Parker, Lisa, Dr

Dr Lisa Parker

BSc, MRes, PhD

School of Medicine and Population Health

Lecturer in Inflammation Biology

l.c.parker@sheffield.ac.uk
+44 114 215 9544

The Medical School

Full contact details

Dr Lisa Parker
School of Medicine and Population Health
The Medical School
Beech Hill Road
��«Ӱҵ
S10 2RX

Profile

For enquiries please contact - SMPH-West-Operational@sheffield.ac.uk

I graduated from the University of Manchester in 1996 with a BSc (First Class Honours) in Neuroscience. I then completed an MRes in Neuroscience (University of Manchester, 1997) followed by my PhD entitled `Interleukin-1 and its receptors in the brain´ under the supervision of Professor Dame Nancy Rothwell (University of Manchester, 1997-2000).

I joined the University of ��«Ӱҵ in 2001 to take up my first post-doctoral position, where I was keen to maintain and develop my interest into inflammatory mechanisms in disease, with a focus on the respiratory system. In 2010 I was appointed to a lectureship within the Inflammation Biology Research Group in the Department of Infection, Immunity & Cardiovascular Disease.

During my time at the University of ��«Ӱҵ my interest in learning and teaching has also continued to develop. In 2014 I was awarded the Postgraduate Certificate in Learning and Teaching (PG CiLT), and also became a Fellow of The Higher Education Academy (FHEA). I am currently the Deputy Departmental Director of Learning and Teaching for the Department of Infection, Immunity & Cardiovascular Disease.

Qualifications

Academic:

2000 PhD. Division of Neuroscience. The University of Manchester. Professor Dame Nancy Rothwell & Dr Giamal Luheshi.
1997 MRes. Division of Neuroscience. The University of Manchester.
1996 BSc (Hons) First class. Neuroscience. The University of Manchester.

Professional:

2014 Postgraduate Certificate in Learning and Teaching (PGCert Learning and Teaching). ��«Ӱҵ.
2014 Fellow of the Higher Education Academy (FHEA).

Research interests

My current research aims to identify how respiratory viruses infect and trigger proinflammatory responses in airway epithelial cells and to determine how the responses that are generated may be modified. Pathogens are detected by Toll-Like receptors (TLRs), a family of receptors that regulate cell activation, however the mechanisms through which pathogens initiate airway exacerbations remain inadequately defined. A more complete understanding of the host innate immune responses and the complex signalling pathways that are triggered by viral pathogens is crucial, as viruses are a major trigger of acute exacerbations in asthma and chronic obstructive pulmonary disease (COPD).

My current goals are investigating key players in these pathways to ultimately enable the development of novel therapeutic targets and approaches to manage airway inflammation.

Current Projects

2021-2022 ��«Ӱҵ Children’s NHS Foundation Trust “A potential new treatment for respiratory syncytial viral (RSV) infection, and bacterial co-infections, in children”. Dr Lisa Parker, Dr Kelechi Ugonna.
2018-2021 Rosetrees Trust PhD research grant “Reversing viral-induced cell stress to treat asthma”. Dr Lisa Parker, Prof Alison Condliffe.
2018-2021 PhD studentship FMDH Summer 2018 PGT to PGR Scholarship “Investigating the role of membrane microdomains in Respiratory Syncytial Viral infection and their potential as novel therapeutic targets”. Dr Lisa Parker, Prof I Sabroe.

