Bingle, Colin D, Professor

Professor Colin D Bingle

Clinical Medicine, School of Medicine and Population Health

Professor of Respiratory Cell and Molecular Biology

Departmental Director of Research and Innovation

c.d.bingle@sheffield.ac.uk
+44 114 215 9514

+44 114 271 1863 (Fax)

The Medical School

Full contact details

Professor Colin D Bingle
Clinical Medicine, School of Medicine and Population Health
The Medical School
Beech Hill Road
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S10 2RX

Profile: For enquiries please contact - SMPH-West-Operational@sheffield.ac.uk

I was promoted to Professor of Respiratory Cell and Molecular Biology at the University of ��«Ӱҵ in 2016. I have been at ��«Ӱҵ since 1997 when I was appointed to a Lectureship to support the development of molecular and cell biology within the Department of Medicine and Pharmacology.

My research has been focused on lung epithelial cell biology since I undertook a Postdoctoral Fellowship at Washington University in St Louis between 1991 and 1993. During that time I became interested in the molecular basis of cell type specific gene expression and I published the first ever paper that identified a specific functional role for a transcription factor (HNF-3α) in the regulation of a lung specific gene (Biochem J 1993;295:227-232). Since this time my work has continued to employ molecular biology techniques to address questions relating to the regulation, structure, expression and function of pulmonary epithelial genes.

Research interests

My long-standing research interests have been focused on cellular differentiation and regulation of gene expression within the developing and adult pulmonary epithelium. This work involves the isolation of pulmonary epithelial cell specific genes as well as the transcription factors, which regulate their expression.

My interests have expanded into the fields of the genetics of complex diseases, pulmonary immunology, innate immunity and host defence.

Current projects

My research projects largely focus on the identification and characterisation of novel innate immune regulators, particularly members of the WFDC (Oncogene 2002;21:2768-2773) and BPIF/PLUNC (Hum Mol Gen 2002;11:937-943) protein families. Indeed, we identified the later family of proteins and they have gone on to become a significant area of my research focus.

Latterly, I have become involved in studies designed to investigate the function and expression of these genes in the developing and diseased respiratory tract using a wide range of clinical samples and understanding the biology of these genes is a key focus of my work. My continuing studies in this area are designed to elucidate the role these proteins play in a range of pulmonary disease including chronic obstructive pulmonary disease (COPD), pulmonary fibrosis, cystic fibrosis (CF) and asthma in adults as well as in neonatal and paediatric diseases including RSV bronchiolitis and otitis media.

I have expanded my studies into the more tractable murine model systems with the aim of identifying the function of individual genes from these gene families.

My group works extensively with primary airway epithelial cells (both human and murine) in differentiated air liquid interface cultures as tools to understand the regulation of airway epithelial cell specific genes. This involves the respiratory epithelium in its’ very widest sense and we work with airway, nasal and middle ear cells. This work also now involves studies of salivary gland biology. At a more clinical level we also studye blurb host/pathogen interactions using both viral (Influenza A, RSV) and bacterial (Staphylococcus aureus and NTHi) infections. We are presently developing these models to understand the biology of co-infections as well as the role of inflammatory cells in this process.

This applied work has allowed me to continue to study the role of epithelial differentiation in the respiratory tract and to use disease models and our novel genes to study aspects of pulmonary cell plasticity in the respiratory tract. It has also led to new avenues of work on epithelial responses in nasopharyngeal infections and in otitis media and latterly to more applied studies on the biology of multiciliogenesis, an interest of mice since working with FOXJ1 as a post-doc in St Louis.

