Professor Janet Brown
BMedSci, MB BS, MSc, MD, FRCP
Clinical Medicine, School of Medicine and Population Health
Chair in Medical Oncology
Professor of Translational Medical Oncology
+44 114 226 5007
Full contact details
Clinical Medicine, School of Medicine and Population Health
Weston Park Hospital
Whitham Road
葫芦影业
S10 2SJ
- Profile
-
For enquiries please contact - SMPH-West-Operational@sheffield.ac.uk
Professor Janet Brown was appointed to a Chair in Translational Medical Oncology in the University of 葫芦影业, UK and as Honorary Consultant in Medical Oncology at the 葫芦影业 NHS Foundation Trust in 2012. She also holds a Visiting Professorship in Medical Oncology at the University of Leeds, UK.
After graduating in Medicine from the University of Newcastle upon Tyne and training in Oncology in Newcastle, Christie Hospital Manchester and Weston Park Hospital, 葫芦影业, she obtained her MD research degree from University of 葫芦影业 and was appointed Senior Clinical Lecturer and Honorary Consultant in Medical Oncology at the University of Leeds in 2006. Her specialist areas of clinical practice are breast, prostate and renal cancers.
Amongst a range of awards, she gained the American Society for Clinical Oncology Pain Merit Award in 2003 and the UK McElwain Research Prize for Medical Oncology in 2005. In 2008, she won a Cancer Research UK Clinician Scientist Fellowship for studies in bone oncology, which she held until 2014. She has gained international clinical experience, including study visits to Massachusetts General Hospital/ Harvard Medical School and Princess Margaret鈥檚 Hospital in Toronto.
Professor Brown is currently Head of Clinical Oncology in 葫芦影业 which, with the Cancer Clinical Trials Centre, encompasses responsibility for around 100 clinical and scientific researchers and associated funding. She is also Deputy Director (and Oncology Lead) of the Mellanby Centre for Musculoskeletal Research.
Other current roles include her leadership of the 拢4.5 million Yorkshire Cancer Research Senior Fellowships Award for 葫芦影业. She is Translational Lead for the 葫芦影业 Experimental Cancer Medicine Centre (funded by Cancer Research UK), the 葫芦影业 Clinical Academic Training Lead for Oncology and the Yorkshire Network Research lead for urological cancer.
Current PhD Opportunities
- .
- Research interests
-
Prof Brown has around 150 published, peer-reviewed research papers and 230 published abstracts. She has had more than 50 successful grant applications in the last 5 years and has recent and current research funding totalling over 拢15 million, with more than 拢10 million as Principal Investigator, from Cancer Research UK, National Institute for Health Research (NIHR), Yorkshire Cancer Research, Breast Cancer Campaign, Prostate Cancer UK, Weston Park Hospital Cancer Charity and other bodies. She is leading on an Impact case for REF 2021.
As an academic leader and clinician-scientist, Prof Brown engages in both clinical and laboratory research, which is internationally recognised, with publications in Lancet, Journal of Clinical Oncology, Journal of the National Cancer Institute, Nature Clinical Oncology, Clinical Cancer Research, Annals of Oncology Breast Cancer Research and Treatment and other journals. She leads the Clinical Bone Oncology and Biomarkers Group in the University of 葫芦影业, which has a particular focus on the impact of cancer on the skeleton in patients with breast, prostate and renal cancer. Recent research includes the use of biomarkers in established bone metastasis to aid patient management and studies of the negative impact of cancer treatments on bone health. One of the main objectives of her current clinical and laboratory work is to develop novel prognostic and predictive biomarkers for clinical use in patients with early cancer to help in prevention or delay of cancer metastasis to bone, after which disease is incurable, including new developments with exosomes and microRNAs. Prof Brown also runs a range of clinical studies to develop innovative therapeutic approaches in breast, renal and prostate cancer eg combining novel agents such as the radiopharmaceutical Radium-223 with PD1 inhibitors. As Chief Investigator, she currently leads a large UK-wide, 40 centre, clinical trial (STAR) funded by NIHR, to determine whether treatment breaks in patients with renal cancer receiving targeted therapies, can reduce toxicity and have health economic benefits, without loss in efficacy. She is also Chief Investigator on two multi-site clinical studies assessing the potential of therapies combining Radium-223 with other anti-cancer agents in breast cancer.
- Publications
-
Show: Featured publications All publications
Featured publications
Journal articles
- . The Lancet Oncology, 24(3), 213-227.
- . Journal of Bone Oncology, 29.
- . Bone, 147, 115907-115907.
- . Journal of Bone Oncology, 28.
- . Trials, 21(1).
- . Journal of Urology, 202(6), 1101-1101.
- . JAMA Oncology, 5(11), 1556-1564.
- . Health Technology Assessment, 23(30), 1-328.
- . Clinical Cancer Research, 25(9), 2769-2782.
