Muimo, Richmond, Dr

Dr Richmond Muimo

PhD

Clinical Medicine, School of Medicine and Population Health

Lecturer in Cell Biology

r.muimo@sheffield.ac.uk
+44 114 215 9515

+44 114 271 1863 (fax)

The Medical School

Full contact details

Dr Richmond Muimo
Clinical Medicine, School of Medicine and Population Health
The Medical School
Beech Hill Road
��«Ӱҵ
S10 2RX

Profile

For enquiries please contact - ClinMed-Operational@sheffield.ac.uk

After completing my PhD at the University of Leeds in 1993, I took up a post as a PostDoctoral Researcher. In 1993 I became a Research Fellow at Dundee University where I went on to become a Lecturer in 2001.

I joined ��«Ӱҵ in 2003 where I continue to work as a Lecturer.

Current PhD Opportunities

Research interests

I am focused on understanding the mechanisms that regulate ion transport in secretory epithelia, particularly in relation to cystic fibrosis. I have identified a number of CFTR-associated proteins that are involved in regulating ion channel function.

Over the past few years my interests have expanded into understanding the role of CFTR-associated proteins in neutrophil function and inflammation.

Current Projects

Application of stable analogues of phosphohistidine to the study of cell signaling pathways.
Nucleoside diphosphate kinase (NDPK) regulates CFTR function.
Roles of NDPK in neutrophilic inflammation.

Publications

Show: Featured publications All publications

Featured publications

Journal articles

Mambwe B, Neo K, Javanmard Khameneh H, Leong KWK, Colantuoni M, Vacca M, Muimo R & Mortellaro A (2019) . Frontiers in Immunology, 10.
Borthwick LA, Neal A, Hobson L, Gerke V, Robson L & Muimo R (2008) . Cell Calcium, 44(2), 147-157.
Borthwick LA, Riemen C, Goddard C, Colledge WH, Mehta A, Gerke V & Muimo R (2008) . Cell Signal, 20(6), 1073-1083.
Borthwick LA, McGaw J, Conner G, Taylor CJ, Gerke V, Mehta A, Robson L & Muimo R (2007) . Mol Biol Cell, 18(9), 3388-3397.
Muimo R, Crawford RM & Mehta A (2006) . J Bioenerg Biomembr, 38(3-4), 181-187.
Muimo R, Hornickova Z, Riemen CE, Gerke V, Matthews H & Mehta A (2000) . J Biol Chem, 275(47), 36632-36636.
Makwana M, dos Santos Souza C, Pickup BT, Thompson, MJ, Lomada SK, Feng Y, Wieland T, Jackson RFW & Muimo R () . ChemBioChem.

