de Silva, Thushan, Professor

Professor Thushan de Silva

MBChB BSc (Hons) DTM&H MRCP FRCPath PhD

School of Medicine and Population Health

Professor of Infectious Diseases

Honorary Consultant Physician in Infectious Diseases

t.desilva@sheffield.ac.uk
+44 114 215 9532

The Medical School

Full contact details

Professor Thushan de Silva
School of Medicine and Population Health
The Medical School
Beech Hill Road
��«Ӱҵ
S10 2RX

Profile

I am an Infectious Diseases Clinician Scientist with a programme of research centred around clinical discovery science in the UK and Africa. Our group applies a broad range of methods including human immunology, epidemiology, molecular diagnostics and genomics, to establish how pathogens interact with human hosts at population and individual levels. We work primarily on respiratory viruses such as influenza and SARS-CoV-2, and Streptococcus pyogenes (Group A Streptococcus), investigating the natural history of infection and immunity to inform the design of diagnostic tools, vaccines, and other preventative measures. A specific area of interest is also how immunocompromising conditions such as HIV and haematopoietic stem cell transplantation impact the clinical risk and vaccine-induced immunity to respiratory viruses.

I am part of the Clinical Infection Research Group (CIRG) in the Medical School at the University of ��«Ӱҵ and am an Honorary Consultant Physician in Infectious Diseases in the South Yorkshire Regional Department of Infection and Tropical Medicine in ��«Ӱҵ. I am co-director of the Florey Institute of Infection and lead the host-pathogen interactions theme. I am also a Principal Investigator in the Vaccines and Immunity Theme at the Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine.

I completed my undergraduate medical training at the University of Bristol in 2000. Following postgraduate clinical training in General Internal Medicine, Infectious Diseases and HIV in Oxford and London, I moved to ��«Ӱҵ for higher specialist training in Infectious Diseases & Microbiology in 2004. After relocating to The MRC Unit The Gambia in 2007, I was awarded a British Infection Society Research Fellowship (2007-8), followed by a MRC Clinical Research Training Fellowship and PhD (2008 – 11) under the supervision of Professor Sarah Rowland-Jones and , to study the pathogenesis of HIV-2 infection and the molecular epidemiology of HIV-1 and HIV-2 in West Africa.

I joined the University of ��«Ӱҵ in 2013 as an NIHR Academic Clinical Lecturer in Infectious Diseases & Microbiology. I was awarded a Wellcome Trust Intermediate Clinical Fellowship (2016 -2021), based between Imperial College London and the MRC Unit The Gambia, to study the immunogenicity of intranasal Live Attenuated Influenza Vaccine in children and bidirectional interactions with nasopharyngeal microbiota. I returned to the University of ��«Ӱҵ as a Senior Clinical Lecturer in 2020 and led a programme of SARS-CoV-2 research through the COVID-19 pandemic, including roles as lead PI in ��«Ӱҵ for the and the study. I was awarded an MBE in 2021 for services to COVID-19 research.

