Wilson, Heather L, Dr

Qualifications

BSc (First Class) in Pharmacology, University College London
Research Scientist, Pharmacology Department, Wellcome Research Laboratories, Beckenham, Kent
D.Phil. in Pharmacology, University of Oxford. Laboratory of Prof. Antony Galione

Research interests

My overarching research focus is to understand how immune activation is linked to heart disease. Following a severe infection like pneumonia, individuals are at a higher risk of heart attack or stroke for up to 3 weeks after the infection.

We believe this is because immune cells in the atherosclerotic plaque become activated by inflammation, making the plaque more prone to rupture. Macrophages are a key immune cell in the arterial plaque, that alter their response and cellular function when exposed to infection or inflammatory signals.

We have investigated how these atherosclerotic macrophages alter functionally according to their environment. Specifically we have addressed how P2X7 receptors, interleukin-1 secretion and Tribbles expression affect macrophage function.

We are currently also interested in understanding the function of adipose tissue macrophages, since different fat depots are more or less associated with inflammation and disease: abdominal fat is associated with cardiovascular diseases and cancer susceptibility, while peripheral fat confers a lower disease risk.

We work closely with cardiology and stroke consultants within IICD and the Medical School in ��«Ӱҵ so that our basic science is connected to patient disease. We are also fortunate to be part of a European Commission funded International Training Network, where we connect with scientists across Europe who have complimentary interests to link immunity, metabolism and disease together. We are increasingly aware that obesity is connected to cancer risk as well as cardiovascular diseases, and seek to understand the underlying mechanisms.

Current projects

Biotechnology and Biological Sciences Research Council Project Grant. "Novel zebrafish approaches to investigate leaderless protein secretion in vivo."
British Heart Foundation Project Grant. "Mechanisms and consequences of in vivo targeting of IL-1 to the endothelium."
British Heart Foundation PhD studentship. "Regulation of the Endothelial P2X4/7 Receptor Axis.”
Heart Research UK. Clinical Training Fellowship (supervisor). "Neutrophil delivery of IL-1 as a mechanism of MI risk after lung infection."
A*Star Studentship. "Contribution of blood immune cell subtypes in inflammatory function and the development of cardiovascular disease."
Horizon 2020 European Commission. Marie Curie Innovative Training Network Programme Award. TRAIN ‘Tribbles Research and Innovation Network’ 2016-2021