Publications

Show: Featured publications All publications

Featured publications

Journal articles

Gui M, Farley H, Anujan P, Anderson JR, Maxwell DW, Whitchurch JB, Botsch JJ, Qiu T, Meleppattu S, Singh SK , Zhang Q et al (2021) . Cell.
Ziegler CGK, Allon SJ, Nyquist SK, Mbano IM, Miao VN, Tzouanas CN, Cao Y, Yousif AS, Bals J, Hauser BM , Feldman J et al (2020) . Cell.
Lu H, Anujan P, Zhou F, Zhang Y, Chong YL, Bingle CD & Roy S (2019) . Development, 146(6).
Mulay A, Hood DW, Williams D, Russell C, Brown SDM, Bingle L, Cheeseman M & Bingle CD (2018) . Scientific Reports, 8(1).
Akram K, Moyo N, Leeming G, Bingle L, Jasim S, Hussain S, Schorlemmer A, Kipar A, Digard P, Tripp R , Shohet V et al (2017) . Mucosal immunology, 11, 71-81.
Mulay A, Akram K, Williams D, Armes H, Russell C, Hood D, Armstrong S, Stewart JP, Brown SD, Bingle L & Bingle CD (2016) . Disease Models and Mechanisms, 9, 1405-1417.
Saferali A, Obeidat M, Bérubé J-C, Lamontagne M, Bossé Y, Laviolette M, Hao K, Nickle DC, Timens W, Sin DD , Postma DS et al (2015) . American Journal of Respiratory Cell and Molecular Biology, 53(5), 607-614.
Gao J, Ohlmeier S, Nieminen P, Toljamo T, Tiitinen S, Kanerva T, Bingle L, Araujo B, Rönty M, Höyhtyä M , Bingle CD et al (2015) . American Journal of Physiology-Lung Cellular and Molecular Physiology, 309(1), L17-L26.
Leeming GH, Kipar A, Hughes DJ, Bingle L, Bennett E, Moyo NA, Tripp RA, Bigley AL, Bingle CD, Sample JT & Stewart JP (2015) . Laboratory Investigation, 95(6), 610-624.
Bingle CD, Araujo B, Wallace WA, Hirani N & Bingle L (2013) . Thorax, 68(12), 1167-1168.
Musa M, Wilson K, Sun L, Mulay A, Bingle L, Marriott HM, LeClair EE & Bingle CD (2012) . Cell Tissue Res, 350(3), 455-464.
Bingle L, Wilson K, Musa M, Araujo B, Rassl D, Wallace WA, LeClair EE, Mauad T, Zhou Z, Mall MA & Bingle CD (2012) . Histochem Cell Biol, 138(5), 749-758.
Bingle CD (2011) . Biochem Soc Trans, 39(5), 1393-1397.
Shin OS, Uddin T, Citorik R, Wang JP, Della Pelle P, Kradin RL, Bingle CD, Bingle L, Camilli A, Bhuiyan TR , Shirin T et al (2011) . J Infect Dis, 204(9), 1349-1357.
Bingle CD, Seal RL & Craven CJ (2011) . Biochemical Society Transactions, 39(4), 977-983.
Bingle CD, Wilson K, Lunn H, Barnes FA, High AS, Wallace WA, Rassl D, Campos MA, Ribeiro M & Bingle L (2010) . Histochem Cell Biol, 133(5), 505-515.
Bingle L, Barnes FA, Lunn H, Musa M, Webster S, Douglas CWI, Cross SS, High AS & Bingle CD (2009) . Histochem Cell Biol, 132(3), 339-349.
Bingle L, Barnes FA, Cross SS, Rassl D, Wallace WA, Campos MA & Bingle CD (2007) . Respir Res, 8, 79.
Bingle L, Cross SS, High AS, Wallace WA, Rassl D, Yuan G, Hellstrom I, Campos MA & Bingle CD (2006) . Respir Res, 7, 61.
Bingle CD & Craven CJ (2002) . Hum Mol Genet, 11(8), 937-943.

