Professor Penelope D Ottewell
Clinical Medicine, School of Medicine and Population Health
Professor of Cancer Biology
+44 114 215 9058
Full contact details
Clinical Medicine, School of Medicine and Population Health
Office: GU21
The Medical School
Beech Hill Road
ºù«Ӱҵ
S10 2RX
- Profile
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For enquiries please contact - ClinMed-Operational@sheffield.ac.uk
I am a senior lecturer in the Academic Unit of Clinical Oncology, University of ºù«Ӱҵ UK. I was awarded a PhD from the Department of Gastroenterology at The University of Liverpool in 2005 before taking up my first position in ºù«Ӱҵ a post-doctoral scientist working on breast cancer and bone metastasis.
During my time in ºù«Ӱҵ I have carried out international collaborative work spending time at INSERM (University of Lyon), France and at TUFTS University in Boston, USA.
I have been awarded a total of 10 prizes for my research including the prestigious Breast Cancer Campaign Research Team of the year award in 2008 and the International Bone and Mineral Society Gregory Mundy Research Fellowship in 2011.
- Research interests
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My research is focused on advanced breast cancer with particular emphasis on bone metastasis. Primarily, this involves using a complement of in vitro and in vivo model systems to investigate the molecular alterations that are acquired by breast cancer cells causing them to metastases to bone.
I hypothesise that metastases are a result of a stepwise accumulation of genetic mutations and that distinct molecular alterations are required at the different stages in the metastatic process; molecules involved in intravasation are not those involved in tissue homing and colonisation.
The aims of my research are to identify specific molecular determinants involved in tumour cell intravasation, homing to bone and colonisation of the metastatic site and to use this information to develop and apply new therapies for the treatment of breast cancer bone metastasis.
- Publications
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Show: Featured publications All publications
All publications
Journal articles
- . Bone Reports, 22, 101795-101795.
- . Journal of Bone Oncology, 46, 100608-100608.
- . Medical Research Archives, 12(6).
- . Expert Reviews in Molecular Medicine, 24.
- . Frontiers in Endocrinology, 12.
- . npj Breast Cancer, 7(1).
- . Bone Reports, 14, 101024.
- . Bone Reports, 14, 100899.
- . Journal of Cancer Metastasis and Treatment, 7.
- . Cancer Letters, 488, 27-39.
- . Journal of Bone Oncology, 25, 100317-100317.
- . Oncogene.
- . Breast Cancer Research, 21(1).
- . Nature Communications, 10(1).
- . Breast Cancer: Basic and Clinical Research, 13.
- . Journal of Bone Oncology, 17.
- . Cancer Letters, 450, 76-87.
- . Clinical Cancer Research, 25(9), 2769-2782.
- . International Journal of Cancer, 144(2), 334-344.
- . Clinical and Experimental Metastasis.
- . International Journal of Molecular Sciences, 19(10).
- . Endocrine-Related Cancer, 25(7), R421-R434.
- . Breast Cancer Research, 19.
- . Oncotarget, 7, 75571-75584.
- . Journal of Bone Oncology, 5(3), 124-127.
- . European Journal of Cancer, 61, S74-S75.
- . BoneKEy Reports, 5, 804-804.
- . Journal of the National Cancer Institute, 108(4).
- . Clinical & Experimental Metastasis, 33(3), 211-224.
- . Journal of Experimental and Clinical Cancer Research, 34(1), 124-124.
- . International Journal of Cancer, 137(4), 968-977.
- . Clinical & Experimental Metastasis, 32(7), 689-702.
- . The FASEB Journal, 29(8), 3141-3150.
- . Current Cancer Drug Targets, 15(6), 469-480.
- . BMC Cancer, 15(1).
- . BoneKEy Reports, 4.
- . J Bone Miner Res, 29(12), 2688-2696.
- . Endocrine Related Cancer, 21(5), 769-781.
- . Clin Cancer Res, 20(11), 2922-2932.
