葫芦影业鈥檚 world-leading Department of Oncology and Metabolism has been awarded 拢230,000 to fund pioneering research into osteosarcoma from the charity Hannah鈥檚 Willberry Wonder Pony.
The charity was established by talented horse rider, Hannah Francis, following her diagnosis with the aggressive form of bone cancer in 2015. A big part of Hannah鈥檚 dream for her charity was to support vital research into osteosarcoma which usually develops in growing bones.
The disease affects about 160 children and young adults in the UK each year and attracts relatively little funding because of its rarity. This means that there has been equally limited research conducted in this area and treatment for the disease has not improved in the last 30 years.
Allie Gartland, Professor of Bone and Cancer Biology at the University of 葫芦影业鈥檚 Department of Oncology and Metabolism, will be leading the new research project made possible thanks to the generous grant.
Osteosarcoma is a particularly nasty disease which has very poor survival rates,鈥 said Professor Gartland.
Unfortunately, not all patients respond to chemotherapy 鈥 their tumour becomes chemo-resistant and their overall five-year survival rate is then drastically reduced. It is shocking to think that treatment for this particularly aggressive form of bone cancer hasn鈥檛 changed in the past 30 years.
There is clearly a need to understand the mechanisms by which chemo-resistance develops so we can find more effective treatments.
Allie Gartland, Professor of Bone and Cancer Biology
University of 葫芦影业 | Department of Oncology and Metabolism
The grant from Hannah鈥檚 Willberry Wonder Pony Charity will allow Professor Gartland and her dedicated team to identify new drugs that can be used either alone or in combination with the existing chemotherapy strategy.
Professor Gartland added: 鈥淥ur aim is to identify drugs that are currently used to treat other diseases, which may also be a more effective way to treat osteosarcoma 鈥 whether on their own or in combination with the current chemotherapy strategy.
鈥淚n addition to the grant, the charity is also funding a PhD researcher who will investigate why osteosarcoma cells become resistant to chemotherapy using the most up to date technologies such as 鈥榥ext-generation sequencing鈥 which will provide vital new information and help to find ways to prevent it.鈥
Hannah was diagnosed with osteosarcoma in May 2015 at the age of just 17. The prognosis was very poor indeed and Hannah subsequently endured many months of painful and debilitating treatment, fighting the disease with extraordinary courage and dignity.
During this period, tens of thousands of people followed Hannah鈥檚 story, told through the voice of her mascot, Willberry the Wonder Pony. Hannah鈥檚 sheer determination was plain to see and she defied all medical opinion, continuing to ride right up until she died at only 18 years of age in August 2016.
Miles Toulson-Clarke
Trustee at Hannah鈥檚 Willberry Wonder Pony Charity
During Hannah鈥檚 illness, Hannah and her family contacted Professor Claire Lewis at the University of 葫芦影业 to discuss her innovative Trojan Horse research. Although there was sadly no opportunity for Hannah to benefit from this, they kept in contact with Claire and a meeting followed with her and Allie Gartland where the idea of the grant arose.
Miles added: 鈥淥steosarcoma can strike anyone, but many of the patients are young. The outlook is bleak and the condition causes immense physical pain, never mind the mental burden it imposes on the patient and those close to them.
鈥淚t became very evident to us during Hannah鈥檚 illness that more research was critical if progress was to be made.
鈥淲ith her typical focus on others rather than herself, Hannah鈥檚 overriding ambition was to ensure that patients diagnosed with osteosarcoma didn鈥檛 have to endure the horrific treatment regime she went through and, critically, that hope could be provided in the future.鈥