Murdoch, Craig, Professor

Professor Craig Murdoch

BSc (Hons), PhD

School of Clinical Dentistry

Professor in Oral Bioscience

c.murdoch@sheffield.ac.uk
+44 114 215 9367

19 Claremont Crescent

Full contact details

Professor Craig Murdoch
School of Clinical Dentistry
19 Claremont Crescent
��«Ӱҵ
S10 2TA

Profile

After graduating with a BSc dual honours in Biochemistry/Microbiology I gained a PhD at the Institute of Child Health, University of ��«Ӱҵ investigating the role of chemokine receptors on endothelial and epithelial cells within the research group of Prof Adam Finn. Following a brief spell researching the pathogenesis of pneumococcal pneumonia, I spent five years working as a post-doctoral researcher in Prof Claire Lewis’s group on tumour-associated macrophages in the Department of Oncology at the University of ��«Ӱҵ Medical School.

I was appointed Lecturer at the School of Clinical Dentistry in 2006, Senior Lecturer in 2012, Reader in 2015 and then to Personal Chair in 2019 where my research encompasses understanding the molecular mechanism of oral disease.

Research interests

My main interests are centred on oral epithelial biology and the molecular mechanisms of oral diseases and their systemic sequalae. I am particularly interested in how immune cells are recruited to diseased oral sites and how they interact with other cells/microbes within the local microenvironment. As part of this research my group has developed novel tissue engineered in vitro models of both healthy and diseased oral mucosa to investigate pathogenic mechanisms. I have a long-standing track record of developing and utilising in vitro 3D tissue constructs and zebrafish larvae as direct replacements for animal models and have used these experimental models to study the role of oral microorganisms in mucosal and systemic disease. I am also involved with projects aimed at developing novel oral patches for mucosal drug delivery (with AFYX Therapeutics) and how mathematical modelling of oral tissue can aid the development of drug delivery systems (with University of Liverpool) and non-invasive diagnostics for the detection and management of oral pre-malignant lesions (with Zilico).

Current projects include:

Role of innate immune cells in head and neck cancer.
Development of tissue engineered immunocompetent oral mucosal and skin models.
Host-pathogen interactions at the mucosal surface.
Use of zebrafish to examine the role of oral microbes in systemic disease.
Novel forms of oral mucosal drug delivery and the role of xenobiotic metabolising enzymes in the oral mucosa.

Research group

Amy Harding (PDRA): Development and validation of tissue-engineered skin equivalents to detect skin irritation. (Rohto Pharmaceutical Company Limited) with Dr Helen Colley & Dr Simon Danby.
Bethany Ollington: Use of immune-competent tissue engineered oral mucosal equivalents to model oral infection. (with Dr Helen Colley, MRC DiMeN Studentship)
Inmaculada Barragan Vazquez: Tissue engineered modelling of atopic dermatitis (with Dr Helen Colley & Dr Simon Danby, Almirall S.A.-funded PhD Studentship)
Asma El-Howati: Development of tissue engineered oral inflammatory lesions (with Dr Helen Colley, Funded by Libyan Government Scholarship)
Antonia Cutts: Use of in vitro and in vivo zebrafish embryo infection models to investigate the role of oral microorganisms in cardiovascular disease. (with Prof Graham Stafford, University Faculty Studentship)
Klaudia Slowik: The role of xenobiotic metabolising enzymes in drug delivery for prevention of alveolar osteitis. (with Dr Helen Colley, EPSRC-Funded Studentship)
Jake Edmans: Peptide delivery using electrospun mucoadhesive patches (with Dr Helen Colley, Dr Seb Spain and Prof Paul Hatton, EPSRC Centre for Doctoral Training in Polymers and Soft Matter/ AFYX Therapeutics studentship)
Asmaa Zanki: Fabrication of dentures with anti-fungal properties by additive manufacturing. (with Prof Paul Hatton - Funded by Kuwait Government Scholarship)