- . Oncogene, 38(-), 1751-1763.
- . The Journal of Pathology, 247(3), 381-391.
- . JNCI: Journal of the National Cancer Institute, 110(8), 871-879.
- . European Journal of Cancer, 94, 70-78.
- . Clinical Cancer Research.
- . Health Technol Assess, 20(53), 1-288.
- . JAMA Oncology, 2(4), 493-493.
- . Journal of the National Cancer Institute, 108(4), ---.
- . European Urology, 68(1), 42-50.
- . Endocrine-Related Cancer, 21(2), 327-341.
- Denosumab in patients with cancer-a surgical strike against the osteoclast. Nature Reviews Clinical Oncology.
- . Journal of Clinical Oncology, 28(18_suppl), LBA4507-LBA4507.
- . Journal of Clinical Oncology, 27(15_suppl), e16016-e16016.
- . J Natl Cancer Inst, 97(1), 59-69.
- . Cancers, 12(8), 2109-2109.
- . Annals of Oncology, 1-12.
Chapters
Reports
All publications
Journal articles
- . Journal for ImmunoTherapy of Cancer, 12(7), e009368-e009368.
- . British Journal of General Practice, 74(suppl 1), bjgp24X737637-bjgp24X737637.
- . Journal of Bone Oncology, 47.
- . Cancer Treatment Reviews, 102792-102792.
- . Journal of Bone Oncology, 45, 100568-100568.
- . Journal of Bone Oncology, 45, 100570-100570.
- . Journal of Bone Oncology, 45, 100566-100566.
- . Journal of Bone Oncology, 45, 100529-100529.
- . European Urology Oncology.
- . J Clin Oncol, JCO2300236.
- . Annals of Oncology, 34, S956-S957.
- . British Journal of General Practice, 73(suppl 1), bjgp23X733797-bjgp23X733797.
- . British Journal of General Practice, 73(732), 326-329.
- . The Lancet Oncology, 24(3), 213-227.
- . Annals of Oncology, 33, S1215-S1215.
- . Journal of Bone Oncology, 35, 100442-100442.
- . Eur Urol.
- . Bone Reports, 16, 101362-101362.
- . Bone Reports, 16, 101363-101363.
- . British Journal of Cancer, 126(3), 419-429.
- . Journal of Bone Oncology, 31, 100402-100402.
- . Journal of Clinical Medicine, 10(17).
- . Annals of Oncology, 32, S1303-S1304.
- . Annals of Oncology, 32, S701-S701.
- . Annals of Oncology, 32, S1304-S1305.
- . Journal of Bone Oncology, 29.
- . Scientific Reports, 11(1).
- . Bone, 147, 115907-115907.
- . Journal of Bone Oncology, 28.
- . Bone Reports, 14, 100840-100840.
- . BMC Health Services Research, 21.
- . BMC Health Services Research, 21(1).
- . Cancer Research, 81(4_Supplement).
- . Molecular Cancer Therapeutics, 20(3), 589-601.
- . Supportive Care in Cancer, 29(2), 1145-1145.
- . Addiction, 116(5), 1196-1211.
- . Trials, 21(1).
- . Journal of Clinical Oncology, 38(34), 4064-4075.
- . Journal of Bone Oncology, 25.
- . European Urology Focus, 6(5), 991-998.
- . European Urology Focus, 6(5), 999-1005.
- . Annals of Oncology, 31, S26-S26.
- Abstract P2-18-08: Inclusion of adjuvant bone-modifying agents for early breast cancer into standard clinical practice: Challenges and lessons learnt from an international collaboration. Abstracts: 2019 San Antonio Breast Cancer Symposium.
- . Journal of Urology, 202(6), 1101-1101.
- . Current Osteoporosis Reports, 17(6), 527-537.
- . JAMA Oncology, 5(11), 1556-1564.
- . Cancer Informatics, 18, 1-3.
- . Health Technology Assessment, 23(30), 1-328.
- . European Urology, 75(6), 891-893.
- . Clinical Cancer Research, 25(9), 2769-2782.
- . Journal of Bone Oncology, 15.
- . Oncogene, 38(-), 1751-1763.
- . The Journal of Pathology, 247(3), 381-391.
- . Supportive Care in Cancer, 27(5), 1755-1763.
- . Annals of Translational Medicine, 6(S1), S71-S71.
- . Journal of Bone Oncology, 13, 123-135.
- . Cancer Research, 78(18), 5300-5314.
- . JNCI: Journal of the National Cancer Institute, 110(8), 871-879.
- . BMC Cancer, 18(1).
- . European Journal of Cancer, 94, 70-78.
- . Calcified Tissue International, 102(2), 251-264.
- . Journal of Bone Oncology, 9, 1-9.
- . Journal of Bone Oncology, 8, 13-17.
- . Annals of Oncology, 28, v315-v315.
- . European Journal of Cancer Care.
