Lacroix, Damien, Professor

Professor Damien Lacroix

School of Mechanical, Aerospace and Civil Engineering

Professor of Mechanobiology

Insigneo Institute Co-Director

d.lacroix@sheffield.ac.uk

F21, Pam Liversidge Building

Full contact details

Professor Damien Lacroix
School of Mechanical, Aerospace and Civil Engineering
F21
Pam Liversidge Building
Mappin Street
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S1 3JD

Profile

I am a Professor of Mechanobiology in Mechanical Engineering. I hold a first degree in Mechanical Engineering from the National Institute of Applied Science (INSA Lyon, France) and a PhD in Biomechanics from Trinity College Dublin.

After a post-doc in 2001 in Toulouse (France) for Smith and Nephew at the Purpan Hospital, I was awarded a Marie-Curie TMR EU fellowship in 2002 and a Ramon y Cajal senior fellowship in 2004 at the Technical University of Catalonia (Spain).

In 2008 I was appointed Group Leader of Biomechanics and Mechanobiology at the Institute of Bioengineering of Catalonia (Spain) and I joined Mechanical Engineering in 2012 when I took a Chair in Biomedical Engineering within the INSIGNEO research institute.

Research interests

My research covers bone mechanobiology (osteoarthritis, bone tissue engineering, fracture healing) and spine biomechanics (mechanobiology of disc degeneration, disc angiogenesis, disc implant analysis).

The focus of my research group is the study of the effect of mechanical stimuli on biological response. The group's objective is to make scientific advancements in simulations of in vitro and in vivo biomechanics and mechanobiology and in experimental in vitro mechanobiology.

The current focus of the group is mainly on the development of simulations in spine biomechanics and modelling of inflammation in osteoarthritic joints. These numerical simulations based on the finite element method are complemented with in vitro tests using bioreactors and microfluid chambers.

Projects

Multiscale modelling of the musculoskeletal system
Development of a predictive computational platform for disc degeneration and bone fracture
Simulation of a biological / biomaterials interactions in tissue engineering
Simulation of inflammation in osteoarthritic joints

Publications

Books

Lacroix D, Brunelli M, Perrault C, Baldit A, Shariatzadeh M, Campos Marin A, Castro A & Barreto S (2019) . Springer Singapore.

