Marriott, Helen, Dr

Dr Helen Marriott

PhD

Clinical Medicine, School of Medicine and Population Health

Lecturer in Respiratory Infection

h.m.marriott@sheffield.ac.uk
+44 114 215 9537

+44 114 271 1863 (fax)

The Medical School

Full contact details

Dr Helen Marriott
Clinical Medicine, School of Medicine and Population Health
The Medical School
Beech Hill Road
��«Ӱҵ
S10 2RX

Profile

For enquiries please contact - ClinMed-Operational@sheffield.ac.uk

I joined the University of ��«Ӱҵ in 1995 from the Department of Respiratory Physiology, Papworth Hospital, Cambridge. From 1995 to 2001 my research was on the pulmonary circulation, focusing on animal models of pulmonary hypertension. This formed the basis of my PhD, "Pulmonary hypertension: susceptibility and treatment in rat models".

In 2001 I joined Professor David Dockrell´s group as a post-doctoral research associate investigating the role of macrophage apoptosis in pneumococcal infection.

In 2005 I was awarded an independent fellowship from the British Lung Foundation to investigate the effects of influenza A virus on macrophage innate immune function.

In 2015 I was appointed Lecturer in Respiratory Infection.

Since 2016 I have been the academic lead of the Medical School Flow Cytometry Core Facility.

Research interests

My main research interest is in the role of macrophages in host defense against respiratory pathogens, in particular Streptococcus pneumoniae. I am also interested in the effect of influenza A virus on macrophage function, its effect on the regulation of macrophage apoptosis and how this may lead to increased susceptibility to bacterial superinfections. I have been using a variety of in vitro, in vivo models and computational models to support this research.

Current projects

Re-engaging antimicrobial killing by macrophages to combat antimicrobial resistance.

I was awarded an Innovation grant from the MRC as part of the cross research council initiative Tackling Antimicrobial Resistance to identify new targets for novel antibacterials. We have described macrophage apoptosis associated killing as an alternative means by which macrophages kill bacteria, however we have found that this is subverted in some patients at increased risk of bacterial infections, such as Chronic Obstructive Lung Disease. In addition some bacteria, notably S. aureus, can prevent macrophage apoptosis associated killing to survive within macrophages. In this grant we will screen and develop compounds to engage macrophage apoptosis as a means to improve bacterial killing and modify inflammation. By targeting the host, rather than the pathogen, we anticipate this will avoid antimicrobial resistance. This concept is a focus of the MRC Collaborative Grant, Optimising Innate Host Defence to Combat Antimicrobial Resistance of which I am a co-investigator.

Molecular analysis of the effects of influenza A virus on macrophage innate immune function (Wellcome Trust VIP award and Personal fellowship from the British Lung Foundation).

The aim of my fellowship was to characterise the effect of influenza A virus on macrophage function, with particular emphasis on its effect on the regulation of macrophage apoptosis. I have established in vitro macrophage and in vivo murine models of IAV infection and shown that both human monocyte derived macrophages and murine macrophages undergo apoptosis after influenza A virus infection. I am investigating how this relates to cytokine production, generation of antimicrobial molecules and killing of bacteria.

Role of ubiquitination in regulation of macrophage viability after bacterial infection.

Macrophages do not undergo apoptosis after infection with S. aureus or N. meningitidis, and I have shown this is associated with an increase in the anti-apoptotic protein Mcl-1. I am currently investigating the mechanism behind this up-regulation focusing on the role of post-translational modifications, in particular ubiquitination, and identifying the bacterial factors responsible.