All publications

Journal articles

Bingle C (2024) . The Biochemist, 46(4), 1-2.
Pérez-de-Oliveira ME, Wagner VP, Bingle CD, Vargas PA & Bingle L (2024) . Oral Oncology, 159, 107029-107029.
Vargas PPA, Pérez-de-Oliveira DME, Wagner DVP, Bingle PCD & Bingle PL (2024) . Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 138(2), e45-e45.
Bingle C (2024) . The Biochemist, 46(3), 1-2.
PÉREZ-DE-OLIVEIRA ME, WAGNER VP, BINGLE CD, VARGAS PA & BINGLE L (2024) . Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 137(6), e291-e291.
Bingle CD (2024) . The Biochemist, 46(2), 1-2.
Bingle C (2024) . The Biochemist, 46(1), 1-2.
Dudchenko O, Ordovas-Montanes J & Bingle CD (2023) . Biochemical Journal, 480(13), 921-939.
Wagner VP, Ferrarotto R, Vargas PA, Martins MD, Bingle CD & Bingle L (2023) . Critical Reviews in Oncology/Hematology, 181, 103886-103886.
Wagner VP, Bingle CD & Bingle L (2022) . Critical Reviews in Oncology/Hematology, 103745-103745.
Costa-Martins AG, Mane K, Lindsey BB, Ogava RLT, Castro IC, Jagne YJ, Sallah HJ, Armitage EP, Jarju S, Ahadzie B , Ellis-Watson R et al (2022) . Cell Reports Medicine, 3(2), 100516-100516.
Costa-Martins AG, Mane K, Lindsey BB, Ogava RLT, Castro Í, Jagne YJ, Sallah HJ, Armitage EP, Jarju S, Ahadzie B , Ellis-Watson R et al (2021) . Cell Reports Medicine, 2(12).
Bingle CD & Bingle L (2021) . European Respiratory Journal, 58(5), 2101569-2101569.
Gui M, Farley H, Anujan P, Anderson JR, Maxwell DW, Whitchurch JB, Botsch JJ, Qiu T, Meleppattu S, Singh SK , Zhang Q et al (2021) . Cell.
Mather MW, Verdon B, Botting RA, Engelbert J, Delpiano L, Xu X, Hatton C, Davey T, Lisgo S, Yates P , Dawe N et al (2021) . Laryngoscope Investigative Otolaryngology.
Mather MW, Powell S, Talks B, Ward C, Bingle CD, Haniffa M & Powell J (2021) . Expert Reviews in Molecular Medicine, 23.
Amoura EB, Hunter KD, Bingle CD & Bingle LB (2021) . Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 132(1), e6-e7.
Mulay A, Chowdhury M, James C, Bingle L & Bingle C (2021) . Biology Open, 10(4).
Innocentini LMAR, Silva AA, Carvalho MA, Coletta RD, Pizzigatti Corrêa ME, Bingle L, Bingle CD, Vargas PA & Lopes MA (2021) . Oral Diseases.
Wagner VP, Martins MD, Amoura E, Zanella VG, Roesler R, de Farias CB, Bingle CD, Vargas PA & Bingle L (2020) . Biomedicines, 8(12).
Ziegler CGK, Allon SJ, Nyquist SK, Mbano IM, Miao VN, Tzouanas CN, Cao Y, Yousif AS, Bals J, Hauser BM , Feldman J et al (2020) . Cell.
PEREIRA DL, BINGLE L, BINGLE CD, PIRES FR, LOPES MA & VARGAS PA (2020) . Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 129(1), e152-e152.
Lu H, Anujan P, Zhou F, Zhang Y, Chong YL, Bingle CD & Roy S (2019) . Development, 146(6).
Preston JA, Bewley MA, Marriott HM, Houghton AM, Mohasin M, Jubrail J, Morris L, Stephenson YL, Cross S, Greaves DR , Craig RW et al (2019) . American Journal of Respiratory and Critical Care Medicine.
De Smet EG, Seys LJM, Verhamme FM, Vanaudenaerde BM, Brusselle GG, Bingle CD & Bracke KR (2018) . International Journal of COPD, 13, 11-27.
Pereira DL, Bingle L, Bingle CD, Lopes MA & Vargas PA (2018) . Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 126(3), e158-e158.
Akram KM, Moyo NA, Leeming GH, Bingle L, Jasim S, Hussain S, Schorlemmer A, Kipar A, Digard P, Tripp RA , Shohet RV et al (2018) . Mucosal Immunology, 11(3), 1008-1008.
Mulay A, Hood DW, Williams D, Russell C, Brown SDM, Bingle L, Cheeseman M & Bingle CD (2018) . Scientific Reports, 8(1).