Publications

Show: Featured publications All publications

Featured publications

Journal articles

Bradley KL, Stokes CA, Marciniak SJ, Parker LC & Condliffe AM (2020) . Thorax.
Marsh EK, Prestwich EC, Williams L, Hart AR, Muir CF, Parker LC, Jonker MR, Heijink IH, Timens W, Fife M , Hussell T et al (2020) . Frontiers in Cellular and Infection Microbiology, 10.
Mills JT, Schwenzer A, Marsh EK, Edwards MR, Sabroe I, Midwood KS & Parker LC (2019) . Frontiers in Immunology, 10.
Manley GCA, Stokes CA, Marsh EK, Sabroe I & Parker LC (2019) . Journal of Virology.
Stokes CA, Kaur R, Edwards MR, Mondhe M, Robinson D, Prestwich EC, Hume RD, Marshall CA, Perrie Y, O'Donnell VB , Harwood JL et al (2016) . Mucosal Immunology, 9(5), 1303-1303.
Ismail S, Stokes CA, Prestwich EC, Roberts RL, Juss JK, Sabroe I & Parker LC (2014) . PLoS One, 9(12).
Parker LC, Stokes CA & Sabroe I (2014) . Clin Exp Allergy, 44(1), 20-28.
Bennett JA, Prince LR, Parker LC, Stokes CA, de Bruin HG, van den Berge M, Heijink IH, Whyte MK & Sabroe I (2012) . J Virol, 86(12), 6595-6604.
Stokes CA, Ismail S, Dick EP, Bennett JA, Johnston SL, Edwards MR, Sabroe I & Parker LC (2011) . J Virol, 85(15), 7912-7921.
Parker LC, Prestwich EC, Ward JR, Smythe E, Berry A, Triantafilou M, Triantafilou K & Sabroe I (2008) . J Immunol, 181(8), 5606-5617.

