Mrs Jennifer Down
Clinical Medicine, School of Medicine and Population Health
Research Associate
j.m.down@sheffield.ac.uk
+44 114 215 9209
+44 114 215 9209
EU25, E Floor, The Medical School
Full contact details
Mrs Jennifer Down
Clinical Medicine, School of Medicine and Population Health
EU25, E Floor
The Medical School
Beech Hill Road
葫芦影业
S10 2RX
Clinical Medicine, School of Medicine and Population Health
EU25, E Floor
The Medical School
Beech Hill Road
葫芦影业
S10 2RX
- Publications
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Show: Featured publications All publications
Featured publications
Journal articles
- . Journal for ImmunoTherapy of Cancer, 9(3).
- . Oncogene.
- . Journal of Bone and Mineral Research, 34(12), 2311-2326.
- . Blood, 132(Supplement 1), 3213-3213.
- . Journal of Bone and Mineral Research.
- . Oncotarget, 8, 68047-68058.
- . Cancer Discovery, 5(1), 35-42.
- . Cancer Research, 70(12), 5163-5173.
- . The Prostate, 70(8), 875-882.
- Zoledronic acid prevents the development of myeloma bone disease and increases survival. JOURNAL OF BONE AND MINERAL RESEARCH, 17(7), 1328-1328.
- Zoledronic acid prevents the development of osteolytic bone disease and increases survival in a murine model of multiple myeloma. BONE, 30(3), 39S-39S.
- Osteoprotegerin inhibits the development of osteolytic bone disease in multiple myeloma. BONE, 28(5), S81-S81.
- . British Journal of Haematology, 111(1), 283-286.
- . Journal of Bone and Mineral Research, 18(3), 482-492.
All publications
Journal articles
- . Journal of Clinical Oncology, 42(16_suppl), TPS4621-TPS4621.
- . The Journal of Pathology: Clinical Research, 10(2).
- . Cancers, 14(19).
- . Journal of Bone Oncology, 31.
- . Journal for ImmunoTherapy of Cancer, 9(3).
- . Oncogene.
- . Journal of Bone and Mineral Research, 34(12), 2311-2326.
- . Blood, 132(Supplement 1), 3213-3213.
- . Journal of Bone and Mineral Research.
- . PLoS One, 13(6).
- . Endocrinology, 159(4), 1762-1762.
- . Oncotarget, 8, 68047-68058.
- . Haematologica, 102, e336-e339.
- . Nature Communications, 6(1), ---.
- . Endocrinology, 156(9), 3098-3113.
- . International Journal of Cancer, 136(7), 1731-1740.
- . Cancer Discovery, 5(1), 35-42.
- . Scientific Reports, 3(1).
- iTRAQ Identification of Candidate Serum Biomarkers Associated with Metastatic Progression of Human Prostate Cancer.. PLoS ONE.
- . Cancer Research, 70(12), 5163-5173.
- . The Prostate, 70(8), 875-882.
- . The Prostate, n/a-n/a.
- . Histopathology, 53(5), 561-566.
- . International Journal of Cancer, 121(9), 1958-1966.
- . Journal of Clinical Pathology, 59(7), 716-720.
- . International Journal of Cancer, 118(8), 1901-1908.
- . Breast Cancer Research and Treatment, 92(3), 207-215.
- . Immunity, 19(6), 849-861.
- Zoledronic acid prevents the development of myeloma bone disease and increases survival. JOURNAL OF BONE AND MINERAL RESEARCH, 17(7), 1328-1328.
- Zoledronic acid prevents the development of osteolytic bone disease and increases survival in a murine model of multiple myeloma. BONE, 30(3), 39S-39S.
- Myeloma cells can down-regulate release of osteoprotegerin (OPG) from human bone cells - A contributing factor in myeloma bone loss?. BONE, 30(3), 32S-32S.
- Interleukin 2 deficiency induces bone destruction associated with dysregulation of the rank/rank ligand/osteoprotegerin system. Blood, 98(11 PART I).
- Zoledronic acid inhibits the development of osteolytic bone disease and increases disease free survival in a murine model of multiple myeloma. Blood, 98(11 PART I).
- Osteoprotegerin inhibits the development of osteolytic bone disease in multiple myeloma. BONE, 28(5), S81-S81.
- . Blood, 98(13), 3534-3540.
- . British Journal of Haematology, 111(1), 283-286.
- Tumour cells isolated from patients with multiple myeloma express the critical osteoclastogenic factor, RANKL.. BLOOD, 96(11), 360A-360A.