- . Clinical Cancer Research.
- . The Lancet, 388(10053), 1459-1544.
- . Health Technol Assess, 20(53), 1-288.
- . British Journal of Surgery, 103(8), 971-988.
- . BJU International.
- . Scientific Data, 3.
- . Journal of Clinical Oncology, 34(14), 1660-1668.
- . Annals of Oncology, 27(5), 880-886.
- . Journal of Instrumentation, 11(04), P04008-P04008.
- . JAMA Oncology, 2(4), 493-493.
- . Journal of the National Cancer Institute, 108(4), ---.
- . Supportive Care in Cancer, 24(3), 1327-1337.
- . Supportive Care in Cancer, 24(1), 447-455.
- . European Journal of Cancer, 53, 75-83.
- . Annals of Oncology, 27(1), 159-165.
- . Supportive Care in Cancer, 24(1), 457-458.
- . European Urology, 68(1), 42-50.
- . Journal of Urology, 193(4S).
- . PROTEOMICS - Clinical Applications, 9(3-4), 295-300.
- . European Urology, 66(3), 510-511.
- . Supportive Care in Cancer, 22(8), 2309-2310.
- Omic-profiling in breast cancer metastasis to bone: implications for mechanisms, biomarkers and treatment..
- . Endocrine-Related Cancer, 21(2), 327-341.
- , 95-124.
- . Clinical Cancer Research, 19(24), 6863-6872.
- . Patient Preference and Adherence, 7, 855-865.
- . Supportive Care in Cancer, 21(12), 3497-3507.
- . Cancer Treatment Reviews.
- Denosumab and zoledronic acid (ZA) treatment in patients with genitourinary (GU) cancers and bone metastases. BJU INTERNATIONAL, 112, 11-11.
- . J Clin Oncol, 31(21), 2685-2691.
- . Journal of Clinical Oncology, 31(18_suppl), LBA5000-LBA5000.
- . Journal of Bone Oncology, 2(2), 70-76.
- . Journal of Clinical Oncology, 31(15_suppl), lba5000-lba5000.
- . Nat Rev Rheumatol, 9(6), 365-374.
- Efficacy of bisphosphonates and other bone-targeted agents in metastatic bone disease from solid tumors other than breast and prostate cancers. Clinical Advances in Hematology and Oncology, 11(5), 281-287.
- . General Session Abstracts.
- . Clinical Oncology.
- . BMC CANCER, 12.
- HEALTH RESOURCE UTILISATION (HRU) AND PATIENT BURDEN ASSOCIATED WITH SKELETAL-RELATED EVENTS (SRES) IN A RANDOMISED CONTROLLED TRIAL SETTING. ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, 8, 354-354.
- . EUROPEAN JOURNAL OF CANCER, 48(16), 3082-3092.
- . Clin Cancer Res, 18(22), 6348-6355.
- . Journal of Bone Oncology, 1(2), 57-62.
- . Annals of Oncology, 23, ix309-ix309.
- . Cancer Treatment Reviews, 38(4), 284-291.
- . Journal of Clinical Oncology, 30(15_suppl), e16528-e16528.
- . Clinical Investigation, 2(5), 519-526.
- Denosumab in patients with cancer-a surgical strike against the osteoclast. Nature Reviews Clinical Oncology.
- Denosumab in patients with cancer-a surgical strike against the osteoclast. Nature Reviews Clinical Oncology, 9(2), 110-118.
- . Annals of Oncology, 23(5), 1341-1347.
- . Poster Session Abstracts.
- . Trials, 12(S1).
- . Crit Rev Oncol Hematol, 80(3), 411-432.
- . VALUE IN HEALTH, 14(3), A158-A158.
- . VALUE IN HEALTH, 14(3), A158-A158.
- . Breast Cancer Res Treat, 127(2), 429-438.
- . LANCET, 377(9768), 813-822.
- . EUROPEAN UROLOGY SUPPLEMENTS, 10(2), 336-336.
- . Bone, 48(1), 160-166.
- . Medical Oncology, 28(SUPPL. 1).
- . Expert Opin Drug Saf, 10(1), 133-145.
- . Clinical Cancer Research, 16(21), 5312-5319.
- . Current Opinion in Supportive and Palliative Care, 4(3), 189-194.
- . BJU INTERNATIONAL, 106(5), 726-727.
- . BJU International, 106(5), 727.
- . Breast Cancer Research and Treatment, 123(3), 805-814.
- A randomized phase III trial of denosumab versus zoledronic acid in patients with bone metastases from castration-resistant prostate cancer.. J Clin Oncol, 28(18_suppl), LBA4507.
- . Journal of Clinical Oncology, 28(18_suppl), LBA4507-LBA4507.
- . BJU International, 105(8), 1042-1043.
- . Expert Opinion on Medical Diagnostics, 4(2), 125-138.
- . Bone, 46(3), 801-805.
