Professor Alex Rothman
MA, BM BCh, MRes, PhD, MRCP, EEGC
Clinical Medicine, School of Medicine and Population Health
Professor of Cardiology
Honorary Consultant Cardiologist
+44 114 215 9521
Full contact details
Clinical Medicine, School of Medicine and Population Health
The Medical School
Beech Hill Road
葫芦影业
S10 2RX
- Profile
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For enquiries please contact - SMPH-West-Operational@sheffield.ac.uk
I trained in medicine at Cambridge and Oxford and joined the University of 葫芦影业 in 2008 as an Academic Clinical Fellow working as part of a team investigating the therapeutic tractability of inflammation in patients suffering heart attacks (the MRC ILA Heart study).
Through my MRC Clinical Research Training Fellowship I developed an interest in the pathology and treatment of cardiovascular diseases and have been closely involved in studies investigating new therapies and devices for the treatment of pulmonary arterial hypertension, atherosclerosis and heart failure.
I am currently a Wellcome Trust Career Development Fellow and an Honorary Consultant Cardiologist at 葫芦影业 Teaching Hospitals NHS Trust.
- Research interests
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My research interests are the pathology and treatment of cardiovascular and pulmonary vascular diseases.
The MRC ILA Heart study was the first randomised study to demonstrate the therapeutic tractability of inflammatory signalling in coronary artery disease. Findings were published in the European Heart Journal and the New England Journal of Medicine and validated by CANTOS, a phase III study of the interleukin-1 beta targeted therapy Canakinumab that demonstrated a reduction in recurrent cardiac events.
My current work focuses on the pathology of pulmonary arterial hypertension and the development of novel therapeutic strategies. Recent pre-clinical studies have led to early phase clinical studies of pulmonary artery denervation, implantable pulmonary artery pressure monitors and new drug studies.
Current projects:
- Wellcome Trust Clinical Research Career Development Fellowship: Determining Novel SMURF1 Signalling Pathways and Precision Medicine Strategies in Patients with Pulmonary Arterial Hypertension, 拢460,409.
- MRC Confidence in Concepts, The Feasibility of Novel Clinical Trial Infrastructure, Design and Technology for Early Phase Studies in Patients with Pulmonary Arterial Hypertension (FIT-PH), 拢65,610 (PI)
- British Heart Foundation, Development of a Prototype Pericardial Left Ventricular Assist Device, 拢249,967 (Co-I)
- Medtronic Inc. Non-invasive phenotyping of arrhythmias in pulmonary arterial hypertension, 拢200,000
- Association of Physicians of Great Britain and Ireland Young Investigator Award, 拢19,973
- Academy of Medical Sciences, Starter Grants for Clinical Lecturers: Inhibition of SMURF1 for the Treatment of Pulmonary Arterial Hypertension, 拢30,000
- EPSRC/HEFCE and Endotronix: Intra-arterial Pulmonary Artery Pressure Monitoring in Pulmonary Hypertension: Re-defining Clinical Measurement of Treatment Effect and Disease Progression, 拢84,711
- TROPHY: Therapeutic Intravascular Ultrasound for the treatment of pulmonary arterial hypertension ()
- SIRONA: A Prospective, Multi-Center, Open-Label, Single-Arm Clinical Trial Evaluating the Safety and Efficacy of the Cordella Heart Failure System in NYHA Class III Heart Failure Patients. ()
- Publications
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Show: Featured publications All publications
Featured publications
Journal articles
- . JACC: Cardiovascular Interventions, 13(8), 989-999.
- . European Respiratory Journal, 55(4), 2000314-2000314.
- . American Journal of Respiratory and Critical Care Medicine, 201(4), 458-468.
- . Hypertension, 75(2), 477-482.
- . Nature Communications, 10(1).
- . Frontiers in Medicine, 6.
- . EuroIntervention.
- . Pulmonary Circulation.
- . European Respiratory Journal, 52(3).
- . Journal of Thoracic Disease, 10(S26), S3084-S3087.
- . Journal of the American Heart Association, 7(13).
- . The New England journal of medicine, 378(2), 196-200.
- . Journal of Thoracic Disease, 9, 4922-4925.
