Collis, Spencer, Professor

Professor Spencer Collis

School of Medicine and Population Health

Professor of Genome Stability

s.collis@sheffield.ac.uk
+44 114 215 9043

The Medical School

Full contact details

Professor Spencer Collis
School of Medicine and Population Health
The Medical School
Beech Hill Road
��«Ӱҵ
S10 2RX

Profile

For enquiries please contact - SMPH-West-Operational@sheffield.ac.uk

1994 - 1997
BSc (Hons): Biochemistry, UMIST

1997 - 2000
PhD: Oncology, CRUK Paterson Institute for Cancer Research

2001 - 2004
Post-Doc: Prof. Theodore DeWeese laboratory, Johns Hopkins University

2004 - 2009
Post-Doc: Dr Simon Boulton laboratory, Clare Hall Laboratories, CRUK London Research Institute

2009 - 2013
Group leader: Institute for Cancer Studies, University of ��«Ӱҵ

2013 - 2015
Senior Lecturer: Academic unit of Molecular Oncology, Department of Oncology, University of ��«Ӱҵ

2016 - 2024
Reader: Academic unit of Molecular Oncology, Department of Oncology, University of ��«Ӱҵ

2024 - present
Professor: Division of Clinical Medicine, University of ��«Ӱҵ

Current PhD Opportunities:

Research interests

The overarching research goals of the Collis laboratory is to identify and functionally characterise novel factors that are important for the maintenance of genome integrity in human cells. This research also aims to establish if such factors are novel drug targets and/or biomarkers that can be exploited to improve the treatment of diseases such as cancer, either alone, or in combination with existing chemo- and/or radio-therapeutic regimes. To achieve this, the Collis group collaborate with a range of national and international scientists and clinicians to maximise the potential therapeutic impact of their basic biological discoveries.

Funding Sources

Publications

Show: Featured publications All publications

Featured publications

Journal articles

Cheng VWT, Vaughn-Beaucaire P, Shaw GC, Kriegs M, Droop A, Psakis G, Mittelbronn M, Humphries M, Esteves F, Hayes J , Cockle JV et al (2025) . Cell Reports, 44(3), 115361-115361.
Zhao A, Maple L, Jiang J, Myers KN, Jones CG, Gagg H, McGarrity-Cottrell C, Rominiyi O, Collis SJ, Wells G , Rahman M et al (2024) . Cell Death & Disease, 15(12).
Jones CG, Vanderlinden A, Rominiyi O & Collis SJ (2024) . Cancers, 16(5).
Gagg H, Williams ST, Conroy S, Myers KN, McGarrity-Cottrell C, Jones C, Helleday T, Rantala J, Rominiyi O, Danson SJ , Collis SJ et al (2024) . F1000Research, 12.
