Image-based Kinematic Ankle Models for Children affected by Juvenile Idiopathic Arthritis

Diagrams of Kinematic Ankle Models

This study, carried on as part of the  project, presents an innovative application for kinematic ankle models, used here to understand possible disease-specific gait patterns in children affected by Juvenile Idiopathic Arthritis.

The proposed methodology is based on the identification of the tibiotalar and subtalar axes from medical images through morphological fitting of the articular surfaces of the talus. Axes measurements proved to be repeatable and in line with ex-vivo data. Kinematic results confirmed the absence of a disease-specific gait pattern in the ankle, as suggested by the heterogeneity of the children鈥檚 clinical profile, including various diseases sub-types and manifestations.

Montefiori, E., Modenese, L., Di Marco, R., Magni-Manzoni, S., Malattia, C., Petrarca, M., Ronchetti, A., de Horatio, L. T., van Dijkhuizen, P., Wang, A., Wesarg, S., Viceconti, M., Mazz脿, C.; MD-PAEDIGREE Consortium (2019), 鈥淎n image-based kinematic model of the tibiotalar and subtalar joints and its application to gait analysis in children with Juvenile Idiopathic Arthritis鈥, Journal of Biomechanics

MultiSim-Logo-Small

MultiSim Project

Aiming to create a new generation of predictive models capable of handling complex multi-scale and multiphysics problems, characterised by uncertain and incomplete information.