- . American Journal of Respiratory and Critical Care Medicine, 196(2).
- . The Journal of Heart and Lung Transplantation.
- . Epigenomics.
- . Journal of Clinical Investigation, 126(7), 2495-2508.
- . JACC: Cardiovascular Interventions, 8(15), 2013-2023.
- . Circulation: Cardiovascular Interventions, 8(11), e002569-e002569.
- . Circulation: Cardiovascular Interventions, 8(11).
- . Prog Mol Biol Transl Sci, 124, 43-63.
- The Effect of Interleukin-1 Receptor Antagonist Therapy on Markers of Inflammation in Non-ST Elevation Acute Coronary Syndromes: The MRC-ILA Heart Study. CIRCULATION, 128(22).
- . Cardiovasc Res, 100(2), 252-261.
- Intracellular retention of mutant retinoschisin is the pathological mechanism underlying X-linked retinoschisis. Human molecular genetics, 11(24), 3097-3105.
- . European Journal of Heart Failure.
- . PLoS ONE, 10(10).
All publications
Journal articles
- . The Journal of Heart and Lung Transplantation, 43(10), 1629-1639.
- . Pulmonary Circulation, 14(3).
- . Heart.
- . BMJ Open, 14(3).
- . Pulmonary Circulation, 14(1).
- . European Respiratory Journal, 63(3).
- . JACC: Basic to Translational Science, 9(2), 257-259.
- . Radiology, 310(2).
- . BMJ Open, 14(1).
- . Medicina, 59(11).
- The Left Atrial Area Derived Cardiovascular Magnetic Resonance Left Ventricular Filling Pressure Equation Shows Superiority over Integrated Echocardiography. Medicina (Kaunas, Lithuania), 59(11).
- . European Respiratory Journal, 62(2), 2202225-2202225.
- . The Lancet Digital Health, 5(7), e467-e476.
- . Frontiers in Cardiovascular Medicine, 10.
- . JACC: Basic to Translational Science, 8(4), 386-388.
- . Cardiovascular Research, 118(Supplement_2).
- . Radiology, 304(3), E56-E56.
- . International Journal of Cardiology.
- . Heart.
- . Eur Heart J.
- . European Heart Journal - Digital Health.
- . Journal of Cardiovascular Magnetic Resonance, 24(1).
- . Nature Communications, 12.
- . Pulmonary Circulation, 11(4).
- . European Stroke Journal, 6(3), 283-290.
- . EBioMedicine, 69, 103444-103444.
- Design of a randomised, double-blind, crossover, placebo-controlled trial of effects of sildenafil on cerebrovascular function in small vessel disease: Oxford haemodynamic adaptation to reduce pulsatility trial (OxHARP). European stroke journal, 6(3), 283-290.
- . Canadian Journal of Cardiology.
- . Int J Cardiovasc Imaging.
- . European Heart Journal Acute Cardiovascular Care, 10(Supplement_1), zuab020.035.
- Preclinical testing of a novel pericardial left ventricular assist device (PALVAD). European Heart Journal. Acute Cardiovascular Care, 10(Suppl 1).
- . International Journal of Cardiology.
- . ESC Heart Failure.
- . JACC: Cardiovascular Imaging.
- . European Heart Journal, 41(Supplement_2).
- . Pulmonary Circulation, 10(4).
- . Journal of the American College of Cardiology, 76(17), B77-B77.
- . Cardiovascular Diagnosis and Therapy, 10(5), 1735-1767.
- . Scientific Reports, 10(1).
- . Scientific Reports, 10(1).
- . JACC: Cardiovascular Interventions, 13(8), 989-999.
- . European Respiratory Journal, 55(4), 2000314-2000314.
- . American Journal of Respiratory and Critical Care Medicine, 201(4), 458-468.
- . Hypertension, 75(2), 477-482.
- . ESC Heart Failure, 7(3), 865-872.
- . Nature Communications, 10(1).
- . Canadian Journal of Cardiology.
- . Frontiers in Cardiovascular Medicine, 6.
- . Frontiers in Medicine, 6.
- . EuroIntervention.
- . Pulmonary Circulation.
- . Clinical Radiology, 74(6), 435-436.
