Dr Thomas Darton
DTM&H MRCP(UK)(Infectious Diseases) FRCPath
Clinical Medicine, School of Medicine and Population Health
Florey Advanced Clinical Fellow
Honorary Consultant in Infectious Diseases
+44 114 215 9507
Full contact details
Clinical Medicine, School of Medicine and Population Health
LU109
The Medical School
Beech Hill Road
ºù«Ӱҵ
S10 2RX
- Profile
-
For enquiries, please contact – ClinMed-Operational@sheffield.ac.uk
I graduated from Nottingham in 2002 and completed general medical training in ºù«Ӱҵ. During an Academic Clinical Fellowship in ºù«Ӱҵ I became interested in the host-pathogen interactions occurring during invasive bacterial infection with Streptococcus pneumoniae and Neisseria meningitidis.
Between 2010 and 2014 I worked on the development of human challenge models of enteric fever (Salmonella Typhi and S. Paratyphi A) at the Oxford Vaccine Group (Oxford) and explored how these models relate to natural infection and how they might accelerate vaccine and diagnostic development. This work led to further studies of diagnostics, disease burden and vaccine implementation in endemic regions.
Antimicrobial resistance (AMR) is a major threat to global health and, for human-restricted pathogens such as S. Typhi, prevention by vaccination is a vital control strategy. After completion of specialist training and a Clinical Lectureship placement at the Oxford Clinical Research Unit in Ho Chi Minh City, Vietnam, I joined the Florey Institute for Host-Pathogen Interactions and the School of Medicine & Population Health in 2018 as a Florey Advanced Fellow.
- Research interests
-
-
Investigating the drivers of antimicrobial resistance in lower- and middle-income country settings.
-
Understanding the role and developing vaccines and diagnostics for enteric fever and other causes of non-specific febrile illness in low-resource settings.
-
The ethical use of human challenge studies to advance the discovery and translation of tools for patient benefit.
Current Projects
- Investigating the effects of environmental exposure to fluoroquinolone-resistant Enterobacteriaceae on the gastrointestinal microbiota of children in Vietnam (AMS CLSG 2016–2018).
- STRATAA: Understanding the burden of enteric fever in Africa and Asia: a study of transmission and antibiotic resistance to improve diagnostics and inform vaccine strategies (Wellcome Trust Strategic Award 2015–2019).
- Identification of serological diagnostic markers for typhoid fever by protein microarray (BMFG 2015–2017)
-
- Publications
-
Show: Featured publications All publications
Featured publications
Journal articles
- . The Lancet.
- . EMBO Molecular Medicine.
- . Clin Infect Dis.
- . mBio, 9(3).
- . BMJ Open, 7(6), e016283-e016283.
- . Clinical Infectious Diseases.
- . PLoS Neglected Tropical Diseases, 10(8).
- . The Journal of Experimental Medicine, 213(6), 1061-1077.
- . The Lancet Infectious Diseases, 15(7), 840-851.
- . Clinical Infectious Diseases, 58(9), 1230-1240.
- . Clinical Infectious Diseases, 48(5), 587-594.
- Epidemiology and control of tuberculosis in Western European cities. International Journal of Tuberculosis and Lung Disease, 7(8), 751-757.
- . Frontiers in Immunology, 8.
- . Frontiers in Microbiology, 8.
- . PLOS Neglected Tropical Diseases, 9(9), e0004029-e0004029.
All publications
Journal articles
- . Scientific Reports, 14(1).
- . The Lancet Microbe.
- . The Lancet Microbe, 5(3), e226-e234.
- . Nature Communications, 15.
- . Journal of Infection, 88(3), 106109-106109.
- . The Lancet Child & Adolescent Health, 8(3), 190-200.
- . The Lancet Microbe, 100902-100902.
- . Clinical Infection in Practice, 20, 100311-100311.
- . Clinical Infection in Practice, 20, 100304-100304.
- . Immunotherapy Advances, 3(1), ltad024.
- . The Lancet Diabetes & Endocrinology.
- . Frontiers in Cellular and Infection Microbiology, 13.
- . Infection and Immunity, 19(10).
- . The Lancet Global Health, 11(9), e1422-e1431.
- . BMC Infectious Diseases, 23(1).
- . The Lancet Infectious Diseases.
- . The Lancet.
- . Journal of Infection.
- . Nature Medicine, 29(1), 147-157.
- . Cochrane Database of Systematic Reviews, 2022(11).
- . PLoS ONE, 17(11).
- . The Lancet Infectious Diseases.
- . PLOS Global Public Health, 2(9).
- . The Lancet, 400(10349), 359-368.
- . Wellcome Open Research, 6.
- . Cellular Immunology, 378, 104572-104572.
- . Journal of Hospital Infection.
- . Infection and Immunity.
- . The Lancet, 399(10325), 665-676.
- . The Lancet, 399(10320), 143-151.
- . The Lancet.
- . The Lancet Global Health, 9(12), e1688-e1696.
- . Wellcome Open Research, 6.
- . Science Translational Medicine.
- . Journal of Infectious Diseases.
- . The Lancet.
- . Vaccine.
- . The Lancet, 397(10285), 1637-1645.
- . The Lancet.
- . The Lancet, 397(10282), 1351-1362.
- . The American Journal of Tropical Medicine and Hygiene.
- . The Lancet, 397(10277), 881-891.
