Professor Penelope D Ottewell

Clinical Medicine, School of Medicine and Population Health

Professor of Cancer Biology

Penny Ottewell
Profile picture of Penny Ottewell
p.d.ottewell@sheffield.ac.uk
+44 114 215 9058

Full contact details

Professor Penelope D Ottewell
Clinical Medicine, School of Medicine and Population Health
Office: GU21
The Medical School
Beech Hill Road
ºù«Ӱҵ
S10 2RX
Profile

For enquiries please contact - ClinMed-Operational@sheffield.ac.uk

I am a senior lecturer in the Academic Unit of Clinical Oncology, University of ºù«Ӱҵ UK. I was awarded a PhD from the Department of Gastroenterology at The University of Liverpool in 2005 before taking up my first position in ºù«Ӱҵ a post-doctoral scientist working on breast cancer and bone metastasis.

During my time in ºù«Ӱҵ I have carried out international collaborative work spending time at INSERM (University of Lyon), France and at TUFTS University in Boston, USA.

I have been awarded a total of 10 prizes for my research including the prestigious Breast Cancer Campaign Research Team of the year award in 2008 and the International Bone and Mineral Society Gregory Mundy Research Fellowship in 2011.

Research interests

My research is focused on advanced breast cancer with particular emphasis on bone metastasis. Primarily, this involves using a complement of in vitro and in vivo model systems to investigate the molecular alterations that are acquired by breast cancer cells causing them to metastases to bone.

I hypothesise that metastases are a result of a stepwise accumulation of genetic mutations and that distinct molecular alterations are required at the different stages in the metastatic process; molecules involved in intravasation are not those involved in tissue homing and colonisation.

The aims of my research are to identify specific molecular determinants involved in tumour cell intravasation, homing to bone and colonisation of the metastatic site and to use this information to develop and apply new therapies for the treatment of breast cancer bone metastasis.

Publications

Show: Featured publications All publications

Journal articles

  • Eyre R, Alférez DG, Santiago-Gómez A, Spence K, McConnell JC, Hart C, Simões BM, Lefley D, Tulotta C, Storer J , Gurney A et al (2019) . Nature Communications, 10(1). RIS download Bibtex download

