Professor Chris Toseland

Clinical Medicine, School of Medicine and Population Health

Professor of Cancer Biophysics

Chris Toseland
Profile picture of Chris Toseland
c.toseland@sheffield.ac.uk
+44 114 215 9080

Full contact details

Professor Chris Toseland
Clinical Medicine, School of Medicine and Population Health
FU34, F Floor
The Medical School
Beech Hill Road
葫芦影业
S10 2RX
Profile

For enquiries please contact - ClinMed-Operational@sheffield.ac.uk

2019: Senior Lecturer/MRC Career Development Award Fellowship
School of Medicine & Population Health - University of 葫芦影业

2015 - 2019: MRC Career Development Award
Schools of Biosciences - University of Kent

April 2015: Leverhulme Early Career Research Fellow
Schools of Biosciences - University of Kent

2013 鈥 2015: Senior Post-Doc Researcher
Max-Planck Institute for Biochemistry, Munich, Germany

2010 鈥 2013: EMBO Long Term Fellow
LMU Munich, Munich, Germany

2009 鈥 2010: Post-Doctoral Research Associate
MRC National Institute for Medical Research, London, UK

2006 鈥 2009: PhD
MRC National Institute for Medical Research, London, UK

2002 鈥 2006: BSc Biochemistry
University of Wales - Aberystwyth

Research interests

The lab specialises in application of fluorescence and mechanical measurements from whole cells to single molecules. We are a multidisciplinary lab drawing upon core techniques in Cell Biology, Biochemistry, Biophysics, Mechanobiology, Super Resolution single molecule imaging and Genomics Gene expression, the transfer of the genetic code into cellular proteins is one of the most fundamental processes in living cells. This process is orchestrated by RNA polymerases, which are highly regulated to ensure correct expression.

A breakdown in this regulation leads to development disabilities and most notably cancer formation. Furthermore, changes in expression control embryonic development and stem cell differentiation.

Over the past decade it has become established that myosin motors are present in the nucleus and function in transcription, but what role they play in the organisation and transcription of genetic information is unclear.

For the first time we combine classical biochemical and single molecule assays to provide a quantitative high-resolution description of the activity of these nuclear myosins; providing a mechanistic insight into the activity of these proteins.

Please see External Lab HomePage for more information.

Publications

Show: Featured publications All publications

Journal articles

  • Santos 脕D, Fili N, Pearson DS, Hari-Gupta Y & Toseland CP (2021) . Biophysical Journal. RIS download Bibtex download
  • dos Santos A, Cook A, Gough R, Schilling M, Aleida Olszok N, Brown I, Wang L, Aaron J, Martin-Fernandez M, Rehfeldt F & Toseland C (2021) . Nucleic Acids Research, 49(1), 340-353. RIS download Bibtex download
  • Cook AW, Gough RE & Toseland CP (2020) . Journal of Cell Science, 133(11), jcs242420-jcs242420. RIS download Bibtex download
  • Fili N, Hari-Gupta Y, Aston B, dos Santos 脕, Gough RE, Alamad B, Wang L, Martin-Fernandez ML & Toseland CP (2019) . Journal of Biological Chemistry. RIS download Bibtex download
  • Acton S, Bell A, Toseland C & Twelvetrees A (2019) . eLife, 2019(8). RIS download Bibtex download
  • Fili N, Hari-Gupta Y, dos Santos 脕, Cook A, Poland S, Ameer-Beg SM, Parsons M & Toseland CP (2017) . Nature Communications, 8. RIS download Bibtex download
  • Lherbette M, dos Santos 脕, Hari-Gupta Y, Fili N, Toseland CP & Schaap IAT (2017) . Scientific Reports, 7. RIS download Bibtex download
  • Fili N & Toseland CP () . International Journal of Molecular Sciences, 21(1), 67-67. RIS download Bibtex download