Publications

Journal articles

Edwards SM, Harding AL, Leedale JA, Webb SD, Colley HE, Murdoch C & Bearon RN (2024) . International Journal of Pharmaceutics, 124827-124827.
Slowik KM, Edmans JG, Harrison S, Edwards SM, Bolt R, Spain SG, Hatton PV, Murdoch C & Colley HE (2024) . J Control Release.
El-Howati A, Edmans JG, Santocildes-Romero ME, Madsen LS, Murdoch C & Colley HE (2024) . Journal of Investigative Dermatology.
Edmans JG, Harrison S, Hatton PV, Murdoch C, Spain SG & Colley HE (2024) . Biomaterials Advances, 157.
Edmans JG, Murdoch C, Hatton PV, Madsen LS, Santocildes-Romero ME, Spain SG & Colley HE (2023) . Biomedical Materials & Devices.
Edmans JG, Ollington B, Colley HE, Santocildes-Romero ME, Siim Madsen L, Hatton PV, Spain SG & Murdoch C (2022) . Journal of Controlled Release, 350, 146-157.
Heath JP, Hunter KD, Murdoch C & Walker DC (2022) . Sensors, 22(15).
Farrugia C, Stafford GP, Gains AF, Cutts AR & Murdoch C (2022) . Journal of Periodontology.
Niklander SE, Murdoch C & Hunter KD (2021) . Frontiers in Oral Health, 2.
Ollington B, Colley HE & Murdoch C (2021) . Tissue Engineering Part C: Methods.
West H, Roberts F, Sweeney P, Walker-Samuel S, Leedale J, Colley H, Murdoch C, Shipley RJ & Webb S (2021) . PLoS ONE, 16(7).
Harding AL, Murdoch C, Danby S, Hasan MZ, Nakanishi H, Furuno T, Hadad S, Turner R & Colley HE (2021) . JID Innovations, 1(2), 100011-100011.
McRae MP, Kerr AR, Janal MN, Thornhill M, Redding S, Vigneswaran N, Kang SK, Niederman R, Christodoulides NJ, Trochesset DA , Murdoch C et al (2021) . Journal of Dental Research, 100(5), 479-486.
Farrugia C, Stafford GP, Potempa J, Wilkinson RN, Chen Y, Murdoch C & Widziolek M (2021) . The FEBS Journal, 288(5), 1479-1495.
Said Z, Murdoch C, Hansen J, Siim Madsen L & Colley HE (2021) . European Journal of Oral Sciences.
Al-Sahaf S, Hendawi NB, Ollington B, Bolt R, Ottewell PD, Hunter KD & Murdoch C (2021) . Frontiers in Oral Health, 2.
Farrugia C, Stafford GP & Murdoch C (2020) . Journal of Dental Research, 99(13), 1494-1501.
Mouhat M, Moorehead R & Murdoch C (2020) . Biomaterial Investigations in Dentistry, 7(1), 146-157.
Edmans JG, Murdoch C, Santocildes-Romero ME, Hatton PV, Colley HE & Spain SG (2020) . Materials Science and Engineering: C, 112.
Edmans JG, Clitherow KH, Murdoch C, Hatton PV, Spain SG & Colley HE (2020) . Pharmaceutics, 12(6).
Clitherow KH, Binaljadm TM, Hansen J, Spain SG, Hatton PV & Murdoch C (2020) . ACS Biomaterials Science & Engineering.
Ferreira SBDS, Hoshino LVDC, Slowik K, Baesso ML, Murdoch C, Colley H & Bruschi ML (2020) . European Journal of Pharmaceutical Sciences.
Leedale JA, Kyffin JA, Harding AL, Colley HE, Murdoch C, Sharma P, Williams DP, Webb SD & Bearon RN (2020) . Interface Focus, 10(2).
McRae MP, Modak SS, Simmons GW, Trochesset DA, Kerr AR, Thornhill MH, Redding SW, Vigneswaran N, Kang SK, Christodoulides NJ , Murdoch C et al (2020) . Cancer Cytopathology, 128(3), 207-220.
Ferreira SBDS, Braga G, Oliveira ÉL, da Silva JB, Rosseto HC, de Castro Hoshino LV, Baesso ML, Caetano W, Murdoch C, Colley HE & Bruschi ML (2019) . Beilstein Journal of Nanotechnology, 10, 2304-2328.
Leedale J, Colley HE, Gaskell H, Williams DP, Bearon RN, Chadwick AE, Murdoch C & Webb SD (2019) . Computational Toxicology, 12.
Sah P, Patel P, Chandrashekar C, Martena S, Ballal M, Hegde M, Guddattu V, Murdoch C, Sharma M & Radhakrishnan R (2019) . Journal of Investigative and Clinical Dentistry, 10(4).
Kyffin JA, Cox CR, Leedale J, Colley HE, Murdoch C, Mistry P, Webb SD & Sharma P (2019) . Current Protocols in Toxicology, 81(1).