All publications

Journal articles

  • Morita M, Arshad F, Quayle LA, George CN, Lefley DV, Kalajzic I, Balsubramanian M, Cebe T, Reilly G, Bishop NJ & Ottewell PD (2024) . Bone Reports, 22, 101795-101795. RIS download Bibtex download
  • Zhou J & Ottewell PD (2024) . Journal of Bone Oncology, 46, 100608-100608. RIS download Bibtex download
  • Kwan A, Stark K, Allen R, Ottewell P & Muthana M (2024) . Medical Research Archives, 12(6). RIS download Bibtex download
  • Zhou J, Tulotta C & Ottewell PD (2022) . Expert Reviews in Molecular Medicine, 24. RIS download Bibtex download
  • Canuas-Landero VG, George CN, Lefley DV, Corness H, Muthana M, Wilson C & Ottewell PD (2021) . Frontiers in Endocrinology, 12. RIS download Bibtex download
  • Tulotta C, Lefley DV, Moore CK, Amariutei AE, Spicer-Hadlington AR, Quayle LA, Hughes RO, Ahmed K, Cookson V, Evans CA , Vadakekolathu J et al (2021) . npj Breast Cancer, 7(1). RIS download Bibtex download
  • George C, Lefley D, Canuas-Landero V, Tulotta C, Corness H, Wilson C, Muthana M & Ottewell P (2021) . Bone Reports, 14, 101024. RIS download Bibtex download
  • Canuas-Landero V, George C, Lefley D, Wilson C & Ottewell P (2021) . Bone Reports, 14, 100899. RIS download Bibtex download
  • Ottewell PD & Lawson MA (2021) . Journal of Cancer Metastasis and Treatment, 7. RIS download Bibtex download
  • Bishop RT, Marino S, Carrasco G, Li B, Allen RJ, Sparatore A, Ottewell PD, Mollat P, Sims AH, Capulli M , Wang N et al (2020) . Cancer Letters, 488, 27-39. RIS download Bibtex download
  • George CN, Canuas-Landero V, Theodoulou E, Muthana M, Wilson C & Ottewell P (2020) . Journal of Bone Oncology, 25, 100317-100317. RIS download Bibtex download
  • Ran R, Harrison H, Syamimi Ariffin N, Ayub R, Pegg HJ, Deng W, Mastro A, Ottewell PD, Mason SM, Blyth K , Holen I et al (2020) . Oncogene. RIS download Bibtex download
  • Lefley D, Howard F, Arshad F, Bradbury S, Brown H, Tulotta C, Eyre R, Alférez D, Wilkinson JM, Holen I , Clarke RB et al (2019) . Breast Cancer Research, 21(1). RIS download Bibtex download
  • Eyre R, Alférez DG, Santiago-Gómez A, Spence K, McConnell JC, Hart C, Simões BM, Lefley D, Tulotta C, Storer J , Gurney A et al (2019) . Nature Communications, 10(1). RIS download Bibtex download
  • Ottewell P & Wilson C (2019) . Breast Cancer: Basic and Clinical Research, 13. RIS download Bibtex download
  • Allocca G, Hughes R, Wang N, Brown HK, Ottewell PD, Brown NJ & Holen I (2019) . Journal of Bone Oncology, 17. RIS download Bibtex download
  • Bishop RT, Marino S, de Ridder D, Allen RJ, Lefley DV, Sims AH, Wang N, Ottewell PD & Idris AI (2019) . Cancer Letters, 450, 76-87. RIS download Bibtex download
  • Tulotta C, Lefley DV, Freeman K, Gregory WM, Hanby AM, Heath PR, Nutter-Howard F, Wilkinson JM, Spicer-Hadlington AR, Liu X , Bradbury S et al (2019) . Clinical Cancer Research, 25(9), 2769-2782. RIS download Bibtex download
  • Al-Sahaf S, Hunter KD, Bolt R, Ottewell PD & Murdoch C (2019) . International Journal of Cancer, 144(2), 334-344. RIS download Bibtex download
  • Quayle LA, Ottewell PD & Holen I (2018) . Clinical and Experimental Metastasis. RIS download Bibtex download
  • Brown HK, Allocca G, Ottewell PD, Wang N, Brown NJ, Croucher PI, Eaton CL & Holen I (2018) . International Journal of Molecular Sciences, 19(10). RIS download Bibtex download