All publications

Journal articles

Bradley KL, Stokes CA, Marciniak SJ, Parker LC & Condliffe AM (2020) . Thorax.
Marsh EK, Prestwich EC, Williams L, Hart AR, Muir CF, Parker LC, Jonker MR, Heijink IH, Timens W, Fife M , Hussell T et al (2020) . Frontiers in Cellular and Infection Microbiology, 10.
Mills JT, Schwenzer A, Marsh EK, Edwards MR, Sabroe I, Midwood KS & Parker LC (2019) . Frontiers in Immunology, 10.
Manley GCA, Parker LC & Zhang Y (2019) . International Journal of Molecular Sciences, 20(3).
Manley GCA, Stokes CA, Marsh EK, Sabroe I & Parker LC (2019) . Journal of Virology.
Stokes C, Kaur R, Edwards MR, Mohdhe M, Robinson D, Prestwich EC, Hume RD, Marshall CA, Perrie Y, O'Donnell VB , Harwood JL et al (2017) . Mucosal Immunology, 10.
Stokes CA, Kaur R, Edwards MR, Mondhe M, Robinson D, Prestwich EC, Hume RD, Marshall CA, Perrie Y, O'Donnell VB , Harwood JL et al (2016) . Mucosal Immunology, 9(5), 1303-1303.
Ismail S, Stokes CA, Prestwich EC, Roberts RL, Juss JK, Sabroe I & Parker LC (2014) . PLoS One, 9(12).
Parker LC, Stokes CA & Sabroe I (2014) . Clin Exp Allergy, 44(1), 20-28.
Piper SC, Ferguson J, Kay L, Parker LC, Sabroe I, Sleeman MA, Briend E & Finch DK (2013) . PLoS One, 8(5), e63365.
Sabroe RA, Stokes CA, Parker LC, Higgins K, Prince LR & Sabroe I (2013) . Clinical and Experimental Dermatology.
Basran A, Jabeen M, Bingle L, Stokes CA, Dockrell DH, Whyte MKB, Walmsley SR, Higgins KR, Vogel SN, Wilson HL , Prince LR et al (2013) . J Leukoc Biol, 93(1), 7-19.
Chaudhuri N, Jary H, Lea S, Khan N, Piddock KC, Dockrell DH, Donaldson K, Duffin R, Singh D, Parker LC & Sabroe I (2012) . PLoS One, 7(12), e51107.
Bennett JA, Prince LR, Parker LC, Stokes CA, de Bruin HG, van den Berge M, Heijink IH, Whyte MK & Sabroe I (2012) . J Virol, 86(12), 6595-6604.
Prince LR, Whyte MK, Sabroe I & Parker LC (2011) . CURR OPIN PHARMACOL, 11(4), 397-403.
Walmsley SR, Chilvers ER, Thompson AA, Vaughan K, Marriott HM, Parker LC, Shaw G, Parmar S, Schneider M, Sabroe I , Dockrell DH et al (2011) . J Clin Invest, 121(3), 1053-1063.
Walmsley SR, Chilvers ER, Thompson A, Vaughan K, Marriott H, Parker L, Shaw G, Parmar S, Schneider M, Sabroe I , Dockrell D et al (2011) . C13. PATHOGENESIS OF ACUTE LUNG INJURY.
Stokes CA, Ismail S, Dick EP, Bennett JA, Johnston SL, Edwards MR, Sabroe I & Parker LC (2011) . J Virol, 85(15), 7912-7921.
Ward JR, West PW, Ariaans MP, Parker LC, Francis SE, Crossman DC, Sabroe I & Wilson HL (2010) . J Biol Chem, 285(30), 23147-23158.
Chaudhuri N, Paiva C, Donaldson K, Duffin R, Parker LC & Sabroe I (2010) . Am J Physiol Lung Cell Mol Physiol, 299(2), L263-L271.
Chaudhuri N, Piddock K, Donaldson K, Parker L & Sabroe I (2010) Diesel Exhaust Particles Alter Monocyte Differentiation In Vitro. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 181.
Chaudhuri N, Donaldson K, Parker LC & Sabroe I (2009) The Role of Cell Networks in Response to Diesel Exhaust Particles. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 179.
Parker LC, Prince LR, Buttle DJ & Sabroe I (2009) . Methods Mol Biol, 517, 191-204.
Parker LC, Prestwich EC, Ward JR, Smythe E, Berry A, Triantafilou M, Triantafilou K & Sabroe I (2008) . J Immunol, 181(8), 5606-5617.
West PW, Parker LC, Ward JR & Sabroe I (2008) . Immunology, 125(1), 101-110.
Sabroe I, Parker LC, Calverley PMA, Dower SK & Whyte MKB (2008) . Postgrad Med J, 84(991), 259-264.
Sabroe I, Parker LC, Dower SK & Whyte MKB (2008) . J Pathol, 214(2), 126-135.
Sabroe I, Parker LC, Dower SK & Whyte MKB (2007) . Proc Am Thorac Soc, 4(8), 606-610.
Sabroe I, Parker LC, Calverley PMA, Dower SK & Whyte MKB (2007) . Thorax, 62(8), 733-738.
Sabroe I, Parker LC, Dockrell DH, Davies DE, Dower SK & Whyte MKB (2007) . Am J Respir Crit Care Med, 175(4), 306-311.
Parker LC, Prince LR & Sabroe I (2007) . Clin Exp Immunol, 147(2), 199-207.
Morris GE, Parker LC, Ward JR, Jones EC, Whyte MKB, Brightling CE, Bradding P, Dower SK & Sabroe I (2006) . FASEB J, 20(12), 2153-2155.
Parker LC, Jones EC, Prince LR, Dower SK, Whyte MKB & Sabroe I (2005) . J Leukoc Biol, 78(6), 1301-1305.
Parker LC, Whyte MKB, Dower SK & Sabroe I (2005) . J Leukoc Biol, 77(6), 886-892.
Parker LC, Whyte MKB, Vogel SN, Dower SK & Sabroe I (2004) . J Immunol, 172(8), 4977-4986.
Pinteaux E, Parker LC, Rothwell NJ & Luheshi GN (2002) . J Neurochem, 83(4), 754-763.
Sabroe IAN, Jones EC, Usher LR, Alapati S, Parker LC, Whyte MKB & Dower SK (2002) . Clinical Science, 103(s47), 55P-55P.
Sabroe I, Parker LC, Wilson AG, Whyte MKB & Dower SK (2002) . Clin Exp Allergy, 32(7), 984-989.
Parker LC, Luheshi GN, Rothwell NJ & Pinteaux E (2002) . Br J Pharmacol, 136(2), 312-320.
Touzani O, Boutin H, LeFeuvre R, Parker L, Miller A, Luheshi G & Rothwell N (2002) Interleukin-1 influences ischemic brain damage in the mouse independently of the interleukin-1 type I receptor.. J Neurosci, 22(1), 38-43.
Parker LC, Rushforth DA, Rothwell NJ & Luheshi GN (2000) . Brain Res Mol Brain Res, 79(1-2), 156-158.
Allan SM, Parker LC, Collins B, Davies R, Luheshi GN & Rothwell NJ (2000) . Proc Natl Acad Sci U S A, 97(10), 5580-5585.
Parker LC, Luheshi GN, Rothwell NJ & Pinteaux E (2000) Expression of the IL-1 type I receptor and accessory protein in mouse primary glial cell cultures. EUR J NEUROSCI, 12, 359-359.
Parker LC, Balderson DJ, Owen F, Rothwell NJ & Luheshi GN (1998) Interleukin-1 type-1 receptor expression in the rat hypothalamus. BRIT J PHARMACOL, 123, U106-U106.
Cody FW, Henley NC, Parker L & Turner G (1998) . Electroencephalogr Clin Neurophysiol, 109(1), 24-35.
Cody FWJ, Henley NC, Parker LC & Turner GR (1997) Autogenetic and reciprocal tonic reflex actions of muscle vibration-evoked afferent input studied in human wrist muscles.. J PHYSIOL-LONDON, 504P, P119-P119.