Al-Zubidi M, Widziolek M, Court EK, Gains AF, Smith RE, Ansbro K, Alrafaie A, Evans C, Murdoch C, Mesnage S , Douglas CWI et al (2019) . Infection and Immunity.
Swidergall M, Khalaji M, Solis NV, Moyes DL, Drummond RA, Hube B, Lionakis MS, Murdoch C, Filler SG & Naglik JR (2019) . The Journal of Infectious Diseases.
Tomlinson L, Lu ZQ, Bentley RA, Colley HE, Murdoch C, Webb SD, Cross MJ, Copple IM & Sharma P (2019) . BIOMEDICINE, 112.
Mariño-Crespo Ó, Cuevas-Álvarez E, Harding AL, Murdoch C, Fernández-Briera A & Gil-Martín E (2019) . Cellular and molecular biology.
Kyffin JA, Sharma P, Leedale J, Colley HE, Murdoch C, Harding AL, Mistry P & Webb SD (2019) . Toxicology in Vitro, 55, 160-172.
Al-Sahaf S, Hunter KD, Bolt R, Ottewell PD & Murdoch C (2019) . International Journal of Cancer, 144(2), 334-344.
Colley HE, Said Z, Santocildes-Romero ME, Baker SR, D'Apice K, Hansen J, Madsen LS, Thornhill MH, Hatton PV & Murdoch C (2018) . Biomaterials, 178, 134-146.
Hearnden V, Murdoch C, D'Apice K, Duthie S, Hayward NJ & Powers HJ (2018) . BMJ Open, 8(8).
Leedale J, Sharkey KJ, Colley HE, Norton ÁM, Peeney D, Mason CL, Sathish JG, Murdoch C, Sharma P & Webb SD (2018) . iScience, 4, 84-96.
Smith SA, Colley HE, Sharma P, Slowik KM, Sison-Young R, Sneddon A, Webb SD & Murdoch C (2018) . Experimental Dermatology, 27(5), 473-475.
Hearnden V, Powers HJ, Elmogassabi A, Lowe R & Murdoch C (2018) . European Journal of Nutrition, 57(4), 1321-1332.
Kyffin JA, Sharma P, Leedale J, Colley HE, Murdoch C, Mistry P & Webb SD (2018) . Toxicology in Vitro, 48, 262-275.
Grayson A , Hearnden VL, Bolt R, Jebreel A, Colley HE & Murdoch C (2018) . Journal of Tissue Engineering and Regenerative Medicine, 12(3), e1636-e1646.
Walladbegi J, Smith SA, Grayson A, Murdoch C, Jontell M & Colley HE (2018) . Journal of Oral Pathology and Medicine.
Bolt RW, Foran B, Murdoch , Lambert , Thomas S & Hunter K (2018) . Carcinogenesis, 39(2), 170-179.
Morse DJ, Wilson MJ, Wei X , Lewis MAO , Bradshaw DJ , Murdoch C & Williams DW (2018) . Journal of Medical Microbiology.
Madden JC, Webb S, Enoch SJ, Colley HE, Murdoch C, Shipley R, Sharma P, Yang C & Cronin MTD (2017) . Computational Toxicology, 3, 44-57.
Santocildes-Romero ME, Hadley L, Clitherow KH, Hansen J, Murdoch C, Colley HE, Thornhill M & Hatton PV (2017) . ACS Applied Materials and Interfaces, 9(13), 11557-11567.
Naylor KL, Widziolek M, Hunt S, Conolly M, Hicks M, Stafford P, Potempa J, Murdoch C, Douglas CWI & Stafford GP (2017) . MicrobiologyOpen, 6(1).
Jennings L, Colley HE, Ong J, Panagakos F, Masters J, Trivedi H, Murdoch C & Whawell S (2016) . Tissue Engineering Part C: Methods, 22(2), 1108-1117.
Widziolek M, Prajsnar TK, Tazzyman S, Stafford GP, Potempa J & Murdoch C (2016) . Scientific Reports, 6, 36023-36023.
Abram TJ, Floriano PN, Christodoulides N, James R, Kerr AR, Thornhill MH, Redding SW, Vigneswaran N, Speight PM, Vick J , Murdoch C et al (2016) . Oral Oncology, 60, 103-111.
Bolt R, Lambert D, Murdoch C, Thomas S, Foran B & Hunter K (2016) . European Journal of Cancer, 61, S60-S60.
Gaskell H, Sharma P, Colley HE, Murdoch C, Williams DP & Webb SD (2016) . Toxicology Research, 5, 1053-1065.
Speight PM, Abram TJ, Floriano PN, James R, Vick J, Thornhill MH, Murdoch C, Freeman C, Hegarty AM, D'Apice K , Kerr AR et al (2015) . Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 120(4), 474-482.e2.
Muthana M, Kennerley AJ, Hughes R, Faganano E, Richardson J, Paul M, Murdoch C, Wright F, Payne C, Lythgoe MF , Farrow N et al (2015) . Nature Communications, 6.
Boadi J, Fernandes J, Mittar S, Hearnden V, Lu Z, MacNeil S, Thornhill MH, Murdoch C, Hunter KD & Matcher SJ (2015) . Sovremennye tehnologii v medicine, 7(1), 60-68.