Vanderlinden A, Jones CG, Myers KN, Rominiyi O & Collis SJ (2023) . British Journal of Cancer.
Williams ST, Wells G, Conroy S, Gagg H, Allen R, Rominiyi O, Helleday T, Hullock K, Pennington CEW, Rantala J , Collis SJ et al (2022) . Expert Reviews in Molecular Medicine, 24.
Rominiyi O & Collis SJ (2022) . Molecular Oncology, 16(1), 11-41.
Carmell N, Rominiyi O, Myers KN, McGarrity-Cottrell C, Vanderlinden A, Lad N, Perroux-David E, El-Khamisy SF, Fernando M, Finegan KG , Brown S et al (2021) . Cancers, 13(5).
Rominiyi O, Vanderlinden A, Clenton SJ, Bridgewater C, Al-Tamimi Y & Collis SJ (2021) . Br J Cancer, 124(4), 697-709.
Bennett LG, Wilkie AM, Antonopoulou E, Ceppi I, Sanchez A, Vernon EG, Gamble A, Myers KN, Collis SJ, Cejka P & Staples CJ (2020) . Sci Adv, 6(28), eaba5974.
Rominiyi O, Al-Tamimi Y & Collis SJ (2019) . Cancers (Basel), 11(3).
Barone G, Arora A, Ganesh A, Abdel-Fatah T, Moseley P, Ali R, Chan SY, Savva C, Schiavone K, Carmell N , Myers KN et al (2018) . Oncotarget, 9(50), 29508-29524.
Myers KN, Barone G, Ganesh A, Staples CJ, Howard AE, Beveridge RD, Maslen S, Skehel JM & Collis SJ (2016) . Sci Rep, 6, 35548.
Barone G, Staples CJ, Ganesh A, Patterson KW, Bryne DP, Myers KN, Patil AA, Eyers CE, Maslen S, Skehel JM , Eyers PA et al (2016) . Nucleic Acids Res, 44(18), 8772-8785.
Staples CJ, Barone G, Myers KN, Ganesh A, Gibbs-Seymour I, Patil AA, Beveridge RD, Daye C, Beniston R, Maslen S , Ahel I et al (2016) . Cell Rep, 16(10), 2565-2575.
Johnson CA & Collis SJ (2016) . Cilia, 5, 19.
Beveridge RD, Staples CJ, Patil AA, Myers KN, Maslen S, Skehel JM, Boulton SJ & Collis SJ (2014) . Cell Cycle, 13(21), 3450-3459.
Patil AA, Sayal P, Depondt M-L, Beveridge RD, Roylance A, Kriplani DH, Myers KN, Cox A, Jellinek D, Fernando M , Carroll TA et al (2014) . Oncotarget, 5(15), 6414-6424.
Staples CJ, Myers KN, Beveridge RDD, Patil AA, Howard AE, Barone G, Lee AJX, Swanton C, Howell M, Maslen S , Skehel JM et al (2014) . J Cell Sci, 127(Pt 13), 2910-2919.
Staples CJ, Myers KN, Beveridge RDD, Patil AA, Lee AJX, Swanton C, Howell M, Boulton SJ & Collis SJ (2012) . J Cell Sci, 125(Pt 20), 4770-4779.
Rominiyi O, McGarrity-Cottrell C, Myers KN, Jones CG, Wosnitzka K, Williams ST, Vanderlinden A, Antohi A-G, Gomez-Roman N, Chalmers AJ , Sinha S et al () . F1000Research, 13, 1316-1316.

