Maib, Hannes, Dr

Dr Hannes Maib

School of Biosciences

Research Fellow

h.maib@sheffield.ac.uk

Addison Building

Full contact details

Dr Hannes Maib
School of Biosciences
Addison Building
��«Ӱҵ
S10 2TN

Profile: • 2023 – Present - Wellcome Trust Early Career Fellow, University of ��«Ӱҵ

• 2019-2023 - Postdoctoral Research Assistant, University of Dundee, Cell and Developmental Biology, Supervisor: Dr. David Murray

• 2015-2019 - PhD University of ��«Ӱҵ, Supervisor: Prof Elizabeth Smythe

• 2013-2015 - MSc, Life and Medical Sciences, University of Bonn, Germany Supervisor: Prof Thorsten Lang

• 2010-2013 - Bsc, Molekulare Biomedizin, University of Bonn

Research interests: Membrane identity changes in control of contact site formation

Membrane identity is key to cellular function, with each organelle displaying distinct identity determinants. Among the main factors imposing this are phosphoinositides, a small family of phospholipids that act as signpost of membrane identity. Lipid kinases and phosphatases are capable of interconverting these lipids by addition or removal of phosphate groups, leading to 8 distinct phosphoinositides. Key interest of my lab is to understand how these conversion cascades are regulated and how these changes to membrane identity influence cellular processes. The recent realisation that almost all organelles are in constant communication with each other, through formation of dynamic membrane contact sites, has opened up new questions regarding the interplay of membrane identity and contact site formation. Importantly, these contact sites are essential for the intracellular transport of lipids and misregulation is associated with disease and hereditary disorders. Therefore, it is essential to gain a better understanding of the molecular mechanisms that regulate this fundamental aspect of cell biology in order to develop novel interventions.

Publications

Maib H, Adarska P, Hunton R, Vines JH, Strutt D, Bottanelli F & Murray DH (2024) . Journal of Cell Biology, 223(6).
Vines JH, Maib H, Buckley CM, Gueho A, Zhu Z, Soldati T, Murray DH & King JS (2023) . Journal of Cell Biology, 222(9).
Maib H & Murray DH (2022) . Current Biology, 32(13), 2821-2833.e6.
Gill MR, Jarman PJ, Hearnden V, Fairbanks SD, Bassetto M, Maib H, Palmer J, Ayscough KR, Thomas JA & Smythe C (2022) . Angew Chem Weinheim Bergstr Ger, 134(27), e202117449.
Maib H, Ferreira F, Vassilopoulos S & Smythe E (2018) . The Journal of Cell Biology, 217(12), 4253-4266.
Maib H, Smythe E & Ayscough KR (2017) . Molecular Biology of the Cell, 28(7), 843-847.
Edwards-Hicks J, Apostolova P, Buescher JM, Maib H, Stanczak MA, Corrado M, Klein Geltink RI, Maccari ME, Villa M, Carrizo GE , Sanin DE et al () . Nature Immunology.

Maib H, Adarska P, Hunton R, Vines J, Strutt D, Bottanelli F & Murray DH (2023) , Cold Spring Harbor Laboratory.
Alshahrani F, Zhu Z, Ferreira F, McComb A, Maib H, Pruzina S, Robinson D, Murray D & Smythe E (2023) , Cold Spring Harbor Laboratory.