Murdoch C, D'Apice K, Brown B, Hearnden V, Speight P, Hegarty A, Healey J, Highfield P, Tidy J & Thornhill M (2014) . International Journal of Nanomedicine, 9, 4521-4532.
Colley HE, Hearnden V, Avila-Olias M, Cecchin D, Canton I, Madsen J, MacNeil S, Warren N, Hu K, McKeating JA , Armes SP et al (2014) . Mol Pharm, 11(4), 1176-1188.
Pinnock A, Murdoch C, Moharamzadeh K, Whawell S & Douglas CWI (2014) . Microbes Infect, 16(4), 310-319.
Sorrell I, Shipley RJ, Hearnden V, Colley HE, Thornhill MH, Murdoch C & Webb SD (2014) . Nanomedicine: Nanotechnology, Biology and Medicine, 10(2), 339-348.
Tazzyman S, Murdoch C, Harrison J, Yeomans J & Muthana M (2014) . Hypoxia, 2, 185-196.
Wayakanon K, Thornhill MH, Douglas CWI, Lewis AL, Warren NJ, Pinnock A, Armes SP, Battaglia G & Murdoch C (2013) . FASEB J, 27(11), 4455-4465.
Stafford P, Higham J, Pinnock A, Murdoch C, Douglas CWI, Stafford GP & Lambert DW (2013) . Mol Oral Microbiol, 28(5), 366-378.
Murdoch C, Speight PM, D'Apice K, Hearnden V, Hegarty A, Tidy J, Healey J, Brown B & Thornhill MH (2013) . Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 116(3), e201-e201.
Colley HE, Eves PC, Pinnock A, Thornhill MH & Murdoch C (2013) . Int J Radiat Biol, 89(11), 907-914.
West L, Lowman DW, Mora-Montes HM, Grubb S, Murdoch C, Thornhill MH, Gow NAR, Williams D & Haynes K (2013) . J Biol Chem, 288(30), 22006-22018.
Tazzyman S, Niaz H & Murdoch C (2013) . Semin Cancer Biol, 23(3), 149-158.
Al-Husari M, Murdoch C & Webb SD (2013) . Journal of Mathematical Biology, 69(4), 839-873.
Pal A, Melling G, Hinsley EE, Kabir TD, Colley HE, Murdoch C & Lambert DW (2013) . J Oral Pathol Med, 42(4), 309-314.
Elbarghati L, Azzouz L, Murdoch C, Corke K, Burton J & Lewis C (2012) . Egyptian Journal of Pathology, 32(2), 217-226.
Moharamzadeh K, Colley H, Murdoch C, Hearnden V, Chai WL, Brook IM, Thornhill MH & Macneil S (2012) . J Dent Res, 91(7), 642-650.
Smith LE, Hearnden V, Lu Z, Smallwood R, Hunter KD, Matcher SJ, Thornhill MH, Murdoch C & MacNeil S (2011) . J Biomed Opt, 16(11), 116015.
Cleary IA, Reinhard SM, Miller CL, Murdoch C, Thornhill MH, Lazzell AL, Monteagudo C, Thomas DP & Saville SP (2011) . Microbiology, 157(Pt 6), 1806-1815.
Coffelt SB, Chen Y-Y, Muthana M, Welford AF, Tal AO, Scholz A, Plate KH, Reiss Y, Murdoch C, De Palma M & Lewis CE (2011) . J Immunol, 186(7), 4183-4190.
Tazzyman S, Barry ST, Ashton S, Wood P, Blakey D, Lewis CE & Murdoch C (2011) . Int J Cancer, 129(4), 847-858.
Muthana M, Giannoudis A, Scott SD, Fang H-Y, Coffelt SB, Morrow FJ, Murdoch C, Burton J, Cross N, Burke B , Mistry R et al (2011) . Cancer Res, 71(5), 1805-1815.
Murdoch C, Aziz HA, Fang HY, Jezan H, Musaid R & Muthana M (2011) . Journal of Ethnopharmacology, 138(3), 780-787.
Colley HE, Hearnden V, Jones AV, Weinreb PH, Violette SM, MacNeil S, Thornhill MH & Murdoch C (2011) . British Journal of Cancer, 105(10), 1582-1592.
Yadev NP, Murdoch C, Saville SP & Thornhill MH (2011) . Microbial Pathogenesis, 50(6), 278-285.
Dogan S, Zhang Q, Pridmore AC, Mitchell TJ, Finn A & Murdoch C (2011) . Microbes and Infection, 13(1), 65-75.
Murdoch C, Reeves KJ, Hearnden V, Colley H, Massignani M, Canton I, Madsen J, Blanazs A, Armes SP, Lewis AL , Macneil S et al (2010) . Nanomedicine (Lond), 5(7), 1025-1036.
Cleary IA, Mulabagal P, Reinhard SM, Yadev NP, Murdoch C, Thornhill MH, Lazzell AL, Monteagudo C, Thomas DP & Saville SP (2010) . Eukaryot Cell, 9(9), 1363-1373.
Coffelt SB, Tal AO, Scholz A, De Palma M, Patel S, Urbich C, Biswas SK, Murdoch C, Plate KH, Reiss Y & Lewis CE (2010) . Cancer Res, 70(13), 5270-5280.