  • Tulotta C & Ottewell PD (2018) . Endocrine-Related Cancer, 25(7), R421-R434. RIS download Bibtex download
  • Holen I, Whitworth J, Nutter F, Evans A, Brown HK, Lefley DV, Barbaric I, Jones M & Ottewell PD (2017) . Breast Cancer Research, 19. RIS download Bibtex download
  • Holen I, Lefley DV, Francis SE, Rennicks S, Bradbury S, Coleman RE & Ottewell P (2016) . Oncotarget, 7, 75571-75584. RIS download Bibtex download
  • Ottewell PD (2016) . Journal of Bone Oncology, 5(3), 124-127. RIS download Bibtex download
  • Ottewell P, Brown H, Allocca G, Haider MT, Brown N & Holen I (2016) . European Journal of Cancer, 61, S74-S75. RIS download Bibtex download
  • Wright LE, Ottewell PD, Rucci N, Peyruchaud O, Pagnotti GM, Chiechi A, Buijs JT & Sterling JA (2016) . BoneKEy Reports, 5, 804-804. RIS download Bibtex download
  • Westbrook JA, Cairns DA, Peng J, Speirs V, Hanby AM, Holen I, Wood SL, Ottewell PD, Marshall H, Banks RE , Selby PJ et al (2016) . Journal of the National Cancer Institute, 108(4). RIS download Bibtex download
  • Holen I, Walker M, Nutter F, Fowles A, Evans CA, Eaton CL & Ottewell PD (2016) . Clinical & Experimental Metastasis, 33(3), 211-224. RIS download Bibtex download
  • Wang N, Reeves KJ, Brown HK, Fowles ACM, Docherty FE, Ottewell PD, Croucher PI, Holen I & Eaton CL (2015) . Journal of Experimental and Clinical Cancer Research, 34(1), 124-124. RIS download Bibtex download
  • Ottewell PD, Wang N, Brown HK, Fowles CA, Croucher PI, Eaton CL & Holen I (2015) . International Journal of Cancer, 137(4), 968-977. RIS download Bibtex download
  • Holen I, Nutter F, Wilkinson JM, Evans CA, Avgoustou P & Ottewell PD (2015) . Clinical & Experimental Metastasis, 32(7), 689-702. RIS download Bibtex download
  • Wang N, Docherty F, Brown HK, Reeves K, Fowles A, Lawson M, Ottewell PD, Holen I, Croucher PI & Eaton CL (2015) . The FASEB Journal, 29(8), 3141-3150. RIS download Bibtex download
  • Quayle L, Ottewell P & Holen I (2015) . Current Cancer Drug Targets, 15(6), 469-480. RIS download Bibtex download
  • Wilson C, Ottewell P, Coleman RE & Holen I (2015) . BMC Cancer, 15(1). RIS download Bibtex download
  • Ottewell PD, O’Donnell L & Holen I (2015) . BoneKEy Reports, 4. RIS download Bibtex download
  • Wang N, Docherty FE, Brown HK, Reeves KJ, Fowles ACM, Ottewell PD, Dear TN, Holen I, Croucher PI & Eaton CL (2014) . J Bone Miner Res, 29(12), 2688-2696. RIS download Bibtex download
  • Ottewell PD, Wang N, Meek J, Fowles CA, Croucher PI, Eaton CL & Holen I (2014) . Endocrine Related Cancer, 21(5), 769-781. RIS download Bibtex download
  • Ottewell PD, Wang N, Brown HK, Reeves KJ, Fowles CA, Croucher PI, Eaton CL & Holen I (2014) . Clin Cancer Res, 20(11), 2922-2932. RIS download Bibtex download
  • David M, Machuca-Gayet I, Kikuta J, Ottewell P, Mima F, Leblanc R, Bonnelye E, Ribeiro J, Holen I, Vales RL , Jurdic P et al (2014) . Journal of Biological Chemistry, 289(10), 6551-6564. RIS download Bibtex download
  • David M, Machuca-Gayet I, Kikuta A, Ottewell PD, Mima F, Leblanc R, Bonnelye E, Ribeiro J, Holen I, Vales RJ , Jurdic P et al (2014) Lysophosphatidic acid receptor type 1 (LPA1) plays a functional role in osteoclast differentiation and bone resorption activity.. Journal of Biological Chemistry, 10(289), 6551-6564. RIS download Bibtex download