Journal articles

Pan J, Lacroix D, Zhou Y & Wang B (2023) . Frontiers in Bioengineering and Biotechnology, 11.
Eltes PE, Turbucz M, Fayad J, Bereczki F, Szőke G, Terebessy T, Lacroix D, Varga PP & Lazary A (2022) . Frontiers in Surgery, 8(1).
Bhattacharya P, Li Q, Lacroix D, Kadirkamanathan V & Viceconti M (2021) . PLoS ONE, 16(5).
Ascolani G, Skerry TM, Lacroix D, Dall'Ara E & Shuaib A (2021) . Interface Focus, 11(1).
Eltes PE, Bartos M, Hajnal B, Pokorni AJ, Kiss L, Lacroix D, Varga PP & Lazary A (2021) . Frontiers in Surgery, 7.
Yang W, Lacroix D, Tan LP & Chen J (2021) . Journal of Materials Research.
Demir E, Eltes P, Castro APG, Lacroix D & Toktaş İ (2020) . Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine.
Zhao F, Lacroix D, Ito K, van Rietbergen B & Hofmann S (2020) . Bone Reports, 12.
Ascolani G, Skerry TM, Lacroix D, Dall’Ara E & Shuaib A (2020) . BMC Bioinformatics, 21(1).
Benemerito I, Modenese L, Montefiori E, Mazzà C, Viceconti M, Lacroix D & Guo L (2020) . Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine.
Cheong VS, Campos Marin A, Lacroix D & Dall’Ara E (2019) . Biomechanics and Modeling in Mechanobiology.
Shuaib A, Motan D, Bhattacharya P, McNabb A, Skerry TM & Lacroix D (2019) . Scientific Reports, 9(1).
Castro APG, Altai Z, Offiah AC, Shelmerdine SC, Arthurs OJ, Li X & Lacroix D (2019) . PLoS ONE, 14(6).
Marcotti S, Reilly GC & Lacroix D (2019) . Journal of the Mechanical Behavior of Biomedical Materials, 94, 259-266.
Alsayednoor J, Metcalf L, Rochester J, Dall’Ara E, McCloskey E & Lacroix D (2018) . Biomechanics and Modeling in Mechanobiology, 17(6), 1715-1730.
Marcotti S, Maki K, Reilly GC, Lacroix D & Adachi T (2018) . PLoS ONE, 13(10).
Castro APG, Yao J, Battisti T & Lacroix D (2018) . Frontiers in Bioengineering and Biotechnology, 6.
Borg SA, Buckley H, Owen R, Marin AC, Lu Y, Eyles D, Lacroix D, Reilly GC, Skerry TM & Bishop NJ (2018) . PLoS ONE, 13(1).
Campos Marín A, Brunelli M & Lacroix D (2018) . Biomechanics and Modeling in Mechanobiology, 17(3), 675-687.
Castro APG & Lacroix D (2018) . Biomechanics and Modeling in Mechanobiology, 17(2), 531-541.
Marin AC, Grossi T, Bianchi E, Dubini G & Lacroix D (2017) . Journal of the Mechanical Behavior of Biomedical Materials, 75, 463-469.
Brunelli M, Perrault CM & Lacroix D (2017) . Journal of the Mechanical Behavior of Biomedical Materials, 71, 165-174.
Palanca M, Bodey AJ, Giorgi M, Viceconti M, Lacroix D, Cristofolini L & Dall'Ara E (2017) . Journal of Biomechanics, 58, 27-36.
Campos Marin A, Grossi T, Bianchi E, Dubini G & Lacroix D (2017) . Annals of Biomedical Engineering, 45(5), 1341-1351.
Brunelli M, Perrault CM & Lacroix D (2017) . Journal of the Mechanical Behavior of Biomedical Materials, 65, 478-489.
Yao Y, Lacroix D & Mak AFT (2016) . Biomechanics and Modeling in Mechanobiology, 15(6), 1495-1508.
Wittkowske C, Reilly GC, Lacroix D & Perrault CM (2016) . Frontiers in Bioengineering and Biotechnology, 4.
Giorgi M, Verbruggen SW & Lacroix D (2016) . Wiley Interdiscip Rev Syst Biol Med.
Wills CR, Malandrino A, van Rijsbergen MM, Lacroix D, Ito K & Noailly J (2016) . Journal of the Mechanics and Physics of Solids, 90, 108-123.
Castro APG, Laity P, Shariatzadeh M, Wittkowske C, Holland C & Lacroix D (2016) . Journal of Materials Science: Materials in Medicine, 27(4).
Perrault C, Brugues A, Bazellieres E, Ricco P, Lacroix D & Trepat X (2015) . Biophysical Journal, 109(8), 1533-1536.
Khayyeri H, Barreto S & Lacroix D (2015) . Journal of Theoretical Biology, 379, 38-46.
Campos Marin A & Lacroix D (2015) . Interface Focus, 5(2), 20140097-20140097.
Yao Y, Lacroix D & Mak AFT (2015) . The Proceedings of the Asian Pacific Conference on Biomechanics : emerging science and technology in biomechanics, 2015.8(0), 219-219.
