Dr Laura Flight

MMath, MSc, PhD

Population Health, School of Medicine and Population Health

Honorary Research Fellow

Scientific Adviser, National Institute for Health and Care Excellence

Laura Flight
Profile picture of Laura Flight
l.flight@sheffield.ac.uk

Full contact details

Dr Laura Flight
Population Health, School of Medicine and Population Health
Profile

I am currently a Scientific Adviser in the Science Policy and Research Team at the National Institute for Health and Care Excellence (NICE).

Previously I worked in SCHARR as a Research Fellow in Health Economics and Statistics. I still maintain an interest in methodological research focussing on innovative approaches to the design and conduct of clinical trials with an emphasis on how novel statistical methods can be applied in practice.

My PhD research explored the use of health economics in the design and analysis of adaptive clinical trials.

Qualifications

MMath (ºù«Ӱҵ), MSc (ºù«Ӱҵ), PhD (ºù«Ӱҵ)

Research interests
  • Methods for undertaking health economic evaluations alongside clinical trials.
  • Value of information analysis.
  • The use of health economics in the design, monitoring and analysis of adaptive clinical trials.
Publications

Show: Featured publications All publications

Journal articles

  • Wason JMS, Dimairo M, Biggs K, Bowden S, Brown J, Flight L, Hall J, Jaki T, Lowe R, Pallmann P , Pilling MA et al (2022) . BMC Medicine, 20(1). RIS download Bibtex download
  • Flight L, Julious S, Brennan A & Todd S (2021) . Medical Decision Making. RIS download Bibtex download
  • Wilson N, Biggs K, Bowden S, Brown J, Dimairo M, Flight L, Hall J, Hockaday A, Jaki T, Lowe R , Murphy C et al (2021) . BMC Medicine, 19(1). RIS download Bibtex download
  • Qian Y, Walters SJ, Jacques R & Flight L (2021) . BMJ Open, 11(9). RIS download Bibtex download
  • Hykin P, Prevost AT, Sivaprasad S, Vasconcelos JC, Murphy C, Kelly J, Ramu J, Alshreef A, Flight L, Pennington R , Hounsome B et al (2021) . Health Technology Assessment, 25(83). RIS download Bibtex download
  • Pennington R, Alshreef A, Flight L, Metry A, Poku E, Hykin P, Sivaprasad S, Prevost AT, Vasconcelos JC, Murphy C , Kelly J et al (2021) . PharmacoEconomics. RIS download Bibtex download
  • Pennington BM, Hernández-Alava M, Hykin P, Sivaprasad S, Flight L, Alshreef A & Brazier J (2020) . Value in Health. RIS download Bibtex download
  • Flight L, Julious S, Brennan A, Todd S & Hind D (2020) . Trials, 21(1). RIS download Bibtex download
  • Flight L, Arshad F, Barnsley R, Patel K, Julious S, Brennan A & Todd S (2019) . Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research, 22(4), 391-398. RIS download Bibtex download
  • Candlish J, Teare MD, Dimairo M, Flight L, Mandefield L & Walters SJ (2018) . BMC Medical Research Methodology, 18(1), 105-105. RIS download Bibtex download
  • Pallmann P, Bedding AW, Choodari-Oskooei B, Dimairo M, Flight L, Hampson LV, Holmes J, Mander AP, Odondi L, Sydes MR , Villar SS et al (2018) . BMC Medicine, 16. RIS download Bibtex download
  • Flight L, Allison A, Dimairo M, Lee E, Mandefield L & Walters SJ (2016) . BMC Medical Research Methodology, 16. RIS download Bibtex download
  • Flight L, Julious SA & Goodacre S (2016) . Emergency Medicine Journal, 34, 243-248. RIS download Bibtex download
  • Hatfield I, Allison A, Flight L, Julious SA & Dimairo M (2016) . Trials, 17(1). RIS download Bibtex download

Reports

  • Forster M, Flight L, Corbacho B, Keding A, Ronaldson S, Tharmanathan P, Welch C, Brennan A & Chick S (2021) Report for the EcoNomics of Adaptive Clinical Trials (ENACT) project: Application of a Bayesian Value-Based Sequential Model of a Clinical Trial to the CACTUS and HERO Case Studies (with Guidance Material for Clinical Trials Units) RIS download Bibtex download

Preprints

  • Flight L, Brennan A, Chick SE, Forster M, Julious S & Tharmanathan P () Value-Adaptive Clinical Trial Designs for Efficient Delivery of Research – Actions, Opportunities and Challenges for Publicly Funded Trials. RIS download Bibtex download