- . BMJ (Online), 340(7738), 118.
- . Neoplasia, 12(9), 685-696.
- Prognostic factors for skeletal complications from metastatic bone disease in breast cancer. Breast Cancer Research and Treatment, 1-13.
- . Journal of Clinical Oncology, 27(15_suppl), e16016-e16016.
- . Cancer Treat Rev, 34(7), 629-639.
- . Clin Cancer Res, 14(19), 6336-6342.
- . CANCER, 113(1), 193-201.
- Survival benefits of zoledronic acid in patients with bone metastases from non-small cell lung cancer and high NTX levels: The role of BALP.. J Clin Oncol, 26(15_suppl), 19003.
- Use of monthly oral ibandronate to prevent anastrozole-induced bone loss during adjuvant treatment for breast cancer: Two-year results from the ARIBON study.. J Clin Oncol, 26(15_suppl), 554.
- . CLINICAL ONCOLOGY, 20(4), 318-319.
- . Clinical Cancer Research, 14(6), 1775-1781.
- Zoledronic acid and survival in patients with metastatic bone disease from lung cancer and elevated markers of osteoclast activity. J THORAC ONCOL, 3(3), 228-236.
- . Cancer Treatment Reviews, 34, 51-52.
- . Calcif Tissue Int, 81(5), 341-351.
- . Clin Cancer Res, 13(18 Pt 1), 5406-5410.
- . Journal of Clinical Oncology, 25(18_suppl), 9013-9013.
- . Journal of Clinical Oncology, 25(18_suppl), 10601-10601.
- . Journal of Clinical Oncology, 25(18_suppl), 553-553.
- . UROLOGY, 70(2), 315-319.
- . Clin Cancer Res, 12(21), 6480-6486.
- . Journal of Clinical Oncology, 24(18_suppl), 4555-4555.
- . CLIN CANCER RES, 12(11), 3361-3367.
- Changes in bone resorption and vascular endothelial growth factor after a single zoledronic acid infusion in cancer patients with bone metastases from solid tumours. ONCOL REP, 15(5), 1351-1357.
- . Br J Cancer, 94(4), 469-472.
- . APPL PHYS LETT, 87(23).
- . J Clin Oncol, 23(22), 4925-4935.
- . Journal of Clinical Oncology, 23(16_suppl), 8023-8023.
- . J Natl Cancer Inst, 97(1), 59-69.
- . Journal of Clinical Oncology, 22(14_suppl), 8056-8056.
- . Journal of Clinical Oncology, 22(14_suppl), 8056-8056.
- . American Journal of Cancer, 3(4), 265-265.
- . Endocr Relat Cancer, 11(2), 207-224.
- . American Journal of Cancer, 3(4), 265-265.
- . Br J Cancer, 89(11), 2031-2037.
- . American Journal of Cancer, 2(4), 269-281.
- . Clin Oncol (R Coll Radiol), 15(7), 371-377.
- . Breast Cancer Res, 4(1), 24-29.
- . Breast, 11(5), 375-385.
- . British Journal of Haematology, 110(4), 1010-1012.
- Career focus on medical oncology. BMJ, 11, 2-3.
- Cancer Genetics: Friend or foe of the junior doctor. Morecambe Bay Medical Journal, 8, 272-272.
- Photodynamic therapy, its impact in clinical practice. Photodynamics, 3(2), 2-5.
- . Expert Opinion on Investigational Drugs, 8(12), 1967-1979.
- Photodynamic therapy - new light on cancer treatment. JOURNAL OF THE SOCIETY OF DYERS AND COLOURISTS, 115(9), 249-253.
- . Journal of Cancer Survivorship.
- . Health Technology Assessment, 1-171.
- . Nature Communications, 15(1).
- . JBMR Plus.
- . Trials, 25(1).
- . Drugs - Real World Outcomes.
- . Journal of Bone and Mineral Research.
- . Frontiers in Immunology, 14.
- . BJU International.
- . Cancers, 15(8), 2211-2211.
- . Future Pharmacology, 2(4), 444-459.
- . JAMA Oncology.
- . Diagnostics, 11(7), 1302-1302.
- . Cancers, 12(8), 2109-2109.
- . Annals of Oncology, 1-12.
- . PLOS ONE, 13(7), e0197606-e0197606.