Publications

Show: Featured publications All publications

Featured publications

Journal articles

Marsh EK, Prestwich EC, Williams L, Hart AR, Muir CF, Parker LC, Jonker MR, Heijink IH, Timens W, Fife M , Hussell T et al (2020) . Frontiers in Cellular and Infection Microbiology, 10.
Best A, Jubrail J, Boots M, Dockrell D & Marriott H (2020) . Journal of Theoretical Biology, 497.
Preston JA, Bewley MA, Marriott HM, Houghton AM, Mohasin M, Jubrail J, Morris L, Stephenson YL, Cross S, Greaves DR , Craig RW et al (2019) . American Journal of Respiratory and Critical Care Medicine.
Collini PJ, Bewley MA, Mohasin M, Marriott HM, Miller RF, Geretti AM, Beloukas A, Papadimitropoulos A, Read RC, Noursadeghi M & Dockrell D (2018) . American Journal of Respiratory and Critical Care Medicine, 197(12).
Bewley MA, Preston JA, Mohasin M, Marriott HM, Budd RC, Swales J, Collini P, Greaves DR, Craig RW, Brightling CE , Donnelly LE et al (2017) . American Journal of Respiratory and Critical Care Medicine, 196(7), 845-855.
Thompson AAR, Dickinson RS, Murphy F, Thomson JP, Marriott HM, Tavares A, Willson J, Williams L, Lewis A, Mirchandani A , Coelho PDS et al (2017) . Science Immunology, 2(8).
Jubrail J, Morris P, Bewley MA, Stoneham S, Johnston SA, Foster SJ, Peden AA, Read RC, Marriott HM & Dockrell DH (2015) . Cellular Microbiology, 18(1), 80-96.
Bewley MA, Naughton M, Preston J, Mitchell A, Holmes A, Marriott HM, Read RC, Mitchell TJ, Whyte MKB & Dockrell DH (2014) . mBio, 5(5).
Thompson AAR, Elks PM, Marriott HM, Eamsamarng S, Higgins KR, Lewis A, Williams L, Parmar S, Shaw G, McGrath EE , Formenti F et al (2013) . Blood, 123(3), 366-376.
Marriott HM, Daigneault M, Thompson AAR, Walmsley SR, Gill SK, Witcher DR, Wroblewski VJ, Hellewell PG, Whyte MKB & Dockrell DH (2012) . Thorax, 67(11), 985-992.
Daigneault M, de Silva TI, Bewley MA, Preston JA, Marriott HM, Mitchell AM, Mitchell TJ, Read RC, Whyte MKB & Dockrell DH (2012) . PLoS Pathogens, 8(7), 30.
McGrath EE, Lawrie A, Marriott HM, Mercer P, Cross SS, Arnold N, Singleton V, Thompson AAR, Walmsley SR, Renshaw SA , Sabroe I et al (2012) . Thorax, 67(9), 796-803.
Marriott HM, Gascoyne KA, Gowda R, Geary I, Nicklin MJH, Iannelli F, Pozzi G, Mitchell TJ, Whyte MKB, Sabroe I & Dockrell DH (2012) . Infect Immun, 80(3), 1140-1149.
McGrath EE, Marriott HM, Lawrie A, Francis SE, Sabroe I, Renshaw SA, Dockrell DH & Whyte MKB (2011) . J Leukoc Biol, 90(5), 855-865.
Bewley MA, Pham TK, Marriott HM, Noirel J, Chu H-P, Ow SY, Ryazanov AG, Read RC, Whyte MKB, Chain B , Wright PC et al (2011) . Mol Cell Proteomics, 10(6), M111.008193.
Walmsley SR, Chilvers ER, Thompson AA, Vaughan K, Marriott HM, Parker LC, Shaw G, Parmar S, Schneider M, Sabroe I , Dockrell DH et al (2011) . J Clin Invest, 121(3), 1053-1063.
Bewley MA, Marriott HM, Tulone C, Francis SE, Mitchell TJ, Read RC, Chain B, Kroemer G, Whyte MKB & Dockrell DH (2011) . PLoS Pathog, 7(1), e1001262.
Webster SJ, Daigneault M, Bewley MA, Preston JA, Marriott HM, Walmsley SR, Read RC, Whyte MKB & Dockrell DH (2010) . J Immunol, 185(5), 2968-2979.
Daigneault M, Preston JA, Marriott HM, Whyte MK & Dockrell DH (2010) . PLoS One, 5(1), e8668.
Marriott HM, Jackson LE, Wilkinson TS, Simpson AJ, Mitchell TJ, Buttle DJ, Cross SS, Ince PG, Hellewell PG, Whyte MKB & Dockrell DH (2008) . Am J Respir Crit Care Med, 177(8), 887-895.
Marriott HM, Hellewell PG, Cross SS, Ince PG, Whyte MKB & Dockrell DH (2006) . J Immunol, 177(9), 6480-6488.
Tunbridge AJ, Stevanin TM, Lee M, Marriott HM, Moir JWB, Read RC & Dockrell DH (2006) . Infect Immun, 74(1), 729-733.
Marriott HM, Bingle CD, Read RC, Braley KE, Kroemer G, Hellewell PG, Craig RW, Whyte MKB & Dockrell DH (2005) . J CLIN INVEST, 115(2), 359-368.
Marriott HM, Ali F, Read RC, Mitchell TJ, Whyte MKB & Dockrell DH (2004) . FASEB J, 18(10), 1126-1128.
Dockrell DH, Marriott HM, Prince LR, Ridger VC, Ince PG, Hellewell PG & Whyte MKB (2003) . J Immunol, 171(10), 5380-5388.