Lacroix D, Brunelli M, Shariatzadeh M, Campos A & Perrault CM (2014) The effect of mechanical stimuli on cell adhesion. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 8, 33-34.
Shariatzadeh M, Perrault C & Lacroix D (2014) Effect of mechanical stimulation on osteogenesis of self-assembled collagen-heMSC/MG63 microspheres. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 8, 258-258.
Brunelli M, Perrault C & Lacroix D (2014) Microfluidic bioreactor for high-throughput and prolonged perfusion of bone scaffolds. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 8, 480-480.
Anderson DD, Thomas TP, Campos Marin A, Elkins JM, Lack WD & Lacroix D (2014) . Injury, 45 Suppl 2, S23-S31.
Malandrino A, Lacroix D, Hellmich C, Ito K, Ferguson SJ & Noailly J (2014) . Osteoarthritis Cartilage, 22(7), 1053-1060.
Malandrino A, Noailly J & Lacroix D (2014) . Journal of Biomechanics.
Sánchez Egea AJ, Parraga Quiroga JM, Noailly J, Lacroix D, Valera M & Proubasta I (2014) . Clinical Biomechanics.
Barreto S, Perrault CM & Lacroix D (2014) . J Mech Behav Biomed Mater, 38, 219-231.
Ruiz C, Noailly J & Lacroix D (2013) . J Mech Behav Biomed Mater, 26, 1-10.
Barreto S, Clausen CH, Perrault CM, Fletcher DA & Lacroix D (2013) . Biomaterials, 34(26), 6119-6126.
Malandrino A, Noailly J & Lacroix D (2013) . Comput Methods Biomech Biomed Engin, 16(9), 923-928.
Perrault CM, Trepat X, Navajas D, Planell JA & Lacroix D (2012) . Journal of Biomechanics, 45, S414-S414.
Olivares AL, Perrault CM & Lacroix D (2012) . Journal of Biomechanics, 45, S646-S646.
Barreto S, Perrault CM & Lacroix D (2012) . Journal of Biomechanics, 45, S418-S418.
Olivares AL & Lacroix D (2012) . Tissue Eng Part C Methods, 18(8), 624-631.
Noailly J & Lacroix D (2012) , 144-232.
Malandrino A, Fritsch A, Lahayne O, Kropik K, Redl H, Noailly J, Lacroix D & Hellmich C (2012) . Materials Letters, 78, 154-158.
Noailly J, Ambrosio L, Elizabeth Tanner K, Planell JA & Lacroix D (2012) . Eur Spine J, 21 Suppl 5, S675-S687.
Renart I, Gómez C, Aparicio N, Villalobos I & Lacroix D (2011) . Revista Iberoamericana de Cirugía de la Mano, 39(01), 022-031.
Byrne DP, Lacroix D & Prendergast PJ (2011) . JOURNAL OF ORTHOPAEDIC RESEARCH, 29(10), 1496-1503.
Galbusera F, Schmidt H, Noailly J, Malandrino A, Lacroix D, Wilke H-J & Shirazi-Adl A (2011) . JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS, 4(7), 1234-1241.
Malandrino A, Noailly J & Lacroix D (2011) . PLoS Computational Biology, 7(8).
Sandino C & Lacroix D (2011) . Biomech Model Mechanobiol, 10(4), 565-576.
Noailly J, Planell JA & Lacroix D (2011) . Biomech Model Mechanobiol, 10(2), 203-219.
Bohner M, Loosli Y, Baroud G & Lacroix D (2011) . ACTA BIOMATERIALIA, 7(2), 478-484.
Melchels FPW, Tonnarelli B, Olivares AL, Martin I, Lacroix D, Feijen J, Wendt DJ & Grijpma DW (2011) . Biomaterials, 32(11), 2878-2884.
Lacroix D & Ramírez Patiño JF (2011) . Annals of Biomedical Engineering, 39(12), 2972-2983.
Santoro R, Olivares AL, Brans G, Wirz D, Longinotti C, Lacroix D, Martin I & Wendt D (2010) . Biomaterials, 31(34), 8946-8952.
Fariña NM, Muñoz-Guzón F, López-Peña M, Permuy-Mendaña M, Koch M, Lacroix D & González-Cantalapiedra A (2010) . Bone, 47, S127-S128.
Sandino C, Checa S, Prendergast PJ & Lacroix D (2010) . Biomaterials, 31(8), 2446-2452.
Prendergast PJ, Checa S & Lacroix D (2010) , 353-372.
Koch MA, Vrij EJ, Engel E, Planell JA & Lacroix D (2010) . Journal of Biomedical Materials Research - Part A, 95(4), 1011-1018.
Milan JL, Planell JA & Lacroix D (2010) . Biomechanics and Modeling in Mechanobiology, 9(5), 583-596.
Malandrino A, Planell JA & Lacroix D (2009) . J Biomech, 42(16), 2780-2788.