Chapters
- , 50 Landmark Papers every Breast Surgeon Should Know (pp. 243-248). CRC Press
- , 50 Landmark Papers every Breast Surgeon Should Know (pp. 165-170). CRC Press
- , 50 Landmark Papers every Breast Surgeon Should Know (pp. 237-242). CRC Press
- , 50 Landmark Papers every Breast Surgeon Should Know (pp. 159-164). CRC Press
- , Bone Cancer (pp. 783-803). Elsevier
- , Bone Cancer (pp. 987-1002). Elsevier
- Identification of new therapeutic targets of bone cancers by proteomic strategies In Heymann D (Ed.), Bone Cancer Bone Sarcomas and Bone Metastases - From Bench to Bedside (pp. 783-803). Elsevier
- , Abeloff's Clinical Oncology (pp. 809-830.e3). Elsevier
- Metabolic complications In Young A, Board R, Leonard P, Cooksley T, Stewart A & Michie C (Ed.), Problem solving in acute oncology (pp. 84-88). ebn Health
- , Oncogenomics (pp. xv-xx). Elsevier
- , Oncogenomics (pp. 551-563). Elsevier
- In Martini L & Huhtaniemi I (Ed.), Encyclopedia of Endocrine Diseases (pp. 310-319). Oxford: Elsevier.
- , Encyclopedia of Endocrine Diseases (pp. 310-319). Elsevier
- (pp. 799-808). Wiley
- , Oncogenomics: From Basic Research to Precision Medicine (pp. 551-563).
- , Breast Cancer Management for Surgeons (pp. 673-679). Springer International Publishing
- , Management of Prostate Cancer (pp. 343-356). Springer International Publishing
- In Vassiliou V, Chow E & Kardamakis D (Ed.), Bone Metastases A translational and Clinical Approach (pp. 95-124). Springer Netherlands
- In Vassiliou V, Chow E & Kardamakis D (Ed.), Bone Metastases (pp. 125-153). Springer Netherlands
- Metabolic Complications In Marshall E, Clark P, Selby P & Young A (Ed.), Problem Solving in Acute Oncology Clinical Publishing
- Expert Commentary for Breast Disease. In - (Ed.), A Year Book Quarterly 21 (pp. 1-1).
- , Bone Metastases (pp. 93-116). Springer Netherlands
- The role of photodynamic therapy in cancer treatment opportunities and limitations In Griffiths J (Ed.), Colour science Volume (pp. 200-210).
- , Textbook of Bone Metastases (pp. 105-121). John Wiley & Sons, Ltd
Conference proceedings papers
- Enhancement and Size-based Response Criteria for Evaluating Tyrosine Kinase Inhibitor Dosing Strategy in Metastatic Renal Cancer: Prospective Imaging Study from the UK STAR Trial. CLINICAL ONCOLOGY, Vol. 36(1) (pp E78-E79)
- Fracture-related hospitalisations in de novo advanced or metastatic hormonesensitive prostate cancer: Secondary analysis of the STAMPEDE abiraterone acetate plus prednisone plus /- enzalutamide and M1|RT phase 3 trials using health systems data. EUROPEAN UROLOGY, Vol. 85 (pp S1583-S1583)
- THE IMPACT OF ANDROGEN DEPRIVATION THERAPY ON BONE HEALTH IN PATIENTS WITH PROSTATE CANCER. AGING CLINICAL AND EXPERIMENTAL RESEARCH, Vol. 36 (pp S77-S77)
- Fracture and fall risk in men with advanced or metastatic prostate cancer treated with novel androgen receptor signalling inhibitors: A systematic review and meta-analysis of randomised controlled trials. EUROPEAN UROLOGY, Vol. 83
- Clinical fracture incidence in metastatic hormone-sensitive prostate cancer and risk-reduction following addition of zoledronic acid to androgen deprivation therapy with or without docetaxel: Long-term results from the STAMPEDE trial. EUROPEAN UROLOGY, Vol. 83
- Addition of ATM Inhibitors to Radium223 Reduces Prostate Cancer Bone Metastases In Vivo. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 38 (pp 214-215)
- . Annals of Oncology, Vol. 33 (pp S1220-S1220)
- . Cancer Research, Vol. 81(13_Supplement) (pp 2904-2904)
- . Cancer Research, Vol. 81(13_Supplement) (pp 2797-2797)
- Mechanical loading induced osteogenic response does not interfere with the colonization of breast cancer in bone.. CANCER RESEARCH, Vol. 81(13)
- Changes in the phenotype of macrophages and CD8+T Cells in the perivascular niche of prostate tumours following androgen deprivation.. CANCER RESEARCH, Vol. 81(13)
- A randomised phase IB/IIA study of CApecitabine plus Radium-223 in breast cancer patients with BONe metastases (CARBON) - Safety and preliminary efficacy findings. CANCER RESEARCH, Vol. 81(4)
- . Poster Session Abstracts
- Preventing the progression of breast cancer bone metastasis by CDK inhibition. BREAST CANCER RESEARCH AND TREATMENT, Vol. 180(2) (pp 537-538)
- . Annals of Oncology, Vol. 30(Suppl 5) (pp v334-v335). Barcelona, Spain, 27 September 2019 - 1 October 2019.