All publications

Journal articles

Marsh EK, Prestwich EC, Williams L, Hart AR, Muir CF, Parker LC, Jonker MR, Heijink IH, Timens W, Fife M , Hussell T et al (2020) . Frontiers in Cellular and Infection Microbiology, 10.
Best A, Jubrail J, Boots M, Dockrell D & Marriott H (2020) . Journal of Theoretical Biology, 497.
Fenaroli F, Robertson JD, Scarpa E, Gouveia VM, Di Guglielmo C, De Pace C, Elks PM, Poma A, Evangelopoulos D, Canseco JO , Prajsnar TK et al (2020) . ACS Nano.
Hughes BM, Burton CS, Reese A, Jabeen MF, Wright C, Willis J, Khoshaein N, Marsh EK, Peachell P, Sun SC , Dockrell DH et al (2019) . Frontiers in Immunology, 10.
Preston JA, Bewley MA, Marriott HM, Houghton AM, Mohasin M, Jubrail J, Morris L, Stephenson YL, Cross S, Greaves DR , Craig RW et al (2019) . American Journal of Respiratory and Critical Care Medicine.
Braithwaite AT, Marriott H & Lawrie A (2018) . Frontiers in Medicine, 5.
Collini PJ, Bewley MA, Mohasin M, Marriott HM, Miller RF, Geretti AM, Beloukas A, Papadimitropoulos A, Read RC, Noursadeghi M & Dockrell D (2018) . American Journal of Respiratory and Critical Care Medicine, 197(12).
Bewley MA, Preston JA, Mohasin M, Marriott HM, Budd RC, Swales J, Collini P, Greaves DR, Craig RW, Brightling CE , Donnelly LE et al (2017) . American Journal of Respiratory and Critical Care Medicine, 196(7), 845-855.
Sadiku P, Willson JA, Dickinson RS, Murphy F, Harris AJ, Lewis A, Sammut D, Mirchandani AS, Ryan E, Watts ER , Thompson AAR et al (2017) . Journal of Clinical Investigation, 127(9), 3407-3420.
Thompson AAR, Dickinson RS, Murphy F, Thomson JP, Marriott HM, Tavares A, Willson J, Williams L, Lewis A, Mirchandani A , Coelho PDS et al (2017) . Science Immunology, 2(8).
Gill SK, Marriott HM, Suvarna SK & Peachell PT (2016) . European Journal of Pharmacology, 793, 49-55.
Gill SK, Yao Y, Kay LJ, Bewley MA, Marriott HM & Peachell PT (2016) . British Journal of Pharmacology, 173(21), 3099-3109.
Jubrail J, Morris P, Bewley MA, Stoneham S, Johnston SA, Foster SJ, Peden AA, Read RC, Marriott HM & Dockrell DH (2015) . Cellular Microbiology, 18(1), 80-96.
Bewley MA, Naughton M, Preston J, Mitchell A, Holmes A, Marriott HM, Read RC, Mitchell TJ, Whyte MKB & Dockrell DH (2014) . mBio, 5(5).
Aberdein JD, Cole J, Bewley MA, Marriott HM & Dockrell DH (2013) . Clin Exp Immunol, 174(2), 193-202.
Thompson AAR, Elks PM, Marriott HM, Eamsamarng S, Higgins KR, Lewis A, Williams L, Parmar S, Shaw G, McGrath EE , Formenti F et al (2013) . Blood, 123(3), 366-376.
Bazaz R, Marriott HM, Francis SE & Dockrell DH (2013) . J Infect, 66(1), 1-17.
Musa M, Wilson K, Sun L, Mulay A, Bingle L, Marriott HM, LeClair EE & Bingle CD (2012) . Cell Tissue Res, 350(3), 455-464.