Publications

Show: Featured publications All publications

Featured publications

Journal articles

Colton H, Barratt N, Temperton N, Hornsby H, Angyal A, Grouneva I, Lindsey BB, Kearns P, Barnes E, Goodyear CS , Richter A et al (2024) . British Journal of Haematology.
Jarju S, Wenlock RD, Danso M, Jobe D, Jagne YJ, Darboe A, Kumado M, Jallow Y, Touray M, Ceesay EA , Gaye H et al (2024) . Nature Communications, 15(1).
Armitage EP, de Crombrugghe G, Keeley AJ, Senghore E, Camara FE, Jammeh M, Bittaye A, Ceesay H, Ceesay I, Samateh B , Manneh M et al (2024) . The Lancet Microbe.
Hornsby H, Nicols AR, Longet S, Liu C, Tomic A, Angyal A, Kronsteiner B, Tyerman JK, Tipton T, Zhang P , Gallis M et al (2023) . Nature Communications, 14(1).
Barnes E, Goodyear CS, Willicombe M, Gaskell C, Siebert S, I de Silva T, Murray SM, Rea D, Snowden JA, Carroll M , Pirrie S et al (2023) . Nature Medicine, 29(7), 1760-1774.
Asante IA, Hsu SN, Boatemaa L, Kwasah L, Adusei-Poku M, Odoom JK, Awuku-Larbi Y, Foulkes BH, Oliver-Commey J, Asiedu EK , Parker MD et al (2023) . The Lancet Global Health, 11(7), e1075-e1085.
Keeley AJ, Groves D, Armitage EP, Senghore E, Jagne YJ, Sallah HJ, Drammeh S, Angyal A, Hornsby H, de Crombrugghe G , Smeesters PR et al (2023) . The Journal of Infectious Diseases, 228(7), 957-965.
Moore SC, Kronsteiner B, Longet S, Adele S, Deeks AS, Liu C, Dejnirattisai W, Reyes LS, Meardon N, Faustini S , Al-Taei S et al (2023) . Med, 4(3), 191-215.e9.
Kanteh A, Jallow HS, Manneh J, Sanyang B, Kujabi MA, Ndure SL, Jarju S, Sey AP, Damilare K D, Bah Y , Sambou S et al (2023) . The Lancet Global Health, 11(3), e414-e424.
Carabelli AM, Peacock TP, Thorne LG, Harvey WT, Hughes J, de Silva TI, Peacock SJ, Barclay WS, Towers GJ & Robertson DL (2023) . Nature Reviews Microbiology, 21(3), 162-177.
Miller PDE, Patel SR, Skinner R, Dignan F, Richter A, Jeffery K, Khan A, Heath PT, Clark A, Orchard K , Snowden JA et al (2023) . Journal of Infection, 86(1), 1-8.
Longet S, Hargreaves A, Healy S, Brown R, Hornsby HR, Meardon N, Tipton T, Barnes E, Dunachie S, Duncan CJA , Klenerman P et al (2022) . Frontiers in Immunology, 13.
Costa-Martins AG, Mane K, Lindsey BB, Ogava RLT, Castro IC, Jagne YJ, Sallah HJ, Armitage EP, Jarju S, Ahadzie B , Ellis-Watson R et al (2022) . Cell Reports Medicine, 3(2), 100516-100516.
Lindsey BB, Villabona-Arenas CJ, Campbell F, Keeley AJ, Parker MD, Shah DR, Parsons H, Zhang P, Kakkar N, Gallis M , Foulkes BH et al (2022) . Nature Communications, 13(1).
Angyal A, Longet S, Moore SC, Payne RP, Harding A, Tipton T, Rongkard P, Ali M, Hering LM, Meardon N , Austin J et al (2022) . The Lancet Microbe, 3(1), e21-e31.
Payne RP, Longet S, Austin JA, Skelly DT, Dejnirattisai W, Adele S, Meardon N, Faustini S, Al-Taei S, Moore SC , Tipton T et al (2021) . Cell, 184(23), 5699-5714.e11.
de Silva TI, Liu G, Lindsey BB, Dong D, Moore SC, Hsu NS, Shah D, Wellington D, Mentzer AJ, Angyal A , Brown R et al (2021) . iScience, 103353-103353.
Peno C, Armitage EP, Clerc M, Balcazar Lopez C, Jagne YJ, Drammeh S, Jarju S, Sallah H, Senghore E, Lindsey BB , Camara J et al (2021) . The Lancet Microbe, 2(12), e656-e665.
Weissman D, Alameh M-G, de Silva T, Collini P, Hornsby H, Brown R, LaBranche CC, Edwards RJ, Sutherland L, Santra S , Mansouri K et al (2020) . Cell Host & Microbe.
Minter A, Hoschler K, Jagne YJ, Sallah H, Armitage E, Lindsey B, Hay JA, Riley S, de Silva TI & Kucharski A (2020) . The Journal of Infectious Diseases.
Korber B, Fischer WM, Gnanakaran S, Yoon H, Theiler J, Abfalterer W, Hengartner N, Giorgi EE, Bhattacharya T, Foley B , Hastie KM et al (2020) . Cell.
Armitage EP, Senghore E, Darboe S, Barry M, Camara J, Bah S, Marks M, Cerami C, Roca A, Antonio M , Turner CE et al (2019) . PLOS Neglected Tropical Diseases, 13(10).
de Lima DS, Cardozo LE, Maracaja-Coutinho V, Suhrbier A, Mane K, Jeffries D, Silveira ELV, Amaral PP, Rappuoli R, de Silva TI & Nakaya HI (2019) . Proceedings of the National Academy of Sciences, 116(34), 17121-17126.
Lindsey BB, Jagne YJ, Armitage EP, Singanayagam A, Sallah HJ, Drammeh S, Senghore E, Mohammed NI, Jeffries D, Höschler K , Tregoning JS et al (2019) . The Lancet Respiratory Medicine.
Lindsey BB, Armitage EP, Kampmann B & de Silva TI (2018) . The Lancet Infectious Diseases.
de Silva TI, Gould V, Mohammed NI, Cope A, Meijer A, Zutt I, Reimerink J, Kampmann B, Hoschler K, Zambon M & Tregoning JS (2017) . Journal of Immunological Methods.
de Silva TI, Peng Y, Leligdowicz A, Zaidi I, Li L, Griffin H, Blais M-E, Vincent T, Saraiva M, Yindom L-M , van Tienen C et al (2013) . Blood, 121(21), 4330-4339.
de Silva TI, Aasa-Chapman M, Cotten M, Hue S, Robinson J, Bibollet-Ruche F, Sarge-Njie R, Berry N, Jaye A, Aaby P , Whittle H et al (2012) . Journal of Virology, 86(2), 930-946.

