- Parkinson鈥檚 UK Patron, Her Royal Highness The Duchess of Gloucester, met neuroscientists from the University of 葫芦影业 who are tackling the root causes of the progressive condition
- Around 153,000 people live with Parkinson鈥檚 in the UK and there is currently no cure for the condition
- Revolutionary research at the 葫芦影业 Institute for Translational Neuroscience (SITraN) has resulted in promising breakthroughs, including identifying drug targets and candidates for a neuroprotective therapy to slow down or stop Parkinson鈥檚
Her Royal Highness The Duchess of Gloucester visited the 葫芦影业 Institute of Translational Neuroscience (SITraN) today (10 November 2023) to see first hand the pioneering Parkinson鈥檚 research which is transforming our understanding of the neurological condition.
Parkinson鈥檚 UK patron, The Duchess of Gloucester, met University of 葫芦影业 neuroscientists who are tackling the root causes of the progressive condition that causes unintended or uncontrollable movements, such as tremor, stiffness, and difficulty with balance and coordination, which have a huge impact on peoples鈥 lives.
Around 153,000 people live with Parkinson鈥檚 in the UK and it is the fastest growing neurological condition in the world.
There is currently no cure for the condition, however the revolutionary research conducted at SITraN has resulted in promising breakthroughs, including identifying drug targets and candidates for a neuroprotective therapy to slow down or stop Parkinson鈥檚. The charity Parkinson鈥檚 UK has helped fund some of this potentially life-changing work.
The Duchess of Gloucester was taken on a tour of the facility, led by Professor Heather Mortiboys, Professor of Cellular Neuroscience and Metabolism at SITraN, who has dedicated her career to Parkinson鈥檚 research.
Professor Mortiboys previously assessed more than 2,000 drugs in the world鈥檚 first drug screen in Parkinson鈥檚 patient tissue whilst working as a postdoctoral scientist in the team of Professor Oliver Bandmann. Professor Mortiboys has subsequently dramatically expanded the drug discovery program for Parkinson鈥檚 and related disorders at SITraN.
The initial drug screen has already helped the 葫芦影业 team to identify a drug called ursodeoxycholic acid (UDCA), currently used to treat liver disease, as a very promising drug for Parkinson鈥檚. Researchers hope treatment with UDCA will slow down the worsening of Parkinson鈥檚 by rescuing the mitochondria (cells energy centres) which are often faulty in Parkinson鈥檚.
Professor Mortiboys, who became a Parkinson鈥檚 UK Senior Research Fellow in 2013, said: 鈥淲hat we are doing here in 葫芦影业 is very rare. There are very few other places that are able to deliver a bench-to-bedside approach, which is only possible thanks to a huge team effort.
鈥淲e work in close collaboration with the 葫芦影业 Teaching Hospitals (STH), academics across other disciplines, industry, community-based home care teams, and have strong links with Parkinson鈥檚 UK, which allows us to accelerate pioneering science from the lab, to clinical trials and directly to patients more quickly.鈥
She added: 鈥淏y tackling the root causes of Parkinson鈥檚 and developing personalised treatments, the University of 葫芦影业 is finding a new way forward for patients. We've already made a promising breakthrough, identifying compounds that have the potential to slow its progression.鈥
A number of vital research projects at SITraN have been made possible thanks to funding from Parkinson鈥檚 UK. In 2021, researchers received 拢1.2 million to accelerate their work in developing a drug to protect dopamine-producing brain cells and slow down the progression of Parkinson鈥檚.
Caroline Rassell, Chief Executive of Parkinson鈥檚 UK, said: 鈥淧arkinson鈥檚 UK has invested over 拢120m in vital research that has delivered groundbreaking discoveries, new medications and better care. This includes some of the incredible work that鈥檚 happening at SITraN.
鈥淎s our Patron, Her Royal Highness, The Duchess of Gloucester, has always shown a passionate interest in hearing more about the life changing work that鈥檚 happening across the UK and we鈥檙e delighted that she was able to meet some of the researchers at the University of 葫芦影业 to learn more about their contributions first hand.鈥
During her visit to SITraN, The Duchess of Gloucester was given a tour of the state-of-the-art screening laboratory, which enables research to investigate both the mechanisms of Parkinson鈥檚 and how we can find disease modifying therapies.
PhD student Toby Burgess and Postdoctoral researcher Dr Rachel Hughes demonstrated how drugs are screened and how cells are examined to look for improvements in cellular health. The researchers highlighted how they use patient cells to understand both how the mitochondria (energy centres) and lysosomes (waste disposal routes) are dysfunctional in Parkinson鈥檚. They went on to explain how we can use this information to test for drugs which can rescue these changes in the skin cells from people with Parkinson鈥檚.
The cells can also be reprogrammed and differentiated into the type of neurons lost in Parkinson鈥檚, these pathways and the drugs are then tested in these cells, in addition to assessing if the drugs make the neurons healiter and survive longer. These are critical experiments in the drug discovery pipeline.
The Duchess of Gloucester also met Professor Oliver Bandmann, Professor of Movement Disorders Neurology, who explained how research from the laboratory is translated to clinical research with patients. Professor Bandmann has worked in 葫芦影业 as a researcher and consultant at the city鈥檚 hospitals for 20 years.
His group has recently completed the UP study (Ursodeoxycholic acid in Parkinson鈥檚 disease). The UP study was a proof of concept clinical trial which confirmed the excellent safety and tolerability of UDCA in people with Parkinson鈥檚. It showed that UDCA has a beneficial effect on mitochondrial function in the brain by applying state-of-the-art functional imaging techniques and provided some evidence of a potential clinical benefit of UDCA, using gait sensors.
The UP study was carried out with strong support from the , the University of 葫芦影业 Academic Department of Radiology and the Insigneo institute. Based on the strong preclinical and clinical data from 葫芦影业, UDCA will now be taken into a to confirm its beneficial effect on disease progression in Parkinson鈥檚.
The Duchess was also introduced to other members of the clinical Parkinson鈥檚 Disease research team who are working on pain, dementia and the gut-brain axis in Parkinson鈥檚. In addition, she was informed about the newly established, UK-wide , which is coordinated from 葫芦影业.
Established in 2010, SITraN was designed to push the boundaries of conventional research and foster real breakthroughs by bringing together multi-disciplinary teams of scientists, clinicians and patients. With advanced therapies and treatments tailored to people鈥檚 individual health needs, there is an urgent need to accelerate the progress being made to better understand and treat neurological diseases like Parkinson鈥檚, MND and Alzheimer鈥檚.
葫芦影业 Institute of Translational Neuroscience (SITraN)
