Fenwick, Mark, Dr

Dr Mark Fenwick

BSc (Hons), PhD, PGCertHE, SFHEA

Clinical Medicine, School of Medicine and Population Health

Senior Lecturer in Reproductive and Developmental Medicine

m.a.fenwick@sheffield.ac.uk
+44 114 215 9664

Level 4, JW4 57, Jessop Wing

Full contact details

Dr Mark Fenwick
Clinical Medicine, School of Medicine and Population Health
Level 4, JW4 57
Jessop Wing
Tree Root Walk
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S10 2SF

Profile

For enquiries, please contact – ClinMed-Operational@sheffield.ac.uk

I obtained my BSc (Hons) and PhD (2004) from the University of Otago in Dunedin, New Zealand. Shortly after I undertook two Postdoctoral positions in London - firstly at the Royal Veterinary College looking at the effect of negative energy balance on reproduction in dairy cows (2005-2007), and then Imperial College London working on projects relating to early follicle development in the ovary (2007-2012). I joined the University of ��«Ӱҵ in December 2012 as a Lecturer in Reproductive and Developmental Medicine and then Senior Lecturer in Jan 2020.

Current PhD Opportunities:

Research interests

The ovary is an incredibly dynamic organ that is constantly producing and responding to internal molecular ‘cues’. Both environmental and genetic factors can exert influences on these internal signals, leading to dysregulation or failure of oocytes to develop. We are interested in understanding how these cues (i) coordinate the development of oocytes for ovulation and (ii) produce steroid hormones for other reproductive processes. For this, we use molecular tools and microscopic imaging to investigate these details in ovarian cells and tissue cultures. Our research is motivated by its translational potential within the clinical context of infertility and disorders that affect follicle development such as endometriosis, premature ovarian insufficiency (POI) and polycystic ovary syndrome (PCOS).

Current projects:

Molecular mechanisms regulating TGFβ signalling during early follicle development.
Mechanisms of primordial follicle maintenance and activation.
Effect of endometriosis on ovarian function and fertility.
Effects of nicotine and derivatives from e-cigarettes on the ovarian reserve.

Publications

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Featured publications

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All publications

Journal articles

Idrees SM, Waite SL, Granados Aparici S & Fenwick MA (2024) . Ecotoxicology and Environmental Safety, 288, 117302-117302.
Kaune H, Montiel JF, Fenwick M & Williams SA (2022) . Reproduction and Fertility, 3(3), 173-186.
Alshehre SM, Narice BF, Fenwick MA & Metwally M (2020) . Archives of Gynecology and Obstetrics.
Granados-Aparici S, Hardy K, Franks S, Sharum IB, Waite SL & Fenwick MA (2019) . Scientific Reports, 9.
Hardy K, Mora JM, Dunlop C, Carzaniga R, Franks S & Fenwick MA (2018) . Journal of Cell Science, 131(17).
Laird M, Thomson K, Fenwick M, Mora J, Franks S & Hardy K (2017) . Endocrinology, 158(4), 920-935.
Sharum IB, Granados-Aparici S, Warrander FC, Tournant FP & Fenwick MA (2017) . Reproduction, 153(2), 221-231.
Hardy K, Fenwick M, Mora J, Laird M, Thomson K & Franks S (2017) . Endocrinology, 158(1), 134-147.
Sharum I, Granados Aparici S & Fenwick M (2015) Serine/threonine kinase receptor associated protein (Strap) inhibits early follicle development in mouse ovaries.
Fenwick MA, Mora JM, Mansour YT, Baithun C, Franks S & Hardy K (2013) . Endocrinology, 154(9), 3423-3436.
Swangchan-Uthai T, Chen Q, Kirton SE, Fenwick MA, Cheng Z, Patton J, Fouladi-Nashta AA & Wathes DC (2013) . Reproduction, 145(5), 527-539.
Lavial F, Bessonnard S, Ohnishi Y, Tsumura A, Chandrashekran A, Fenwick MA, Tomaz RA, Hosokawa H, Nakayama T, Chambers I , Hiiragi T et al (2012) . Genes Dev, 26(13), 1445-1458.
Mora JM, Fenwick MA, Castle L, Baithun M, Ryder TA, Mobberley M, Carzaniga R, Franks S & Hardy K (2012) . Biol Reprod, 86(5), 153-14.
Fenwick MA, Mansour YT, Franks S & Hardy K (2011) . Endocrinology, 152(9), 3515-3526.
Fenwick MA, Franks S & Hardy K (2011) . Biology of Reproduction, 85(Suppl_1), 659-659.
Wathes DC, Cheng Z, Fenwick MA, Fitzpatrick R & Patton J (2011) . Reproduction, 141(2), 269-281.
Fenwick MA, Mora JM, Franks S & Hardy K (2010) . Biology of Reproduction, 83(Suppl_1), 62-62.
Mani AM, Fenwick MA, Cheng Z, Sharma MK, Singh D & Wathes DC (2010) . Reproduction, 139(1), 139-151.
Wathes DC, Cheng Z, Chowdhury W, Fenwick MA, Fitzpatrick R, Morris DG, Patton J & Murphy JJ (2009) . Physiol Genomics, 39(1), 1-13.
Skodras A, Giannarou S, Fenwick M, Franks S, Stark J & Hardy K (2009) . DSP 2009: 16th International Conference on Digital Signal Processing, Proceedings.
Fenwick MA, Fitzpatrick R, Kenny DA, Diskin MG, Patton J, Murphy JJ & Wathes DC (2008) . Domest Anim Endocrinol, 34(1), 31-44.
Fenwick MA, Llewellyn S, Fitzpatrick R, Kenny DA, Murphy JJ, Patton J & Wathes DC (2008) . Reproduction, 135(1), 63-75.
Wathes DC, Fenwick M, Cheng Z, Bourne N, Llewellyn S, Morris DG, Kenny D, Murphy J & Fitzpatrick R (2007) . Theriogenology, 68 Suppl 1, S232-S241.
Assinder S, Davis R, Fenwick M & Glover A (2007) . Reproduction, 133(1), 11-19.
Anderson GM, Beijer P, Bang AS, Fenwick MA, Bunn SJ & Grattan DR (2006) . Endocrinology, 147(10), 4996-5005.
Hurst PR, Mora JM & Fenwick MA (2006) . Hum Reprod, 21(8), 1974-1980.
Molteno ACB, Suter AJ, Fenwick M, Bevin TH & Dempster AG (2006) . Invest Ophthalmol Vis Sci, 47(5), 1975-1981.
Fenwick MA & Hurst PR (2002) . Reproduction, 124(5), 659-665.