  • Nutter F, Holen I, Brown HK, Cross SS, Evans CA, Walker M, Coleman RE, Westbrook JA, Selby PJ, Brown JE & Ottewell PD (2014) . Endocr Relat Cancer, 21(2), 327-341. RIS download Bibtex download
  • Rogers TL, Wind N, Hughes R, Nutter F, Brown HK, Vasiliadou I, Ottewell PD & Holen I (2013) . Cell Oncol (Dordr), 36(6), 505-514. RIS download Bibtex download
  • Holen I, Wang N, Reeves KJ, Fowles AM, Croucher PI, Eaton CL & Ottewell PD (2012) . Poster Discussion Abstracts. RIS download Bibtex download
  • Brown HK, Ottewell PD, Evans CA, Coleman RE & Holen I (2012) A single administration of combination therapy inhibits breast tumour progress bone and modifies both osteoblasts and osteoclasts. Journal of Bone Oncology, 1(2), 47-56. RIS download Bibtex download
  • Holen I, Whitworth J, Nutter F, Evans A, Brown HK, Lefley DV, Barbaric I, Jones M & Ottewell PD (2012) . Breast Cancer Res, 14(3), R86. RIS download Bibtex download
  • Brown HK, Ottewell PD, Evans CA & Holen I (2012) . Clin Exp Metastasis, 29(8), 927-938. RIS download Bibtex download
  • Ottewell PD, Brown HK, Jones M, Rogers TL, Cross SS, Brown NJ, Coleman RE & Holen I (2012) . Breast Cancer Res Treat, 133(2), 523-536. RIS download Bibtex download
  • Ottewell PD, Whitworth J, Cross SS, Nutter FH & Holen I (2011) . Poster Session Abstracts. RIS download Bibtex download
  • Ottewell PD (2011) . IBMS BoneKEy, 8(1), 41-45. RIS download Bibtex download
  • Brown HK, Ottewell PD, Coleman RE & Holen I (2011) . J Cell Mol Med, 15(3), 501-513. RIS download Bibtex download
  • Syddall SP, Ottewell PD & Holen I (2010) . Curr Pharm Des, 16(27), 2988-2997. RIS download Bibtex download
  • Ottewell PD, Lefley DV, Cross SS, Evans CA, Coleman RE & Holen I (2010) . Int J Cancer, 126(2), 522-532. RIS download Bibtex download
  • Ottewell PD (2010) Effects of gastrin and its precursor peptides upon intestinal epithelia.. RIS download Bibtex download
  • Ottewell PD, Woodward JK, Lefley DV, Evans CA, Coleman RE & Holen I (2009) . Mol Cancer Ther, 8(10), 2821-2832. RIS download Bibtex download
  • Ottewell PD, Lefley DV, Coleman RE & Holen I (2009) . Poster Session Abstracts. RIS download Bibtex download
  • Ottewell PD, Mönkkönen H, Jones M, Lefley DV, Coleman RE & Holen I (2008) . J Natl Cancer Inst, 100(16), 1167-1178. RIS download Bibtex download
  • Ottewell PD, Deux B, Mönkkönen H, Cross S, Coleman RE, Clezardin P & Holen I (2008) . Clin Cancer Res, 14(14), 4658-4666. RIS download Bibtex download
  • Mönkkönen H, Ottewell PD, Kuokkanen J, Mönkkönen J, Auriola S & Holen I (2007) . Life Sci, 81(13), 1066-1070. RIS download Bibtex download
  • Ottewell PD, Duckworth CA, Varro A, Dimaline R, Wang TC, Watson AJM, Dockray GJ & Pritchard DM (2006) . Gastroenterology, 130(4), 1169-1180. RIS download Bibtex download
  • Ottewell PD, Coleman RE & Holen I (2006) . Breast Cancer Res Treat, 96(2), 101-113. RIS download Bibtex download
  • Keen H, Dekker B, Lyons S, Disley L, Hastings D, Reader A, Ottewell PD, Watson A & Zweit J (2005) . Nucl Med Biol, 4(32), 395-402. RIS download Bibtex download
  • Dekker B, Keen H, Lyons S, Disley L, Hastings D, Reader A, Ottewell PD, Watson A & Zweit M (2005) . Nucl Med Biol, 3(32), 241-252. RIS download Bibtex download