- . The American Journal of Bioethics.
- . The Lancet.
- . The Lancet.
- . BMJ, 371.
- . The Lancet, 396(10267), 1979-1993.
- . PLOS Neglected Tropical Diseases, 14(10).
- . Wellcome Open Research, 5.
- . Clinical & Translational Immunology, 9(9).
- . Wellcome Open Research, 5.
- . Clinical Infectious Diseases, 71(Supplement_2), S64-S70.
- . Science, 369(6500), 151-151.
- . Clinical Infectious Diseases.
- . Bioethics.
- . Science.
- . Frontiers in Cellular and Infection Microbiology, 9.
- . Wellcome Open Research, 4.
- . EMBO Molecular Medicine.
- . Clin Infect Dis.
- . Frontiers in Medicine, 5, 262-262.
- . mBio, 9(3).
- . Antimicrobial Agents and Chemotherapy, 62(4).
- . BMJ Open, 8(1), e019611-e019611.
- . Transactions of The Royal Society of Tropical Medicine and Hygiene, 111(9), 418-424.
- . Vaccine, 35(38), 5081-5088.
- . BMJ Open, 7(6), e016283-e016283.
- . Journal of Infection.
- . Clinical Infectious Diseases, 64(8), 1066-1073.
- . BMC Infectious Diseases, 17.
- . Frontiers in Immunology, 8.
- . Frontiers in Immunology, 8.
- . Clinical Infectious Diseases.
- . Journal of Infection.
- . PLoS Neglected Tropical Diseases, 10(8).
- . PLoS Negl Trop Dis, 10(8), e0004888-e0004888.
- . PLOS Neglected Tropical Diseases, 10(6), e0004766-e0004766.
- . The Journal of Experimental Medicine, 213(6), 1061-1077.
- . PLoS ONE, 11(3).
- . Journal of Translational Medicine, 14(1).
- . Journal of Infection, 71(6), 689-689.
- . Clinical Infectious Diseases, 61(suppl 4), S266-S271.
- . BMJ Open, 5(6), e007481-e007481.
- . The Lancet Infectious Diseases, 15(7), 840-851.
- . Immunology, 143(3), 438-446.
- . Clinical Infectious Diseases, 59(8), 1198-1199.
- . Clinical Microbiology and Infection, 20(12), 1337-1342.
- . Clinical Infectious Diseases, 58(9), 1230-1240.
- . Journal of Infection, 68(5), 405-418.
- . Current Opinion in Gastroenterology, 30(1), 7-17.
- . Journal of Infection, 68, S38-S50.
- . Vaccine, 31(25), 2744-2748.
- . Surgery (Oxford), 31(4), 187-192.
- . International Journal of Infectious Diseases, 16, e244-e244.
- . International Journal of Infectious Diseases, 16, e224-e224.
- . International Journal of Infectious Diseases, 16, e215-e215.
- . Journal of Infection, 63(6), 496-497.
- . Clinical Infectious Diseases, 53(5), 463-467.
- . Clinical Infectious Diseases, 52(9), 1133-1136.
- . European Journal of Clinical Microbiology & Infectious Diseases, 29(3), 347-349.
- . Surgery (Oxford), 28(2), 95-100.
- . Journal of Infection, 59(5), 371-372.
- . Clinical Infectious Diseases, 48(5), 587-594.
- . Journal of Infection, 58(2), 172-173.
- . Critical Care, 12(Suppl 5), P25-P25.
- . Critical Care, 12(Suppl 5), P24-P24.
- . European Journal of Internal Medicine, 14, S151-S152.
- Epidemiology and control of tuberculosis in Western European cities. International Journal of Tuberculosis and Lung Disease, 7(8), 751-757.
- . Frontiers in Immunology, 15, 1384642.
- . Frontiers in Immunology, 15, 1454857.
- . The Journal of Infectious Diseases.
- . International Journal of Molecular Sciences, 24(22), 16053-16053.
- . Wellcome Open Research, 8, 111-111.
- . Communications Biology, 6(1).
- . Wellcome Open Research, 8, 111-111.
- . Wellcome Open Research, 6, 220-220.
- . Wellcome Open Research, 6, 220-220.
- .
- .
- . Frontiers in Immunology, 8.
- . PLOS Neglected Tropical Diseases, 11(11), e0006051-e0006051.
- . Frontiers in Immunology, 8.
- . Frontiers in Microbiology, 8.
- . Frontiers in Microbiology, 8.
- . PLOS Neglected Tropical Diseases, 9(9), e0004029-e0004029.
- . PLOS Neglected Tropical Diseases, 9(6), e0003837-e0003837.
- . PLOS Pathogens, 11(5), e1004914-e1004914.
- . Frontiers in Microbiology, 5.
- . Clinical Epidemiology, 465-465.
- . International Journal of Clinical Practice, 59(5), 605-611.
- . The American Journal of Bioethics, 1-4.
Chapters
Preprints
- Teaching interests
-
I teach on the Diploma of Tropical Medicine and Hygiene (DTM&H) in ºù«Ӱҵ, the in Nepal and Masters courses in molecular medicine and vaccinology. I am also involved in undergraduate and postgraduate teaching, demonstrating and supervision at the Medical School.
- Professional activities and memberships
-
- Member of the British HIV Association, British Infection Association, and the British Global and Travel Health Association.
- Member of the
Links