All publications

Journal articles

  • Wason JMS, Dimairo M, Biggs K, Bowden S, Brown J, Flight L, Hall J, Jaki T, Lowe R, Pallmann P , Pilling MA et al (2022) . BMC Medicine, 20(1). RIS download Bibtex download
  • Flight L & Julious SA (2022) . Pharm Stat. RIS download Bibtex download
  • Flight L, Julious S, Brennan A & Todd S (2021) . Medical Decision Making. RIS download Bibtex download
  • Wilson N, Biggs K, Bowden S, Brown J, Dimairo M, Flight L, Hall J, Hockaday A, Jaki T, Lowe R , Murphy C et al (2021) . BMC Medicine, 19(1). RIS download Bibtex download
  • Qian Y, Walters SJ, Jacques R & Flight L (2021) . BMJ Open, 11(9). RIS download Bibtex download
  • Hykin P, Prevost AT, Sivaprasad S, Vasconcelos JC, Murphy C, Kelly J, Ramu J, Alshreef A, Flight L, Pennington R , Hounsome B et al (2021) . Health Technology Assessment, 25(83). RIS download Bibtex download
  • Pennington R, Alshreef A, Flight L, Metry A, Poku E, Hykin P, Sivaprasad S, Prevost AT, Vasconcelos JC, Murphy C , Kelly J et al (2021) . PharmacoEconomics. RIS download Bibtex download
  • Pennington BM, Hernández-Alava M, Hykin P, Sivaprasad S, Flight L, Alshreef A & Brazier J (2020) . Value in Health. RIS download Bibtex download
  • Flight L, Julious S, Brennan A, Todd S & Hind D (2020) . Trials, 21(1). RIS download Bibtex download
  • Flight L, Arshad F, Barnsley R, Patel K, Julious S, Brennan A & Todd S (2019) . Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research, 22(4), 391-398. RIS download Bibtex download
  • Candlish J, Teare MD, Dimairo M, Flight L, Mandefield L & Walters SJ (2018) . BMC Medical Research Methodology, 18(1), 105-105. RIS download Bibtex download
  • Pallmann P, Bedding AW, Choodari-Oskooei B, Dimairo M, Flight L, Hampson LV, Holmes J, Mander AP, Odondi L, Sydes MR , Villar SS et al (2018) . BMC Medicine, 16. RIS download Bibtex download
  • Flight L & Julious SA (2016) . Pharmaceutical Statistics. RIS download Bibtex download
  • Flight L, Allison A, Dimairo M, Lee E, Mandefield L & Walters SJ (2016) . BMC Medical Research Methodology, 16. RIS download Bibtex download
  • Flight L, Julious SA & Goodacre S (2016) . Emergency Medicine Journal, 34, 243-248. RIS download Bibtex download
  • Hatfield I, Allison A, Flight L, Julious SA & Dimairo M (2016) . Trials, 17(1). RIS download Bibtex download
  • Flight L & Julious SA (2016) . Pharmaceutical Statistics, 15(1), 80-89. RIS download Bibtex download
  • Flight L & Julious SA (2016) . Pharmaceutical Statistics, 15(1), 68-74. RIS download Bibtex download
  • Flight L & Julious SA (2016) . Pharmaceutical Statistics, 15(1), 75-79. RIS download Bibtex download
  • Flight L & Julious SA (2015) . Pharmaceutical Statistics, 14(1), 74-78. RIS download Bibtex download
  • Pennington B, Alshreef A, Flight L, Metry A, Poku E, Hykin P, Sivaprasad S, Prevost AT, Vasconcelos JC, Murphy C , Kelly J et al () . PharmacoEconomics. RIS download Bibtex download

Conference proceedings papers

  • Flight L, Julious S, Brennan A & Todd S (2020) . 41st Annual Meeting of the Society for Medical Decision Making Portland, Oregon, October 20–23, 2019, Vol. 40(1) (pp E1-E379) RIS download Bibtex download
  • Pennington B, Alshreef A, Flight L, Hykin P, Sivaprasad S, Brazier JE & Hernández M (2019) . Value in Health, Vol. 22(Suppl. 3) (pp S891-S891). Copenhagen, Denmark, 2 November 2019 - 6 November 2019. RIS download Bibtex download
  • Flight L, Alshreef A, Hykin PG, Sivaprasad S, Pennington B, Kelly J, Murphy CL & Brazier JE (2019) . Value in Health, Vol. 22(Suppl 3) (pp S664-S664). Copenhagen, Denmark, 2 November 2019 - 6 November 2019. RIS download Bibtex download
  • Flight L, Baxter S & Khan S (2019) . Trials, Vol. 20(Supplement 1) (pp 25-25). Brighton, UK, 6 October 2019 - 9 October 2019. RIS download Bibtex download
  • Flight L, Hind D, Julious S, Brennan A & Todd S (2019) . Trials, Vol. 20(Supplement 1) (pp 109-109). Brighton, UK, 6 October 2019 - 9 October 2019. RIS download Bibtex download

Reports

  • Forster M, Flight L, Corbacho B, Keding A, Ronaldson S, Tharmanathan P, Welch C, Brennan A & Chick S (2021) Report for the EcoNomics of Adaptive Clinical Trials (ENACT) project: Application of a Bayesian Value-Based Sequential Model of a Clinical Trial to the CACTUS and HERO Case Studies (with Guidance Material for Clinical Trials Units) RIS download Bibtex download

Posters

  • Candlish J, Teare D, Cohen J, Dimairo M, Flight L, Mandefield L & Walters S (2017) Methods to analyse partially nested randomised controlled trials. RIS download Bibtex download
  • Walters S, Lee E, Flight L, Mandefield L, Dimario M & Allison A (2015) Analysis and reporting of individually randomised controlled trials with clustering in one arm only: how should we do it?. RIS download Bibtex download

Datasets

  • Pennington R, Hernandez M, Hykin P, Sivaprasad S, Flight L, Alshreef A & Brazier J . RIS download Bibtex download

Preprints

  • Robertson DS, Choodari-Oskooei B, Dimairo M, Flight L, Pallmann P & Jaki T (2021) Point estimation for adaptive trial designs, arXiv. RIS download Bibtex download
  • Flight L, Brennan A, Chick SE, Forster M, Julious S & Tharmanathan P () Value-Adaptive Clinical Trial Designs for Efficient Delivery of Research – Actions, Opportunities and Challenges for Publicly Funded Trials. RIS download Bibtex download