All publications

Journal articles

Cheng VWT, Vaughn-Beaucaire P, Shaw GC, Kriegs M, Droop A, Psakis G, Mittelbronn M, Humphries M, Esteves F, Hayes J , Cockle JV et al (2025) . Cell Reports, 44(3), 115361-115361.
Zhao A, Maple L, Jiang J, Myers KN, Jones CG, Gagg H, McGarrity-Cottrell C, Rominiyi O, Collis SJ, Wells G , Rahman M et al (2024) . Cell Death & Disease, 15(12).
Lad N, Jones CG, Myers KN, McGarrity-Cottrell CL, Finegan KG, Rominiyi O & Collis SJ (2024) . Neuro-Oncology, 26(Supplement_8), viii118-viii118.
Jones C, Collis S, Rominiyi O, Myers K, Vanderlinden A & McGarrity-Cottrell C (2024) . Neuro-Oncology, 26(Supplement_8), viii117-viii118.
Jones CG, Vanderlinden A, Rominiyi O & Collis SJ (2024) . Cancers, 16(5).
Gagg H, Williams ST, Conroy S, Myers KN, McGarrity-Cottrell C, Jones C, Helleday T, Rantala J, Rominiyi O, Danson SJ , Collis SJ et al (2024) . F1000Research, 12.
Derby S, Dutton L, Strathdee KE, Stevenson K, Koessinger A, Jackson M, Tian Y, Yu W, Mclay K, Misquitta J , Alsharif S et al (2023) . Neuro-Oncology, noad210.
Vanderlinden A, Jones CG, Myers KN, Rominiyi O & Collis SJ (2023) . British Journal of Cancer.
McGarrity-Cottrell C, Myers K, Dunning M, Bagga V, Sinna S, Al-Tamimi Y, Rominiyi O & Collis S (2023) . Neuro-Oncology, 25(Supplement_3), iii14-iii14.
Patel P, Alghamdi A, Shaw G, Legge C, Glover M, Freeman D, Hodgetts H, Wilson E, Howard F, Staniland S , Kennerley AJ et al (2023) . Nanotheranostics, 7(1), 102-116.
McGarrity - Cottrell C, Myers K, Wang D, Dunning M, Bagga V, Al-Tamimi Y, Sinha S, Rominiyi O & Collis S (2022) . Neuro-Oncology, 24(Supplement_7), vii31-vii31.
Vanderlinden A, Rominiyi O, Collis S, Jones C, Myers K & McGarrity - Cottrell C (2022) . Neuro-Oncology, 24(Supplement_7), vii93-vii93.
Williams ST, Wells G, Conroy S, Gagg H, Allen R, Rominiyi O, Helleday T, Hullock K, Pennington CEW, Rantala J , Collis SJ et al (2022) . Expert Reviews in Molecular Medicine, 24.
Rominiyi O & Collis SJ (2022) . Molecular Oncology, 16(1), 11-41.
Rominiyi O, Vanderlinden A, Clenton SJ, Bridgewater C, Al-Tamimi Y & Collis SJ (2021) . BRITISH JOURNAL OF CANCER, 125(4), 623-623.
Rominiyi O, Vanderlinden A, Myers K, Gomez-Roman N, Dar D, Bagga V, Jellinek DA, Chalmers AJ, Carroll TA, Al-Tamimi Y & Collis SJ (2021) . British Journal of Surgery, 108(Supplement_1).
Carmell N, Rominiyi O, Myers KN, McGarrity-Cottrell C, Vanderlinden A, Lad N, Perroux-David E, El-Khamisy SF, Fernando M, Finegan KG , Brown S et al (2021) . Cancers, 13(5).
Rominiyi O, Vanderlinden A, Clenton SJ, Bridgewater C, Al-Tamimi Y & Collis SJ (2021) . Br J Cancer, 124(4), 697-709.
Bennett LG, Wilkie AM, Antonopoulou E, Ceppi I, Sanchez A, Vernon EG, Gamble A, Myers KN, Collis SJ, Cejka P & Staples CJ (2020) . Sci Adv, 6(28), eaba5974.
