology and Crystallization Communications, 61(8), 769-772.
Ariza A (2005) . Nucleic Acids Research, 33(5), 1465-1473.
Fontana P, Buch-Larsen SC, Suyari O, Smith R, Suskiewicz MJ, Schützenhofer K, Ariza A, Rack JGM, Nielsen ML & Ahel I () . Nature Communications, 14(1).

Teaching interests

Teaching activities

Level 1 Modules

BISC001: Level 1 Tutorials, Skills and Employability
MBB225: Practical Molecular Bioscience 2

Level 2 Modules

BIS220: Philosophy and Ethics of Bioscience
MBB224: Skills in Molecular Biology

Level 3 Modules

BIS303: Research project
MBB31002: Literature Review
MBB303: Cellular Systems Engineering for Biotechnology
MBB340: The Microbiology of Extreme Environments

Level 4 Modules

MBB405: Advanced Research Topics

MSc Modules

MBB61006: Laboratory Techniques in Molecular Biology
MBB6303: Cellular Systems Engineering for Biotechnology
MBB6402: Literature Review
MBB6403: Research Project
MBB6405: Advanced Research Topics