Zeidler, Martin, Dr

Dr Martin Zeidler

School of Biosciences

Reader in Cell Signalling

m.zeidler@sheffield.ac.uk
+44 114 222 6093

+44 114 222 6094 (Lab phone)

Firth Court

Full contact details

Dr Martin Zeidler
School of Biosciences
Firth Court
Western Bank
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S10 2TN

Profile

Brief career history

2007-present: Reader, University of ��«Ӱҵ, UK.
2006-2007: Senior Lecturer, University of ��«Ӱҵ, UK.
2001-2006: Emmy Noether Independent Group Leader, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.
1996-2001: Postdoctoral Fellow, Department of Genetics, Harvard Medical School, Boston, MA, USA
1991-1996: Pre-doctoral student at the European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.
1987-1991: BSc in Biology with European Studies (German), The University of Sussex, Brighton, UK.

Research interests

Research interests

My lab is interested in identifying and analysing regulators of the JAK/STAT pathway– a signaling cascade frequently misactivated in haematopoietic malignancies.

We use both high throughput RNAi screening technologies and developmental genetic assays in Drosophila to determine the mechanisms of action of pathway regulators and their interactions in vivo.

JAK/STAT signalling in development and disease

My lab studies the regulators and roles of the JAK/STAT signal transduction cascade using a combination of human cell based approaches, Drosophila-based genetic screening and in vivo biology.

This work is aimed at generating insights into human inflammatory and haematopoietic disease.

The JAK/STAT pathway transduces the signals provided by multiple cytokines, growth factors and interferons. As a consequence, it plays a central role in development, cellular proliferation, stem cell maintenance, haematopoiesis and immunity.

In addition, inappropriate pathway activation is also linked to a wide range of human diseases including cancers, leukaemias, myeloproliferative neoplasms (MPNs) and inflammatory diseases such as rheumatoid arthritis.

Conserved throughout evolution, the pathways biological roles have also been largely maintained and as a result, many of the findings made in low complexity model systems such as Drosophila are applicable to humans.

The Zeidler lab has collaborations with a number of high profile groups including that of Tony Green (Cambridge) and Stefan Constantinescu (Brussels).

I have also collaborated and co-supervised joint PhD students with the Strutt and Smythe labs (BMS) and the Bellantuono lab (Human Metabolism).

In the future, I anticipate working more closely on Drosophila haematopoiesis (with lab of Iwan Evans) and on inflammatory aspects of JAK/STAT signalling humans.

In addition, we are also developing Zebrafish models of human myeloproliferative neoplasms in collaboration with the laboratory of Dr Rob Wilkinson (Cardiovascular Science). Insights gained from this work will also inform analysis using patient material which will be undertaken with Sally Thomas and John Snowden (NHS, Haematology).

Finally, ‘drug repurposing’ relating to our discovery of Methotrexate as a potent inhibitor of JAK/STAT pathway signalling will also be pursued.

Publications

Show: Featured publications All publications

Featured publications

Journal articles

Chinnaiya K, Lawson MA, Thomas S, Haider M-T, Down J, Chantry AD, Hughes D, Green A, Sayers JR, Snowden JA & Zeidler MP (2017) . Haematologica, 102, e336-e339.
Thomas S, Fisher KH, Snowden JA, Danson SJ, Brown S & Zeidler MP (2015) . PLOS ONE, 10(7).
Wells RE, Barry JD, Warrington SJ, Cuhlmann S, Evans P, Huber W, Strutt D & Zeidler MP (2013) . Development, 140(18), 3858-3868.
Bausek N & Zeidler MP (2013) Gα73Β is a downstream effector of JAK/STAT signaling and a regulator of Rho1 in Drosophila hematopoiesis. J Cell Sci.
Müller P, Kuttenkeuler D, Gesellchen V, Zeidler MP & Boutros M (2005) . Nature, 436(7052), 871-875.