- . Tumor Biology
- . Tumor Biology
- . Poster Session Abstracts
- . Early Clinical Opportunities
- Plasma G-CSF levels are predictive of lack of response to zoledronic acid treatment in reducing breast cancer recurrence.. MOLECULAR CANCER RESEARCH, Vol. 16(8) (pp 68-69)
- . General Session Abstracts
- Prospective comparison of RECIST and alternative response assessment criteria in the evaluation of metastatic renal cell cancer patients from phase II of the multi-centre randomised STAR trial. ANNALS OF ONCOLOGY, Vol. 28
- . Journal of Clinical Oncology, Vol. 35(15_suppl) (pp e16061-e16061)
- . Clinical Oncology, Vol. 29(3) (pp e89-e89)
- . Journal of Clinical Oncology, Vol. 33(7_suppl) (pp 267-267)
- . Journal of Clinical Oncology, Vol. 32(15_suppl) (pp 4525-4525)
- . Poster Session Abstracts
- Effect of skeletal-related events on pain interference in patients with solid tumors and bone metastases. EUROPEAN JOURNAL OF CANCER, Vol. 49 (pp S269-S269)
- Skeletal-related events in patients with solid tumors receiving denosumab or zoledronic acid by baseline pain status: Results from three phase 3 trials. EUROPEAN JOURNAL OF CANCER, Vol. 49 (pp S268-S268)
- Risk factors for developing osteonecrosis of the jaw (ONJ) in patients receiving denosumab or zoledronic acid for bone metastases: Results from three phase 3 trials. EUROPEAN JOURNAL OF CANCER, Vol. 49 (pp S268-S269)
- Clinical outcomes in patients with castrate-refractory prostate cancer (CRPC) metastatic to bone randomized in the factorial TRAPEZE trial to docetaxel (D) with strontium-89 (Sr89), zoledronic acid (ZA), neither, or both (ISRCTN 12808747).. JOURNAL OF CLINICAL ONCOLOGY, Vol. 31(18)
- Impact of skeletal-related events on pain and analgesic use in patients with solid tumors and bone metastases.. JOURNAL OF CLINICAL ONCOLOGY, Vol. 31(15)
- Clinical outcomes in patients with castrate-refractory prostate cancer (CRPC) metastatic to bone randomized in the factorial trapeze trial to docetaxel (D) with strontium-89 (Sr89), zoledronic acid (ZA), neither, or both (ISRCTN 12808747).. JOURNAL OF CLINICAL ONCOLOGY, Vol. 31(15)
- Incidence of osteonecrosis of the jaw in patients receiving denosumab or zoledronic acid for bone metastases from solid tumors or multiple myeloma: Results from three phase III trials.. JOURNAL OF CLINICAL ONCOLOGY, Vol. 31(15)
- Denosumab and zoledronic acid treatment in patients with genitourinary cancers and bone metastases. JOURNAL OF CLINICAL ONCOLOGY, Vol. 31(15)
- 2-year open-label extension phase results from the pivotal phase 3 study of denosumab in patients with metastatic castration-resistant prostate cancer (CRPC) previously treated with denosumab or zoledronic acid. BJU INTERNATIONAL, Vol. 111 (pp 91-92)
- DENOSUMAB IN PATIENTS WITH METASTATIC PROSTATE CANCER PREVIOUSLY TREATED WITH DENOSUMAB OR ZOLEDRONIC ACID: 2-YEAR OPEN-LABEL EXTENSION PHASE RESULTS FROM THE PIVOTAL PHASE 3 STUDY. ANNALS OF ONCOLOGY, Vol. 23 (pp 309-309)
- Health state preferences associated with subcutaneous injections and intravenous infusions for treatment of bone metastases. JOURNAL OF CLINICAL ONCOLOGY, Vol. 30(15)
- Baseline covariates impacting overall survival (OS) in a phase III study of men with bone metastases from castration-resistant prostate cancer.. JOURNAL OF CLINICAL ONCOLOGY, Vol. 30(15)
- Health resource utilization and patient burden associated with SREs in a randomized controlled trial setting. JOURNAL OF CLINICAL ONCOLOGY, Vol. 30(15)
- . EUROPEAN JOURNAL OF CANCER, Vol. 48 (pp S8-S8)
- . EUROPEAN JOURNAL OF CANCER, Vol. 47 (pp S240-S240)
- UK INNOVATORS IN BREAST CANCER: AN INITIATIVE TO SUPPORT THE NEXT GENERATION OF BREAST CANCER RESEARCHERS (ON BEHALF OF PAST AND PRESENT 'UK INNOVATORS'). ANNALS OF ONCOLOGY, Vol. 22 (pp 58-58)
- UK INNOVATORS IN BREAST CANCER: AN INITIATIVE TO SUPPORT THE NEXT GENERATION OF BREAST CANCER RESEARCHERS (ON BEHALF OF PAST AND PRESENT 'UK INNOVATORS'). ANNALS OF ONCOLOGY, Vol. 22
- . BONE, Vol. 48(1) (pp S50-S51)
- . BONE, Vol. 48(1) (pp S16-S16)
- . BONE, Vol. 48(1) (pp S18-S19)
