Cooper, Gordon, Dr

Dr Gordon Cooper

School of Biosciences

Senior University Teacher

Examinations Officer

g.j.cooper@sheffield.ac.uk
+44 114 222 4667

B2 222a, Alfred Denny Building

Full contact details

Dr Gordon Cooper
School of Biosciences
B2 222a
Alfred Denny Building
Western Bank
��«Ӱҵ
S10 2TN

Profile

2019 - Present: Senior University Teacher and Examination Officer, School of Biosciences, University of ��«Ӱҵ
2014 - 2019: Senior Lecturer and Examination Officer, Department of Biomedical Science, University of ��«Ӱҵ
2002-2014: Lecturer, Department of Biomedical Science, University of ��«Ӱҵ
2000-02: Research Associate, Department of Biomedical Science, University of ��«Ӱҵ
1999-00: Research Associate - School of Biological Science, University of Manchester
1996-99: Postdoctoral Fellow - Dept. Cellular & Molecular Physiology, Yale University, New Haven, Ct, USA
1993-96: Research Associate - Dept. Physiology, University of Leeds
1990-93: Ph.D. - University of Leeds
1987-90: B.Sc. Physiology (Hons) - University of Leeds

Research interests

Transport of gases and urea by membrane proteins
Function of renal potassium channels

Epithelial Transport and the movement of small solutes across biological membranes

The underlying theme to my research has been the transport of small solutes and ions across biological membranes, in particular within the kidney and other epithelia. The regulated transport of small solutes such as urea and carbon dioxide plays a critical role in whole body homeostasis.

In classifying my current research I would split it into two major themes. Firstly is the transport of water and gases across biological membranes via Aquaporins. This theme incorporates collaborations with Walter Boron (Case Western) and Gordon Cramb (St Andrews). The second theme focuses on the handling of urea by the kidney, a process critical in the ability of the body to concentrate urine. This process of renal urea handling also has implications in the regulation of blood pressure. This theme involves collaborations with Craig Smith (Manchester) and Gavin Stewart (Dublin).

Over the last few years I have been actively involved in the redevelopment of the delivery of Physiology practical classes within the University. As part of a Physiological Society funded project I have co-ordinated the production of an online teaching resource that has facilitated the delivery of undergraduate practical sessions.

Publications

Show: Featured publications All publications

Featured publications

Journal articles

Abbas L, Hajihashemi S, Stead LF, Cooper GJ, Ware TL, Munsey TS, Whitfield TT & White SJ (2011) . J Physiol, 589(Pt 6), 1489-1503.
Endeward V, Musa-Aziz R, Cooper GJ, Chen LM, Pelletier MF, Virkki LV, Supuran CT, King LS, Boron WF & Gros G (2006) . FASEB Journal, 20(12), 1974-1981.
Cooper GJ & Boron WF (1998) . American Journal of Physiology-Cell Physiology, 275(6), C1481-C1486.