All publications

Journal articles

  • dos Santos 脕, Fili N, Hari-Gupta Y, Gough RE, Wang L, Martin-Fernandez M, Aaron J, Wait E, Chew T-L & Toseland CP (2022) . Biochemical Journal, 479(13), 1409-1428. RIS download Bibtex download
  • Hari-Gupta Y, Fili N, dos Santos 脕, Cook AW, Gough RE, Reed HCW, Wang L, Aaron J, Venit T, Wait E , Grosse-Berkenbusch A et al (2022) . Nature Communications, 13(1). RIS download Bibtex download
  • Dos Santos 脕, Rehfeldt F & Toseland CP (2022) . Methods Mol Biol, 2476, 171-181. RIS download Bibtex download
  • Dos Santos 脕, Gough RE, Wang L & Toseland CP (2022) . Methods Mol Biol, 2476, 293-309. RIS download Bibtex download
  • dos Santos 脕 & Toseland CP (2021) . International Journal of Molecular Sciences, 22(6). RIS download Bibtex download
  • Emmanouilidis I, Fili N, Cook AW, Hari-Gupta Y, dos Santos 脕, Wang L, Martin-Fernandez ML, Ellis PJI & Toseland CP (2021) . Biomolecules, 11(2). RIS download Bibtex download
  • Santos 脕D, Fili N, Pearson DS, Hari-Gupta Y & Toseland CP (2021) . Biophysical Journal. RIS download Bibtex download
  • dos Santos A, Cook A, Gough R, Schilling M, Aleida Olszok N, Brown I, Wang L, Aaron J, Martin-Fernandez M, Rehfeldt F & Toseland C (2021) . Nucleic Acids Research, 49(1), 340-353. RIS download Bibtex download
  • Cook AW & Toseland CP (2020) . The Journal of Biochemistry. RIS download Bibtex download
  • Cook AW, Gough RE & Toseland CP (2020) . Journal of Cell Science, 133(11), jcs242420-jcs242420. RIS download Bibtex download
  • Fili N, Hari-Gupta Y, Aston B, dos Santos 脕, Gough RE, Alamad B, Wang L, Martin-Fernandez ML & Toseland CP (2019) . Journal of Biological Chemistry. RIS download Bibtex download
  • Acton S, Bell A, Toseland C & Twelvetrees A (2019) . eLife, 2019(8). RIS download Bibtex download
  • Cook A, Hari-Gupta Y & Toseland CP (2018) . Biochemical and Biophysical Research Communications, 496(3), 820-825. RIS download Bibtex download
  • Fili N, Hari-Gupta Y, dos Santos 脕, Cook A, Poland S, Ameer-Beg SM, Parsons M & Toseland CP (2017) . Nature Communications, 8. RIS download Bibtex download
  • Toseland C (2017) . Impact, 2017(10), 49-51. RIS download Bibtex download
  • Lherbette M, dos Santos 脕, Hari-Gupta Y, Fili N, Toseland CP & Schaap IAT (2017) . Scientific Reports, 7. RIS download Bibtex download
  • Yao M, Goult BT, Klapholz B, Hu X, Toseland CP, Guo Y, Cong P, Sheetz MP & Yan J (2016) . Nature Communications, 7. RIS download Bibtex download
  • Kang H-A, Shin H-C, Kalantzi A-S, Toseland CP, Kim H-M, Gruber S, Peraro MD & Oh B-H (2015) . Nucleic Acids Research, 43(7), 3841-3856. RIS download Bibtex download
  • Soh Y-M, B眉rmann F, Shin H-C, Oda T, Jin KS, Toseland CP, Kim C, Lee H, Kim SJ, Kong M-S , Durand-Diebold M-L et al (2015) . Molecular Cell, 57(2), 290-303. RIS download Bibtex download
  • Toseland CP & Geeves MA (2014) , 49-65. RIS download Bibtex download
  • Fili N & Toseland CP (2014) , 1-24. RIS download Bibtex download
  • Toseland CP (2014) , 67-86. RIS download Bibtex download
  • Toseland CP & Webb MR (2013) . Journal of Biological Chemistry, 288(35), 25183-25193. RIS download Bibtex download
  • Chisty LT, Toseland CP, Fili N, Mashanov GI, Dillingham MS, Molloy JE & Webb MR (2013) . Nucleic Acids Research, 41(9), 5010-5023. RIS download Bibtex download
  • Toseland CP (2013) . Journal of Chemical Biology, 6(3), 85-95. RIS download Bibtex download
  • Batters C, Woodall KA, Toseland CP, Hundschell C & Veigel C (2012) . Journal of Biological Chemistry, 287(33), 27556-27566. RIS download Bibtex download
  • Batters C, Woodall K, Toseland C & Veigel C (2012) . Biophysical Journal, 102(3), 570a-570a. RIS download Bibtex download