- . Journal of Biological Chemistry, 289(10), 6551-6564.
- Lysophosphatidic acid receptor type 1 (LPA1) plays a functional role in osteoclast differentiation and bone resorption activity.. Journal of Biological Chemistry, 10(289), 6551-6564.
- . Endocr Relat Cancer, 21(2), 327-341.
- . Cell Oncol (Dordr), 36(6), 505-514.
- . Poster Discussion Abstracts.
- A single administration of combination therapy inhibits breast tumour progress bone and modifies both osteoblasts and osteoclasts. Journal of Bone Oncology, 1(2), 47-56.
- . Breast Cancer Res, 14(3), R86.
- . Clin Exp Metastasis, 29(8), 927-938.
- . Breast Cancer Res Treat, 133(2), 523-536.
- . Poster Session Abstracts.
- . IBMS BoneKEy, 8(1), 41-45.
- . J Cell Mol Med, 15(3), 501-513.
- . Curr Pharm Des, 16(27), 2988-2997.
- . Int J Cancer, 126(2), 522-532.
- Effects of gastrin and its precursor peptides upon intestinal epithelia..
- . Mol Cancer Ther, 8(10), 2821-2832.
- . Poster Session Abstracts.
- . J Natl Cancer Inst, 100(16), 1167-1178.
- . Clin Cancer Res, 14(14), 4658-4666.
- . Life Sci, 81(13), 1066-1070.
- . Gastroenterology, 130(4), 1169-1180.
- . Breast Cancer Res Treat, 96(2), 101-113.
- . Nucl Med Biol, 4(32), 395-402.
- . Nucl Med Biol, 3(32), 241-252.
- . Am J Physiol Gastrointest Liver Physiol, 288(3), G541-G549.
- . Gastroenterology, 124(5), 1348-1357.
- . Clinical Science, 103(s47), 43P-43P.
- Progastrin stimulates murine colonic epithelial mitosis after DNA damage. GUT, 50, A93-A93.
- Progastrin stimulates murine colonic epithelial mitosis after DNA damage. GASTROENTEROLOGY, 122(4), A684-A684.
- . J Pathol, 195(3), 285-292.
- . Gastroenterology, 120(5), A660-A660.
- Gene array and knockout mouse analysis of VP-16 induced apoptosis in the murine small intestine. GASTROENTEROLOGY, 120(5), A660-A660.
- . Gut, 48(90001), 60a-64.
- . British Journal of Cancer.
- . Cancers, 15(8), 2211-2211.
- . Future Pharmacology, 2(4), 444-459.
- . Cancers, 14(19), 4816-4816.
- . Cancers, 13(6), 1366-1366.
- . Frontiers in Oral Health, 2.
- . Physiological Reviews.
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- . Bone Abstracts.
- . Bone Abstracts.
- . IBMS BoneKEy, 9.
- . Molecular Cancer Therapeutics, molcanther.0748.2020-molcanther.0748.2020.
- . Cancers, 13(16), 3922-3922.