  • Ottewell PD, Varro A, Dockray GJ, Kirton CM, Watson AJM, Wang TC, Dimaline R & Pritchard DM (2005) . Am J Physiol Gastrointest Liver Physiol, 288(3), G541-G549. RIS download Bibtex download
  • Ottewell PD, Watson AJM, Wang TC, Varro A, Dockray GJ & Pritchard DM (2003) . Gastroenterology, 124(5), 1348-1357. RIS download Bibtex download
  • Pritchard DM, Ottewell PD, Watson AJM, Wang TC & Dockray GJ (2002) . Clinical Science, 103(s47), 43P-43P. RIS download Bibtex download
  • Ottewell PD, Watson AJM, Wang TC, Dockray GJ & Pritchard DM (2002) Progastrin stimulates murine colonic epithelial mitosis after DNA damage. GUT, 50, A93-A93. RIS download Bibtex download
  • Pritchard D, Ottewell PD, Watson AJM, Wang TC & Dockray GJ (2002) Progastrin stimulates murine colonic epithelial mitosis after DNA damage. GASTROENTEROLOGY, 122(4), A684-A684. RIS download Bibtex download
  • Marshman E, Ottewell PD, Potten CS & Watson AJ (2001) . J Pathol, 195(3), 285-292. RIS download Bibtex download
  • MCMICHAEL D, DAVIES A, MARSHMAN E, OTTEWELL P, JENKINS J & WATSON A (2001) . Gastroenterology, 120(5), A660-A660. RIS download Bibtex download
  • McMichael DP, Davies A, Marshman E, Ottewell PD, Jenkins JR & Watson AJM (2001) Gene array and knockout mouse analysis of VP-16 induced apoptosis in the murine small intestine. GASTROENTEROLOGY, 120(5), A660-A660. RIS download Bibtex download
  • (2001) . Gut, 48(90001), 60a-64. RIS download Bibtex download
  • Puppo M, Valluru MK, Croset M, Ceresa D, Iuliani M, Khan A, Wicinski J, Charafe-Jauffret E, Ginestier C, Pantano F , Ottewell PD et al () . British Journal of Cancer. RIS download Bibtex download
  • Saleh L, Ottewell PD, Brown JE, Wood SL, Brown NJ, Wilson C, Park C, Ali S & Holen I () . Cancers, 15(8), 2211-2211. RIS download Bibtex download
  • Kwan A, Howard F, Winder N, Atkinson E, Jailani A, Patel PB, Allen R, Ottewell PD, Shaw GC, Conner J , Wilson C et al () . Future Pharmacology, 2(4), 444-459. RIS download Bibtex download
  • Zhou J, Down JM, George CN, Murphy J, Lefley DV, Tulotta C, Alsharif MA, Leach M & Ottewell PD () . Cancers, 14(19), 4816-4816. RIS download Bibtex download
  • Hughes R, Chen X, Cowley N, Ottewell PD, Hawkins RJ, Hunter KD, Hobbs JK, Brown NJ & Holen I () . Cancers, 13(6), 1366-1366. RIS download Bibtex download
  • Al-Sahaf S, Hendawi NB, Ollington B, Bolt R, Ottewell PD, Hunter KD & Murdoch C () . Frontiers in Oral Health, 2. RIS download Bibtex download
  • Clezardin P, Coleman R, Puppo M, Ottewell P, Bonnelye E, Paycha F, Confavreux CB & Holen I () . Physiological Reviews. RIS download Bibtex download
  • Ran R, Harrison H, Ariffin NS, Ayub R, Pegg HJ, Deng W, Mastro A, Ottewell PD, Fowles AM, Blyth SMMK , Holen I et al () . RIS download Bibtex download
  • Haider M-T, Ottewell PD, Brown NJ, Lefley DV & Holen I () . Bone Abstracts. RIS download Bibtex download
  • Bradbury S, Rennicks S, Evans A, del CBM, Holen I & Ottewell P () . Bone Abstracts. RIS download Bibtex download
  • Ottewell PD () . IBMS BoneKEy, 9. RIS download Bibtex download
  • Kwan A, Winder NJ, Atkinson E, Al-Janabi HH, Allen RJ, Hughes R, Moamin MR, Louie R, Evans D, Hutchinson M , Capper DT et al () . Molecular Cancer Therapeutics, molcanther.0748.2020-molcanther.0748.2020. RIS download Bibtex download
  • Quayle LA, Spicer A, Ottewell PD & Holen I () . Cancers, 13(16), 3922-3922. RIS download Bibtex download