Publications

Show: Featured publications All publications

Featured publications

Journal articles

Moss CE, Johnston SA, Kimble JV, Clements M, Codd V, Hamby S, Goodall AH, Deshmukh S, Sudbery I, Coca D , Wilson HL et al (2024) . Cell Reports, 43(4), 114073-114073.
Hernández-Quiles M, Martinez Campesino L, Morris I, Ilyas Z, Reynolds S, Soon Tan N, Sobrevals Alcaraz P, Stigter ECA, Varga Á, Varga J , van Es R et al (2023) . Molecular Metabolism, 78, 101829-101829.
Moss CE, Phipps H, Wilson HL & Kiss-Toth E (2023) . Frontiers in Immunology, 14.
Martinez-Campesino L, Kocsy K, Cañedo J, Johnston JM, Moss CE, Johnston SA, Hamby S, Goodall AH, Redgrave J, Francis SE , Kiss-Toth E et al (2022) . Frontiers in Cardiovascular Medicine, 9.
Johnston JM, Angyal A, Bauer RC, Hamby S, Suvarna SK, Baidžajevas K, Hegedus Z, Dear TN, Turner M, Wilson HL , Goodall AH et al (2019) . Science Advances, 5(10), ---.
Li Y, James SJ, Wyllie DH, Wynne C, Czibula A, Bukhari A, Pye K, Bte Mustafah SM, Fajka-Boja R, Szabo E , Angyal A et al (2019) . Proceedings of the National Academy of Sciences, 116(33), 16479-16488.
Savage AM, Kurusamy S, Chen Y, Jiang Z, Chhabria K, MacDonald RB, Kim HR, Wilson HL, van Eeden FJM, Armesilla AL , Chico TJA et al (2019) . Nature Communications, 10.
Ogryzko NV, Lewis A, Wilson HL, Meijer AH, Renshaw SA & Elks PM (2019) . The Journal of Immunology, 202(2), 494-502.
Green J, Souilhiol C, Xanthis I, Martinez-Campesino L, Bowden N, Evans P & Wilson H (2018) . Cardiovascular Research, 114(2), 324-335.
Li Y, Wilson HL & Kiss-Toth E (2017) . J Inflamm (Lond), 14, 11-11.
Hadadi E, Zhang B, Baidzajevas K, Yusof N, Puan KJ, Ong SM, Yeap WH, Rotzschke O, Kiss-Toth E, Wilson H & Wong SC (2016) . Scientific Reports, 6.
Alfaidi M, Wilson H, Daigneault M, Burnett A, Ridger V, Chamberlain J & Francis SE (2015) . Journal of Biological Chemistry, 290, 24067-24078.
Ogryzko NV, Renshaw SA & Wilson HL (2014) . Dev Comp Immunol, 46(1), 53-62.
Ogryzko NV, Hoggett EE, Solaymani-Kohal S, Tazzyman S, Chico TJA, Renshaw SA & Wilson HL (2014) . Dis Model Mech, 7(2), 259-264.
Basran A, Jabeen M, Bingle L, Stokes CA, Dockrell DH, Whyte MKB, Walmsley SR, Higgins KR, Vogel SN, Wilson HL , Prince LR et al (2013) . J Leukoc Biol, 93(1), 7-19.
Ward JR, West PW, Ariaans MP, Parker LC, Francis SE, Crossman DC, Sabroe I & Wilson HL (2010) . J Biol Chem, 285(30), 23147-23158.
Ward JR, Wilson HL, Francis SE, Crossman DC & Sabroe I (2009) . Clin Exp Immunol, 156(3), 386-394.
Wilson HL, Varcoe RW, Stokes L, Holland KL, Francis SE, Dower SK, Surprenant A & Crossman DC (2007) . Br J Pharmacol, 151(1), 115-127.
Evans I, Dower SK, Francis SE, Crossman DC & Wilson HL (2006) . Cytokine, 33(5), 274-280.
Wilson HL, Francis SE, Dower SK & Crossman DC (2004) . J Immunol, 173(2), 1202-1208.