Marriott HM, Daigneault M, Thompson AAR, Walmsley SR, Gill SK, Witcher DR, Wroblewski VJ, Hellewell PG, Whyte MKB & Dockrell DH (2012) . Thorax, 67(11), 985-992.
Daigneault M, de Silva TI, Bewley MA, Preston JA, Marriott HM, Mitchell AM, Mitchell TJ, Read RC, Whyte MKB & Dockrell DH (2012) . PLoS Pathogens, 8(7), 30.
McGrath EE, Lawrie A, Marriott HM, Mercer P, Cross SS, Arnold N, Singleton V, Thompson AAR, Walmsley SR, Renshaw SA , Sabroe I et al (2012) . Thorax, 67(9), 796-803.
Marriott HM, Gascoyne KA, Gowda R, Geary I, Nicklin MJH, Iannelli F, Pozzi G, Mitchell TJ, Whyte MKB, Sabroe I & Dockrell DH (2012) . Infect Immun, 80(3), 1140-1149.
McGrath EE, Marriott HM, Lawrie A, Francis SE, Sabroe I, Renshaw SA, Dockrell DH & Whyte MKB (2011) . J Leukoc Biol, 90(5), 855-865.
Bewley MA, Pham TK, Marriott HM, Noirel J, Chu H-P, Ow SY, Ryazanov AG, Read RC, Whyte MKB, Chain B , Wright PC et al (2011) . Mol Cell Proteomics, 10(6), M111.008193.
Walmsley SR, Chilvers ER, Thompson AA, Vaughan K, Marriott HM, Parker LC, Shaw G, Parmar S, Schneider M, Sabroe I , Dockrell DH et al (2011) . J Clin Invest, 121(3), 1053-1063.
Walmsley SR, Chilvers ER, Thompson A, Vaughan K, Marriott H, Parker L, Shaw G, Parmar S, Schneider M, Sabroe I , Dockrell D et al (2011) . C13. PATHOGENESIS OF ACUTE LUNG INJURY.
Bewley MA, Marriott HM, Tulone C, Francis SE, Mitchell TJ, Read RC, Chain B, Kroemer G, Whyte MKB & Dockrell DH (2011) . PLoS Pathog, 7(1), e1001262.
Webster SJ, Daigneault M, Bewley MA, Preston JA, Marriott HM, Walmsley SR, Read RC, Whyte MKB & Dockrell DH (2010) . J Immunol, 185(5), 2968-2979.
Daigneault M, Preston JA, Marriott HM, Whyte MK & Dockrell DH (2010) . PLoS One, 5(1), e8668.
Marriott HM, Mitchell TJ & Dockrell DH (2008) . Curr Mol Med, 8(6), 497-509.
Marriott HM, Jackson LE, Wilkinson TS, Simpson AJ, Mitchell TJ, Buttle DJ, Cross SS, Ince PG, Hellewell PG, Whyte MKB & Dockrell DH (2008) . Am J Respir Crit Care Med, 177(8), 887-895.
Prince LR, Bianchi SM, Vaughan KM, Bewley MA, Marriott HM, Walmsley SR, Taylor GW, Buttle DJ, Sabroe I, Dockrell DH & Whyte MKB (2008) . J Immunol, 180(5), 3502-3511.
Bianchi SM, Prince LR, McPhillips K, Allen L, Marriott HM, Taylor GW, Hellewell PG, Sabroe I, Dockrell DH, Henson PW & Whyte MKB (2008) . Am J Respir Crit Care Med, 177(1), 35-43.
Vaughan KR, Stokes L, Prince LR, Marriott HM, Meis S, Kassack MU, Bingle CD, Sabroe I, Surprenant A & Whyte MKB (2007) . J Immunol, 179(12), 8544-8553.
Marriott HM & Dockrell DH (2007) . Exp Lung Res, 33(10), 493-505.
Marriott HM, Hellewell PG, Whyte MKB & Dockrell DH (2007) . Vaccine, 25(13), 2485-2490.