Khurram SA, Whawell SA, Bingle L, Murdoch C, McCabe BM & Farthing PM (2010) . J Pathol, 221(2), 153-163.
Grubb SEW, Murdoch C, Sudbery PE, Saville SP, Lopez-Ribot JL & Thornhill MH (2009) . Infect Immun, 77(9), 3872-3878.
Fang H-Y, Hughes R, Murdoch C, Coffelt SB, Biswas SK, Harris AL, Johnson RS, Imityaz HZ, Simon MC, Fredlund E , Greten FR et al (2009) . Blood, 114(4), 844-859.
Hearnden V, Lomas H, Macneil S, Thornhill M, Murdoch C, Lewis A, Madsen J, Blanazs A, Armes S & Battaglia G (2009) . Pharm Res, 26(7), 1718-1728.
Tazzyman S, Lewis CE & Murdoch C (2009) . Int J Exp Pathol, 90(3), 222-231.
Grubb SEW, Murdoch C, Sudbery PE, Saville SP, Lopez-Ribot JL & Thornhill MH (2008) . Infect Immun, 76(10), 4370-4377.
Murdoch C, Muthana M, Coffelt SB & Lewis CE (2008) . Nat Rev Cancer, 8(8), 618-631.
Larsen M, Tazzyman S, Lund EL, Junker N, Lewis CE, Kristjansen PEG & Murdoch C (2008) . CANCER LETT, 265(2), 239-249.
Muthana M, Scott SD, Farrow N, Morrow F, Murdoch C, Grubb S, Brown N, Dobson J & Lewis CE (2008) . Gene Ther, 15(12), 902-910.
Pahler JC, Tazzyman S, Erez N, Chen YY, Murdoch C, Nozawa H, Lewis CE & Hanahan D (2008) . Neoplasia, 10(4), 329-339.
Elbarghati L, Murdoch C & Lewis CE (2008) . Immunobiology, 213(9-10), 899-908.
De Palma M, Murdoch C, Venneri MA, Naldin L & Lewis CE (2007) . TRENDS IMMUNOL, 28(12), 519-524.
Webb SD, Owen MR, Byrne HM, Murdoch C & Lewis CE (2007) . B MATH BIOL, 69(5), 1747-1776.
Murdoch C, Tazzyman S, Webster S & Lewis CE (2007) Expression of Tie-2 by human monocytes and their responses to angiopoietin-2. J.Immunol., 178(11), 7405-7411.
Faber J, Schuessler T, Finn A, Murdoch C, Zenz W, Habermehl P, Meyer CU, Zabel BU, Schmitt HJ, Zepp F & Knuf M (2007) . PEDIATR INFECT DIS J, 26(3), 243-246.
Faber J, Meyer CU, Gemmer C, Russo A, Finn A, Murdoch C, Zenz W & Mannhalter C (2006) . PEDIATR INFECT DIS J, 25(1), 80-81.
Murdoch C & Lewis CE (2005) . Int J Cancer, 117(5), 701-708.
Murdoch C, Muthana M & Lewis CE (2005) . J Immunol, 175(10), 6257-6263.
Lewis C & Murdoch C (2005) . Am J Pathol, 167(3), 627-635.
Murdoch C, Giannoudis A & Lewis CE (2004) . Blood, 104(8), 2224-2234.
Zhang Q, Arnaoutakis K, Murdoch C, Lakshman R, Race G, Burkinshaw R & Finn A (2004) . Pediatr Infect Dis J, 23(4), 307-313.
Lakshman R, Murdoch C, Race G, Burkinshaw R, Shaw L & Finn A (2003) . Arch Dis Child, 88(3), 211-214.
Murdoch C, Read RC, Zhang Q & Finn A (2002) . J Infect Dis, 186(9), 1253-1260.
Rao WH, Murdoch C, Johnson JR, Evans GS & Finn A (2001) . Urol Res, 29(2), 102-107.
Murdoch C (2000) . Immunol Rev, 177, 175-184.
Murdoch C & Finn A (2000) Chemokine receptors and their role in inflammation and infectious diseases.. Blood, 95(10), 3032-3043.
Murdoch C & Finn A (2000) . Blood, 95(10), 3032-3043.
Murdoch C & Finn A (2000) . J Vasc Res, 37(1), 1-7.
Murdoch C, Monk PN & Finn A (1999) . Immunology, 98(1), 36-41.
Murdoch C, Monk PN & Finn A (1999) . Cytokine, 11(9), 704-712.
Prest SJ, Rees RC, Murdoch C, Marshall JF, Cooper PA, Bibby M, Li G & Ali SA (1999) Chemokines induce the cellular migration of MCF-7 human breast carcinoma cells: Subpopulations of tumour cells display positive and negative chemotaxis and differential in vivo growth potentials. CLIN EXP METASTAS, 17(5), 389-396.
Murdoch C, Monk PN, Pease JE, Barker MD & Finn A (1997) . Immunology Letters, 56, 101-101.
El‐Howati A, Thornhill MH, Colley HE & Murdoch C () . Oral Diseases.
Clitherow KH, Murdoch C, Spain SG, Handler AM, Colley HE, Stie MB, Mørck Nielsen H, Janfelt C, Hatton PV & Jacobsen J () . Molecular Pharmaceutics.
Darda L, Hakami F, Morgan R, Murdoch C, Lambert DW & Hunter KD () . PLOS ONE, 10(4), e0122285-e0122285.