- Osteoprotegerin (OPG) inhibits the development of osteolytic bone disease in the 5T2MM model of multiple myeloma.. BLOOD, 96(11), 761A-761A.
- Myeloma cells isolated from patients with multiple myeloma express osteoprotegerin ligand.. JOURNAL OF BONE AND MINERAL RESEARCH, 15(6), 1217-1217.
- . Molecular Cancer Therapeutics.
- . PLoS ONE, 7(5).
- . Rheumatology, 45(12), 1529-1533.
- . Journal of Bone and Mineral Research, 19(10), 1712-1721.
- . Journal of Bone and Mineral Research, 18(3), 482-492.
Conference proceedings papers
- Use of gene expression patterns to identify unique molecular subtypes in muscle invasive bladder cancer: GUSTO. JOURNAL OF CLINICAL ONCOLOGY, Vol. 42(16)
- Pathology Against the Clock: Verification of Gene Expression Subtyping for the GUSTO Clinical Trial. JOURNAL OF PATHOLOGY, Vol. 261(SUPPL1) (pp S49-S49)
- Myeloma-specific oncolytic adenovirus induces significant tumour oncolysis in vitro and in vivo and prevents cell line regrowth. BRITISH JOURNAL OF HAEMATOLOGY, Vol. 185 (pp 97-97)
- . Experimental Hematology, Vol. 64(Suppl) (pp S74-S75). Los Angeles, USA, 23 August 2018 - 26 August 2018.
- TARGETING FREE LIGHT CHAIN (FLC) SECRETION AND THE UNFOLDED PROTEIN RESPONSE IN MYELOMA CELLS USING VAN, A COMBINATION OF REPURPOSED DRUGS. EXPERIMENTAL HEMATOLOGY, Vol. 64 (pp S75-S75)
- . Bone, Vol. 48(1) (pp S46-S47)
- Bone marrow stromal cell-derived insulin-like growth factor (IGF) II enhances growth and survival of prostate cancer cells and potentiates androgen action. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, Vol. 88(6) (pp A94-A94)
- There is a general loss of expression of receptor activator of nFkB ligand (RANKL) in human breast cancers but retention of expression has a significant negative association with expression of oestrogen receptor (ER). JOURNAL OF PATHOLOGY, Vol. 207 (pp 27-27)
- Tumour necrosis factor-related apoptosis inducing ligand (TRAIL) is expressed in human breast cancers and has a significant negative association with tumours with poor prognosis.. JOURNAL OF PATHOLOGY, Vol. 207 (pp 27-27)
- Loss of intercellular expression of beta-dystroglycan is a common event in breast cancer. JOURNAL OF PATHOLOGY, Vol. 205 (pp 8-8)
- Loss of intercellular expression of beta-dystroglycan is a common event in prostate cancer and is significantly associated with loss of differentiation. JOURNAL OF PATHOLOGY, Vol. 205 (pp 15-15)
- beta-dystroglycan is constitutively expressed at the intercellular junctions of epithelial cells and this expression is frequently absent in common cancers. JOURNAL OF PATHOLOGY, Vol. 205 (pp 6-6)
- Human bone marrow stromal cell derived IGF signaling enhances PSA production as well as proliferation/survival of androgen sensitive prostate cancer cells in vitro. CANCER TREATMENT REVIEWS, Vol. 31 (pp S36-S36)
- T-cell-mediated colitis and bone destruction in a murine model of autoimmunity are both driven by RANK/RANK LIGAND interactions and modulated by recombinant Fc-OPG. BRITISH JOURNAL OF HAEMATOLOGY, Vol. 125 (pp 67-67)
- Human breast cancers express osteoprotegerin (OPG), tumor necrosis factor-related apoptosis inducing ligand (TRAIL) and receptor activator of nFkB ligand (RANKL). BONE, Vol. 34 (pp S29-S29)
- T cell mediated colitis and bone destruction are driven by RANK/RANK LIGAND interactions and can be modulated by recombinant Fc-OPG.. BLOOD, Vol. 102(11) (pp 528A-528A)
- Source of maternal serum osteoprotegerin during human pregnancy. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 18(7) (pp 1376-1376)
- The role of osteoprotegerin in breast and prostate cancer. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 17(7) (pp 1339-1339)
- OPG is a survival factor for breast- and prostate cancer cells in vitro. BONE, Vol. 30(3) (pp 28S-28S)
Preprints