Chapters

Prince L, Parker L & Sabroe I (2020) , Reference Module in Biomedical Sciences Elsevier

Conference proceedings papers

Marsh EK, Prestwich EC, Marriott HM, Williams L, Hart AR, Muir CF, Parker LC, Jonker MR, Heijink IH, Timens W , Fife M et al (2018) . The influence of influenza: from cells to humans
Mills J, Sabroe I, Midwood K & Parker L (2018) Human rhinovirus infection of airway epithelial cells induces tenascin-C release mas. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, Vol. 99(6) (pp A59-A59)
Bradley KL, Stokes CA, Parker LC & Condliffe AM (2017) . Cellular insights into lung injury repair
Marsh EK, Prestwich EC, Marriott HM, Paiva C, Bennett JA, Jonker MR, Timens W, Heijink IH, Parker LC, Dockrell DH & Sabroe I (2016) The Role Of Pellino-1 In Modulating Signalling Pathways Controlling The Inflammatory Response To Viral Stimuli In Airway Epithelial Cells. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 193
Ismail S, Roberts RL, Stokes CA, Juss JK, Sabroe I & Parker LC (2013) Phosphoinositide 3-kinase (PI3K) inhibition modulates responses to rhinovirus by mechanisms that are predominantly independent of autophagy. IMMUNOLOGY, Vol. 140 (pp 84-85)
Prestwich E, Paiva C, Parker L & Sabroe I (2013) The role of Pellino1 in modulating signalling pathways controlling the inflammatory response to viruses in airway epithelial cells. IMMUNOLOGY, Vol. 140 (pp 82-82)
Stokes CA, Glanville N, Kaur R, Hume RD, Robinson D, Perrie Y, Edwards MR, O'Donnell V, Harwood J, Parker LC & Sabroe I (2013) Phosphatidylserine-containing liposomes: modulators of rhinovirus induced inflammatory responses. IMMUNOLOGY, Vol. 140 (pp 108-108)
Parmar S, Thompson AAR, Higgins KR, Sabroe I, Parker LC, Lawrie A, Arnold J, Walker S, Elliot CA, Condliffe R , Kiely DG et al (2012) . D33. ASTHMA PATHOGENESIS
Bennett JA, Prince LR, Stokes CA, Parker LC, Whyte MK & Sabroe I (2011) . THORAX, Vol. 66 (pp A60-A61)
Chaudhuri N, Jary H, Lea S, Khan N, Parker LC, Singh D & Sabroe I (2011) . THORAX, Vol. 66 (pp A114-A114)
Jabeen M, Stokes CA, Prince LR, Sabroe I & Parker L (2011) The role of neutrophils as anti-inflammatory mediators of airway inflammation. CLINICAL AND EXPERIMENTAL ALLERGY, Vol. 41(12) (pp 1830-1830)
Jary H, Piddock K, Donaldson K, Prince LR, Parker LC, Sabroe I & Chaudhuri N (2010) . THORAX, Vol. 65 (pp A66-A67)
Stokes CA, Dick EP, Bennett JA, Ismail S, Edwards MR, Sabroe L & Parker LC (2010) . THORAX, Vol. 65 (pp A37-A38)
Chaudhuri N, Parker LC, Sabroe I & Donaldson K (2009) . THORAX, Vol. 64 (pp A54-A55)
Parker LC, Jones EC, Ward JR & Sabroe I (2007) Inhibition of TLR-induced inflammatory responses by SAPS. JOURNAL OF LEUKOCYTE BIOLOGY (pp 51-51)
West PW, Parker LC, Ward JR & Sabroe I (2007) Regulation of TLR induced human inflammatory responses by macrophage migration inhibitory factor. JOURNAL OF LEUKOCYTE BIOLOGY (pp 60-60)
Chaudhuri N, Donaldson K, Parker LC & Sabroe I (2007) The role of Cell networks in the response to Diesel Exhaust Particles (DEP).. JOURNAL OF LEUKOCYTE BIOLOGY (pp 25-25)
Parker LC, Jones EC, Morris GE, Dower SK, Whyte MK & Sabroe I (2006) The induction of antiviral responses in human airway smooth muscle and epithelial cells. THORAX, Vol. 61 (pp II9-II9)
Parker LC, Jones EC, Whyte MKB, Dower SK & Sabroe I (2005) Toll-like receptor (TLR) 4 activation induces tolerance in the human neutrophil. FASEB JOURNAL, Vol. 19(4) (pp A912-A912)
Parker LC, Jones EC, Whyte MK, Dower SK & Sabroe I (2004) Endotoxin tolerance in the human neutrophil. JOURNAL OF LEUKOCYTE BIOLOGY (pp 43-44)
Allan SM, Parker LC, Grundy RI & Collins B (2000) Site-specific actions of interleukin-1 in neurodegeneration. PHARMACOLOGY OF CEREBRAL ISCHEMIA 2000 (pp 425-431)