Marriott HM, Hellewell PG, Cross SS, Ince PG, Whyte MKB & Dockrell DH (2006) . J Immunol, 177(9), 6480-6488.
Marriott HM & Dockrell DH (2006) . Int J Biochem Cell Biol, 38(11), 1848-1854.
Tunbridge AJ, Stevanin TM, Lee M, Marriott HM, Moir JWB, Read RC & Dockrell DH (2006) . Infect Immun, 74(1), 729-733.
Marriott HM, Bingle CD, Read RC, Braley KE, Kroemer G, Hellewell PG, Craig RW, Whyte MKB & Dockrell DH (2005) . J CLIN INVEST, 115(2), 359-368.
Marriott HM, Bingle CD, Read RC, Braley KE, Kroemer G, Hellewell PG, Craig RW, Whyte MKB & Dockrell DH (2005) . Journal of Clinical Investigation, 115(2), 359-368.
Marriott HM, Ali F, Read RC, Mitchell TJ, Whyte MKB & Dockrell DH (2004) . FASEB J, 18(10), 1126-1128.
Dockrell DH, Marriott HM, Prince LR, Ridger VC, Ince PG, Hellewell PG & Whyte MKB (2003) . J Immunol, 171(10), 5380-5388.
DEMONCHEAUX EAG, HIGENBOTTAM TW, FOSTER PJ, BORLAND CDR, SMITH APL, MARRIOTT HM, BEE D, AKAMINE S & DAVIES MB (2002) . Clinical Science, 103(1), 107-107.
DEMONCHEAUX EAG, HIGENBOTTAM TW, FOSTER PJ, BORLAND CDR, SMITH APL, MARRIOTT HM, BEE D, AKAMINE S & DAVIES MB (2002) . Clinical Science, 103(1), 107-107.
Demoncheaux EAG, Higenbottam TW, Foster PJ, Borland CDR, Smith APL, Marriott HM, Bee D, Akamine S & Davies MB (2002) Is circulating nitrite a directly acting vasodilator?: authors' reply. CLIN SCI, 103(1), 108-110.
DEMONCHEAUX EAG, HIGENBOTTAM TW, FOSTER PJ, BORLAND CDR, SMITH APL, MARRIOTT HM, BEE D, AKAMINE S & DAVIES MB (2002) . Clinical Science, 102(1), 77-83.
Demoncheaux EAG, Higenbottam TW, Foster PJ, Borland CDR, Smith APL, Marriott HM, Bee D, Akamine S & Davies MB (2002) Circulating nitrite anions are a directly acting vasodilator and are donors for nitric oxide.. Clin Sci (Lond), 102(1), 77-83.
Higenbottam T, Marriott H, Cremona G, Laude E & Bee D (1999) . Chest, 116(4), 921-930.
Higenbottam T, Marriott H, Siddons T & Smith A (1998) . Seminars in Respiratory and Critical Care Medicine, 19(01), 91-95.
Marriott H & Higenbottam T (1997) The role of nitric oxide in respiratory disease. Schweizerische Medizinische Wochenschrift, 127(17), 709-714.
Bazaz R, Marriott HM, Wright C, Chamberlain J, West LE, Gelsthorpe C, Heath PR, Maleki-Dizaji A, Francis SE & Dockrell DH () . Frontiers in Cellular and Infection Microbiology, 13.
Herman KD, Wright CG, Marriott HM, McCaughran SC, Bowden KA, Collins MO, Renshaw SA & Prince LR () . Frontiers in Immunology, 13.
Masca NGD, Hensor EMA, Cornelius VR, Buffa FM, Marriott HM, Eales JM, Messenger MP, Anderson AE, Boot C, Bunce C , Goldin RD et al () . eLife, 4.
Hatzifoti C, Bacon A, Marriott H, Laing P & Heath AW () . PLoS ONE, 3(6), e2368-e2368.
Rudman J, Marriott HM, Carlin LM & Johnston SA () .