Qiu Q, Peng Y, Zhu Z, Chen Z, Zhang C, Ong HH, Tan KS, Hong H, Yan Y, Huang H , Liu J et al (2018) . The Laryngoscope, 128(3), E97-E104.
Akram K, Moyo N, Leeming G, Bingle L, Jasim S, Hussain S, Schorlemmer A, Kipar A, Digard P, Tripp R , Shohet V et al (2017) . Mucosal immunology, 11, 71-81.
Alves DBM, Bingle L, Bingle CD, Lourenco SV, Silva AA, Pereira DL & Vargas PA (2017) . Brazilian Oral Research, 31.
Mulay A, Akram K, Williams D, Armes H, Russell C, Hood D, Armstrong S, Stewart JP, Brown SD, Bingle L & Bingle CD (2016) . Disease Models and Mechanisms, 9, 1405-1417.
Ugonna K, Douros K, Bingle CD & Everard ML (2016) . Pediatric Research, 79, 946-950.
Leeming GH, Moyo N, Akram K, Tompkins M, Chapman G, Walsh T, Bingle L, Bingle C, Tripp R & Stewart JP (2016) . Journal of Comparative Pathology, 154(1), 76-76.
Saferali A, Obeidat M, Bérubé J-C, Lamontagne M, Bossé Y, Laviolette M, Hao K, Nickle DC, Timens W, Sin DD , Postma DS et al (2015) . American Journal of Respiratory Cell and Molecular Biology, 53(5), 607-614.
Gao J, Ohlmeier S, Nieminen P, Toljamo T, Tiitinen S, Kanerva T, Bingle L, Araujo B, Rönty M, Höyhtyä M , Bingle CD et al (2015) . American Journal of Physiology-Lung Cellular and Molecular Physiology, 309(1), L17-L26.
Leeming GH, Kipar A, Hughes DJ, Bingle L, Bennett E, Moyo NA, Tripp RA, Bigley AL, Bingle CD, Sample JT & Stewart JP (2015) . Laboratory Investigation, 95(6), 610-624.
Ugonna K, Bingle CD, Plant K, Wilson K & Everard ML (2014) . PLoS One, 9(3), e91855.
Bingle CD, Araujo B, Wallace WA, Hirani N & Bingle L (2013) . Thorax, 68(12), 1167-1168.
Dean C, Bingle C & Hind M (2013) . Clin Sci (Lond), 125(10), 495-500.
Bingle CD, Araujo B, Wallace WA, Hirani N & Bingle L (2013) . Thorax, 68(12), 1167-1168.
Taylor R, Bingle L & Bingle C (2013) Transcriptional analysis of the human BPIFA1/SPLUNC1 gene. EUROPEAN RESPIRATORY JOURNAL, 42.
Musa M, Wilson K, Sun L, Mulay A, Bingle L, Marriott HM, LeClair EE & Bingle CD (2012) . Cell Tissue Res, 350(3), 455-464.
Bingle L, Wilson K, Musa M, Araujo B, Rassl D, Wallace WA, LeClair EE, Mauad T, Zhou Z, Mall MA & Bingle CD (2012) . Histochem Cell Biol, 138(5), 749-758.
Leeming G, Stewart J, Hughes D, Bingle L, Bingle C & Kipar A (2012) . JOURNAL OF COMPARATIVE PATHOLOGY, 146(1), 49-49.
Bingle CD (2011) . Biochem Soc Trans, 39(5), 1393-1397.
Shin OS, Uddin T, Citorik R, Wang JP, Della Pelle P, Kradin RL, Bingle CD, Bingle L, Camilli A, Bhuiyan TR , Shirin T et al (2011) . J Infect Dis, 204(9), 1349-1357.
Bingle L & Bingle CD (2011) . Biochem Soc Trans, 39(4), 1023-1027.
Bingle CD, Bingle L & Craven CJ (2011) . Biochem Soc Trans, 39(4), 961-965.
Bingle CD, Seal RL & Craven CJ (2011) . Biochemical Society Transactions, 39(4), 977-983.
Bingle CD (2011) . Thorax, 66(8), 647-648.
Chiang SC, Veldhuizen EJA, Barnes FA, Craven CJ, Haagsman HP & Bingle CD (2011) . Developmental and Comparative Immunology, 35(3), 285-295.
Wardle DJ, Burgon J, Sabroe I, Bingle CD, Whyte MKB & Renshaw SA (2011) . PLoS One, 6(1), e15768.
Chiang S-C, Veldhuizen EJA, Barnes FA, Craven CJ, Haagsman HP & Bingle CD (2011) . Dev Comp Immunol, 35(3), 285-295.
da Silva AA, Bingle L, Speight PM, Bingle CD, Mauad T, da Silva LFF & Vargas PA (2011) . Oral Dis, 17(3), 258-264.
Waby JS, Chirakkal H, Yu C, Griffiths GJ, Benson RSP, Bingle CD & Corfe BM (2010) . Mol Cancer, 9, 275.
