Professor Syed Hussain
MBBS, MSc, MD, FRCP
School of Medicine and Population Health
Professor of Medical Oncology


+44 114 215 9682
Full contact details
School of Medicine and Population Health
Room 228, 2nd Floor, Broomcross Building
Weston Park Hospital
Whitham Road
葫芦影业
S10 2SJ
- Profile
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For enquiries please contact - SMPH-West-Operational@sheffield.ac.uk
Professor Hussain graduated from Dow Medical College Karachi in 1994. He completed his general medical professional training in UK. He did his Doctorate in Oncology from University of Birmingham. He completed his medical oncology training in Birmingham, United Kingdom and received his certification and specialist registration in medical oncology.
Professor Hussain is Professor and Honorary Consultant in Medical Oncology at the University of 葫芦影业 and 葫芦影业 Teaching Hospitals NHS Trust. His major areas of interest are management of urological cancers, clinical trials, early drug development and translational medicine. He has set up several clinical trials from early phase to late phase studies during his career. His work on organ preservation in bladder cancer moved all the way from an early phase I study (Hussain et al Annals of Oncology 2001) to phase II efficacy study (Hussain et al BJC 2004) that led to a Cancer Research UK funded study BC2001 trial that was reported in New England Journal of Medicine (James, Hussain, Hall et al April 2012). This study has now changed the standard of care for patients with muscle invasive bladder cancer opting for organ preservation treatment globally. He has tailored split dose cisplatin regimen that has led to expand the spectrum of patients receiving cisplatin-based chemotherapy in bladder cancer (Hussain et al BJC 2004). He is a principal investigator of several studies in urological cancers. He was chief investigator of a national randomised placebo-controlled phase II neo-adjuvant study (NEOBLADE) in muscle invasive bladder cancer. He has served as a chief investigator of various early phase clinical trials, and translational studies. He is a chief investigator of a first in human window of opportunity study (INVEST) investigating the role of intravesical/intratumoral atezolizumab in patients with bladder cancer undergoing curative cystectomy. This is sponsored by STH and funded by Roche. He is also chief investigator of an international window of opportunity trial SOGUG NEOWIN investigating the role of erdafitinib and cetrelimab in FGF mutant bladder cancer patients undergoing curative cystectomy. This is jointly led by Hussain (UK), with Andrea Necchi (Italy), Yohann Loriot (France) and Guillermo Velasco (Spain) as other co-chief investigators. This study is funded by Janssen. He has authored over 125 peer-reviewed publications including 4 book chapters in textbooks of oncology. His Google scholar H-index is 40 with over 9800 citations (April 2023). He has published in high impact journals including New England Journal of Medicine, Lancet, Lancet Oncology, JAMA, JAMA Oncology, Journal of Clinical Oncology, European Urology, Annals of Oncology, Nature Communications, Clinical Cancer Research, British Journal of Cancer. He has been an invited speaker to number of national and international meetings and have delivered over 110 invited lectures. He has secured funding from cancer charities, national funding bodies and industries of over 拢15 million.
Professor Hussain was the member of NCRI Bladder and Renal group and Chair of the NCRI- Advanced Bladder Cancer sub-group in his national role. Professor Hussain was the expert witness to NICE on successful technology appraisals of Atezolizumab (2017), Avelumab (2021) and Nivolumab in Bladder cancer (2022).
- Research interests
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My major areas of interest are management of urological cancers, clinical trials, early drug development and translational medicine. I have set up a large number of clinical trials from early phase to late phase studies during my career.
My work on organ preservation in bladder cancer moved all the way from an early phase I study (Hussain et al Annals of Oncology 2001), to phase II efficacy study (Hussain et al BJC 2004) that led to a Cancer Research UK funded study BC2001 trial that was reported in New England Journal of Medicine (James, Hussain, Hall et al April 2012).
This study has now changed the standard of care for patients with muscle invasive bladder cancer opting for organ preservation treatment. I am principal investigator of a number of studies in urological cancers.
I am chief investigator of a national randomised placebo-controlled phase II neo-adjuvant study in muscle invasive bladder cancer and have served as chief investigator of various early phase trials, and translational studies.
I have authored over 125 peer-reviewed publications including 4 book chapters in textbooks of oncology. My Google scholar H-index is 40 with over 9800 citations (April 2023). I have published in high impact journals including New England Journal of Medicine, Lancet, Lancet Oncology, JAMA, JAMA Oncology, Journal of Clinical Oncology, European Urology, Annals of Oncology, Nature Communications, Clinical Cancer Research, British Journal of Cancer. I have been an invited speaker at a number of national and international meetings and have delivered over 110 invited lectures. I have secured funding from cancer charities, national funding bodies and industries of over 拢15 million.
Current Projects
- Setting up of clinical trials in bladder cancers.
- Early phase studies in bladder cancer.
- Development of panel of Biomarkers in bladder cancer.
- Translational research linked to bladder cancer clinical trials.
- Publications
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- Teaching interests
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I regularly taught pharmacology to both undergraduate and postgraduate students in my previous roles and supervised both MSc and PhD students in both their projects and research. I am also:
- Deputy Lead of Urology & Renal Phase 2a MBChB
- Academic Lead for Medical Oncology Clinical Academic Training Programme.
- Professional activities and memberships
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- Association of Cancer Physicians (ACP)
- European Society of Medical Oncology (ESMO)
- American Society of Clinical Oncology (ASCO)
- NCRI Blader & Renal Clinical studies group
- British Medical Association
- Chair of the NCRI Advanced Bladder Cancer 鈥 subgroup