Chapters
- , Bone Cancer (pp. 35-53). Elsevier
- , Bone Cancer (pp. 121-128). Elsevier
- In Caplan M (Ed.), Reference Module in Biomedical Sciences Elsevier
- , Methods in Molecular Biology (pp. 309-330). Springer New York
Conference proceedings papers
- Preventing the progression of breast cancer bone metastasis by CDK inhibition. BREAST CANCER RESEARCH AND TREATMENT, Vol. 180(2) (pp 537-538)
- Inhibition of breast cancer bone metastasis through Interleukin-1B regulated tumour-associated innate immune response. BREAST CANCER RESEARCH AND TREATMENT, Vol. 180(2) (pp 538-539)
- . Tumor Biology
- . Tumor Biology
- . Poster Session Abstracts
- Breast Cancer Metastasis to Bone: The Role of the Perivascular Niche in Regulating Tumour Cell Dormancy. JOURNAL OF VASCULAR RESEARCH, Vol. 56 (pp 17-18)
- . Breast Cancer Research and Treatment, Vol. 167(1) (pp 309-405)
- Targeting IL-1 beta-Wnt signalling to prevent breast cancer colonisation in the bone microenvironment. CLINICAL & EXPERIMENTAL METASTASIS, Vol. 34(8) (pp 493-493)
- IL-1B signalling regulates breast cancer bone metastasis. CLINICAL & EXPERIMENTAL METASTASIS, Vol. 34(8) (pp 516-516)
- Human specific models for studying ER plus ve and ER- ve breast cancer bone metastasis. CLINICAL & EXPERIMENTAL METASTASIS, Vol. 34(8) (pp 516-516)
- . Poster Session Abstracts
- The bone microenvironment as a master regulator of tumour cell dormancy in breast cancer - evidence from novel in vivo models. EUROPEAN JOURNAL OF CANCER, Vol. 61 (pp S74-S75)
- The Use of p63 in Distinguishing In Situ and Invasive Tumour in the PyMT Mouse Model of Breast Cancer. JOURNAL OF PATHOLOGY, Vol. 228 (pp S38-S38)
- . BONE, Vol. 48 (pp S255-S255)
- THE ROLE OF PLAKOGLOBIN IN THE INITIATION OF BREAST CANCER METASTASES. ANNALS OF ONCOLOGY, Vol. 22 (pp 32-32)
- PREVENTION OF SPONTANEOUS MAMMARY TUMOUR GROWTH BY SEQUENTIAL ADMINISTRATION OF DOXORUBICIN AND ZOLEDRONIC ACID IN AN IMMUNOCOMPETENT MOUSE MODEL. ANNALS OF ONCOLOGY, Vol. 22 (pp 29-29)
- THE ROLE OF PLAKOGLOBIN IN THE INITIATION OF BREAST CANCER METASTASES. ANNALS OF ONCOLOGY, Vol. 22 (pp 32-32)
- PREVENTION OF SPONTANEOUS MAMMARY TUMOUR GROWTH BY SEQUENTIAL ADMINISTRATION OF DOXORUBICIN AND ZOLEDRONIC ACID IN AN IMMUNOCOMPETENT MOUSE MODEL. ANNALS OF ONCOLOGY, Vol. 22 (pp 29-29)
- . BONE, Vol. 48(1) (pp S45-S45)
- . BONE, Vol. 48(1) (pp S41-S41)
- . BONE, Vol. 48(1) (pp S42-S42)
- . BONE, Vol. 48(1) (pp S33-S33)
- . BONE, Vol. 48(1) (pp S40-S41)
- . Poster Session Abstracts
- . BONE, Vol. 47 (pp S317-S317)
- . BONE, Vol. 47 (pp S318-S319)
- Breast cancer-bone marrow stromal cell interactions modify expression of proteolytic enzymes and regulators of bone turnover. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, Vol. 91(2) (pp A45-A46)
- Evaluation of the molecular mechanisms for the sequence-dependent, synergistic anti-tumour effects of doxorubicin and zoledronic acid in breast cancer.. CANCER RESEARCH, Vol. 69(2) (pp 200S-201S)
- . European Journal of Cancer Supplements, Vol. 6(9) (pp 18-18)
- . BREAST CANCER RESEARCH, Vol. 10 (pp S40-S41)
- . BREAST CANCER RESEARCH, Vol. 10 (pp S40-S40)
- . Cancer Treatment Reviews, Vol. 34 (pp 12-12)
- . Cancer Treatment Reviews, Vol. 34 (pp 19-19)
- Tumour cell-bone marrow stromal cell interactions modify expression of cathepsin K, ADAMTS-15, TIMP-3 and osteoprotegerin (OPG). INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, Vol. 88(6) (pp A97-A97)