O'Regan L, Barone G, Adib R, Woo CG, Jeong HJ, Richardson EL, Richards MW, Muller PAJ, Collis SJ, Fennell DA , Choi J et al (2020) . J Cell Sci, 133(9).
Rominiyi O, Myers K, Gomez-Roman N, Lad N, Dar D, Jellinek D, Chalmers A, Carroll T, Chen B, Al-Tamimi Y & Collis S (2019) . Neuro-Oncology, 21(Supplement_6), vi209-vi209.
Rominiyi O, Myers K, Vanderlinden A, Dar D, Bagga V, Gomez-Roman N, Jellinek D, Carroll T, Chalmers A, Al-Tamimi Y & Collis S (2019) . Neuro-Oncology, 21(Supplement_6), vi271-vi271.
Rominiyi O, Al-Tamimi Y & Collis SJ (2019) . Cancers (Basel), 11(3).
Carmell N, Brown S, Khamisy S & Collis S (2018) NOVEL DRUG TARGETS TO AUGMENT TEMOZOLOMIDE SENSITIVITY IN HIGH-GRADE BRAIN TUMOURS. NEURO-ONCOLOGY, 20, 346-346.
Rominiyi O, Gomez-Roman N, Lad N, Al-Tamimi Y, Jellinek DA, Chalmers AJ, Carroll TA, Chen B & Collis SJ (2018) . Neuro-Oncology, 20(suppl_3), iii297-iii297.
Barone G, Arora A, Ganesh A, Abdel-Fatah T, Moseley P, Ali R, Chan SY, Savva C, Schiavone K, Carmell N , Myers KN et al (2018) . Oncotarget, 9(50), 29508-29524.
Myers KN, Barone G, Ganesh A, Staples CJ, Howard AE, Beveridge RD, Maslen S, Skehel JM & Collis SJ (2016) . Sci Rep, 6, 35548.
Barone G, Staples CJ, Ganesh A, Patterson KW, Bryne DP, Myers KN, Patil AA, Eyers CE, Maslen S, Skehel JM , Eyers PA et al (2016) . Nucleic Acids Res, 44(18), 8772-8785.
Staples CJ, Barone G, Myers KN, Ganesh A, Gibbs-Seymour I, Patil AA, Beveridge RD, Daye C, Beniston R, Maslen S , Ahel I et al (2016) . Cell Rep, 16(10), 2565-2575.
Johnson CA & Collis SJ (2016) . Cilia, 5, 19.
Patil AA, Hua P, Sellwood MA, Jellinek DA, Carroll TA, Chen B & Collis SJ (2015) . Neuro-Oncology, 17(suppl 8), viii20.1-viii20.
Beveridge RD, Staples CJ, Patil AA, Myers KN, Maslen S, Skehel JM, Boulton SJ & Collis SJ (2014) . Cell Cycle, 13(21), 3450-3459.
Patil AA, Sayal P, Depondt M-L, Beveridge RD, Roylance A, Kriplani DH, Myers KN, Cox A, Jellinek D, Fernando M , Carroll TA et al (2014) . Oncotarget, 5(15), 6414-6424.
Staples CJ, Myers KN, Beveridge RDD, Patil AA, Howard AE, Barone G, Lee AJX, Swanton C, Howell M, Maslen S , Skehel JM et al (2014) . J Cell Sci, 127(Pt 13), 2910-2919.
Staples CJ, Myers KN, Beveridge RDD, Patil AA, Lee AJX, Swanton C, Howell M, Boulton SJ & Collis SJ (2013) . Development, 140(2), e207-e207.
Staples CJ, Myers KN, Beveridge RDD, Patil AA, Lee AJX, Swanton C, Howell M, Boulton SJ & Collis SJ (2012) . J Cell Sci, 125(Pt 20), 4770-4779.
Horejsí Z, Takai H, Adelman CA, Collis SJ, Flynn H, Maslen S, Skehel JM, de Lange T & Boulton SJ (2010) . Mol Cell, 39(6), 839-850.
Adamo A, Collis SJ, Adelman CA, Silva N, Horejsi Z, Ward JD, Martinez-Perez E, Boulton SJ & La Volpe A (2010) . Mol Cell, 39(1), 25-35.
Kachhap SK, Rosmus N, Collis SJ, Kortenhorst MSQ, Wissing MD, Hedayati M, Shabbeer S, Mendonca J, Deangelis J, Marchionni L , Lin J et al (2010) . PLoS One, 5(6), e11208.
Collis SJ & Boulton SJ (2010) . EMBO J, 29(4), 703-705.