- . BioMed Research International, 2019.
- . European Respiratory Journal, 52(3).
- . Journal of Thoracic Disease, 10(S26), S3084-S3087.
- . Journal of the American Heart Association, 7(13).
- . The New England journal of medicine, 378(2), 196-200.
- . Annals of Behavioral Medicine, 52(6), 501-512.
- . Journal of Thoracic Disease, 9, 4922-4925.
- . American Journal of Respiratory and Critical Care Medicine, 196(11).
- . Pulmonary Circulation.
- . American Journal of Respiratory and Critical Care Medicine, 196(2).
- . The Journal of Heart and Lung Transplantation.
- . Cardiovascular Research, 112(3), 689-701.
- . Epigenomics.
- . Journal of Clinical Investigation, 126(7), 2495-2508.
- . Circulation: Cardiovascular Interventions, 9(1).
- . JACC: Cardiovascular Interventions, 8(15), 2013-2023.
- . Circulation: Cardiovascular Interventions, 8(11), e002569-e002569.
- . Circulation: Cardiovascular Interventions, 8(11).
- . British Journal of Cardiology, 21, 118-119.
- . Prog Mol Biol Transl Sci, 124, 43-63.
- The Effect of Interleukin-1 Receptor Antagonist Therapy on Markers of Inflammation in Non-ST Elevation Acute Coronary Syndromes: The MRC-ILA Heart Study. CIRCULATION, 128(22).
- . Cardiovasc Res, 100(2), 252-261.
- . Annals of Behavioral Medicine, 38(S1), 4-17.
- Intracellular retention of mutant retinoschisin is the pathological mechanism underlying X-linked retinoschisis. Human molecular genetics, 11(24), 3097-3105.
- . BMC Pulmonary Medicine, 24(1).
- . Expert Review of Cardiovascular Therapy, 1-7.
- . Circulation Research.
- . Annals of Behavioral Medicine.
- . Scientific Reports, 13(1).
- . JMIR mHealth and uHealth.
- . Translational Behavioral Medicine.
- . ESC Heart Failure.
- . Radiology.
- . Radiology.
- . ERJ Open Research, 00503-2021.
- . Frontiers in Cardiovascular Medicine, 9.
- . JMIR Research Protocols.
- . Thorax.
- . European Journal of Heart Failure.
- . Annals of the American Thoracic Society.
- . Interventional Cardiology Review, 16.
- . ESC Heart Failure.
- . Platelets.
- . European Journal of Heart Failure.
- . European Radiology.
- mir-140-5p and SMURF1 regulate pulmonary arterial hypertension. Journal of Clinical Investigation.
- . PLoS ONE, 10(10).
- Left ventricular blood flow kinetic energy is associated with the six-minute walk test and LV remodelling post valvular intervention in aortic stenosis.. Quantitative imaging in medicine and surgery.
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Conference proceedings papers
- . 鈥楻ight here, right now鈥 鈥 Bench to bedside in pulmonary vascular disease
- . D106. HOT OFF THE PRESSES! LATE BREAKERS IN PULMONARY VASCULAR DISEASE
- . B57. INTERMEDIATES, CORRELATES, AND SURROGATES, OH MY!: NOVEL END POINTS AND ASSESSMENTS IN PVD
- . Abstracts
- . 13.01 - Pulmonary hypertension
- . 13.01 - Pulmonary hypertension
- . 13.01 - Pulmonary hypertension
- . 鈥楾he Sixth Sense鈥 鈥 Prognostication in pulmonary vascular disease
- . 鈥楾he Sixth Sense鈥 鈥 Prognostication in pulmonary vascular disease
- . 鈥楾he Sixth Sense鈥 鈥 Prognostication in pulmonary vascular disease
- . 鈥楥ontagion鈥 鈥 The impact of COVID-19
- . 鈥楳ission (Im)possible I鈥 鈥 Pulmonary vascular disease
- . 鈥楾he Sixth Sense鈥 鈥 Prognostication in pulmonary vascular disease
- . 鈥楳ission (Im)possible I鈥 鈥 Pulmonary vascular disease
- . Circulation, Vol. 146(Suppl_1) (pp a13553-a13553)
- . Circulation, Vol. 146(Suppl_1) (pp a13527-a13527)
- . A105. YOU CAN PREDICT ALL YOU WANT, BUT EVERYONE KNOWS...