Milan JL, Planell JA & Lacroix D (2009) . Biomaterials, 30(25), 4219-4226.
Planell JA, Best SM, Lacroix D & Merolli A (2009) . Bone Repair Biomaterials, 1-477.
Lacroix D, Planell JA & Prendergast PJ (2009) . Philos Trans A Math Phys Eng Sci, 367(1895), 1993-2009.
Milan JL, Sandino C, Midderhoff S, Marques L, Planell JA & Lacroix D (2009) Mode of failure of a biomaterial composite scaffold for bone tissue engineering using synchrotron micro-tomography and finite element analysis. 12th International Conference on Fracture 2009, ICF-12, 8, 6179-6186.
Lacroix D & Planell JA (2009) , 123-154.
Olivares AL, Marsal E, Planell JA & Lacroix D (2009) . Biomaterials, 30(30), 6142-6149.
Koch MA, Engel E, Planell JA & Lacroix D (2008) Material characterization and dynamic cell seeding on PLA/glass composite scaffolds for bone tissue engineering. 8th World Biomaterials Congress 2008, 3, 1248.
Charles-Harris M, Koch MA, Navarro M, Lacroix D, Engel E & Planell JA (2008) . Journal of Materials Science: Materials in Medicine, 19(4), 1503-1513.
Engel E, Michiardi A, Navarro M, Lacroix D & Planell JA (2008) . Trends in Biotechnology, 26(1), 39-47.
Sandino C, Planell JA & Lacroix D (2008) . Journal of Biomechanics, 41(5), 1005-1014.
Byrne DP, Lacroix D, Planell JA, Kelly DJ & Prendergast PJ (2007) . BIOMATERIALS, 28(36), 5544-5554.
Charles-Harris M, del Valle S, Hentges E, Bleuet P, Lacroix D & Planell JA (2007) . Biomaterials, 28(30), 4429-4438.
Saló G, Cáceres E, Lacroix D, Planell JA, Molina A, Ramírez M & Lladó A (2007) . Revista Española de Cirugía Ortopédica y Traumatología (English Edition), 51(5), 284-295.
Roca Romalde D, Lacroix D, Caja López VL, Proubasta Renart I & Planell Estany JA (2007) . Revista Española de Cirugía Ortopédica y Traumatología (English Edition), 51(2), 88-93.
Roca Romalde D, Lacroix D, Caja López VL, Proubasta Renart I & Planell Estany JA (2007) . Revista de Ortopedia y Traumatologia, 51(2), 88-93.
Saló G, Cáceres E, Lacroix D, Planell JA, Molina A, Ramírez M & Lladó A (2007) . Revista de Ortopedia y Traumatologia, 51(5), 284-295.
Noailly J, Wilke H-J, Planell JA & Lacroix D (2007) . J Biomech, 40(11), 2414-2425.
Lacroix D, Chateau A, Ginebra M-P & Planell JA (2006) . Biomaterials, 27(30), 5326-5334.
Lacroix D, Noailly J, Salo G, Caceres E & Planell JA (2006) The effect of bone graft geometry on spinal fusion vertebral stresses.. J Appl Biomater Biomech, 4(3), 135-142.
Noailly J, Lacroix D & Planell JA (2005) . Spine (Phila Pa 1976), 30(20), 2257-2264.
Charles-Harris M, Lacroix D, Proubasta I & Planell JA (2005) Intramedullary nails vs osteosynthesis plates for femoral fracture stabilization: A finite element analysis.. J Appl Biomater Biomech, 3(3), 157-167.
Idelsohn S, Peña J, Lacroix D, Planell JA, Gil FJ & Arcas A (2004) . J Mater Sci Mater Med, 15(4), 541-546.
Lacroix D & Prendergast PJ (2002) . Comput Methods Biomech Biomed Engin, 5(5), 369-376.
Lacroix D & Prendergast PJ (2002) . J Biomech, 35(9), 1163-1171.
Lacroix D, Prendergast PJ, Li G & Marsh D (2002) . Med Biol Eng Comput, 40(1), 14-21.
Lacroix D, Murphy LA & Prendergast PJ (2000) . J Biomech Eng, 122(4), 430-436.
Lee TC, Shine JD, FitzPatrick DP, Bradley JA, O’Connor JJ, O’Kelly KU, Carr AJ, McCormack BAO, O’Neill P, Cole JS , Watterson JK et al (1999) . Irish Journal of Medical Science, 168(3), 208-220.
Lacroix D & Prendergast PJ (1997) . Proc Inst Mech Eng H, 211(6), 467-474.
Owen R, Wittkowske C, Lacroix D, Perrault CM & Reilly GC () . Connective Tissue Research, 1-17.
Rijsbergen MV, van Rietbergen B, Barthelemy V, Eltes P, Lazáry Á, Lacroix D, Noailly J, Ho Ba Tho M-C, Wilson W & Ito K () . PLOS ONE, 13(8), e0200899-e0200899.
Isaza JA, Lacroix D & Ramírez J () . Universitas Scientiarum, 24(1), 49-72.