Chapters

  • Holen I, Saleh L, Ottewell PD & Lawson MA (2022) , Bone Cancer (pp. 35-53). Elsevier RIS download Bibtex download
  • George C, Michael N & Ottewell PD (2022) , Bone Cancer (pp. 121-128). Elsevier RIS download Bibtex download
  • Ottewell PD & Quayle LA (2019) In Caplan M (Ed.), Reference Module in Biomedical Sciences Elsevier RIS download Bibtex download
  • Tulotta C, Groenewoud A, Snaar-Jagalska BE & Ottewell P (2019) , Methods in Molecular Biology (pp. 309-330). Springer New York RIS download Bibtex download

Conference proceedings papers

  • Saleh L, Ottewell PD, Brown JE, Wood SL, Brown NJ, Wilson C, Park C & Holen I (2020) Preventing the progression of breast cancer bone metastasis by CDK inhibition. BREAST CANCER RESEARCH AND TREATMENT, Vol. 180(2) (pp 537-538) RIS download Bibtex download
  • Tulotta C, Moore CK, Lefley DV, Amariutei AE, Ahmed K, Spicer-Hadlington AR & Ottewell PD (2020) Inhibition of breast cancer bone metastasis through Interleukin-1B regulated tumour-associated innate immune response. BREAST CANCER RESEARCH AND TREATMENT, Vol. 180(2) (pp 538-539) RIS download Bibtex download
  • Moamin MR, Monk P, Cox A, Ottewell P, Saint-Pol J, Rubinstein E & Muthana M (2019) . Tumor Biology RIS download Bibtex download
  • Moamin MR, Monk P, Cox A, Ottewell P, Saint-Pol J, Rubinstein E & Muthana M (2019) . Tumor Biology RIS download Bibtex download
  • Ottewell PD, Lefley DV, Freeman K, Gregory WM, Hanby AM, Spicer-Hadlington AR, Liu X, Bradbury SM, Hambley L, Allocca G , Cookson V et al (2019) . Poster Session Abstracts RIS download Bibtex download
  • Hughes R, Ottewell P, Hobbs J, Holen I & Brown NJ (2019) Breast Cancer Metastasis to Bone: The Role of the Perivascular Niche in Regulating Tumour Cell Dormancy. JOURNAL OF VASCULAR RESEARCH, Vol. 56 (pp 17-18) RIS download Bibtex download
  • (2018) . Breast Cancer Research and Treatment, Vol. 167(1) (pp 309-405) RIS download Bibtex download
  • Eyre R, Alferez D, Santiago-Gomez A, Spence K, McConnell J, Simoes B, Hart C, Lefley D, Tulotta C, Gurney A , Howell S et al (2017) Targeting IL-1 beta-Wnt signalling to prevent breast cancer colonisation in the bone microenvironment. CLINICAL & EXPERIMENTAL METASTASIS, Vol. 34(8) (pp 493-493) RIS download Bibtex download
  • Tulotta C, Lefley D, Liu X, Spicer-Hadlington A, Hamley L, Cookson V, Allocca G & Ottewell P (2017) IL-1B signalling regulates breast cancer bone metastasis. CLINICAL & EXPERIMENTAL METASTASIS, Vol. 34(8) (pp 516-516) RIS download Bibtex download
  • Lefley D, Nutter F, Brown H, Tulotta C, Eyre R, Clarke R, Alferez D, Wilkinson M, Holen I & Ottewell P (2017) Human specific models for studying ER plus ve and ER- ve breast cancer bone metastasis. CLINICAL & EXPERIMENTAL METASTASIS, Vol. 34(8) (pp 516-516) RIS download Bibtex download
  • Quayle L, Park S, McDonnell DP, Ottewell PD & Holen I (2017) . Poster Session Abstracts RIS download Bibtex download
  • Ottewell P, Brown H, Allocca G, Haider MT, Brown N & Holen I (2016) The bone microenvironment as a master regulator of tumour cell dormancy in breast cancer - evidence from novel in vivo models. EUROPEAN JOURNAL OF CANCER, Vol. 61 (pp S74-S75) RIS download Bibtex download
  • Byrne M, Ottewell PD, Holen I, Sanderson T & Cross SS (2012) The Use of p63 in Distinguishing In Situ and Invasive Tumour in the PyMT Mouse Model of Breast Cancer. JOURNAL OF PATHOLOGY, Vol. 228 (pp S38-S38) RIS download Bibtex download
  • Brown HK, Ottewell PD, Evans CA, Coleman RE & Holen I (2011) . BONE, Vol. 48 (pp S255-S255) RIS download Bibtex download
  • Ottewell PD, Whitworth J & Holen I (2011) THE ROLE OF PLAKOGLOBIN IN THE INITIATION OF BREAST CANCER METASTASES. ANNALS OF ONCOLOGY, Vol. 22 (pp 32-32) RIS download Bibtex download
  • Ottewell PD, Brown H, Rogers TL, Lefley DV, Evans AC, Wind N, Cross SS, Brown N, Coleman R & Holen I (2011) PREVENTION OF SPONTANEOUS MAMMARY TUMOUR GROWTH BY SEQUENTIAL ADMINISTRATION OF DOXORUBICIN AND ZOLEDRONIC ACID IN AN IMMUNOCOMPETENT MOUSE MODEL. ANNALS OF ONCOLOGY, Vol. 22 (pp 29-29) RIS download Bibtex download
  • Ottewell PD, Whitworth J & Holen I (2011) THE ROLE OF PLAKOGLOBIN IN THE INITIATION OF BREAST CANCER METASTASES. ANNALS OF ONCOLOGY, Vol. 22 (pp 32-32) RIS download Bibtex download