Chapters

Dockrell DH, Collini PJ & Marriott HM (2013) , Mucosal Immunology of Acute Bacterial Pneumonia (pp. 1-48). Springer New York
Marriott HM & Higenbottam TW (2000) , Nitric Oxide in Pulmonary Processes: Role in Physiology and Pathophysiology of Lung Disease (pp. 201-208). Birkhäuser Basel

Conference proceedings papers

Marsh EK, Prestwich EC, Marriott HM, Williams L, Hart AR, Muir CF, Parker LC, Jonker MR, Heijink IH, Timens W , Fife M et al (2018) . The influence of influenza: from cells to humans
Braithwaite AT, Pickworth JA, Arnold ND, West LE, Iremonger JE, Thompson AA, Marriott HM & Lawrie A (2018) . BTS/BALR/BLF Early Career Investigators awards symposium
Braithwaite AT, Pickworth JA, Arnold ND, West LE, Iremonger JE, Thompson AA, Marriott HM & Lawrie A (2018) Vascular Smooth Muscle Derived TRAIL is Required for Development of Pulmonary Arterial Hypertension in Sugen 5416 / Hypoxia Mice. CIRCULATION, Vol. 138
Dickinson RS, Thompson AAR, Thomson JP, Murphy F, Marriott HM, Tavares A, Willson J, Williams L, Lewis A, Forbes S , Stimson RH et al (2016) . Thorax, Vol. 71(Suppl 3) (pp A61.2-A62)
Marsh EK, Prestwich EC, Marriott HM, Paiva C, Bennett JA, Jonker MR, Timens W, Heijink IH, Parker LC, Dockrell DH & Sabroe I (2016) The Role Of Pellino-1 In Modulating Signalling Pathways Controlling The Inflammatory Response To Viral Stimuli In Airway Epithelial Cells. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 193
Gill SK, Marriott HM, Peachell PT & Immunity DI (2014) Prostaglandin E2 Activates Ep4 Receptors To Inhibit Pro-Inflammatory Cytokine Release From Human Lung Macrophages. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 189
Bingle CD, Araujo B, Wallace WA, Marriott HM, Hirani N & Bingle L (2013) . THORAX, Vol. 68 (pp A139-A139)
Thompson AAR, Marriott HM, Williams L, Shaw G, Hameed A, Parmar S, Preston JA, Simon MC, Johnson RS, Foster SJ , Dockrell DH et al (2013) . THORAX, Vol. 68 (pp A140-A140)
Thompson AAR, Elks PM, Marriott HM, Higgins KR, Parmar S, Shaw G, Eamsamarng S, McGrath EE, Formenti F, Van Eeden FJ , Kinnula VL et al (2012) . THORAX, Vol. 67 (pp A1-A1)
Araujo B, Bingle L, Marriott H, Howie S, Wallace W, Hirani N & Bingle CD (2012) . B28. EMERGING BIOMARKERS OF COMPLEX LUNG DISEASES
Thompson AAR, Elks PM, Marriott HM, Higgins KR, Shaw G, Parmar S, Formenti F, Van Eden FJ, Pugh CW, Sabroe I , Dockrell DH et al (2012) . C31. REGULATION OF LUNG INFLAMMATION
McGrath EE, Lawrie A, Marriott H, Mercer PF, Cross SS, Chambers RC, Dockrell DH & Whyte MKB (2011) . Thorax, Vol. 66(Suppl 4) (pp A51-A52)
McGrath EE, Marriott H, Lawrie A, Cross S, Mercer P, Hellewell P, Chambers RC, Dockrell D & Whyte MK (2011) . D14. INSIGHTS INTO PATHOGENESIS OF LUNG FIBROSIS AND GRANULOMAS
Marriott HM, Whyte M & Dockrell D (2011) . A35. LESSONS IN LUNG INFECTIONS
Webster SJ, Daigneault M, Marriott HM, Bewley MA, Read RC & Dockrell DH (2010) MONOCYTE DEATH PROCESSES ARE SUBVERTED BY MENINGOCOCCI. J INFECTION, Vol. 61(6) (pp 517-518)
Daigneault M, Collini P, Marriott HM, Preston J, Mitchell T & Dockrell D (2010) Monocytes promote T-lymphocyte apoptosis following Streptococcus pneumoniae challenge. IMMUNOLOGY, Vol. 131 (pp 179-179)
Marriott HM & Dockrell DH (2010) Regulation Of Apoptosis In A549 Cells After Influenza A Virus Infection. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 181
Marriott HM, Whyte MK & Dockrell DH (2009) Macrophage Apoptosis after Influenza A Virus Infection.. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 179
Mcgrath EE, Marriott HM, Hellewell PG, Dockrell DH & Whyte MK (2007) The role of TNF-related apoptosis inducing ligand in acute lung injury. THORAX, Vol. 62 (pp A62-A62)