Bingle CD, Wilson K, Lunn H, Barnes FA, High AS, Wallace WA, Rassl D, Campos MA, Ribeiro M & Bingle L (2010) . Histochem Cell Biol, 133(5), 505-515.
Bingle CD, Wilson K, Lunn H, Barnes FA, High AS, Wallace WA, Rassl D, Campos MA, Ribeiro M & Bingle L (2010) Human LPLUNC1 is a secreted product of goblet cells and minor glands of the respiratory and upper aerodigestive tracts. Histochemistry and Cell Biology, 1-11.
Bingle L, Barnes FA, Lunn H, Musa M, Webster S, Douglas CWI, Cross SS, High AS & Bingle CD (2009) . Histochem Cell Biol, 132(3), 339-349.
Vargas PA, Speight PM, Bingle CD, Barrett AW & Bingle L (2008) . Oral Dis, 14(7), 613-619.
Bingle CD & Vyakarnam A (2008) . Trends Immunol, 29(9), 444-453.
Barnes FA, Bingle L & Bingle CD (2008) . Am J Respir Cell Mol Biol, 38(4), 377-379.
Waby JS, Bingle CD & Corfe BM (2008) . Curr Genomics, 9(5), 301-311.
Vaughan KR, Stokes L, Prince LR, Marriott HM, Meis S, Kassack MU, Bingle CD, Sabroe I, Surprenant A & Whyte MKB (2007) . J Immunol, 179(12), 8544-8553.
Bingle L, Barnes FA, Cross SS, Rassl D, Wallace WA, Campos MA & Bingle CD (2007) . Respir Res, 8, 79.
Wheeler TT, Hood KA, Maqbool NJ, McEwan JC, Bingle CD & Zhao S (2007) . BMC Genomics, 8, 75.
Chen HM, Wilkins LM, Aziz N, Cannings C, Wyllie DH, Bingle C, Rogus J, Beck JD, Offenbacher S, Cork MJ , Rafie-Kolpin M et al (2006) . HUM MOL GENET, 15(4), 519-529.
Bingle L, Cross SS, High AS, Wallace WA, Rassl D, Yuan G, Hellstrom I, Campos MA & Bingle CD (2006) . Respir Res, 7, 61.
Dempsey CE, Dive C, Fletcher DJ, Barnes FA, Lobo A, Bingle CD, Whyte MKB & Renshaw SA (2005) . FEBS Lett, 579(17), 3646-3650.
Bingle L, Cross SS, High AS, Wallace WA, Devine DA, Havard S, Campos MA & Bingle CD (2005) . J Pathol, 205(4), 491-497.
Marriott HM, Bingle CD, Read RC, Braley KE, Kroemer G, Hellewell PG, Craig RW, Whyte MKB & Dockrell DH (2005) . J Clin Invest, 115(2), 359-368.
Geetha C, Venkatesh SG, Bingle L, Bingle CD & Gorr S-U (2005) . J Dent Res, 84(2), 149-153.
Marriott HM, Bingle CD, Read RC, Braley KE, Kroemer G, Hellewell PG, Craig RW, Whyte MKB & Dockrell DH (2005) . Journal of Clinical Investigation, 115(2), 359-368.
Bingle CD & Gorr S-U (2004) . Int J Biochem Cell Biol, 36(11), 2144-2152.
LeClair EE, Nomellini V, Bahena M, Singleton V, Bingle L, Craven CJ & Bingle CD (2004) . Genomics, 83(4), 658-666.
Bingle CD & Craven CJ (2004) . Trends Immunol, 25(2), 53-55.
Bingle CD, LeClair EE, Havard S, Bingle L, Gillingham P & Craven CJ (2004) . Protein Sci, 13(2), 422-430.
Renshaw SA, Dempsey CE, Barnes FA, Bagstaff SM, Dower SK, Bingle CD & Whyte MKB (2004) . J Biol Chem, 279(4), 2846-2855.
Bingle CD & Craven CJ (2003) . Biochem Soc Trans, 31(Pt 4), 806-809.
Renshaw SA, Parmar JS, Singleton V, Rowe SJ, Dower SK, Dockrell DH, Bingle CD, Chilvers ER & Whyte MKB (2003) . Clinical Science, 104(s49), 58P-58P.
Renshaw SA, Parmar JS, Singleton V, Rowe SJ, Dockrell DH, Dower SK, Bingle CD, Chilvers ER & Whyte MKB (2003) . J Immunol, 170(2), 1027-1033.
Renshaw SA, Bingle CD & Whyte MKB (2002) . Clinical Science, 103(s47), 54P-54P.
Vachon E, Bourbonnais Y, Bingle CD, Rowe SJ, Janelle MF & Tremblay GM (2002) . Biol Chem, 383(7-8), 1249-1256.
Bingle L, Singleton V & Bingle CD (2002) . Oncogene, 21(17), 2768-2773.
Bingle CD & Craven CJ (2002) . Hum Mol Genet, 11(8), 937-943.
Usher LR, Lawson RA, Geary I, Taylor CJ, Bingle CD, Taylor GW & Whyte MKB (2002) . J Immunol, 168(4), 1861-1868.
Bingle CD, Singleton V & Bingle L (2002) . Biochemical Society Transactions, 30(1), A38-A38.