  • Toseland CP & Webb MR (2011) , 161-174. RIS download Bibtex download
  • Fili N, Toseland CP, Dillingham MS, Webb MR & Molloy JE (2011) , 193-214. RIS download Bibtex download
  • Fili N, Mashanov GI, Toseland CP, Batters C, Wallace MI, Yeeles JTP, Dillingham MS, Webb MR & Molloy JE (2010) . Nucleic Acids Research, 38(13), 4448-4457. RIS download Bibtex download
  • Toseland CP & Webb MR (2010) . Methods, 51(3), 259-268. RIS download Bibtex download
  • Toseland CP, Martinez-Senac MM, Slatter AF & Webb MR (2009) . Journal of Molecular Biology, 392(4), 1020-1032. RIS download Bibtex download
  • Davies MN, Guan P, Blythe MJ, Salomon J, Toseland CP, Hattotuwagama C, Walshe V, Doytchinova IA & Flower DR (2007) . Expert Opinion on Drug Discovery, 2(1), 19-35. RIS download Bibtex download
  • Taylor PD, Toseland CP, Attwood TK & Flower DR (2006) Alpha helical trans-membrane proteins: Enhanced prediction using a Bayesian approach.. Bioinformation, 1(6), 234-236. RIS download Bibtex download
  • Taylor PD, Toseland CP, Attwood TK & Flower DR (2006) A predictor of membrane class: Discriminating alpha-helical and beta-barrel membrane proteins from non-membranous proteins.. Bioinformation, 1(6), 208-213. RIS download Bibtex download
  • Taylor PD, Toseland CP, Attwood TK & Flower DR (2006) Beta barrel trans-membrane proteins: Enhanced prediction using a Bayesian approach.. Bioinformation, 1(6), 231-233. RIS download Bibtex download
  • Hattotuwagama CK, Toseland CP, Guan P, Taylor DJ, Hemsley SL, Doytchinova IA & Flower DR (2006) . ChemInform, 37(31). RIS download Bibtex download
  • Davies MN, Toseland CP, Moss DS & Flower DR (2006) . BMC Biochemistry, 7(1), 18-18. RIS download Bibtex download
  • Hattotuwagama CK, Toseland CP, Guan P, Taylor DJ, Hemsley SL, Doytchinova IA & Flower DR (2006) . Journal of Chemical Information and Modeling, 46(3), 1491-1502. RIS download Bibtex download
  • Toseland CP (2006) . Nucleic Acids Research, 34(90001), D199-D203. RIS download Bibtex download
  • Toseland CP, McSparron HM & Flower DR (2005) . BMC Bioinformatics, 6(1), 283-283. RIS download Bibtex download
  • Toseland CP, Clayton DJ, McSparron H, Hemsley SL, Blythe MJ, Paine K, Doytchinova IA, Guan P, Hattotuwagama CK & Flower DR (2005) . Immunome Research, 1(1), 4-4. RIS download Bibtex download
  • Guan P, Davies M, Taylor D, Wan S, McSparron H, Hemsley S, Toseland C, Blythe M, Taylor P, Walshe V , Hattotuwagama C et al (2005) . Current Computer Aided-Drug Design, 1(4), 377-395. RIS download Bibtex download
  • Shahid-Fuente IW & Toseland CP () . Biochemical Society Transactions. RIS download Bibtex download
  • Toseland C () Autophagy receptor NDP52 alters DNA conformation to modulate RNA Polymerase II transcription. Nature Communications. RIS download Bibtex download
  • Fili N & Toseland CP () . International Journal of Molecular Sciences, 21(1), 67-67. RIS download Bibtex download
  • Fili N, Hari-Gupta Y, Aston B, dos Santos 脕, Gough RE, Alamad B, Wang L, Martin-Fernandez M & Toseland CP () . RIS download Bibtex download
  • Cook A, Hari-Gupta Y & Toseland CP () . RIS download Bibtex download
  • Wilhelm L, B眉rmann F, Minnen A, Shin H-C, Toseland CP, Oh B-H & Gruber S () . eLife, 4. RIS download Bibtex download
  • Toseland CP, Powell B & Webb MR () . PLoS ONE, 7(6), e38270-e38270. RIS download Bibtex download
  • Taylor PD, Toseland CP, Attwood TK & Flower DR () . Bioinformation, 1(5), 184-187. RIS download Bibtex download
  • Taylor PD, Toseland CP, Attwood TK & Flower DR () . Bioinformation, 1(5), 176-179. RIS download Bibtex download
  • Toseland C & dos Santos A () Magnetic Tweezers in a Microplate Format. Journal of Visualized Experiments. RIS download Bibtex download