  • Ottewell PD, Brown H, Rogers TL, Lefley DV, Evans AC, Wind N, Cross SS, Brown N, Coleman R & Holen I (2011) PREVENTION OF SPONTANEOUS MAMMARY TUMOUR GROWTH BY SEQUENTIAL ADMINISTRATION OF DOXORUBICIN AND ZOLEDRONIC ACID IN AN IMMUNOCOMPETENT MOUSE MODEL. ANNALS OF ONCOLOGY, Vol. 22 (pp 29-29) RIS download Bibtex download
  • Wind NS, Brown H, Ottewell PD, Sadej R, Romanska H, Berditchevski F & Holen I (2011) . BONE, Vol. 48(1) (pp S45-S45) RIS download Bibtex download
  • Brown HK, Ottewell PD, Evans CA, Coleman RE & Nolen I (2011) . BONE, Vol. 48(1) (pp S41-S41) RIS download Bibtex download
  • Ottewell PD, Brown H, Evans CA, Wind NS, Brown NJ, Coleman RE & Holen I (2011) . BONE, Vol. 48(1) (pp S42-S42) RIS download Bibtex download
  • Westbrook JA, Peng J, Cairns DA, Ottewell PD, Holen I, Coleman RE, Selby PJ, Banks RE & Brown JE (2011) . BONE, Vol. 48(1) (pp S33-S33) RIS download Bibtex download
  • Brown HK, Ottewell PD, Evans CA & Holen I (2011) . BONE, Vol. 48(1) (pp S40-S41) RIS download Bibtex download
  • Holen I, Ottewell PD & Coleman RE (2010) . Poster Session Abstracts RIS download Bibtex download
  • Ottewell PD, Lefely DV, Cross SS, Coleman RE & Holen I (2010) . BONE, Vol. 47 (pp S317-S317) RIS download Bibtex download
  • Brown HK, Ottewell PD, Lefely DV, Coleman RE & Holen I (2010) . BONE, Vol. 47 (pp S318-S319) RIS download Bibtex download
  • Woodward J, Holen I, Lefley D, Ottewell P & Buttle D (2010) Breast cancer-bone marrow stromal cell interactions modify expression of proteolytic enzymes and regulators of bone turnover. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, Vol. 91(2) (pp A45-A46) RIS download Bibtex download
  • Ottewell PD, Leftey DV, Coleman RE & Holen I (2009) Evaluation of the molecular mechanisms for the sequence-dependent, synergistic anti-tumour effects of doxorubicin and zoledronic acid in breast cancer.. CANCER RESEARCH, Vol. 69(2) (pp 200S-201S) RIS download Bibtex download
  • Ottewell P, Coleman RE & Holen I (2008) . European Journal of Cancer Supplements, Vol. 6(9) (pp 18-18) RIS download Bibtex download
  • Ottewell PD, Lefley DV, Coleman RE & Holen I (2008) . BREAST CANCER RESEARCH, Vol. 10 (pp S40-S41) RIS download Bibtex download
  • Lefley DV, Holen I, Coleman RE & Ottewell PD (2008) . BREAST CANCER RESEARCH, Vol. 10 (pp S40-S40) RIS download Bibtex download
  • Ottewell P, Croucher P & Holen I (2008) . Cancer Treatment Reviews, Vol. 34 (pp 12-12) RIS download Bibtex download
  • Ottewell P, Coleman R & Holen I (2008) . Cancer Treatment Reviews, Vol. 34 (pp 19-19) RIS download Bibtex download
  • Woodward J, Lefley D, Cross N, Ottewell PD, Buttle DJ, Coleman RE & Holen I (2007) Tumour cell-bone marrow stromal cell interactions modify expression of cathepsin K, ADAMTS-15, TIMP-3 and osteoprotegerin (OPG). INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, Vol. 88(6) (pp A97-A97) RIS download Bibtex download
  • Ottewell PD, Deux B, Monkkonen H, Cross SS, Coleman RE, Clezardin P & Holen I (2007) Differential effects of doxorubicin and zoledronic acid on intra-osseous vs extra-osseous breast tumour growth in vivo.. BREAST CANCER RESEARCH AND TREATMENT, Vol. 106 (pp S39-S39) RIS download Bibtex download
  • Ottewell PD, Deux B, Monkkonen H, Coleman RE, Clezardin P & Holen I (2007) Differential effect of doxorubicin and zoledronic acid on intra-osseous vs extra osseous breast tumour growth in vivo. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 22(7) (pp 1111-1111) RIS download Bibtex download
  • Woodward JKL, Lefley DV, Cross NA, Ottewell PD, Battle DJ, Coleman RE & Holen I (2007) Tumour cell-bone marrow stromal cell interactions modify expression of cathepsin K, ADAMTS-15, TIMP-3 and osteoprotegerin (OPG). JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 22(7) (pp 1142-1143) RIS download Bibtex download
  • Van Pozanki C, Otterwell P, Cross S, Hudis C, Coleman RE & Holen I (2007) Osteoprotegerin (OPG) expression in breast tumors and bone metastases. INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS, Vol. 22(1) (pp 83-84) RIS download Bibtex download
  • Cross SS, Ottewell P, Swinscoe M, Majeed AW & Holen I (2006) Osteoprotegerin is strongly expressed in the intratumoural endothelial cells of gastrointestinal carcinomas. JOURNAL OF PATHOLOGY, Vol. 208 (pp 9A-9A) RIS download Bibtex download
  • Van Poznak C, Ottewell P, Cross S, Hudis C, Coleman RE & Holen I (2006) . Bone, Vol. 38(3) (pp 31-32) RIS download Bibtex download