Horejŝí Z, Collis SJ & Boulton SJ (2009) . Cell Cycle, 8(8), 1133-1137.
Youds JL, Barber LJ, Ward JD, Collis SJ, O'Neil NJ, Boulton SJ & Rose AM (2008) . Mol Cell Biol, 28(5), 1470-1479.
Collis SJ, Ciccia A, Deans AJ, Horejsí Z, Martin JS, Maslen SL, Skehel JM, Elledge SJ, West SC & Boulton SJ (2008) . Mol Cell, 32(3), 313-324.
Barber LJ, Youds JL, Ward JD, McIlwraith MJ, O'Neil NJ, Petalcorin MIR, Martin JS, Collis SJ, Cantor SB, Auclair M , Tissenbaum H et al (2008) . Cell, 135(2), 261-271.
Marples B & Collis SJ (2008) . Int J Radiat Oncol Biol Phys, 70(5), 1310-1318.
Krueger SA, Collis SJ, Joiner MC, Wilson GD & Marples B (2007) . Int J Radiat Oncol Biol Phys, 69(4), 1262-1271.
Collis SJ & Boulton SJ (2007) . Chromosoma, 116(4), 331-339.
Collis SJ, Barber LJ, Clark AJ, Martin JS, Ward JD & Boulton SJ (2007) . Nat Cell Biol, 9(4), 391-401.
Qian DZ, Kachhap SK, Collis SJ, Verheul HMW, Carducci MA, Atadja P & Pili R (2006) . CANCER RES, 66(17), 8814-8821.
Collis SJ, Barber LJ, Ward JD, Martin JS & Boulton SJ (2006) . DNA Repair (Amst), 5(11), 1398-1406.
Collis SJ, DeWeese TL, Jeggo PA & Parker AR (2005) . Oncogene, 24(6), 949-961.
Collis SJ, Schwaninger JM, Ntambi AJ, Keller TW, Nelson WG, Dillehay LE & Deweese TL (2004) . J Biol Chem, 279(48), 49624-49632.
Collis SJ & DeWeese TL (2004) . Cancer Metastasis Rev, 23(3-4), 277-292.
Collis SJ, Neutzel S, Thompson TL, Swartz MJ, Dillehay LE, Collector MI, Sharkis SJ & DeWeese TL (2004) . Radiat Res, 162(1), 48-55.
Marples B, Wouters BG, Collis SJ, Chalmers AJ & Joiner MC (2004) . Radiat Res, 161(3), 247-255.
Collis SJ, Khater K & DeWeese TL (2003) . World J Urol, 21(4), 275-289.
Collis SJ, Swartz MJ, Nelson WG & DeWeese TL (2003) Enhanced radiation and chemotherapy-mediated cell killing of human cancer cells by small inhibitory RNA silencing of DNA repair factors.. Cancer Res, 63(7), 1550-1554.
Collis SJ, Ketner GW, Hicks JL, Nelson WG, Demarzo AM & Deweese TL (2003) Expression of the DNA-PK binding protein E4-34K fails to confer radiation sensitivity to mammalian cells.. Int J Radiat Biol, 79(1), 53-60.
Collis SJ, Sangar VK, Tighe A, Roberts SA, Clarke NW, Hendry JH & Margison GP (2002) . Nucleic Acids Res, 30(2), E1.
Collis SJ, Tighe A, Scott SD, Roberts SA, Hendry JH & Margison GP (2001) . Nucleic Acids Res, 29(7), 1534-1538.
Dada OE, Chisango Z, Nkansah-Poku KAB, Sowah MN, Rodrigues ACLF, Duru O, Myers M, Williams ST, Ushewokunze S, Collis SJ , Shlobin NA et al () . Neuro-Oncology Practice.
Rominiyi O, McGarrity-Cottrell C, Myers KN, Jones CG, Wosnitzka K, Williams ST, Vanderlinden A, Antohi A-G, Gomez-Roman N, Chalmers AJ , Sinha S et al () . F1000Research, 13, 1316-1316.
Gagg H, Williams ST, Conroy S, Myers KN, McGarrity-Cottrell C, Jones C, Helleday T, Rantala J, Rominiyi O, Danson SJ , Collis SJ et al () . F1000Research, 12, 954-954.