Chapters

Fenwick MA (2022) , Manual of Oocyte Retrieval and Preparation in Human Assisted Reproduction (pp. 1-9). Cambridge University Press

Conference proceedings papers

Syeed R, Waite S & Fenwick M (2021) Is early follicle development a model of epithelial-mesenchymal transition?. BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Vol. 128 (pp 237-237)
Idrees S & Fenwick M (2020) Examining the effect of nicotine on a mouse model of the ovarian reserve. HUMAN REPRODUCTION, Vol. 35 (pp 1437-1438)
Idrees S, Fenwick M & Pacey A (2019) Examining the effect of nicotine on a mouse model of the ovarian reserve. HUMAN REPRODUCTION, Vol. 34 (pp 457-457)
Skodras AN, Giannarou S, Fenwick M, Franks S, Stark J & Hardy K (2009) Object recognition in the ovary: Quantification of oocytes from microscopic images.. DPS (pp 1-6)

Research group

I have supervised >30 postgraduate (MSc and PhD) students.

Current PhD students:

Amelia Parkin-Green - Molecular mechanisms governing maintenance of the ovarian reserve.
Aida Luna Perez - Understanding breast tissue structure to tackle cancer.

Teaching interests

I have been the Course Director for the MSc in Reproductive and Developmental Medicine since its inception in 2013. Within this course I lead and provide teaching on the Gonads to Gametes: Fundamentals of Reproduction module (MED6111). I also co-lead the Research project module on this course (MED6116/MED6117) and provide ongoing training to BSc, MBChB (SSC), MSc and PhD research students.

I am also the Departmental Director of Recruitment and work collaboratively to support the portfolio of postgraduate programmes in the department.

Professional activities and memberships

Section Editor (Experimental Reproductive Biology) for the journal Reproductive Biomedicine Online (2020 - present), Editorial Board Member for Scientific Reports (2018-2019).
Member of Council Society for Reproduction and Fertility (SRF) and Programmes Committee member (2019-2023).
External reviewer for a number of international journals in reproductive biology.
External reviewer for funding bodies (e.g. BBSRC, MRC etc).
External examiner for several reproductive science programmes at undergraduate and postgraduate level over the past 10 years (currently University of Leeds, MSc Clinical Embryology & ART - 2023-2026).