All publications

Journal articles

Moss CE, Johnston SA, Kimble JV, Clements M, Codd V, Hamby S, Goodall AH, Deshmukh S, Sudbery I, Coca D , Wilson HL et al (2024) . Cell Reports, 43(4), 114073-114073.
Hernández-Quiles M, Martinez Campesino L, Morris I, Ilyas Z, Reynolds S, Soon Tan N, Sobrevals Alcaraz P, Stigter ECA, Varga Á, Varga J , van Es R et al (2023) . Molecular Metabolism, 78, 101829-101829.
Moss CE, Phipps H, Wilson HL & Kiss-Toth E (2023) . Frontiers in Immunology, 14.
Martinez-Campesino L, Kocsy K, Cañedo J, Johnston JM, Moss CE, Johnston SA, Hamby S, Goodall AH, Redgrave J, Francis SE , Kiss-Toth E et al (2022) . Frontiers in Cardiovascular Medicine, 9.
Niespolo C, Johnston JM, Deshmukh SR, Satam S, Shologu Z, Villacanas O, Sudbery IM, Wilson HL & Kiss-Toth E (2020) . Frontiers in Immunology, 11.
Baidžajevas K, Hadadi É, Lee B, Lum J, Shihui F, Sudbery I, Kiss-Tóth E, Wong SC & Wilson HL (2020) . Atherosclerosis.
Johnston JM, Angyal A, Bauer RC, Hamby S, Suvarna SK, Baidžajevas K, Hegedus Z, Dear TN, Turner M, Wilson HL , Goodall AH et al (2019) . Science Advances, 5(10), ---.
Niespolo C, Shologu Z, Satam S, Iscaro A, Muthana M, Socorro S, Wilson HL & Kiss-Toth E (2019) . European Urology Supplements, 18(8), e3090-e3091.
Narayanan P, Martinez Campesino L, Kim T, Muthana M, Wilson HL & Kiss-Toth E (2019) . European Urology Supplements, 18(8), e3060-e3060.
Li Y, James SJ, Wyllie DH, Wynne C, Czibula A, Bukhari A, Pye K, Bte Mustafah SM, Fajka-Boja R, Szabo E , Angyal A et al (2019) . Proceedings of the National Academy of Sciences, 116(33), 16479-16488.
Savage AM, Kurusamy S, Chen Y, Jiang Z, Chhabria K, MacDonald RB, Kim HR, Wilson HL, van Eeden FJM, Armesilla AL , Chico TJA et al (2019) . Nature Communications, 10.
Ogryzko NV, Lewis A, Wilson HL, Meijer AH, Renshaw SA & Elks PM (2019) . The Journal of Immunology, 202(2), 494-502.
Martinez Campesino L, Johnston JM, Francis SE, Kiss-Toth E & Wilson HL (2018) . Cardiovascular Research, 114(suppl_2), S2-S2.
Green J, Souilhiol C, Xanthis I, Martinez-Campesino L, Bowden N, Evans P & Wilson H (2018) . Cardiovascular Research, 114(2), 324-335.
Li Y, Wilson HL & Kiss-Toth E (2017) . J Inflamm (Lond), 14, 11-11.
Hadadi E, Zhang B, Baidzajevas K, Yusof N, Puan KJ, Ong SM, Yeap WH, Rotzschke O, Kiss-Toth E, Wilson H & Wong SC (2016) . Scientific Reports, 6.
Renshaw SA, robertson A, ogryzko N, Henry K, Loynes C, foulkes M, meloni M, Wang X, Ford C, Jackson M , Ingham P et al (2016) . DMM Disease Models and Mechanisms, 9, 621-632.
Alfaidi M, Wilson H, Daigneault M, Burnett A, Ridger V, Chamberlain J & Francis SE (2015) . Journal of Biological Chemistry, 290, 24067-24078.
Alfaidi M, Wilson H, Ridger V, Chamberlain J & Francis S (2014) Neutrophil elastase enhances IL-1 beta secretion from coronary endothelium via an endolysosomal mediated mechanism, without caspase-1 activation. ANGIOGENESIS, 17(4), 941-941.
Hadadi E, Kiss-Toth E, Wilson HL & Wong SC (2014) . Heart, 100 Suppl 3, A117.
Ogryzko NV, Renshaw SA & Wilson HL (2014) . Dev Comp Immunol, 46(1), 53-62.
Ogryzko NV, Hoggett EE, Solaymani-Kohal S, Tazzyman S, Chico TJA, Renshaw SA & Wilson HL (2014) . Dis Model Mech, 7(2), 259-264.
Alfaidi M, Wilson HL, Burnett A, Abdul-Aema BH, Ridger V, Chamberlain J & Francis SE (2014) . Heart, 100 Suppl 1, A2.
Basran A, Jabeen M, Bingle L, Stokes CA, Dockrell DH, Whyte MKB, Walmsley SR, Higgins KR, Vogel SN, Wilson HL , Prince LR et al (2013) . J Leukoc Biol, 93(1), 7-19.
Basran AK, Bingle L, Jabeen M, Dockrell D, Wilson HL, Whyte M, Sabroe R & Sabroe I (2011) . C34. NEUTROPHILS, MAST CELLS, BASOPHILS AND EOSINOPHILS IN LUNG DISEASE.
Ward JR, West PW, Ariaans MP, Parker LC, Francis SE, Crossman DC, Sabroe I & Wilson HL (2010) . J Biol Chem, 285(30), 23147-23158.
Ward JR, Wilson HL, Francis SE, Crossman DC & Sabroe I (2009) . Clin Exp Immunol, 156(3), 386-394.
Wilson HL, Varcoe RW, Stokes L, Holland KL, Francis SE, Dower SK, Surprenant A & Crossman DC (2007) . Br J Pharmacol, 151(1), 115-127.
Evans I, Dower SK, Francis SE, Crossman DC & Wilson HL (2006) . Cytokine, 33(5), 274-280.
Wilson HL, Francis SE, Dower SK & Crossman DC (2004) . J Immunol, 173(2), 1202-1208.
Bo X, Jiang L-H, Wilson HL, Kim M, Burnstock G, Surprenant A & North RA (2003) . Mol Pharmacol, 63(6), 1407-1416.
Wilson HL, Wilson SA, Surprenant A & North RA (2002) . J Biol Chem, 277(37), 34017-34023.
Kim M, Jiang LH, Wilson HL, North RA & Surprenant A (2002) Proteomic and functional evidence for a P2X(7)receptor complex.. BIOPHYS J, 82(1), 254A-255A.
Kim M, Jiang LH, Wilson HL, North RA & Surprenant A (2001) . EMBO J, 20(22), 6347-6358.
MacKenzie A, Wilson HL, Kiss-Toth E, Dower SK, North RA & Surprenant A (2001) . Immunity, 15(5), 825-835.
Wilson HL, Dipp M, Thomas JM, Lad C, Galione A & Evans AM (2001) . Journal of Biological Chemistry, 276(14), 11180-11188.
Surprenant A, Schneider DA, Wilson HL, Galligan JJ & North RA (2000) . J Auton Nerv Syst, 81(1-3), 249-263.
Genazzani AA, Wilson HL & Galione A (1999) . Journal of the Marine Biological Association of the United Kingdom, 79(2), 323-326.
Galione A, Cui Y, Empson R, Iino S, Wilson H & Terrar D (1998) . Cell Biochemistry and Biophysics, 28(1), 19-30.
WILSON HL & GALIONE A (1998) . Biochemical Journal, 331(3), 837-843.
Giles H, Lansdell SJ, Bolofo M-L, Wilson HL & Martin GR (1996) . British Journal of Pharmacology, 117(6), 1119-1126.