- Differential effects of doxorubicin and zoledronic acid on intra-osseous vs extra-osseous breast tumour growth in vivo.. BREAST CANCER RESEARCH AND TREATMENT, Vol. 106 (pp S39-S39)
- Differential effect of doxorubicin and zoledronic acid on intra-osseous vs extra osseous breast tumour growth in vivo. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 22(7) (pp 1111-1111)
- Tumour cell-bone marrow stromal cell interactions modify expression of cathepsin K, ADAMTS-15, TIMP-3 and osteoprotegerin (OPG). JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 22(7) (pp 1142-1143)
- Osteoprotegerin (OPG) expression in breast tumors and bone metastases. INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS, Vol. 22(1) (pp 83-84)
- Osteoprotegerin is strongly expressed in the intratumoural endothelial cells of gastrointestinal carcinomas. JOURNAL OF PATHOLOGY, Vol. 208 (pp 9A-9A)
- . Bone, Vol. 38(3) (pp 31-32)
- Synergistic effects of zoledronic acid and doxorubicin in breast cancer models in vivo. CANCER TREATMENT REVIEWS, Vol. 32 (pp S30-S30)
- . BREAST CANCER RESEARCH, Vol. 8 (pp S17-S17)
- Synergistic effects of cytotoxic drugs and anti-resorptive agents in vitro and in vivo.. BREAST CANCER RESEARCH AND TREATMENT, Vol. 100 (pp S290-S290)
- Hypergastrinaemia reduces the severity of dextran sulphate sodium induced colitis and 5-fluorouracil induced mucositis in mice. GUT, Vol. 54 (pp A98-A98)
- Hypergastrinaemia reduces the severity of dextran sulphate sodium induced colitis and 5-fluorouracil induced intestinal mucositis in mice.. GASTROENTEROLOGY, Vol. 128(4) (pp A203-A203)
- Radiation induces gastrin-CCKB receptor expression in IEC-6 and IEC-18 intestinal epithelial cells. GUT, Vol. 54 (pp A88-A88)
- Radiation induces p53 dependent apoptosis in the proliferative zone of mouse gastric epithelium. GUT, Vol. 54 (pp A88-A88)
- Etoposide induced p53-dependent gene expression in the GI tract: Analysis of BIRC3, a candidate gene. GASTROENTEROLOGY, Vol. 126(4) (pp A546-A546)
- Progastrin stimulates murine colonic epithelial mitosis after DNA damage in the absence of murine amidated gastrin. GASTROENTEROLOGY, Vol. 126(4) (pp A272-A272)
- Progastrin stimulates murine colonic mitosis after DNA damage via the cyclin D1-cdk4 complex. GASTROENTEROLOGY, Vol. 124(4) (pp A100-A100)
- Elevated plasma concentrations of amidated gastrin cause increased crypt survival in murine intestinal epithelia after Gamma-radiation. GASTROENTEROLOGY, Vol. 124(4) (pp A610-A610)
- Elevated plasma concentrations of amidated gastrin cause increased crypt survival in murine intestinal epithelia after gamma radiation. GUT, Vol. 52 (pp A8-A8)
- P53 dependent differential expression analysis of etoposide induced stress in the murine small intestine. GUT, Vol. 52 (pp A36-A36)
- Progastrin stimulates murine colonic mitosis after DNA damage via the cyclin D-cdk4 complex. GUT, Vol. 52 (pp A55-A55)
- Knockout mouse and gene array analysis of etoposide induced apoptosis in the murine small intestine. GUT, Vol. 48 (pp A61-A62)
- . Bone Abstracts
- . Bone Abstracts
Preprints
- Research group
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- Diane Lefley - Research Technician
- Claudia Tulotta - Post-doctoral Research Associate
- Professional activities and memberships
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- British Association for Cancer Research, executive committee member
- International Bone and Mineral Society, Young Investigators committee member.
- Analytical and Cellular Pathology, editorial board
- Open Journal of Oncology, editorial board