All publications

Journal articles

Cooper GJ, Occhipinti R & Boron WF (2015) . The Journal of Physiology, 593(23), 5033-5033.
Cooper GJ, Occhipinti R & Boron WF (2015) . The Journal of Physiology, 593(23), 5025-5028.
Abbas L, Hajihashemi S, Stead LF, Cooper GJ, Ware TL, Munsey TS, Whitfield TT & White SJ (2011) . J Physiol, 589(Pt 6), 1489-1503.
Laycock S, Taylor HC, Haigh C, Lee AT, Cooper GJ, Ong ACM & Robson L (2009) . Exp Physiol, 94(8), 914-927.
Stewart GS, Thistlethwaite A, Lees H, Cooper GJ & Smith C (2009) . AM J PHYSIOL-RENAL, 296(3), F642-F648.
Millar ID, Taylor HC, Cooper GJ, Kibble JD, Barhanin J & Robson L (2006) . Pflugers Arch, 453(1), 107-116.
Stewart GS, Smith CP & Cooper GJ (2006) . AM J PHYSIOL-RENAL, 290(6), F1437-F1442.
Endeward V, Musa-Aziz R, Cooper GJ, Chen LM, Pelletier MF, Virkki LV, Supuran CT, King LS, Boron WF & Gros G (2006) . FASEB Journal, 20(12), 1974-1981.
Millar ID, Taylor HC, Cooper GJ, Kibble JD & Robson L (2006) . J Membr Biol, 211(3), 173-184.
Fowler MR, Cooper GJ & Hunter M (2004) . AM J PHYSIOL-RENAL, 286(6), F1219-F1225.
Stewart GS, Fenton RA, Wang W, Kwon T-H, White SJ, Collins VM, Cooper G, Nielsen S & Smith CP (2004) . American Journal of Physiology-Renal Physiology, 286(5), F979-F987.
Cooper GJ & Fong P (2003) . Am J Physiol Cell Physiol, 284(2), C331-C338.
Fenton RA, Stewart GS, Carpenter B, Howorth A, Potter EA, Cooper GJ & Smith CP (2002) . AM J PHYSIOL-RENAL, 283(4), F817-F825.
Collins VM, Cooper GJ & White SJ (2002) Functional implications of an N-terminus truncation on rat ROMK2.. J AM SOC NEPHROL, 13, 71A-71A.
Fenton RA, Cooper GJ, Morris ID & Smith CP (2002) . American Journal of Physiology-Cell Physiology, 282(6), C1492-C1501.
Cooper GJ, Hill C & White SJ (2002) Effects of the Bartter's syndrome mutation M357T on ROMK2. J PHYSIOL-LONDON, 539, 3P-3P.
Park K, Hurley PT, Roussa E, Cooper GJ, Smith CP, Thévenod F, Steward MC & Case RM (2002) . Archives of Oral Biology, 47(1), 1-9.
Cooper GJ, Zhou Y, Bouyer P, Grichtchenko II & Boron WF (2002) . Journal of Physiology, 542(1), 17-29.
Virkki LV, Cooper GJ & Boron WF (2001) . American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 281(6), R1994-R2003.
Davis BA, Hogan EM, Cooper GJ, Bashi E, Zhao J & Boron WF (2001) . Journal of Membrane Biology, 183(1), 25-32.
Cooper GJ, Fowler M & Hunter M (2001) . Pflugers Arch, 442(2), 243-247.
Fenton RA, Howorth A, Cooper GJ, Meccariello R, Morris ID & Smith CP (2000) . American Journal of Physiology-Cell Physiology, 279(5), C1425-C1431.
Leipziger J, MacGregor GG, Cooper GJ, Xu J, Hebert SC & Giebisch G (2000) . American Journal of Physiology-Renal Physiology, 279(5), F919-F926.
Walsh PJ, Heitz MJ, Campbell CE, Cooper GJ, Medina M, Wang YS, Goss GG, Vincek V, Wood CM & Smith CP (2000) Molecular characterization of a urea transporter in the gill of the gulf toadfish (Opsanus beta). Journal of Experimental Biology, 203(15), 2357-2364.
Cooper GJ & Boron WF (1998) . American Journal of Physiology-Cell Physiology, 275(6), C1481-C1486.
Cooper GJ & Hunter M (1997) . The Journal of Physiology, 498(1), 49-59.
Cooper GJ & Hunter M (1996) . The Journal of Physiology, 491(1), 219-223.
Cooper GJ & Hunter M (1994) . The Journal of Physiology, 479(3), 423-432.
Cooper G, Hurst A, Lynch P & Hunter M (1994) . Kidney and Blood Pressure Research, 17(3-4), 138-142.
COOPER GJ & KOHN PG (1980) ALPHA-AMINOISOBUTYRIC-ACID TRANSPORT IN RAT SOLEUS MUSCLE AND ITS MODIFICATION BY MEMBRANE STABILIZERS AND INSULIN. J PHYSIOL-LONDON, 302(MAY), 89-105.
Cooper G (1979) . American Journal of Physiology-Heart and Circulatory Physiology, 236(2), H244-H253.
COOPER GJ & KOHN PG (1977) MECHANISM OF 2-AMINO-ISO-BUTYRIC ACID EFFLUX FROM RAT SOLEUS MUSCLE AND ITS MODIFICATION BY MEMBRANE STABILIZER, TETRACAINE. J PHYSIOL-LONDON, 271(2), P20-P20.
COOPER GJ & KOHN PG (1973) EFFECT OF TETRACAINE ON 2-AMINOISOBUTYRIC ACID TRANSPORT IN MUSCLE. J PHYSIOL-LONDON, 229(1), P23-&.

Conference proceedings papers

Collins VM, Cooper GJ & White SJ (2006) Apical membrane targeting of ROMK2 is independent of N-linked glycosylation. FASEB JOURNAL, Vol. 20(4) (pp A328-A328)
White SJ, Cooper GJ, Hajihashemi S, Ware TL & Murray LA (2003) Cloning and functional expression of zebrafish (Danio rerio) ROMK2 (Kir1.1 b).. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, Vol. 14 (pp 79A-79A)
Cooper GJ (2003) The functional unit of a frog urea transporter (fUT) is multimeric.. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, Vol. 14 (pp 75A-75A)
White SJ, Hajihasemi S, Cooper GJ, Robson L & Ortega B (2003) A C-terminal mutation enhances ROMK2 stability in oocytes and MDCK cells.. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, Vol. 14 (pp 78A-78A)
Collins VM, Cooper GJ & White SJ (2002) The N terminus of ROMK2 is necessary for channel function but not membrane trafficking. JOURNAL OF PHYSIOLOGY-LONDON, Vol. 544 (pp 8P-8P)
Cooper GJ & Hunter M (1993) Alteration of Na⁺-H⁺ exchanger setpoint by furosemide (frusemide) in frog isolated early distal tubule (EDT). Journal of Physiology, Vol. 467
Cooper G, Stone V & Hunter M (1992) Furosemide induces cytoplasmic alkalinization in frog early distal tubules. Journal of Physiology, Vol. 446

Grants

The Physiological Society - David Jordan Teaching Grant
NERC
Kidney Research UK.

Teaching activities

Undergraduate and postgraduate taught modules

Undergraduate:

BMS109-108 Physiology with Pharmacology
BMS109 Lab Skills & Skills Sessions
BMS109 Introduction to Organ Systems

BMS221 Physiology at the Extreme
BMS242/43 Career Development Skills (Coordinator)
BMS242/243 Core Phys Pharm
BMS242, 244 CVS Respiratory

BMS311 The Kidney in Health & Disease
BMS346 Epithelial Physiology in Health and Disease
BMS316 Group Research Initiatives (Coordinator)
Level 3 Practical and Dissertation Modules

Masters (MSc):

BMS6063 Epithelial Physiology in Health and Disease

Professional activities and memberships

Fellow of the Physiological Society
Senior Fellow of the Higher Education Academy (SFHEA)
Invited Speaking. September 2013 - Invited speaker at Symposium on Mammalian Urea Transporters held at University College in Dublin.