Chapters

  • Webb MR & Toseland CP (2013) , Encyclopedia of Biophysics (pp. 950-958). Springer Berlin Heidelberg RIS download Bibtex download
  • Fili N, Toseland CP, Dillingham MS, Webb MR & Molloy JE (2011) , Single Molecule Enzymology (pp. E1-E1). Humana Press RIS download Bibtex download
  • Hattotuwagama CK, Guan P, Davies M, Taylor DJ, Walshe V, Hemsley SL, Toseland C, Doytchinova IA, Borrow P & Flower DR () , In Silico Immunology (pp. 139-175). Springer US RIS download Bibtex download

Conference proceedings papers

  • Cook A, Hari Gupta Y, Venit T, Percipalle P & Toseland CP (2019) . Biophysical Journal, Vol. 116(3) (pp 77a-77a) RIS download Bibtex download
  • dos Santos A, Wang L & Toseland CP (2019) . Biophysical Journal, Vol. 116(3) (pp 210a-210a) RIS download Bibtex download
  • Fili N, Cook A, Hari Gupta Y & Toseland CP (2019) . Biophysical Journal, Vol. 116(3) (pp 178a-178a) RIS download Bibtex download
  • Gough RE, Fili N, Hari Gupta Y & Toseland CP (2019) . Biophysical Journal, Vol. 116(3) (pp 260a-260a) RIS download Bibtex download
  • Hari Gupta Y, Fili N, dos Santos A, Chew T-L, Aaron J, Wang L & Toseland CP (2019) . Biophysical Journal, Vol. 116(3) (pp 208a-209a) RIS download Bibtex download
  • Hari Gupta Y, Fili N, dos Santos A, Chew T-L, Aaron J, Wang L & Toseland CP (2019) . Biophysical Journal, Vol. 116(3) (pp 209a-209a) RIS download Bibtex download
  • Fili N, dos Santos A, Hari-Gupta Y & Toseland CP (2016) Activation of nuclear myosin VI leads to enhanced gene expression.. MOLECULAR BIOLOGY OF THE CELL, Vol. 27 RIS download Bibtex download
  • Fili N, Hari-Gupta Y & Toseland CP (2016) Dissecting the role of Myosin VI in the nucleus.. MOLECULAR BIOLOGY OF THE CELL, Vol. 27 RIS download Bibtex download
  • Toseland CP, Ellrich H, Fili N, Batters C & Veigel C (2012) . Biophysical Journal, Vol. 102(3) (pp 569a-569a) RIS download Bibtex download
  • Veigel C, Batters C, Toseland CP & Sellers JR (2011) . Biophysical Journal, Vol. 100(3) (pp 116a-116a) RIS download Bibtex download
  • Toseland CP, Batters C & Veigel C (2011) . Biophysical Journal, Vol. 100(3) (pp 72a-73a) RIS download Bibtex download
  • Toseland CP & Webb MR (2009) . Biophysical Journal, Vol. 96(3) (pp 415a-415a) RIS download Bibtex download

Preprints

  • Gonz谩lez-Novo R, Zamora-Carreras H, de Lope-Planelles A, Men茅ndez HL, Roda-Navarro P, Monroy F, Wang L, Toseland CP & Mu帽oz JR (2023) , Cold Spring Harbor Laboratory. RIS download Bibtex download
  • dos Santos 脕, Rollins DE, Hari-Gupta Y, Reed HCW, Du M, Ru SYZ, Pidlisna K, Stranger A, Lorgat F, Brown I , Howland K et al () , Cold Spring Harbor Laboratory. RIS download Bibtex download
  • Emmanouilidis I, Fili N, Cook AW, Hari-Gupta Y, dos Santos 脕, Wang L, Martin-Fernandez M, Ellis PJI & Toseland CP () . RIS download Bibtex download
  • dos Santos 脕, Cook AW, Gough RE, Schilling M, Olszok NA, Brown I, Wang L, Aaron J, Martin-Fernandez ML, Rehfeldt F & Toseland CP () , Cold Spring Harbor Laboratory. RIS download Bibtex download
  • dos Santos 脕, Fili N, Hari-Gupta Y, Gough RE, Wang L, Martin-Fernandez M, Aaron J, Wait E, Chew T-L & Toseland CP () , Cold Spring Harbor Laboratory. RIS download Bibtex download
  • Santos 脕D, Fili N, Pearson DS, Hari-Gupta Y & Toseland CP () . RIS download Bibtex download
  • Hari-Gupta Y, Fili N, dos Santos 脕, Cook AW, Gough RE, Reed HCW, Wang L, Aaron J, Venit T, Wait E , Grosse-Berkenbusch A et al () , Cold Spring Harbor Laboratory. RIS download Bibtex download
  • Gro脽e-Berkenbusch A, Hettich J, Kuhn T, Fili N, Cook AW, Hari-Gupta Y, Palmer A, Streit L, Ellis PJI, Toseland CP & Gebhardt JCM () , Cold Spring Harbor Laboratory. RIS download Bibtex download
Research group
  • Dr Natalia Fili (Postdoctoral Research Associate)
  • Rosemarie Gough (Postdoctoral Research Associate)
  • Alexander Cook (Postdoctoral Research Associate)
  • Alia dos Santos (PhD Student)
Grants
  • Medical Research Council
  • Cancer Research UK
  • Science and Technology Facilities Council
  • Royal Society
  • Leverhulme Trust