All publications

Journal articles

Makwana MV, Williamson MP, Jackson RFW & Muimo R (2022) . PLoS ONE, 17(9).
Mambwe B, Neo K, Javanmard Khameneh H, Leong KWK, Colantuoni M, Vacca M, Muimo R & Mortellaro A (2019) . Frontiers in Immunology, 10.
Makwana MV, Muimo R & Jackson RFW (2019) . Laboratory Investigation, 99(3), 438-438.
Muimo R, Alothaid HMM & Mehta A (2018) . Laboratory Investigation, 98(3), 272-282.
Makwana MV, Muimo R & Jackson RFW (2018) . Laboratory Investigation, 98(3), 291-303.
Attwood PV & Muimo R (2018) . Laboratory Investigation, 98(3), 283-290.
Muimo R (2017) . Clin Sci (Lond), 131(11), 1141-1145.
Borthwick LA, Kerbiriou M, Taylor CJ, Cozza G, Lascu I, Postel EH, Cassidy D, Trouvé P, Mehta A, Robson L & Muimo R (2016) . PLoS ONE, 11(3), e0149097-e0149097.
Lilley M, Mambwe B, Thompson MJ, Jackson RFW & Muimo R (2015) . Chem. Commun., 51(34), 7305-7308.
Lilley M, Mambwe B, Jackson RFW & Muimo R (2014) . Chem Commun (Camb), 50(66), 9343-9345.
King JD, Lee J, Riemen CE, Neumann D, Xiong S, Foskett JK, Mehta A, Muimo R & Hallows KR (2012) . J Biol Chem, 287(40), 33389-33400.
Little R, Muimo R, Robson L, Harris K & Grabowski PS (2011) . PLoS ONE, 6(11).
England AK, Muimo R & Robson L (2011) THE ROLE OF TYROSINE PHOSPHORYLATION IN REGULATING CFTR FUNCTION IN EPITHELIAL CELLS. PEDIATR PULM, 250-250.
Jr KJD, Lee J, Rieman CE, Mehta A, Muimo R & Hallows KR (2010) Role of Binding and Nucleoside Diphosphate Kinase A (NDPK-A) in the Regulation of CFTR by AMP-Activated Protein Kinase (AMPK). FASEB JOURNAL, 24.
Muimo R, Nagaraj V, Palekar S & Robson L (2009) EFFECT OF RUTHENIUM RED AND cAMP ON Ca2+ HANDLING IN BREAST CANCER CELLS. J PHYSIOL SCI, 59, 249-249.
Harris KL, Muimo R & Robson L (2009) CFTR PLAYS A ROLE IN REGULATING CALCIUM PERMEABLE ION CHANNELS IN AIRWAY EPITHELIA. J PHYSIOL SCI, 59, 299-299.
Muimo R (2009) A ROLE FOR NUCLEOSIDE DIPHOSPHATE KINASE-B (NDPK-B) IN REGULATION OF CFTR BY HETEROTRIMERIC G-PROTEINS IN AIRWAY EPITHELIA. PEDIATR PULM, 224-224.
Borthwick LA, Neal A, Hobson L, Gerke V, Robson L & Muimo R (2008) . Cell Calcium, 44(2), 147-157.
Borthwick LA, Riemen C, Goddard C, Colledge WH, Mehta A, Gerke V & Muimo R (2008) . Cell Signal, 20(6), 1073-1083.
Borthwick LA, McGaw J, Conner G, Taylor CJ, Gerke V, Mehta A, Robson L & Muimo R (2007) . Mol Biol Cell, 18(9), 3388-3397.
Muimo R, Crawford RM & Mehta A (2006) . J Bioenerg Biomembr, 38(3-4), 181-187.
Mwimbi XKMS, Muimo R, Green MW & Mehta A (2003) . Cell Signal, 15(4), 395-402.
Mwimbi XKMS, Muimo R, Treharne KJ, Sijumbila G, Green M & Mehta A (2002) . FEBS Lett, 530(1-3), 31-36.
Ghioni C, Treharne KJ, Mehta A, Olver RE, Land SC & Muimo R (2002) . Biochemical Society Transactions, 30(5), A121-A121.
Treharne KJ, Mehta A & Muimo R (2002) Improved oxygenation promotes nucleoside diphosphate kinase activity in a human bronchial epithelial cell line (HBE). J PHYSIOL-LONDON, 539, 18P-18P.
Best OG, Treharne KJ, Goddard C, Colledge W, Muimo R & Mehta A (2002) Novel regulation of the nucleotide generator NDPK by the AMP-activated kinase. J PHYSIOL-LONDON, 539, 24P-24P.
Treharne KJ, Riemen CE, Marshall LJ, Muimo R & Mehta A (2001) . Pflugers Arch, 443 Suppl 1, S97-102.
Muimo R, Hornickova Z, Riemen CE, Gerke V, Matthews H & Mehta A (2000) . J Biol Chem, 275(47), 36632-36636.
Best OG, Mehta A & Muimo R (2000) A 62 kDa cAMP-binding protein as a putative regulator of nucleoside diphosphate kinase activity. J PHYSIOL-LONDON, 527, 24P-25P.
Mwimbi X, Muimo R & Mehta A (2000) Protein kinase C mitigates against the flow-dependent decline in human nasal ciliary beat frequency in vitro. J PHYSIOL-LONDON, 527, 30P-31P.
Mukhopadhyay S, Muimo R, Campbell FM, Gordon MJ, Monaghan AS & Dutta-Roy AK (2000) . Prostaglandins Leukot Essent Fatty Acids, 62(6), 341-348.
Mwimbi XK, Muimo R, Green M & Mehta A (2000) . J Aerosol Med, 13(3), 273-279.
Monaghan AS, Baines DL, Muimo R & Olver RE (1999) . Pflugers Arch, 438(3), 371-377.
Marshall LJ, Muimo R, Riemen CE & Mehta A (1999) . Am J Physiol, 276(1), C109-C119.
Marshall LJ, Muimo R & Mehta A (1998) [Na+] regulates nucleoside diphosphate kinase in human respiratory epithelium in vitro when ATP (but not GTP) is the kinase substrate. J PHYSIOL-LONDON, 509P, 81P-82P.
Muimo R, Hornickova Z & Mehta A (1998) The chloride-dependent phosphorylated protein in apical membranes from ovine airway is annexin I. J PHYSIOL-LONDON, 509P, 82P-82P.
Riemen CE, Muimo R, Ratcliff RA, Colledge WH, Evans MJ & Mehta A (1998) Defective nucleoside triphosphate synthesis in plasma membranes derived from the tracheal epithelium of CFTR null (-/-) mice. J PHYSIOL-LONDON, 509P, 81P-81P.
Marshall LJ, Muimo R & Mehta A (1998) Na+ and K+ differentially regulate nucleoside diphosphate kinase in human respiratory epithelium in vitro. J PHYSIOL-LONDON, 507P, 3P-4P.
Muimo R, Banner SJ, Marshall LJ & Mehta A (1998) . Am J Respir Cell Mol Biol, 18(2), 270-278.
Banner SJ, Marshall LJ, Muimo R & Mehta A (1996) Intermolecular transfer of guanine nucleotide gamma phosphate to apical membrane proteins in ovine tracheal epithelium in vitro. J PHYSIOL-LONDON, 493P, P72-P72.
Meyer DJ, Muimo R, Thomas M, Coates D & Isaac RE (1996) . Biochem J, 313 ( Pt 1), 223-227.
Muimo R & Isaac RE (1993) . Comp Biochem Physiol B, 106(4), 969-976.
Muimo R & Isaac RE (1993) . Biochem Soc Trans, 21 ( Pt 3)(3), 295S.
MUIMO R & ISAAC RE (1993) N-ACETYLATION OF 5-HT IS A MAJOR METABOLIC PATHWAY IN NEMATODES AND IS DEVELOPMENTALLY REGULATED IN C-ELEGANS. J CELL BIOCHEM, 117-117.
Isaac RE, Eaves L, Muimo R & Lamango N (1991) . Parasitology, 102 Pt 3, 445-450.
Isaac RE, Muimo R & MacGregor AN (1990) . Mol Biochem Parasitol, 43(2), 193-198.
Makwana M, dos Santos Souza C, Pickup BT, Thompson, MJ, Lomada SK, Feng Y, Wieland T, Jackson RFW & Muimo R () . ChemBioChem.
Makwana MV, van Meurs S, Hounslow AM, Williamson MP, Jackson, RFW & Muimo R () .
Makwana M, Dos Santos Souza C, Pickup BT, Thompson MJ, Lomada SK, Feng Y, Wieland T, F. W. Jackson R & MUIMO R () .