Chapters

Marples B, Krueger SA, Collis SJ & Joiner MC (2008) , Targeted Radionuclide Tumor Therapy: Biological Aspects (pp. 329-347).
Collis SJ (2007) Molecular targeting of DNA repair: A means to improve therapeutic index, New Research on DNA Repair (pp. 1-37).

Conference proceedings papers

Gagg H, Williams S, Rominiyi O, Danson S, Collis S & Wells G (2023) . Neuro-Oncology, Vol. 25(Supplement_3) (pp iii5-iii6)
Gagg H, Williams S, Allen R, Conroy S, Rominiyi O, Wells G, Rantala J, Danson S, Helleday T & Collis S (2022) . Brain Tumor Research and Treatment, Vol. 10(Suppl) (pp s240). Seoul, Korea, 24 March 2022 - 24 March 2022.
Rominiyi O, Vanderlinden A, Clenton SJ, Bridgewater C, Al-Tamimi Y & Collis S (2022) . WFNOS 2022 Abstract Book, 24 March 2022 - 27 March 2022.
Zizzo C, Keating J, Sinha S, Al-Tamimi Y, Dyson B, Collis S & Rominiyi O (2022) . WFNOS 2022 Abstract Book, 24 March 2022 - 27 March 2022.
Cottrell CM, Myers K, Dunning M, Bagga V, Sinha S, Al-Tamimi Y, Wang D, Rominiyi O & Collis S (2022) . WFNOS 2022 Abstract Book, 24 March 2022 - 27 March 2022.
Rominiyi O, Myers K, Gomez-Roman N, Jellinek DA, Chalmers AJ, Carroll TA, Chen B, Al-Tamimi Y & Collis S (2022) . WFNOS 2022 Abstract Book, 24 March 2022 - 27 March 2022.
Vanderlinden A, McGarrity-Cottrell C, Myers K, Carroll TA, Al-Tamimi Y, Rominiyi O & Collis S (2022) . WFNOS 2022 Abstract Book, 24 March 2022 - 27 March 2022.
Rominiyi O, Gomez-Roman N, Al-Tamimi Y, Jellinek DA, Chalmers AJ, Carroll TA, Chen B & Collis S (2018) FA-BASED COMBINATIONS TO TARGET THE DNA DAMAGE RESPONSE IN GLIOBLASTOMA. NEURO-ONCOLOGY, Vol. 20 (pp 358-358)
Rominiyi O, Gomez-Roman N, Lad N, Al-Tamimi Y, Jellinek DA, Chalmers AJ, Carroll TA, Chen B & Collis SJ (2018) PRECLINICAL EVALUATION OF COMBINATIONS TARGETING THE DNA DAMAGE RESPONSE IN 2D AND 3D MODELS OF GLIOBLASTOMA STEM CELLS. NEURO-ONCOLOGY, Vol. 20 (pp 297-297)
Marples B, Krueger SA, Wilson TG, Dabjan MB, Lee KC, Hymas RV, Wilson GD & Collis SJ (2016) Improving the Efficacy of Pulsed Radiation Therapy Using DNA Repair Inhibitors: A Preclinical Study. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, Vol. 96(2) (pp E566-E567). Boston, Massachusetts, USA
Patil AA, Hua P, Sellwood MA, Jellinek DA, Carroll TA, Chen B & Collis SJ (2015) IDENTIFICATION OF NOVEL SMALL MOLECULE INHIBITORS OF THE FANCONI ANAEMIA DNA REPAIR PATHWAY AS A MEANS TO SENSITISES GLIOBLASTOMAS TO CHEMOTHERAPEUTIC AGENTS. NEURO-ONCOLOGY, Vol. 17 (pp 20-20)
DeWeese TL, Collis SJ, Lupold SE, Chowdury W, Kudrolli T, Swartz M & Rodriguez R (2007) Optimization of siRNA-transgene expression in adenoviral vector systems for radiation sensitizing strategies. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, Vol. 69(3) (pp S595-S596)
Collis SJ, Barber LJ, Martin JS, Ward JD & Boulton SJ (2006) . BREAST CANCER RESEARCH, Vol. 8 (pp S6-S6)

Preprints

Derby S, Dutton L, Strathdee K, Stevenson K, Clough E, Koessinger A, Yu W, Tian Y, Gilmour L, McGhee E , McGarrity-Cottrell C et al (2023) , Research Square Platform LLC.
Birch J, Strathdee K, Stevenson K, Derby S, Dutton L, Clough E, Koessinger A, Gilmour L, McGhee E, McGarrity-Cottrell C , Dibekeme AA et al (2021) , Research Square Platform LLC.
O’Regan L, Barone G, Adib R, Woo CG, Jeong HJ, Richardson EL, Richards MW, Muller PAJ, Collis SJ, Fennell DA , Choi J et al (2019) , Cold Spring Harbor Laboratory.
O'Regan L, Barone G, Adib R, Woo CG, Jeong HJ, Richardson EL, Richards MW, Muller PAJ, Collis S, Fennell D , Choi J et al () .

Research group

Research Group

Dr. Katie Myers (Research Assistant/Lab Manager)
Dr. Callum Jones (Postdoctoral Research Associate)
Dr. Nikita Lad (Postdoctoral Research Associate)
Dr. Sophie Williams (Clinical PhD Fellow)
Connor McGarrity-Cottrell (PhD student)
Hannah Gagg (PhD student with Dr. Greg Wells and Mr. Ola Rominiyi)
Kelsey Wosnitzka (PhD student with Mr. Ola Rominiyi)
Rebecca Livesey (PhD student with Prof. Fred Claeyssens)
Tegan Torpey (PhD student with Mr. Ola Rominiyi and Prof. Fred Claeyssens)

Teaching interests: M.Sc. Molecular Medicine
M.Sc. Translational Oncology
MSc Genomic Medicine