  • Ottewell PD, Jones M, Coleman RE & Holen I (2006) Synergistic effects of zoledronic acid and doxorubicin in breast cancer models in vivo. CANCER TREATMENT REVIEWS, Vol. 32 (pp S30-S30) RIS download Bibtex download
  • Ottewell PD, Jones M, Coleman RE & Holen I (2006) . BREAST CANCER RESEARCH, Vol. 8 (pp S17-S17) RIS download Bibtex download
  • Ottewell PD, Jones M, Coleman RE & Holen I (2006) Synergistic effects of cytotoxic drugs and anti-resorptive agents in vitro and in vivo.. BREAST CANCER RESEARCH AND TREATMENT, Vol. 100 (pp S290-S290) RIS download Bibtex download
  • Duckworth CA, Ottewell PD, Dimaline R, Varro A & Pritchard DM (2005) Hypergastrinaemia reduces the severity of dextran sulphate sodium induced colitis and 5-fluorouracil induced mucositis in mice. GUT, Vol. 54 (pp A98-A98) RIS download Bibtex download
  • Duckworth CA, Ottewell PD, Varro A, Dimaline R & Pritchard DM (2005) Hypergastrinaemia reduces the severity of dextran sulphate sodium induced colitis and 5-fluorouracil induced intestinal mucositis in mice.. GASTROENTEROLOGY, Vol. 128(4) (pp A203-A203) RIS download Bibtex download
  • Ottewell PD, Watson AJ, Varro A & Pritchard DM (2005) Radiation induces gastrin-CCKB receptor expression in IEC-6 and IEC-18 intestinal epithelial cells. GUT, Vol. 54 (pp A88-A88) RIS download Bibtex download
  • Przemeck SMC, Ottewell PD, Watson AJM & Pritchard DM (2005) Radiation induces p53 dependent apoptosis in the proliferative zone of mouse gastric epithelium. GUT, Vol. 54 (pp A88-A88) RIS download Bibtex download
  • Davies A, Ottewell P, McNamara A, Jenkins JR & Watson AJM (2004) Etoposide induced p53-dependent gene expression in the GI tract: Analysis of BIRC3, a candidate gene. GASTROENTEROLOGY, Vol. 126(4) (pp A546-A546) RIS download Bibtex download
  • Ottewell PD, Varro A, Watson AJM, Dimaline R, Dockray GJ & Pritchard DM (2004) Progastrin stimulates murine colonic epithelial mitosis after DNA damage in the absence of murine amidated gastrin. GASTROENTEROLOGY, Vol. 126(4) (pp A272-A272) RIS download Bibtex download
  • Ottewell PD, Watson A, Wang T, Dockray G & Pritchard M (2003) Progastrin stimulates murine colonic mitosis after DNA damage via the cyclin D1-cdk4 complex. GASTROENTEROLOGY, Vol. 124(4) (pp A100-A100) RIS download Bibtex download
  • Ottewell PD, Watson A, Wang T, Varro A, Dockray G & Pritchard M (2003) Elevated plasma concentrations of amidated gastrin cause increased crypt survival in murine intestinal epithelia after Gamma-radiation. GASTROENTEROLOGY, Vol. 124(4) (pp A610-A610) RIS download Bibtex download
  • Ottewell PD, Watson AJM, Wang TC, Varro A, Dockray GJ & Pritchard DM (2003) Elevated plasma concentrations of amidated gastrin cause increased crypt survival in murine intestinal epithelia after gamma radiation. GUT, Vol. 52 (pp A8-A8) RIS download Bibtex download
  • Davies A, Ottewell PD, McNamara A, Watson AJM & Jenkins JR (2003) P53 dependent differential expression analysis of etoposide induced stress in the murine small intestine. GUT, Vol. 52 (pp A36-A36) RIS download Bibtex download
  • Ottewell PD, Watson AJM, Wang TC, Dockray GJ & Pritchard DM (2003) Progastrin stimulates murine colonic mitosis after DNA damage via the cyclin D-cdk4 complex. GUT, Vol. 52 (pp A55-A55) RIS download Bibtex download
  • McMichael DP, Davies A, Marshman E, Ottewell PD, Jenkins JR & Watson AJM (2001) Knockout mouse and gene array analysis of etoposide induced apoptosis in the murine small intestine. GUT, Vol. 48 (pp A61-A62) RIS download Bibtex download
  • Arshad F, Lefley D, Madan S, Fernandes J, Bishop N & Ottewell P () . Bone Abstracts RIS download Bibtex download
  • Bishop N, Kalajzic I, Arshad F, Lefley D, Gossiel F & Ottewell P () . Bone Abstracts RIS download Bibtex download

Preprints

  • Shah KM, Tattersall L, Hussain A, Macfarlane SC, Williamson A, Acosta-Martin AE, Erler JT, Ottewell PD & Gartland A () , Cold Spring Harbor Laboratory. RIS download Bibtex download
Research group
  • Diane Lefley - Research Technician
  • Claudia Tulotta - Post-doctoral Research Associate
Professional activities and memberships
  • British Association for Cancer Research, executive committee member
  • International Bone and Mineral Society, Young Investigators committee member.
  • Analytical and Cellular Pathology, editorial board
  • Open Journal of Oncology, editorial board