Conference proceedings papers

Clements M, Moss C, Kiss-Toth E & Wilson HL (2023) . Basic Science
Moss C, Clements M, Wilson HL & Kiss-Toth E (2023) . Basic Science
Niespolo C, Salamanca Viloria J, Deshmukh S, Villacanas Perez O, Sudbery I, Wilson H & Kiss-Toth E (2019) . Basic Science
Johnston JM, Martinez-Campesino L, Angyal A, Hadadi E, Kraus R, Wilson HL, Bauer R, Rader D, Hamby SE, Goodall AH , Francis SE et al (2019) Myeloid TRIB1 Controls Metabolic Tissue Resident Macrophage Phenotype Associated with Immuno-Metabolic Diseases. CARDIOVASCULAR DRUGS AND THERAPY, Vol. 33(2) (pp 271-271)
Kocsy K, Alqurashi R, Johnston JM, Baidzajevas K, Majid A, Wilson HL, Kiss-Toth E, Redgrave J & Francis SE (2018) . Cardiovascular Research, Vol. 114(suppl_2) (pp S5-S6)
Campesino LM, Johnston JM, Francis SE, Kiss-Toth E & Wilson HL (2018) CONSEQUENCES OF TRIB3 DEFICIENCY ON EXPERIMENTAL ATHEROSCLEROSIS AND MACROPHAGE PHENOTYPE. CARDIOVASCULAR RESEARCH, Vol. 114 (pp S2-S2)
Niespolo C, Viloria JS, Perez OV, Wilson HL & Kiss-Toth E (2018) . Cardiovascular Research, Vol. 114(suppl_2) (pp S8-S8)
Johnston JM, Angyal A, Bauer R, Hamby SE, Suvarna SK, Baidžajevas K, Hegedus Z, Dear NT, Turner M, Wilson HL , Goodall AH et al (2018) . Cardiovascular Research, Vol. 114(suppl_2) (pp S4-S4)
Campesino LM, Johnston J, Kiss-Toth E & Wilson H (2018) . Basic Science
Niespolo C, Viloria JS, Perez OV, Wilson H & Kiss-Toth E (2018) . Basic Science
Johnston JM, Angyal A, Hadadi E, Hamby SE, Bauer R, Ilyas Z, Szili D, Ariaans M, Wilson HL, Krauss RM , Rader DJ et al (2017) . Heart, Vol. 103(Suppl 5) (pp A113.2-A113)
Baidzajevas K, Hadadi E, Lee B, Lum J, Sudbery I, Lai S, Wong SC, Kiss-Toth E & Wilson H (2017) . Heart, Vol. 103(Suppl 5) (pp A136.1-A136)
Green J, Evans P & Wilson H (2016) . Heart, Vol. 102(Suppl 6) (pp A130.1-A130)
Angyal A, Ilyas Z, Hadadi E, Johnston J, Ariaans M, Kraus R, Wilson H, Bauer R, Rader D, Francis S & Kiss-Toth E (2015) . Atherosclerosis, Vol. 241(1) (pp e34-e34)
Green J, Wilson H & Evans P (2015) . Heart, Vol. 101(Suppl 4) (pp A104.1-A104)
Hadadi E, Kiss-Toth E, Wilson HL & Wong SC (2015) . Heart, Vol. 101(Suppl 4) (pp A101.2-A102)
Angyal A, Daigneault M, Hadadi E, Ariaans M, Burnett A, Wilson H, Ridger V & Kiss-Toth E (2013) . Heart, Vol. 99(suppl 2) (pp A126.1-A126)
Daigneault M, Angyal A, Hadadi E, Baskerville J & Wilson H (2013) . Heart, Vol. 99(suppl 2) (pp A114.2-A115)
Alfaidi M, Wilson H, Burnett A, Chamberlain J & Francis S (2013) . Heart, Vol. 99(suppl 2) (pp A99.2-A99)
Basran A, Bingle L, Dockrell D, Wilson HL, Whyte M, Sabroe R & Sabroe I (2013) Neutrophil recruitment in response to intradermal endotoxin challenge in man. LANCET, Vol. 381 (pp 22-22)
Evans AM, Dipp M, Wilson HL & Galione A (2000) Sarcoplasmic reticulum Ca2+ release, cyclic ADP-ribose and hypoxic pulmonary vasoconstriction in rabbit pulmonary arteries: do O-2-sensing K+ channels play a supporting role?. JOURNAL OF PHYSIOLOGY-LONDON, Vol. 528P (pp 4P-5P)
Wilson HL, Galione A & Evans AM (2000) Differential distribution of the enzyme activities for the synthesis and metabolism of cyclic ADP-ribose in rabbit pulmonary versus systemic artery smooth muscle: a novel redox sensing pathway?. JOURNAL OF PHYSIOLOGY-LONDON, Vol. 526 (pp 124P-125P)
Wilson HL, Evans AM & Galione A (1998) Cyclic AMP and cGMP differentially regulate the production of the calcium-mobilising metabolites, nicotinic acid adenine dinucleotide phosphate and cyclic ADP-ribose. BRITISH JOURNAL OF PHARMACOLOGY, Vol. 124 (pp U19-U19)
Galione A, Empson R, Genazzani A, Sethi J, Summerhill R & Wilson H (1997) Multiple mechanisms for calcium mobilization in the sea urchin egg. JOURNAL OF PHYSIOLOGY-LONDON, Vol. 499P (pp S5-S6)
Alfaidi MAA, Wilson H, Ridger, V, Chamberlain J & Francis S () Neutrophil elastase enhances IL-1 beta secretion from coronary endothelium via an endolysosomal mediated mechanism, without caspase-1 activation. ANGIOGENESIS, Vol. 17(4) (pp 941-941). California, USA, 18 October 2014 - 23 October 2014.