Renshaw SA, Bingle CD & Whyte MKB (2001) . Clinical Science, 101(s45), 2P-2P.
Bingle L, Tetley TD & Bingle CD (2001) . Am J Respir Cell Mol Biol, 25(1), 84-91.
LeClair EE, Nguyen L, Bingle L, MacGowan A, Singleton V, Ward SJ & Bingle CD (2001) . Biochem Biophys Res Commun, 284(3), 792-797.
Bingle CD & Bingle L (2000) . Biochim Biophys Acta, 1493(3), 363-367.
Bingle CD, Craig RW, Swales BM, Singleton V, Zhou P & Whyte MK (2000) . J Biol Chem, 275(29), 22136-22146.
Renshaw SA, Timmons SJ, Eaton V, Usher LR, Akil M, Bingle CD & Whyte MK (2000) . J Leukoc Biol, 67(5), 662-668.
Meléndez J, Maldonado V, Bingle CD, Selman M & Pardo A (2000) . Am J Physiol Lung Cell Mol Physiol, 278(4), L737-L743.
Whitehouse JL, Lee YC, Bingle CD, Antoniou M & Santis G (2000) Transcriptional regulation of thyroid transcription factor-1 (TTF-1) (vol 93, pg A 14, 1999). RESP MED, 94(3), 295-295.
Whyte M, Hubbard R, Meliconi R, Whidborne M, Eaton V, Bingle C, Timms J, Duff G, Facchini A, Pacilli A , Fabbri M et al (2000) . American Journal of Respiratory and Critical Care Medicine, 162(2 I), 755-758.
Baines DL, Folkesson HG, Norlin A, Bingle CD, Yuan HT & Olver RE (2000) . J Physiol, 522 Pt 1, 147-157.
Whyte M, Renshaw S, Lawson R & Bingle C (1999) . Biochem Soc Trans, 27(6), 802-807.
Whyte M, Bingle C, Renshaw S & Lawson R (1999) . Biochemical Society Transactions, 27(5), A134-A134.
Whyte M, Hubbard R, Meliconi R, Whidhorne M, Timms J, Wheatley A, Eaton V, Bingle C, Duff GW, Fabbri M , Facchini A et al (1999) Association of an interleukin-1 receptor antagonist polymorphism with idiopathic pulmonary fibrosis. AM J RESP CRIT CARE, 159(3), A504-A504.
Bingle CD (1999) Molecular cloning and expression of human HNF-3 beta.. AM J RESP CRIT CARE, 159(3), A728-A728.
Lee YC, Whitehouse JL, Santis G, Bingle CD & Antoniou M (1999) DNAse 1 hypersensitive sites of TTF-1 gene. AM J RESP CRIT CARE, 159(3), A445-A445.
Bingle CD (1999) Cloning of human fkh-5: Identification of a SCLC line as an abundant expressor of a neuronally restricted HNF-3/forkhead transcription factor.. AM J RESP CRIT CARE, 159(3), A727-A727.
Witherden IR, Goldstraw P, Ladas G, Ratcliffe C, Bingle CD & Tetley TD (1999) Expression of secretory leukoprotease inhibitor (SLPI) and elafin by primary human alveolar type II pneumocytes (TII) in vitro.. AM J RESP CRIT CARE, 159(3), A193-A193.
Downey JS, Bingle CD, Cottrell S, Ward N, Churchman D, Dobrota M & Powell CJ (1998) . Biochem Biophys Res Commun, 244(2), 463-467.
Bingle CD (1997) . Int J Biochem Cell Biol, 29(12), 1471-1473.
Yuan HT, Gowan S, Kelly FJ & Bingle CD (1997) Cloning of guinea pig surfactant protein A defines a distinct cellular distribution pattern within the lung. AM J PHYSIOL-LUNG C, 17(4), L900-L906.
Yuan HT, Gowan S, Kelly FJ & Bingle CD (1997) . Am J Physiol, 273(4), L900-L906.
Gowan S, Toonen R & Bingle CD (1997) Human thyroid transcription factor-1. Functional characterization of the protein and analysis of protein/DNA interactions on the minimal promoter region.. Chest, 111(6 Suppl), 88S.
Baines DL, Bingle CD, Yuan H, Kemp PJ & Olver RE (1997) The fetal guinea-pig lung, near term, displays a rise in alpha ENaC mRNA expression that is independent of labour. J PHYSIOL-LONDON, 501P, P63-P64.
Bingle CD & Gowan S (1996) . Biochem J, 319 ( Pt 3), 669-674.
Bingle CD (1996) . Biochem Biophys Res Commun, 225(3), 877-882.
Bingle CD & Gowan S (1996) . Biochim Biophys Acta, 1307(1), 17-20.