Chapters

Moharamzadeh K, Colley H, Hearnden V & Murdoch C (2017) , Biomaterials for Oral and Dental Tissue Engineering (pp. 245-255). Elsevier
Akbari Z, Almeida L, Almela T, Amdjadi P, Amrollahi P, Ansari S, Bader R, Baghaban Eslaminejad M, Bardsley K, Bencharit S , Bindal P et al (2017) , Biomaterials for Oral and Dental Tissue Engineering (pp. xiii-xvii). Elsevier
Murdoch C & Finn A (2003) (pp. 38-57).

Conference proceedings papers

Saad S, Murdoch C, Workman V, Hearnden V, Macneil S & Chapple CR (2023) . European Urology, Vol. 83 (pp S1190-S1190)
Edmans J, Ollington B, Murdoch C, Spain S, Hatton P & Colley H (2023) ELECTROSPUN PATCH DELIVERY OF ANTI-TNF. F(AB) ANTIBODY FRAGMENT FOR THE TREATMENT OF ORAL MUCOSAL INFLAMMATORY DISEASES. TISSUE ENGINEERING PART A, Vol. 29(11-12) (pp 360-360)
Slowik K, Edmans J, Spain S, Murdoch C, Hatton P & Colley H (2023) ELECTROSPUN ORAL PATCHES FOR PAIN RELIEF OF DRY SOCKET. TISSUE ENGINEERING PART A, Vol. 29(11-12) (pp 1530-1530)
Vazquez IB, Danby S, Garcia Gonzalez VM, Lopez Almagro R, Crespo Crespo MI, Colley H & Murdoch C (2023) AN IN VITRO IMMUNOCOMPETENT HUMAN TISSUE-ENGINEERED MODEL OF ATOPIC DERMATITIS FOR DRUG TESTING. TISSUE ENGINEERING PART A, Vol. 29(11-12) (pp 492-492)
Barragan Vazquez I, Danby S, Garcia Gonzalez VM, Lopez Almagro R, Colley HE & Murdoch C (2022) Development of an in vitro immunocompetent human skin-equivalent model. BRITISH JOURNAL OF DERMATOLOGY, Vol. 187(1) (pp E29-E29)
Harding A, Danby S, Murdoch C, Hasan MZ & Colley H (2022) Development and validation of tissue-engineered human skin equivalents to detect stinging potential. BRITISH JOURNAL OF DERMATOLOGY, Vol. 187(1) (pp E31-E31)
Colley HE, Said Z, Santocildes-Romero ME, Baker SR, D'Apice K, Hansen J, Madsen LS, Thornhill MH, Hatton PV & Murdoch C (2018) . Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Vol. 126(4) (pp e204-e204)
Amabebe E, Qiao H, Murdoch C & Anumba D (2018) Vaginal epithelial cells co-cultured with Lactobacillus and anaerobes differentially express acetate and CXCL8. BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Vol. 125 (pp 90-90)
Webb S, Sharma P, Colley HE, Sneddon A, Shipley R, Leedale J, Sarah S & Murdoch C (2018) . APPLIED IN VITRO TOXICOLOGY, Vol. 4(1), 23 November 2017 - 24 November 2017.
Amabebe E, Qiao H, Murdoch C & Anumba D (2018) Cervicovaginal Epithelial Cells Differentially Express Acetate and CXCL8 in Co-Culture with Preterm Birth-Associated Bacteria and Protective Lactobacillus Species.. REPRODUCTIVE SCIENCES, Vol. 25 (pp 187A-187A)
Shipley R, Webb SW, Madden J, Smith SA, Cronin M, Colley HE & Murdoch C (2018) Mathematical modelling predicts the spatial distribution of metabolism in skin. European Cells and Materials, Vol. 32 (pp 96-96)
Hadley L, Santocildes-Romero ME, Thornhill MH, Hansen J, Colley HE, Hatton PV & Murdoch C (2016) . Oral Diseases((Suppl. 2)) (pp 10-13), 15 September 2016 - 17 September 2016.
Santocildes-Romero ME, Hadley L, Clitherow KH, Hansen J, Murdoch C, Colley HE, Thornhill MH & Hatton PV (2016) . Oral Diseases, Vol. 22(S2) (pp 11-11), 15 September 2016 - 17 September 2016.
Hadley L, Colley HE & Murdoch C (2016) . Oral Diseases, Vol. 22(S2) (pp 10-11), 15 September 2016 - 17 September 2016.
Chasib NH, Murdoch C & Colley HE (2016) . Oral Diseases, Vol. 22 (pp 10-10)
Colley HE, D'Apice K, Baker SR, Hatton PV, Santocildes-Romero ME, Thornhill MH, Hansen J & Murdoch C (2016) . Oral Diseases, Vol. 22(S2) (pp 19-19), 15 September 2016 - 17 September 2016.
Grayson A, Hearnden VL, Colley H, Bolt R, Jabreel A & Murdoch C (2016) Isolation and immortalisation of tonsillar keratinocytes for three-dimensional tissue engineered tonsil mucosal models. European Cells and Materials, Vol. 31(Suppl 1) (pp 20-20), 28 June 2016 - 1 July 2016.
Boadi J, Byers RA, Fernandes J, Mittar S, Hearnden V, Lu Z, MacNeil S, Thornhill M, Murdoch C, Hunter KD , McKechnie A et al (2016) . Photonic Therapeutics and Diagnostics XII, 13 February 2016 - 18 February 2016.
Sarb JD, Murdoch C & Anumba D (2016) The Effect of Relaxin-2 and Tissue Inhibitors of Matrix Metalloproteinase-2 (TIMP-2) on the Expression Levels of Matrix Metalloproteinase-2 (MMP-2) by Co-Incubation of Endometrial Stromal and Trophoblast Cell Lines.. REPRODUCTIVE SCIENCES, Vol. 23 (pp 335A-335A)
Gaskell H, Sharma P, Colley H, Murdoch C, Antoine D, Sathish J, Williams D & Webb S (2015) . Toxicology Letters, Vol. 238(2) (pp S176-S176)
Sarb JD, Murdoch C & Anumba DOC (2015) Using 3-D Models To Investigate Trophoblast-Endometrial Interactions In Vitro. REPRODUCTIVE SCIENCES, Vol. 22 (pp 226A-226A)
Alkishi A, Khurram SA, Thornhill M & Murdoch C (2014) . Tumor Biology
Hunter K, Hakami F, Darda L, Lambert D, Murdoch C, Morgan R & Woll P (2013) The role of HOX genes in Head and Neck Squamous Cell Carcinoma (HNSCC). VIRCHOWS ARCHIV, Vol. 463(2) (pp 177-177)
Darda L, Lambert D, Morgan R, Murdoch C & Hunter K (2013) The role of miR-196a and HOXB9 in head and neck squamous cell carcinoma. EUROPEAN JOURNAL OF CANCER, Vol. 49 (pp S121-S121)