Marriott HM, Read RC, Whyte MKB & Dockrell DH (2007) Maintenance of macrophage viability after meningococcal infection. IMMUNOLOGY, Vol. 120 (pp 82-82)
Marriott HM, Hellewell PG, Whyte MK & Dockrell DH (2005) Apoptotic macrophages limit inflammation in pneumococcal pneumonia. JOURNAL OF LEUKOCYTE BIOLOGY (pp 77-77)
Eneser M, Barer GR, Marriott HM & Emery CJ (2002) Quantification of pulmonary haemodynamic and vascular changes in chronic hypoxia and recovery in rats. JOURNAL OF PHYSIOLOGY-LONDON, Vol. 544 (pp 116P-116P)
Eneser M, Marriott HM, Emery CJ & Higenbottam TW (2001) Reversal of pulmonary hypertension and vascular remodelling by an endothelin receptor antagonist in the chronic hypoxic rat model. THORAX, Vol. 56 (pp 75-76)
Marriott HM, Emery CJ & Barer GR (2001) Fawn-hooded rats and pulmonary hypertension: histological and haemodynamic comparison with Wistar rats. J PHYSIOL-LONDON, Vol. 533 (pp 80P-81P)
Emery CJ, Lal H, Marriot HM, Whittle BJR, Shorr R, Bentley M, Zhao X & Higenbottam TW (2000) Pulmonary vasodilation by airway delivered prostacyclin analogues, UT-15 & pegylated UT-15. THORAX, Vol. 55 (pp A35-A35)
Marriott HM, Smith APL, Gonzalez AM, Emery CJ & Higenbottam TW (1999) Chronic dexfenfluramine treatment reduces the levels of serotonin transporter mRNA in normoxic and chronically hypoxic Wistar and Fawn hooded rats.. THORAX, Vol. 54 (pp A40-A40)
Emery CJ, Marriott HM, Laude EA, Prevost L & Higenbottam TW (1999) Pulmonary vasoactivity of fenfluramines and selective serotonin reuptake inhibitors, fluoxetine and amitriptyline, in the rat. THORAX, Vol. 54 (pp A40-A40)
Marriott HM, Emery CJ & Higenbottam TW (1999) Inhalation of endothelin(A/B) receptor antagonist partially reverses chronic hypoxic pulmonary hypertension in the rat. THORAX, Vol. 54 (pp A40-A40)
Patel R, Marriott HM, Emery CJ, McCormack K, Smith APL & Higenbottam TW (1999) Anti-ET-1 oligonucleotides as a potential treatment for pulmonary hypertension.. THORAX, Vol. 54 (pp A39-A39)
Patel R, Marriott HM, Smith APL, Emery CJ & Higenbottam TW (1999) Transfer of phosphorothioate oligodeoxynucleotides from the airway to the perfusate in isolated perfused rat lungs. AM J RESP CRIT CARE, Vol. 159(3) (pp A168-A168)
Marriott HM, Smith APL, Gonzalez AM, Emery CJ & Higenbottam TW (1999) Chronic dexfenfluramine treatment reduces the levels of serotonin transporter mRNA in normoxic and chronically hypoxic wistar and fawn hooded rats.. AM J RESP CRIT CARE, Vol. 159(3) (pp A168-A168)
Emery CJ, Marriott HM, Laude EA, Bee D & Higenbottam TW (1999) Attenuated pulmonary and systemic vasodilator response to serotonin in the Fawn Hooded rat. AM J RESP CRIT CARE, Vol. 159(3) (pp A165-A165)
Emery CJ, Phillips HM, Marriott HM, Laude EA & Bee D (1998) Pulmonary and systemic action of 5-HT in the Fawn Hooded rat: a model of inherited pulmonary and systemic hypertension. J PHYSIOL-LONDON, Vol. 511P (pp 108P-109P)
Marriott HM, Smith APL, Emery CJ & Higenbottam TW (1998) Rapid increases in the levels of preproendothelin-1 mRNA in the isolated perfused rat lung exposed to acute hypoxia. Thorax, Vol. 53(SUPPL. 4)
Laude EA, Emery CJ, Marriott HM & Higenbottam TW (1998) Altered vascular reactivity to serotonin in the fawn hooded rat; a model of spontaneous pulmonary and systemic hypertension. Thorax, Vol. 53(SUPPL. 4)
Marriott H, Akamine S & Higenbottam TW (1997) The effect of dexfenfluramine on 5-hydroxytryptamine clearance in the porcine lung. Thorax, Vol. 52(SUPPL. 6)
Marriott HM, Laude EA, Emery CJ & Higenbottam TW (1997) Enhanced pulmonary vasoreactivity to serotonin in the Fawn hooded rat. Thorax, Vol. 52(SUPPL. 6)