- . Circulation, Vol. 144(Suppl_1)
- . Abstracts
- . Heart failure
- . Heart failure
- Heart Rhythm versus Heart Rate Control Strategy in Patients With Pre-Capillary Pulmonary Hypertension and Atrial Arrhythmias. CIRCULATION, Vol. 144
- . Circulation, Vol. 142(Suppl_3)
- . Pulmonary hypertension
- . Pulmonary hypertension
- . D63. PULMONARY EMBOLISM: CASE REPORTS AND LATE BREAKING
- . Pulmonary hypertension
- . European Heart Journal - Cardiovascular Imaging, Vol. 20(Supplement_2)
- . European Heart Journal - Cardiovascular Imaging, Vol. 20(Supplement_2)
- . European Heart Journal - Cardiovascular Imaging, Vol. 20(Supplement_2)
- . A105. GLORY DAYS: THE LATEST CLINICAL RESEARCH IN PAH
- A novel cardiac magnetic resonance imaging model to predict level of mixed venous oxygen levels in pulmonary hypertension. EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING, Vol. 20 (pp 121-121)
- . Fundamental mechanisms of pulmonary arterial hypertension
- Expression of SMURF1 is Increased in Patients With Pulmonary Arterial Hypertension and SiRNA Inhibition of SMURF1 Reduces Pulmonary Artery Smooth Muscle Cell Proliferation. CIRCULATION, Vol. 138
- . European Heart Journal, Vol. 38(suppl_1)
- . Thorax, Vol. 71(Suppl 3) (pp A220.2-A221)
- . 4.3 Pulmonary Circulation and Pulmonary Vascular Diseases
- . EUROPEAN RESPIRATORY JOURNAL, Vol. 48
- . Heart, Vol. 102(Suppl 6) (pp A147-A147)
- . Thorax, Vol. 70(Suppl 3) (pp A5.3-A6)
- . Thorax, Vol. 70(Suppl 3) (pp A3.1-A3)
- . Thorax, Vol. 69(Suppl 2) (pp A2-A3)
- . Heart, Vol. 100(Suppl 3) (pp A102.3-A103), 2 June 2014 - 4 June 2014.
- Novel OPG Protein Interactions Regulate Survival, Proliferation and PAH-Associated Gene Expression in Pulmonary Arterial Smooth Muscle Cells.. Heart, Vol. 100(Suppl 3:A102-3.)
- Bone Marrow Derived Osteoprotegerin Drives Experimental Pulmonary Arterial Hypertension In The Murine Sugen/hypoxia Model. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 189
- Novel Osteoprotegerin Protein Interactions Regulate Pulmonary Arterial Smooth Muscle Cell Survival And Proliferation. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 189
- Radio-Frequency Denervation Of The Pulmonary Artery Reduces Pulmonary Hypertension In An Acute Porcine Model. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 189
- The Effect of Interleukin-1 Receptor Antagonist Therapy on Markers of Inflammation in Non-ST Elevation Acute Coronary Syndromes: The MRC-ILA Heart Study. Circulation, Vol. 128(A14792)
- The Effect of Interleukin-1 Receptor Antagonist Therapy on Markers of Inflammation in Non-ST Elevation Acute Coronary Syndromes: The MRC-ILA Heart Study. Circulation, Vol. 128(A14792)
- . HEART, Vol. 97(20) (pp 7-7)
- . HEART, Vol. 97 (pp A13-A13)
- RS1 mutations causing X-linked Juvenile Retinoschisis lead to intracellular retention of mutant retinoschisin.. AMERICAN JOURNAL OF HUMAN GENETICS, Vol. 71(4) (pp 554-554)
- Intracellular retention of mutant retinoschisin is the pathological mechanism underlying X-linked retinoschisis.. JOURNAL OF MEDICAL GENETICS, Vol. 39 (pp S15-S15)
Website content
Preprints
- Teaching interests
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I enjoy lecturing clinical cardiology to both undergraduates and post-graduates and I teach clinical skills to medical students and doctors.