Alkishi AM, Khurram SA, Thornhill MH & Murdoch C (2013) Sialyl Lewis A and sialyl Lewis X antigens mediate oral cancer cell binding to recombinant E-selectin and TNF-alpha-stimulated endothelial cells. EUROPEAN JOURNAL OF CANCER, Vol. 49 (pp S134-S134)
Colley HE, Hearnden V, Wayakanon K, Cecchin D, Armes S, Battaglia G, Murdoch C & Thornhill MH (2012) Tissue engineered models of oral disease for the study of a novel drug delivery system. ORAL DISEASES, Vol. 18
Murdoch C, Thornhill MH, Fang H-Y, Hearnden V & Colley HE (2012) CXCL12/CXCR4 axis mediates recruitment of monocytes to oral cancer spheroids. ORAL DISEASES, Vol. 18 (pp 8-8)
Kerr AR, Thornhill MH, D'Apice K, Murdoch C, Speight P, Hegarty A, Redding SW, Vigneswaran N, Christodoulides N, Floriano PN & McDevitt JT (2012) Non-invasive lab-on-a-chip characterization of potentially malignant oral disorders. ORAL DISEASES, Vol. 18 (pp 4-4)
Colley HE, Hearnden V, Cecchin D, Armes S, Battaglia G, Murdoch C & Thornhill MH (2012) . EUROPEAN JOURNAL OF CANCER, Vol. 48 (pp S254-S254)
Hearnden V, Rehman IU, MacNeil S, Murdoch C, Thornhill MH, Hunter K & Colley HE (2012) . EUROPEAN JOURNAL OF CANCER, Vol. 48 (pp S287-S287)
Evans T, Tazzyman S, Chico T, Thornhill M & Murdoch C (2012) Using zebrafish as an in vivo model to study Candida albicans-mediated systemic candidiasis. MYCOSES, Vol. 55 (pp 11-11)
Venn PW & Murdoch C (2012) Development of a static adhesion assay to identify host proteins exploited by Candida albicans. MYCOSES, Vol. 55 (pp 303-303)
Sorrell I, Webb SD, Shipley RJ, Hearnden VL, Colley HE & Murdoch C (2012) . Molecular and Cellular Biology
Muthana M, Giannoudis A, Scott SD, Mistry R, Murdoch C, Coffelt S, Georgeopolous L, Hamdy F, Brown N, Maitland N & Lewis CE (2010) . DRUG DISCOVERY TODAY, Vol. 15(23-24) (pp 1097-1098)
Colley HE, Hearnden V, Murdoch C, Armes S, Battaglia G & Thornhill MH (2010) Using polymersomes to deliver chemotherapeutic agents to oral cancer cells. ORAL DIS, Vol. 16(6) (pp 527-527)
Higham JH, Murdoch CM, Douglas CWI & Thornhill MH (2010) Atherosclerosis and oral health: mechanisms for P.gingivalis survival in endothelial-cells. Oral Diseases, Vol. 16 (pp 516-516)
Yadev N, Bubeck S, Murdoch C, Saville SP, Lopez-Ribot J & Thornhill MH (2010) In vitro modelling of oral and vaginal candidiasis host-pathogen interactions. ORAL DIS, Vol. 16(6) (pp 517-517)
Hearnden V, Smith L, Colley H, Thornhill M, Murdoch C, Smallwood R, Matcher S & MacNeil S (2010) Using tissue-engineered oral cancer models to evaluate non-invasive diagnostic technologies. ORAL DIS, Vol. 16(6) (pp 518-518)
Fang H, Hughes R, Murdoch C, Coffelt S, Biswas SK, Imityaz HZ, Simon MC, Greten F, Rius J & Lewis CE (2010) Hypoxia inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing sustained hypoxia. EJC SUPPLEMENTS, Vol. 8(5) (pp 77-77)
Muthana M, Giannoudis A, Scott SD, Mistry R, Murdoch C, Georgeopolous L, Hamdy F, Brown N, Maitland N & Lewis CE (2010) Engineering Macrophages to Synthesize Recombinant Adenoviruses in Hypoxic Areas of Human Prostate Tumours. HUMAN GENE THERAPY, Vol. 21(4) (pp 488-488)
Wayakanon K, Thornhill M, Douglas I, Battaglia G & Murdoch C (2010) . Proceedings of the IASTED International Conference on Nanotechnology and Applications, NANA 2010 (pp 559-564)
Murdoch C, Colley H, MacNeil S & Thornhill M (2009) . ORAL ONCOLOGY (pp 68-68)
Colley HE, MacNeil S, Jones AV, Thornhill MH & Murdoch C (2009) . ORAL ONCOLOGY (pp 160-160)
Hearnden V, Battaglia G, MacNeil S, Murdoch C & Thornhill M (2009) . ORAL ONCOLOGY (pp 66-66)
Hearnden V, Battaglia G, Murdoch C, Thornhill M & MacNeil S (2008) Imaging of polymersome penetration into 3D tissue engineered models of oral mucosa and head and neck cancer. European Cells and Materials, Vol. 16(SUPPL. 3) (pp 58)
Muthana M, Scott S, Farrow N, Murdoch C & Lewis C (2007) Magnetite nanoparticle-loaded macrophages enhance gene delivery to tumours. IMMUNOLOGY, Vol. 120 (pp 82-82)
Hughes R, Murdoch C, Fang HY & Lewis C (2007) Microenvironmental signals regulating the tumour-promoting functions of macrophages: role of hypoxia and necrotic debris. JOURNAL OF LEUKOCYTE BIOLOGY (pp 56-56)
Scott SD, Greco O, Murdoch C & Lewis C (2005) Radiation, hypoxia and chemotherapy-mediated gene therapy and the potential for tumour delivery via macrophages. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, Vol. 63(2) (pp S137-S137)
Murdoch C, Lakshman R, Burkinshaw R, Shaw L & Finn A (2001) Effect of hepatavalent conjugate pneumococcal vaccine in infancy and booster polysaccharide vaccine at 13 months on nasopharyngeal carriage of S-pneumoniae in children aged 2 to 4 years. CLIN INFECT DIS, Vol. 33(7) (pp 1148-1148)
Murdoch C, Monk PN & Finn A (1998) CXC chemokine receptor expression on human endothelial cells. J VASC RES, Vol. 35(5) (pp 388-388)
Murdoch C, Barker MD, Pease JE, Finn A & Monk PN (1996) Leukocyte chemoattractant receptor expression on endothelial and epithelial cells. IMMUNOLOGY, Vol. 89 (pp OM115-OM115)
Murdoch C, Monk PN & Finn A (1996) Analysis of the endothelial panel reactivity against the type II alveolar epithelial cell line, A549.. TISSUE ANTIGENS, Vol. 48(4-II) (pp EC216-EC216)