All publications

Journal articles

Francis S, King T & Zeidler MP (2024) . Frontiers in Medicine, 11.
Brooks EC, Zeidler MP, Ong ACM & Evans IR (2024) . Frontiers in Immunology, 14.
Mullenger JL, Zeidler MP & Fragiadaki M (2023) . International Journal of Molecular Sciences, 24(16).
Coates JA, Brooks E, Brittle AL, Armitage EL, Zeidler MP & Evans IR (2021) . Elife, 10.
Moore R, Vogt K, Acosta-Martin A, Shire P, Zeidler M & Smythe E (2020) . Journal of Cell Science, 133.
Alqarni AM & Zeidler MP (2020) . Biochemical Society Transactions, 48(2), 559-567.
Gremese E, Alivernini S, Tolusso B, Zeidler MP & Ferraccioli G (2019) . Journal of Leukocyte Biology, 106(5), 1063-1068.
Francis S, Thomas S, Luben R, Sousos N, Mead A, Snowden JA & Zeidler MP (2019) . British Journal of Haematology, 187(3).
Bellantuono I, Chen Z, Slack C, Cordero J & Zeidler M (2018) . Innovation in Aging, 2(suppl_1), 545-545.
Fisher KH, Fragiadaki M, Pugazhendhi D, Bausek N, Arredondo MA, Thomas SJ, Brown S & Zeidler MP (2018) . Journal of Cell Science, 131(13).
Fragiadaki M & Zeidler MP (2018) . The Journal of Biological Chemistry, 293, 9570-9579.
Chinnaiya K, Lawson MA, Thomas S, Haider M-T, Down J, Chantry AD, Hughes D, Green A, Sayers JR, Snowden JA & Zeidler MP (2017) . Haematologica, 102, e336-e339.
Fisher KH, Stec W, Brown S & Zeidler MP (2016) . Molecular Biology of the Cell, 27(3), 421-598.
Thomas SJ, Snowden JA, Zeidler MP & Danson SJ (2015) . British Journal of Cancer, 113(3), 365-371.
Thomas S, Fisher KH, Snowden JA, Danson SJ, Brown S & Zeidler MP (2015) . PLOS ONE, 10(7).
Thomas S, Fisher K, Snowden J, Danson S, Brown S & Zeidler M (2015) . The Lancet, 385, S98-S98.
Bausek N & Zeidler MP (2014) . Development, 141(3), e308-e308.
Stec W, Vidal O & Zeidler MP (2013) . Mol Biol Cell, 24(18), 3000-3009.
Wells RE, Barry JD, Warrington SJ, Cuhlmann S, Evans P, Huber W, Strutt D & Zeidler MP (2013) . Development, 140(18), 3858-3868.
Johnstone K, Wells RE, Strutt D & Zeidler MP (2013) . PLoS One, 8(5), e65076.
Zeidler MP & Bausek N (2013) The Drosophila JAK-STAT pathway. JAK-STAT, 2(3).
Bausek N & Zeidler MP (2013) Gα73Β is a downstream effector of JAK/STAT signaling and a regulator of Rho1 in Drosophila hematopoiesis. J Cell Sci.
Fisher KH, Wright VM, Taylor A, Zeidler MP & Brown S (2012) . BMC Genomics, 13, 506.
Bausek N & Zeidler MP (2012) Matters of the heart. JAK-STAT, 1(3), 208-210.
Sun FF, Johnson JE, Zeidler MP & Bateman JR (2012) . G3 (Bethesda), 2(5), 551-553.
Müller P, Pugazhendhi D & Zeidler MP (2012) Modulation of human JAK-STAT pathway signaling by functionally conserved regulators. JAK-STAT, 1(1), 34-43.
Stec WJ & Zeidler MP (2011) . J Signal Transduct, 2011, 894510.
Wright VM, Vogt KL, Smythe E & Zeidler MP (2011) . Cell Signal, 23(5), 920-927.
Wright VM, Vogt KL, Smythe E & Zeidler MP (2011) . Cellular Signalling, 23(5), 920-927.
Vidal OM, Stec W, Bausek N, Smythe E & Zeidler MP (2010) . Development, 137(21), e2107-e2107.
Vidal OM, Stec W, Bausek N, Smythe E & Zeidler MP (2010) . J Cell Sci, 123(Pt 20), 3457-3466.
Bina S, Wright VM, Fisher KH, Milo M & Zeidler MP (2010) . EMBO Rep, 11(3), 201-207.
Rivas ML, Cobreros L, Zeidler MP & Hombría JC-G (2008) . EMBO Rep, 9(11), 1114-1120.
Brown S & Zeidler MP (2008) . Curr Opin Genet Dev, 18(5), 455-460.
Elliott GC & Zeidler MP (2008) . Insect Mol Biol, 17(5), 475-483.
Müller P, Boutros M & Zeidler MP (2008) . Semin Cell Dev Biol, 19(4), 360-369.
Arbouzova NI & Zeidler MP (2006) . Development, 133(14), 2605-2616.
Karsten P, Plischke I, Perrimon N & Zeidler MP (2006) . Cell Signal, 18(6), 819-829.
Brown S, Zeidler MP & Hombría JEC-G (2006) . Dev Dyn, 235(4), 958-966.
Mukherjee T, Schäfer U & Zeidler MP (2006) . Genetics, 172(3), 1683-1697.
Arbouzova NI, Bach EA & Zeidler MP (2006) . Curr Biol, 16(1), 80-88.
Hombría JC-G, Brown S, Häder S & Zeidler MP (2005) . Dev Biol, 288(2), 420-433.
Müller P, Kuttenkeuler D, Gesellchen V, Zeidler MP & Boutros M (2005) . Nature, 436(7052), 871-875.
Mukherjee T, Hombría JC-G & Zeidler MP (2005) . Oncogene, 24(15), 2503-2511.
Zeidler MP, Tan C, Bellaiche Y, Cherry S, Häder S, Gayko U & Perrimon N (2004) . Nat Biotechnol, 22(7), 871-876.
Bach EA, Vincent S, Zeidler MP & Perrimon N (2003) A sensitized genetic screen to identify novel regulators and components of the Drosophila janus kinase/signal transducer and activator of transcription pathway.. Genetics, 165(3), 1149-1166.
Karsten P, Häder S & Zeidler MP (2002) . Mech Dev, 117(1-2), 343-346.
Zeidler MP, Perrimon N & Strutt DI (2000) . Dev Biol, 228(2), 181-196.
Zeidler MP & Perrimon N (2000) . Curr Biol, 10(18), R682-R684.
Zeidler MP, Bach EA & Perrimon N (2000) . Oncogene, 19(21), 2598-2606.
Zeidler MP, Perrimon N & Strutt DI (1999) . Curr Biol, 9(23), 1363-1372.
Zeidler MP, Perrimon N & Strutt DI (1999) . Genes Dev, 13(10), 1342-1353.
Zeidler MP & Mlodzik M (1997) . Biol Chem, 378(10), 1119-1124.
Zeidler MP, Yokomori K, Tjian R & Mlodzik M (1996) . Genes Dev, 10(1), 50-59.
Yokomori K, Zeidler MP, Chen JL, Verrijzer CP, Mlodzik M & Tjian R (1994) . Genes Dev, 8(19), 2313-2323.
Thompson KS, Zeidler MP & Bacon JP (1994) . J Comp Neurol, 347(4), 553-569.
Chen Z, Cordero J, Alqarni AM, Slack C, Zeidler MP & Bellantuono I () . The Journals of Gerontology: Series A.
Chen Z, Cordero J, Slack C, Zeidler M & Bellantuono I () .