- . BONE, Vol. 48(1) (pp S33-S33)
- . BONE, Vol. 48(1) (pp S29-S29)
- . BONE, Vol. 48(1) (pp S20-S21)
- . BONE, Vol. 48(1) (pp S29-S29)
- ZOLEDRONIC ACID (ZOL) REDUCES THE INCIDENCE OF SKELETAL-RELATED EVENT (SRES) AND MAY IMPROVE SURVIVAL IN PATIENTS WITH BONE METASTASES (METS) FROM RENAL CELL CARCINOMA (RCC): A RETROSPECTIVE INTEGRATED ANALYSIS. ANNALS OF ONCOLOGY, Vol. 21 (pp 287-287)
- . BONE, Vol. 47 (pp S312-S312)
- . BONE, Vol. 47 (pp S302-S303)
- . BONE, Vol. 47 (pp S311-S312)
- . BONE, Vol. 47 (pp S311-S311)
- . BONE, Vol. 47 (pp S310-S311)
- Correlation of N-telopeptide of type I collagen (NTX) with survival and fractures in patients (pts) with bone metastases from renal cell carcinoma (RCC). JOURNAL OF CLINICAL ONCOLOGY, Vol. 27(15)
- RISK FACTORS FOR SKELETAL-RELATED EVENT (SRES) IN ZOLEDRONIC ACID-TREATED PATIENTS WITH BONE METASTASES (METS) FROM NON-SMALL CELL LUNG CANCER (NSCLC). ANNALS OF ONCOLOGY, Vol. 19 (pp 275-275)
- . JOURNAL OF CLINICAL ONCOLOGY, Vol. 26(15)
- . JOURNAL OF CLINICAL ONCOLOGY, Vol. 26(15)
- Serum lactate dehydrogenase (LDH) is a significant prognostic variable for survival in patients with metastatic breast cancer - a multivariate analysis. EJC SUPPLEMENTS, Vol. 6(7) (pp 189-189)
- . CANCER TREATMENT REVIEWS, Vol. 34 (pp S81-S82)
- . CANCER TREATMENT REVIEWS, Vol. 34 (pp S78-S78)
- . CANCER TREATMENT REVIEWS, Vol. 34 (pp S79-S79)
- . CANCER TREATMENT REVIEWS, Vol. 34 (pp S51-S51)
- . CANCER TREATMENT REVIEWS, Vol. 34 (pp S78-S79)
- . CANCER TREATMENT REVIEWS, Vol. 34 (pp S85-S85)
- Preoperative sodium concentration as a possible predictor of survival in patients with renal cell carcinoma. JOURNAL OF CLINICAL ONCOLOGY, Vol. 25(18)
- Normalization of bone markers and improved survival during zoledronic acid therapy. JOURNAL OF CLINICAL ONCOLOGY, Vol. 25(18)
- Effect of monthly oral ibandronate on anastrozole-induced bone loss during adjuvant treatment for breast cancer: One-year results from the ARIBON study. JOURNAL OF CLINICAL ONCOLOGY, Vol. 25(18)
- . BONE, Vol. 38(3) (pp S79-S79)
- . BONE, Vol. 38(3) (pp S79-S80)
- . BONE, Vol. 38(3) (pp S70-S70)
- The ARIBON study: Reversal of anastrozole (Arimidex) induced bone loss with oral monthly ibandronate (Bondronat) treatment during adjuvant therapy for breast cancer.. CANCER TREATMENT REVIEWS, Vol. 32 (pp S48-S49)
- Infrequent zoledronic acid produces sustained increases in bone mineral density (BMD) in patients with cancer treatment induced bone loss (CTIBL). CANCER TREATMENT REVIEWS, Vol. 32 (pp S19-S19)
- Effects of clodronate on serum osteoprotogerin (OPG) in patients with metastatic bone disease. CANCER TREATMENT REVIEWS, Vol. 32 (pp S40-S40)
- Baseline N-telopeptide levels correlate with risk of skeletal morbidity in patients with multiple myeloma during zoledronic acid therapy.. BLOOD, Vol. 106(11) (pp 964A-965A)
- Prognostic significance of biochemical markers of bone metabolism in patients with bone lesions from multiple myeloma (MM).. BLOOD, Vol. 106(11) (pp 335B-335B)
- Can an annual infusion of zoledronic acid protect against cancer-treatment induced bone loss (CTIBL)?. JOURNAL OF CLINICAL ONCOLOGY, Vol. 23(16) (pp 734S-734S)
- Using bone turnover markers to direct bisphosphonate therapy: Is this a feasible approach?. CANCER TREATMENT REVIEWS, Vol. 31 (pp S30-S30)
- The use of point of care devices for the monitoring of urinary NTX levels in metastatic breast cancer. CANCER TREATMENT REVIEWS, Vol. 31 (pp S52-S53)
- Do long-term cancer survivors, treated for testicular cancer or lymphoma, suffer chemotherapy-induced bone loss?. CANCER TREATMENT REVIEWS, Vol. 31 (pp S46-S46)
- A study to determine whether the bisphosphonate zoledronic acid can be shown to exert a direct anti tumour effect in vivo. CANCER TREATMENT REVIEWS, Vol. 31 (pp S48-S49)
- An investigation of the long-term effects of chemotherapy on bone in male long-term cancer survivors. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 19(9) (pp 1587-1587)