Research group

PhD students:

Cher Farrugia: Use of in vitro and in vivo zebrafish embryo infection models to investigate the role of oral microorganisms in cardiovascular disease. (co-supervisor: Dr Graham Stafford, University Faculty Studentship)
Bethany Ollington: Immune-competent tissue engineered oral mucosal models to investigate xenobiotic metabolism. (co-supervisor: Dr Helen Colley, DiMeN MRC Studentship)
Inmaculada Barragan Vazquez: Tissue engineered modelling of atopic dermatitis (co-supervisors: Dr Helen Colley & Dr Simon Danby, Almirall S.A. funded PhD Studentship)
Asma El-Howati: Tissue engineered oral inflammatory lesions (lead supervisor: Dr Helen Colley, Funded by Libyan Government Scholarship)
Klaudia Slowik: The role of metabolising enzymes in drug delivery for prevention of alveolar osteitis. (lead supervisor: Dr Helen Colley, EPSRC Funded Studentship)
Jake Edmans: Peptide delivery using electrospun mucoadhesive patches (lead supervisor: Dr Helen Colley, EPSRC Centre for Doctoral Training in Polymers and Soft Matter)
Asmaa Zanki: Fabrication of dentures with anti-fungal properties by additive manufacturing. (lead supervisor: Prof. Paul Hatton - Funded by Kuwait Government Scholarship)

Teaching activities

Undergraduate:

Bachelor of Dental Surgery:

DEN11001 - The Human Body
DEN11002 - The Oral Cavity in Health and Disease
DEN21004 – Nutrition, Disease and Materials
DEN31002 - Integrated Human Disease
DEN41004 - Oral Disease

BSc Bio-Dental Science and Technology:

MbChB Medicine:

MEDU01 – Immunology

Post-Graduate Taught:

DEN616 – Tissue Engineering & Regenerative Dentistry (module lead) taught to both MSc in Dental Materials Science and MMedSci in Diagnostic Oral Pathology
OCP604 – MSc(Res) Translational Oncology (Chemokines in Cancer)
PGT research projects regularly supervised for MSc Dental Materials Science, MMedSci in Diagnostic Oral Pathology, MSc Molecular Medicine and MSc(Res) Translational Oncology.

Professional activities and memberships

British Association for Cancer Research National Executive Committee Member (2017 - 2021).
National Centre for the Replacement Refinement and Reduction of Animals (NC3R) Studentship Grant Review Board Member (2015 - 2020).
PlosOne Academic Editor.
Associate Editor Frontiers in Oral Health

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School of Clinical Dentistry

School of Clinical Dentistry

Professor Craig Murdoch

Current projects include:

Research group

Journal articles

Chapters

Conference proceedings papers

PhD students:

Undergraduate:

Post-Graduate Taught:

Links