Toonen RF, Gowan S & Bingle CD (1996) . Biochem J, 316 ( Pt 2), 467-473.
Yuan HT, Bingle CD & Kelly FJ (1996) . Biochim Biophys Acta, 1305(3), 163-171.
Hackett BP, Bingle CD & Gitlin JD (1996) . Annu Rev Physiol, 58, 51-71.
YUAN HT, BINGLE CD & KELLY FJ (1995) BALR YOUNG INVESTIGATOR COMPETITION. RESP MED, 89(10), 723-750.
Bingle CD, Hackett BP, Moxley M, Longmore W & Gitlin JD (1995) . Biochem J, 308 ( Pt 1), 197-202.
Bingle CD (1994) . Respiratory Medicine, 88(10), 804-805.
Bingle CD & Gitlin JD (1993) . Biochem J, 295 ( Pt 1), 227-232.
Bingle CD, Fleming RE & Gitlin JD (1993) . Biochem J, 294 ( Pt 2), 473-479.
Haris PI, Chowrimootoo G, Bingle C, Chapman D & Srai KS (1993) . Biochem Soc Trans, 21(2), 175S.
BINGLE CD & GITLIN JD (1992) ROLE OF HEPATOCYTE NUCLEAR FACTOR-3-ALPHA IN CLARA CELL SPECIFIC GENE-EXPRESSION. MOL BIOL CELL, 3, A204-A204.
Bingle CD, Kelly F, Epstein O & Srai SK (1992) . Biochim Biophys Acta, 1139(3), 217-221.
Bingle CD, Srai SK & Epstein O (1992) . J Hepatol, 15(1-2), 94-101.
Bingle C, Ghazi S, Owen JS & Srai SK (1991) . Lancet, 338(8781), 1531.
Bingle CD, Epstein O, Srai SK & Gitlin JD (1991) . Biochem J, 276 ( Pt 3), 771-775.
Bingle CD, Srai SKS & Epstein O (1991) . Journal of Hepatology, 13, S11-S11.
BINGLE CD, GITLIN JD, EPSTEIN O & SRAI SKS (1990) TRANSCRIPTIONAL REGULATION OF CERULOPLASMIN GENE-EXPRESSION IN THE DEVELOPING GUINEA-PIG LIVER. HEPATOLOGY, 12(4), 948-948.
BINGLE CD, SRAI SKS & EPSTEIN O (1990) HEPATIC COPPER DISTRIBUTION IN WILSONS-DISEASE AND HEPATIC COPPER OVERLOAD. GUT, 31(10), A1213-A1213.
BINGLE CD, SRAI SKS & EPSTEIN O (1990) COPPER DISTRIBUTION IN WILSONS-DISEASE AND HEPATIC COPPER OVERLOAD - STUDIES OF ITS SUBCELLULAR-DISTRIBUTION AND ASSOCIATION WITH COPPER PROTEINS. HEPATOLOGY, 12(4), 927-927.
Bingle CD, Epstein O & Srai SK (1990) . Biochem Soc Trans, 18(4), 645.
Bingle CD, Srai SK & Epstein O (1990) . J Hepatol, 10(2), 138-143.
Bingle C, Srai K & Epstein O (1990) . Clinical Science, 78(s22), 21P-21P.
Bingle CD, Srai SKS & Epstein O (1990) . Journal of Hepatology, 11, S8-S8.
Bingle CD, Gitlin JD, Epstein O & Srai SKS (1990) . Journal of Hepatology, 11, S7-S7.
Bingle CD, Srai SKS & Epstein O (1989) . Journal of Hepatology, 9, S116-S116.
Bingle CD, Srai SK, Whiteley GS & Epstein O (1988) . Biol Neonate, 54(5), 294-300.
BINGLE CD, SRAI SKS & EPSTEIN O (1987) DEVELOPMENTAL-CHANGES IN HEPATIC COPPER-BINDING PROTEINS IN THE GUINEA-PIG. J HEPATOL, 5, S95-S95.
SRAI SKS, BINGLE CD & EPSTEIN O (1986) DEVELOPMENTAL-CHANGES IN A NOVEL LOW-MOLECULAR-WEIGHT COPPER-BINDING PROTEIN (LMWP) IN GUINEA-PIG LIVER. GUT, 27(10), 1240-1240.
SRAI SKS, BINGLE CD, LEE M & EPSTEIN O (1986) SIMILARITY OF INTRAVENOUS COPPER-64 DISAPPEARANCE AND LIVER COPPER PROTEIN PROFILE IN NEONATAL PIG AND WILSONS-DISEASE - EVIDENCE FOR DEVELOPMENTAL ARREST. HEPATOLOGY, 6(5), 1119-1119.
SRAI SKS, BINGLE CD & EPSTEIN O (1986) DEVELOPMENTAL-CHANGES IN A NOVEL LOW-MOLECULAR-WEIGHT COPPER-BINDING PROTEIN (LMWP) IN GUINEA-PIG LIVER. HEPATOLOGY, 6(5), 1118-1118.
BINGLE CD, SRAI SKS, LEE M & EPSTEIN O (1986) NEONATAL AND ADULT 64 COPPER KINETICS IN THE PIG AND ITS RELATIONSHIP TO COPPER KINETICS IN WILSONS-DISEASE. GUT, 27(5), A623-A623.
Ollett L, Bingle C & Busby S () . The Biochemist.
Mulay A, Chowdhury MMK, James C, Bingle L & Bingle CD () .
Bingle L, Armes H, Williams DJ, Gianfrancesco O, Chowdhury MMK, Drapkin R & Bingle CD () .

