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Our Computational Modelling in Medicine research theme are hosting Dr Carina Dunlop from the University of Surrey, who will give a talk on 'What do cells and tissues feel? The integration of cell contractility, growth and adhesion in mechanosensing' for our Insigneo Mathematical Biology Seminar on Monday 26 February 2024.

Brief Bio:

Dr Carina Dunlop, University of Surrey

Abstract:

The role of tissue stiffness in controlling cell behaviours is well established and includes e.g. cell differentiation and even drug susceptibility, with clear implications for health and disease. However, despite progress at the molecular level, our understanding of how mechanical forces operate across tissues, between cells and within cells to transmit signals into molecular networks is less developed. Here I will explore using theoretical modelling the critical role cell adhesions play in determining mechanical response at both cell and tissues levels. The models developed are based on active matter continuum descriptions. I will also show how this approach can predict regions of peak mechanical activity, and explain the contributory roles of tissue growth. Applications that will be discussed include 3D organoid culture, ovarian follicles and two-dimensional layered tissues, where current collaborations integrating of theoretical models with experimental investigation is delivering new insights.