Chapters

Lacroix D & Planell JA (2021) , Biomedical Materials (pp. 303-336). Springer International Publishing
Lacroix D (2019) , Frontiers of Biomechanics (pp. 195-199). Springer Singapore
Barreto S & Lacroix D (2019) , Frontiers of Biomechanics (pp. 181-193). Springer Singapore
Brunelli M, Perrault C & Lacroix D (2019) , Frontiers of Biomechanics (pp. 1-22). Springer Singapore
Brunelli M, Perrault C & Lacroix D (2019) , Frontiers of Biomechanics (pp. 37-57). Springer Singapore
Baldit A, Brunelli M, Campos Marin A & Lacroix D (2019) , Frontiers of Biomechanics (pp. 23-36). Springer Singapore
Shariatzadeh M, Baldit A, Perrault C & Lacroix D (2019) , Frontiers of Biomechanics (pp. 105-125). Springer Singapore
Campos Marin A & Lacroix D (2019) , Frontiers of Biomechanics (pp. 81-104). Springer Singapore
Campos Marin A & Lacroix D (2019) , Frontiers of Biomechanics (pp. 59-80). Springer Singapore
Castro A, Shariatzadeh M & Lacroix D (2019) , Frontiers of Biomechanics (pp. 143-158). Springer Singapore
Shariatzadeh M, Perrault C & Lacroix D (2019) , Frontiers of Biomechanics (pp. 127-142). Springer Singapore
Al-Maawi S, Ambrosio L, Best SM, Brown O, Chambers P, Chamorro NP, Chatzistavrou X, Cifuentes Cuellar SC, De Santis R, Delgado López JM , Dunne NJ et al (2019) , Bone Repair Biomaterials (pp. xi-xiv). Elsevier
Lacroix D (2019) , Bone Repair Biomaterials (pp. 53-64). Elsevier
Barreto S & Lacroix D (2019) , Frontiers of Biomechanics (pp. 159-179). Springer Singapore
Brunelli M, Perrault C, Baldit A, Marin AC, Shariatzadeh M, Castro A, Barreto S & Lacroix D (2019) Multiscale Mechanobiology in Tissue Engineering Preface, MULTISCALE MECHANOBIOLOGY IN TISSUE ENGINEERING (pp. V-VIII).
Castro APG & Lacroix D (2017) , Biomedical Composites (pp. 479-500). Elsevier
Ambrosio L, Tanner KE, Raucci MG, Gloria A, De Santis R, Ambrosio L, Tanner KE, Alcock B, Quaye M, Harvey J , Wilke H-J et al (2012) , Biomaterials for Spinal Surgery (pp. xiii-xvii). Elsevier
Olivares AL & Lacroix D (2012) , Computational Modeling in Tissue Engineering (pp. 107-126). Springer Berlin Heidelberg
Noailly J & Lacroix D (2012) , Biomaterials for Spinal Surgery (pp. 144-234e). Elsevier
Lacroix D (2009) , Bone Repair Biomaterials (pp. 106-118).