Research group

PhD Students

Joanne Mckenzie
Kirsty Bradley

Teaching interests

I come from a background of scientific research where collaboration, critical thinking and discussion are key to the construction of new knowledge, and I believe these principles can also be applied to my teaching practice within the classroom environment. I am committed to the continual improvement of my own teaching practice, and teaching within my Department and Faculty, and ultimately providing students with the very best learning experiences.

I am Deputy Departmental Director of Learning & Teaching for the Department and I teach at all levels within the Faculty of MDH and for the School of Biosciences (see Teaching activities). I also provide pastoral support to students and am an active member of the Think Ahead mentoring scheme.

Teaching activities

Undergraduate:

CDL21001 Research Skills in Biomedical Science (Course lead)
CDL302 Pharmacology of Respiratory Disease (Module lead)
ORT107 Anatomy & physiology
MBChB Phase 2A Research attachment SSC
MBChB Personal & Academic Tutoring

Postgraduate:

MED6090 Project Literature Review (Module lead)
MED60n3 Project Presentation (Module lead)
MED6006 Modulating Immunity
MED6060 Virulence Mechanisms of Viruses and Fungi
CDL402: Vascular Disease: Models and Clinical Practice (Module lead)
MSc and PhD Personal & Academic Tutoring

Professional activities and memberships

Fellow of the Higher Education Academy (SFHEA).
Research Meeting Working Group representative, Department of Infection, Immunity & Cardiovascular Disease (IICD).
Early Career Group representative, Department of Infection, Immunity & Cardiovascular Disease (IICD).
Think Ahead Career Development Mentor.
Member of the
(STEMNET programme).
Member of Centre for Membrane Interactions and Dynamics (CMIAD).
Member of the