Preprints

Herman KD, Wright CG, Marriott HM, McCaughran SC, Collins MO, Renshaw SA & Prince LR () , Cold Spring Harbor Laboratory.
Bazaz R, Marriott H, Wright C, Chamberlain J, West L, Gelsthorpe C, Heath P, Maleki-Dizaji A, Francis S & Dockrell D () , Research Square Platform LLC.
Mohasin M, Balbirnie-Cumming K, Fisk E, Prestwich EC, Russell CD, Marshall J, Pridans C, Allen SP, Shaw PJ, De Vos KJ , Hill CJ et al () , Cold Spring Harbor Laboratory.
Rizzello L, Robertson JD, Elks PM, Poma A, Daneshpour N, Prajsnar TK, Evangelopoulos D, Canseco JO, Yona S, Marriott HM , Dockrell DH et al () , Cold Spring Harbor Laboratory.

Teaching activities

I contribute to several modules in the MSc in Molecular Medicine. I am the module leader for the following modules:

Modulating Immunity
Molecular and Cellular Basis of Disease
Pathogenicity of Viruses and Fungi

I am also the lead for the Experimental Medicine pathway.

I contribute to the teaching and supervision of students in the Medical School MBChB and Molecular Biology and Biotechnology BSc and MBiolSci courses.

I also teach the Postgraduate Induction course of the Faculty of Health and am the unfair means officer for the Medical School (PGR).

Professional activities and memberships

Member of University of ��«Ӱҵ Animal Welfare and Ethical Review Board / 3Rs Committee