Conference proceedings papers

Burnett A & Lacroix D (2015) MultiSim: Report of Stakeholder Workshop Outcomes. MultiSim: Report of Stakeholder Workshop Outcomes, Vol. 1(1) (pp 1-7). Insigneo Institute for in silico medicine, 7 September 2014 - 7 September 2014.
Shariatzadeh M, Perrault C & Lacroix D (2015) Effect of Mechanical Stimulation on Osteogenic Differentiation of Self-Assembled Collagen-Cell Seeded Hydrogels. TISSUE ENGINEERING PART A, Vol. 21 (pp S271-S271)
Marin AC, Grossi T, Bianchi E, Dubini G & Lacroix D (2015) mu-Particle Image Velocimetry and Computational Fluid Dynamics Study of Perfusion Cell Seeding Within a 3d Porous Scaffold. TISSUE ENGINEERING PART A, Vol. 21 (pp S117-S118)
Malandrino A, Lacroix D & Noailly J (2013) . Poromechanics V
Checa S, Sandino C, Byrne DP, Kelly DJ, Lacroix D & Prendergast PJ (2011) (pp 55-69)
Planell JA, Navarro M, Altankov G, Aparicio C, Engel E, Gil J, Ginebra MP & Lacroix D (2010) . ADVANCES IN REGENERATIVE MEDICINE: ROLE OF NANOTECHNOLOGY AND ENGINEERING PRINCIPLES (pp 233-+)

Datasets

Marcotti S, Lacroix D & Reilly G .
Marcotti S, Lacroix D & Reilly G .
Marcotti S, Lacroix D & Reilly G .
Marcotti S, Lacroix D & Reilly G .
Dall'Ara E, Palanca M, Viceconti M, Lacroix D, Giorgi M & Cristofolini L .
Bhattacharya P, Li Q, Lacroix D, Kadirkamanathan V & Viceconti M .

Presentations

Lacroix D .

Preprints

Ascolani G, Skerry TM, Lacroix D, Dall'Ara E & Shuaib A (2019) ABM of osteoblast's mechanotransduction pathway: time patterns of critical events, arXiv.
Marcotti S, Reilly GC & Lacroix D () .

Grants

European Commission, Horizon Europe Programme 'Computer-aided effective fracture risk stratification of patients with vertebral metastases for personalised treatment through robust computational models validated in clinical settings (METASTRA)' 07/2023-06/2028. €0.98m. Co-Investigator
European Research Council Starting Grant, MECHANOBIO - 'Finite element simulations of mechanobiology in tissue engineering', 10/2011-09/2016. €1.49m
European Commission, FP7 ICT 269909, MySpine - 'Functional prognosis simulation of patient-specific spinal treatment for clinical use', 03/2011-02/2014. €0.68m.
ESPRC Frontier Engineering Award (EP/K03877X/1), M J Hounslow, D Lacroix, M Viceconti, S A Billings, V Kadirkamanathan, A pavic, E McCloskey, T Skerry, 'Modelling Complex and Partially Identified Engineering Problems - Application to the Individualised Multi-scale Simulation of the Musculoskeletal System', 01.09.2013 to 31.08.2018 £4.86m

Teaching interests: Professor Lacroix supervises final year undergraduate and MSc projects.

Professional activities and memberships

Past-President of the European Society of Biomechanics
Council Member of the European Alliance for Medical and Biological Engineering and Science (EAMBES)
Editorial Board member of Biomaterials, Journal of Biomechanics and Clinical Biomechanics
2010 Jean Leray Award from the European Society of Biomaterials
2006 City Award of Barcelona in Technology Research for the development of a new injectable porous material based on calcium phosphate
Recipient of European Research Council Starting Grant in 2011
Member of the Board of Directors, Virtual Physiological Human Institute