Chapters

Fisher KH, Brown S & Zeidler MP (2013) (pp. 81-97).

Conference proceedings papers

Thomas SJ, Fisher K, Brown S, Snowden JA, Danson S & Zeidler M (2014) . Blood, Vol. 124(21) (pp 4577-4577)
Wells R, Strutt D & Zeidler M (2009) . MECHANISMS OF DEVELOPMENT, Vol. 126 (pp S176-S176)
Brown S, Smythe E, Strutt D, Whitworth A & Zeidler M (2009) . MECHANISMS OF DEVELOPMENT, Vol. 126 (pp S290-S290)

Preprints

Brooks EC, Zeidler MP, Ong ACM & Evans IR (2023) , Cold Spring Harbor Laboratory.
Fisher KH, Fragiadaki M, Pugazhendhi D, Bausek N, Brown S & Zeidler MP (2017) , Cold Spring Harbor Laboratory.
Coates JA, Brittle A, Armitage EL, Zeidler MP & Evans IR () .

Grants

Funding

CR-UK Fellowship
UoS Schemes
Cancer Research UK
Wellcome Trust

Teaching activities

Undergraduate

BMS109 Lab Skills & Skills Sessions
BMS242/243 Principles of Developmental Biology
BMS301 Membrane Receptors
BMS356 Biomedical Technology & Drug Discovery (Co-ordinator)

Masters (MSc)

BMS6083 Practical Developmental Genetics

Professional activities and memberships

CR-UK Senior Cancer Research Fellow
Former Emmy Noether Career Development Fellow and CRUK Senior Cancer Research Fellow
Founder and academic director of the (SRSF)
Supervised 13x PhD students
Journal Editor and reviewer for many journals and grant awarding bodies
Fellow of the Higher Education Academy (FHEA)
Teaching at all Undergraduate levels