Chapters

Mulay A, Akram K, Bingle L & Bingle CD (2019) , Methods in Molecular Biology (pp. 157-168). Springer New York
Bingle CD (1996) , Free Radicals (pp. 287-300). Oxford University PressOxford
Srai SKS, Bingle C & Epstein O (1988) , Trace Elements in Man and Animals 6 (pp. 147-148). Springer US

Conference proceedings papers

Chowdhury MMK, Anujan P, Bingle L & Bingle C (2022) . 03.02 - Airway cell biology and immunopathology
Chowdhury MMK, Bingle L & Bingle C (2022) . 03.02 - Airway cell biology and immunopathology
Alkhoshaiban A, Chowdhury MK, Anujan, P, Bingle L & Bingle C (2022) . 03.02 - Airway cell biology and immunopathology
Alharbi Z, Bingle L & Bingle C (2022) . 03.02 - Airway cell biology and immunopathology
Chowdhury MMK, Anujan P, Mulay A, Bingle L & Bingle C (2020) . Molecular pathology and funct. genomics
Alharbi Z, Chowdhury MMK, Bingle L & Bingle C (2020) . Airway cell biology and immunopathology
Chowdhury MMK, Anujan P, Bingle L & Bingle C (2020) . Airway cell biology and immunopathology
Bingle L, Armes H & Bingle C (2020) . Cystic fibrosis
ALJuhani F, Anujan P, Bingle L & Bingle C (2020) . Molecular pathology and funct. genomics
Alkhoshaiban A, Anujan P, Bingle L & Bingle C (2020) . Airway cell biology and immunopathology
Anujan P, Roy S, Bingle L & Bingle CD (2018) . Airway Cell Biology and Immunopathology
Caikauskaite R, Mulay A, Hood D, Brown S, Stewart J, Bingle L & Bingle C (2018) . Airway Cell Biology and Immunopathology
Anujan P, Roy S & Bingle CD (2017) . Mechanisms of Development, Vol. 145 (pp S25-S25)
Marshall C, Bingle L & Bingle C (2016) . 3.2 Airway Cell Biology and Immunopathology
Moyo N, Marchi E, Akram K, Leeming G, Tompkins M, Bingle L, Tripp R, Klenerman P, Bingle C & Stewart J (2016) . ERS Lung Science Conference 2016
De Smet EG, Seys LJ, Verhamme FM, Vanaudenaerde BM, Joos GF, Brusselle GG, Bingle CD & Bracke KR (2016) Elevated Levels Of Bpifa1 (splunc1) And Bpifb1 (lplunc1) In Lungs Of Patients With COPD. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 193
Gao J, Ohlmeier S, Nieminen P, Toljamo T, Tiitinen S, Kanerva T, Bingle L, Araujo B, Rönty M, Höyhtyä M , Bingle C et al (2015) . 5.2 Monitoring Airway Disease
Moyo N, Leeming G, Akram K, Tompkins M, Chapman G, Walsh T, Bingle L, Bingle C, Tripp R & Stewart J (2015) . 10.1 Respiratory Infections
Akram K, Moyo N, Tompkins M, Tripp R, Bingle L, Stewart J & Bingle C (2015) . 3.2 Airway Cell Biology and Immunopathology
Akram K, Anujan P, Mccloskey B, Bingle L & Bingle C (2014) Validation of an in vitro tracheal model for the study of innate host defence mechanism in respiratory tract infections. EUROPEAN RESPIRATORY JOURNAL, Vol. 44
Bingle CD, Araujo B, Wallace WA, Marriott HM, Hirani N & Bingle L (2013) . THORAX, Vol. 68 (pp A139-A139)
Wilson K, Bingle L, Bingle C & Everard M (2012) Differential responses of monolayer and differentiated airway epithelial cell cultures to NTHi infection. EUROPEAN RESPIRATORY JOURNAL, Vol. 40
Bingle C, Araujo B, Marriott H, Wallace W, Hirani N & Bingle L (2012) Do characteristic airway epithelial change precede the development of lung fibrosis? Ectopic epithelial marker protein expression in bleomycin induced fibrosis replicates that seen in bronchiolized epithelium in IPF. EUROPEAN RESPIRATORY JOURNAL, Vol. 40
Araujo B, Bingle L, Marriott H, Howie S, Wallace W, Hirani N & Bingle CD (2012) . B28. EMERGING BIOMARKERS OF COMPLEX LUNG DISEASES
Bingle CD, Wilson K, Mall M, Rassl D & Bingle L (2011) . D25. CYSTIC FIBROSIS
Bingle L, Wallace WA, Cross SS, High AS, Devine DA & Bingle CD (2004) Localisation of the putative mediator of host defence, SPLUNC1, in human tissues. JOURNAL OF PATHOLOGY, Vol. 204 (pp 45A-45A)
Renshaw SA, Bingle CD & Whyte MKB (2003) Regulation of granulocyte apoptosis by 3 novel isoforms of the BCL-2 protein, Bid. THORAX, Vol. 58 (pp 31-31)
LeClair EE, Nomellini V, Bahena M & Bingle CD (2002) Innate immunity in the oral cavity? A mouse tongue tale.. INTEGRATIVE AND COMPARATIVE BIOLOGY, Vol. 42(6) (pp 1264-1264)
Bingle L & Bingle CD (1999) Multiple components of the hedgehog signalling pathway are expressed in human pulmonary epithelial. AM J RESP CRIT CARE, Vol. 159(3) (pp A664-A664)
Gowan S, Toonen R & Bingle CD (1997) Human thyroid transcription factor-1 - Functional characterization of protein/DNA interactions on the minimal promoter region. CHEST, Vol. 111(6) (pp S88-S88)
BINGLE CD, EPSTEIN O & SRAI SKS (1991) COPPER-ZINC SUPEROXIDE-DISMUTASE IN DEVELOPING GUINEA-PIG LIVER IS NOT REGULATED BY HEPATIC COPPER LEVELS. TRACE ELEMENTS IN MAN AND ANIMALS 7 (pp 249-250)
BINGLE CD, EPSTEIN O, SRAI SKS & GITLIN JD (1991) TRANSCRIPTIONAL REGULATION OF CERULOPLASMIN GENE-EXPRESSION IN THE DEVELOPING GUINEA-PIG LIVER. TRACE ELEMENTS IN MAN AND ANIMALS 7 (pp 12-14)

Preprints

Damaa MK, Serizay J, Balagué R, Boudjema A-R, Faucourt M, Delgehyr N, Goh KJ, Lu H, Tan EK, James CT , Faucon C et al (2024) , Cold Spring Harbor Laboratory.
Costa-Martins AG, Mane K, Lindsey BB, Ogava RLT, Castro Í, Jagne YJ, Sallah H, Armitage E, Ahadzie B, Ellis-Watson R , Tregoning JS et al () .
Lu H, Anujan P, Zhou F, Zhang Y, Ling Chong Y, Bingle CD & Roy S () , Cold Spring Harbor Laboratory.

Grants

2018 – 2019: Biotechnology and Biological Sciences Research Council project grant. BPIFA1: from anti-viral peptide to immunomodulator.
2017 – 2021: Commonwealth Scholarship PhD Studentship. Dissecting the genetics and proteomics of the airway epithelia to identify novel mediators of multiciliogenesis pathways.
2018 – 2021: Government of Saudi Arabia PhD Studentship. The role of host cells and Staphylococcus aureus virulence factors in the initiation of respiratory infection.
2018 – 2021: Government of Saudi Arabia PhD Studentship. A role for BPIFB1 in the immunity of the respiratory tract.
2017 – 2020: Government of Saudi Arabia PhD Studentship. Uncovering the role of BPIFA1 in Influenza infection of the lung.

Teaching activities: My teaching interests lie in epithelial host defence and aspects of genetics and comparative genomics, which I teach on the MSc in Molecular Medicine. I also teach on the Undergraduate Medical, Dental and Orthoptics Courses.

Professional activities and memberships

I am Editor-in-Chief of Biochemical Society Transactions.
I am Chair of the Biochemical Society Awards Committee.
I am a member of the Portland Press Publications Committee.