- The predictive value of bone resorption and formation markers in patients with prostate cancer metastatic to bone. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 19(9) (pp 1596-1596)
- The prognostic significance of biochemical markers of bone metabolism in patients with bone metastases from solid tumors other than breast and prostate cancer. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 19(9) (pp 1596-1596)
- Effect of an annual infusion of zoledronic acid on bone mineral density in cancer survivors following antineoplastic therapy. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 19(9) (pp 1596-1596)
- A double blind, parallel, placebo controlled, dose ranging study on efficacy and safety of oral clodronate in cancer induced osteolysis measured by biochemical markers of bone resorption.. JOURNAL OF CLINICAL ONCOLOGY, Vol. 22(14) (pp 743S-743S)
- Prediction of skeletal complications in metastatic bone disease and strategies for management of treatment-induced bone loss. BRITISH JOURNAL OF CANCER, Vol. 91 (pp S20-S20)
- Bone loss in long term cancer survivors. A pilot study to evaluate the effect of annual intravenous zoledronic acid on bone mineral density (BMD) and bone turnover markers. BONE, Vol. 34 (pp S93-S93)
- Development of a touch screen questionnaire approach for measurement of pain assessment scales in cancer patients with bone metastasis. BRITISH JOURNAL OF CANCER, Vol. 88 (pp S67-S67)
- Bone marker directed bisphosphonate therapy in metastatic bone disease. BRIT J CANCER, Vol. 86 (pp S19-S19)
- Relationship between bone resorption and skeletal events in metastatic done disease. BONE, Vol. 30(3) (pp 47S-47S)
- Bone marker directed bisphosphonate treatment. A pilot study to determine feasibility. BONE, Vol. 30(3) (pp 47S-47S)
Reports
- Implementing frailty assessment and management in oncology services
- Expert Panel: evaluation of the Government鈥檚 commitments in the area of cancer services in England
Other
Preprints
- Research group
-
Associated Staff
- Caroline Potts - YCR Support
- Dr Steven Wood, Senior Research Associate
- Maria Oliva, Research Assistant
- Ana Lopez, Research Assistant
- Dr Stella D'Oronzo, Visiting Clinical Fellow, Italy
- Dr Azeez Salawu, Clinical Academic Fellow
- Dr Catherine Handforth, Clinical Research Fellow
- Dr Amy Kwan, Clinical Research Fellow
- Dr Emma Rathbone, CRUK Clinical Research Fellow
- Dr Elisavet Theodoulou, Clinical Research Fellow
- Dr Rebecca Andrews, Clinical Research Fellow (Dr Andrew Chantry, main Clinical Supervisor)
- Dr Amy Adlard, BCN Postdoctoral Fellow (in collaboration with Prof Claire Lewis)
- Dr Ming Want, BCN Postdoctoral Fellow (in collaboration with Prof Claire Lewis)
- Dr Xuan Pu, PCUK Postdoctoral Fellow (in collaboration with Prof Claire Lewis)
- Dr Suruchi Mittal, BCN Postdoctoral Fellow (in collaboration with Prof Ingunn Holen)
- Hind Naffadi, PhD Student (in collaboration with Prof Tim Skerry)
- Andrew Hall, Hallam University Biochemistry Placement Student
- Teaching activities
-
I have been engaged in many aspects of medical teaching including examining at undergraduate and postgraduate levels, being personal tutor for 10 medical students, educational supervisor for 4 SpRs, 2 Clinical Lecturers, 4 SHOs and 2 biological science sandwich students and supervised alone or jointly 8 staff/students (3 postgraduate), including two current clinical fellow PhD students.
- Professional activities and memberships
-
Invited oral presentations at many symposia/conferences in UK and internationally
Member of NCRI Prostate Clinical Studies Group, Advanced Cancer Sub-Group 2009 - 2013
Member of NCRI Renal Cancer Clinical Studies Group 2010-present
Member of NCRI Breast Cancer Clinical Studies Group 2015-present
Chair, National Prostate Cancer Bone Health Guidelines Group 2011-present
Service on various UK and global company advisory boards
NICE expert advisor for adoption of new renal cancer drug 2012-2014 and for appraisal of Tumour Profiling Tests for Early Breast Cancer 2017
EMEA expert advisor for regulatory approval of bone-targeted drug 2011-2012