Conference proceedings papers

Mambwe B, Muimo R & Mortellaro A (2019) Analysing the Role of Tyrosine Phosphorylation in Inflammasome Complex Formation and Function. CARDIOVASCULAR DRUGS AND THERAPY, Vol. 33(2) (pp 270-270)
Jr KJD, Lee J, Rieman CE, Mehta A, Muimo R & Hallows KR (2012) Role of Binding and Nucleoside Diphosphate Kinase A (NDPK-A) in the Regulation of CFTR by AMP-Activated Protein Kinase (AMPK). FASEB JOURNAL, Vol. 26
England AK, Muimo R & Robson L (2011) A potential role of tyrosine phosphorylation in the function of the cystic fibrosis transmembrane conductance regulator (CFTR). FASEB JOURNAL, Vol. 25
Muimo R (2009) Regulation of CFTR function by annexin A2-S100A10 complex in health and disease. GENERAL PHYSIOLOGY AND BIOPHYSICS, Vol. 28 (pp F14-F19)
Mwimbi X, Muimo R & Mehta A (2001) Presentation of ciliary beat frequency results to our peers. CILIA AND MUCUS: FROM DEVELOPMENT TO RESPIRATORY DEFENSE (pp 91-97)
Muimo R, Banner SJ, Marshall L & Mehta A (1998) The nucleoside diphosphate kinase and chloride-sensitive GTP-dependent phosphorylation in apical membrane from ciliated airway cells. CILIA, MUCUS, AND MUCOCILIARY INTERACTIONS (pp 39-42)

Teaching interests: My teaching interests lie in aspects of membrane biology and invertebrate model systems which I teach on the MBChB and MSc in Molecular Medicine, respectively.

Professional activities and memberships

Biochemical Society
European Calcium Society
American Society For Cell Biology