Preprints

Moss CE, Johnston S, Clements M, Codd V, Hamby S, Goodall AH, Deshmukh S, Sudbery I, Coca D, Wilson HL & Kiss-Toth E (2023) , Cold Spring Harbor Laboratory.
Johnston JM, Angyal A, Bauer RC, Hamby S, Suvarna SK, Baidžajevas K, Hegedus Z, Dear TN, Turner M, Wilson HL , Goodall AH et al () , Cold Spring Harbor Laboratory.

Research group

PhD Students

Mrs Rehab Alqurashi
Mr Kajus Baidzajevas
Mr Jack Green
Miss Laura Martinez-Campesino

Teaching interests

Course Deputy, MRes in Cardiovascular Medicine
Cardiovascular Pathway Lead, MSc in Molecular Medicine
CDL401 Vascular Cell Biology module lead
CDL301 lecturer, Cardiovascular Pharmacology, Biomedical Science BSc
BMedSci Cluster lead, 2010-2019
Personal and Academic Tutor to MBChB, BMedSci, MSc & MRes students
Laboratory Project supervisor to PhD, MSc, MRes, BMedSci, MBChB & MBB four-year MBiolSci students & clinical training fellows

Teaching activities

RCUK Fellow, University of ��«Ӱҵ, 2005-2010
Lecturer, University of ��«Ӱҵ, 2010-2017
Senior Lecturer, University of ��«Ӱҵ, 2018-Present

Professional activities and memberships

Departmental REF Lead.
Member of the British Atherosclerosis Society and British Society of Immunology
Ethics reviewer
Member of the Bateson Centre, University of ��«Ӱҵ (formerly Centre for Developmental and Biomedical Genetics)
Wellcome Trust PDRA, Laboratory of Profs Alan North & Annmarie Surprenant
BHF PDRA, Laboratory of Prof. Steven Dower

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School of Medicine and Population Health

School of Medicine and Population Health

Dr Heather L Wilson

Current projects

Featured publications

Journal articles

All publications

Journal articles

Conference proceedings papers

Preprints

PhD Students