All publications

Journal articles

Massai L, Carducci M, Rovetini L, Paterson A, Whitcombe A, McGregor R, Lorenz N, Keeley AJ, de Silva TI, Bennett J , Berlanda Scorza F et al (2025) . Journal of Immunological Methods, 536, 113786-113786.
Locke T, Siribaddana S, Jayaweera JAAS, Suligoy CM, de Silva TI, Corrigan RM & Darton TC (2024) . Microbial Genomics, 10(12).
Colton H, Barratt N, Temperton N, Hornsby H, Angyal A, Grouneva I, Lindsey BB, Kearns P, Barnes E, Goodyear CS , Richter A et al (2024) . British Journal of Haematology.
Saville TJ, Colton H, Jarju S, Armitage EP, Drammeh S, Tazzyman S, Jagne YJ, Sallah HJ, Senghore E, Evans CM , Darton TC et al (2024) . Scientific Reports, 14(1).
Wiseman JP, Scarrott JM, Alves-Cruzeiro J, Saffari A, Böger C, Karyka E, Dawes E, Davies AK, Marchi PM, Graves E , Fernandes F et al (2024) . EMBO Molecular Medicine.
Galgut O, Ashford F, Deeks A, Ghataure A, Islam M, Sambhi T, Ker YW, Duncan CJA, de Silva TI, Hopkins S , Hall V et al (2024) . Vaccine: X, 20, 100546-100546.
Hall JN, Bah SY, Khalid H, Brailey A, Coleman S, Kirk T, Hussain N, Tovey M, Chaudhuri RR, Davies S , Tilley L et al (2024) . Microbial Genomics, 10(8).
Sanyang B, de Silva TI, Camara B, Beloum N, Kanteh A, Manneh J, de Steenhuijsen Piters WAA, Bogaert D, Sesay AK & Roca A (2024) . iScience, 110626-110626.
Goodyear CS, Patel A, Barnes E, Willicombe M, Siebert S, de Silva TI, Snowden JA, Lim SH, Bowden SJ, Billingham L , Richter A et al (2024) . The Lancet Rheumatology, 6(6), e339-e351.
Jarju S, Wenlock RD, Danso M, Jobe D, Jagne YJ, Darboe A, Kumado M, Jallow Y, Touray M, Ceesay EA , Gaye H et al (2024) . Nature Communications, 15(1).
Liu C, Zhou D, Dijokaite-Guraliuc A, Supasa P, Duyvesteyn HME, Ginn HM, Selvaraj M, Mentzer AJ, Das R, de Silva TI , Ritter TG et al (2024) . Cell Reports Medicine, 101553-101553.
Armitage EP, de Crombrugghe G, Keeley AJ, Senghore E, Camara FE, Jammeh M, Bittaye A, Ceesay H, Ceesay I, Samateh B , Manneh M et al (2024) . The Lancet Microbe.
Liew F, Efstathiou C, Fontanella S, Richardson M, Saunders R, Swieboda D, Sidhu JK, Ascough S, Moore SC, Mohamed N , Nunag J et al (2024) . Nature Immunology, 25(4), 607-621.
Suau Sans M, Manneh M, Ceesay I, Bittaye A, de Crombrugghe G, Keeley AJ, de Silva TI, Palmer J, Armitage EP & Marks M (2024) . PLOS Global Public Health, 4(3).
Brittain G, Petrie J, Duffy KEM, Glover R, Hullock K, Papaioannou D, Roldan E, Beecher C, Bursnall M, Ciccarelli O , Coles AJ et al (2024) . BMJ Open, 14(2), e083582-e083582.
Carducci M, Whitcombe A, Rovetini L, Massai L, Keeley AJ, de Silva TI, Bennett J, Berlanda Scorza F, Iturriza M, Moreland NJ , Moriel DG et al (2024) . Journal of Immunological Methods, 526, 113618-113618.
Sidhu JK, Siggins MK, Liew F, Russell CD, Uruchurtu ASS, Davis C, Turtle L, Moore SC, Hardwick HE, Oosthuyzen W , Thomson EC et al (2024) . The Journal of Infectious Diseases, 230(1), e17-e29.
Hall J, Angyal A, Armitage E, Senghore E, Darboe S, Barry M, Camara J, Bah S, Keeley A, McCarthy J , Turner C et al (2023) . Clinical Infection in Practice, 20, 100304-100304.
Armitage EP, Keeley AJ, de Crombrugghe G, Senghore E, Camara FE, Jammeh M, Bittaye A, Ceesay H, Ceesay I, Samateh B , Manneh M et al (2023) . Wellcome Open Research, 8.
Hornsby H, Nicols AR, Longet S, Liu C, Tomic A, Angyal A, Kronsteiner B, Tyerman JK, Tipton T, Zhang P , Gallis M et al (2023) . Nature Communications, 14(1).
Barnes E, Goodyear CS, Willicombe M, Gaskell C, Siebert S, I de Silva T, Murray SM, Rea D, Snowden JA, Carroll M , Pirrie S et al (2023) . Nature Medicine, 29(7), 1760-1774.
Asante IA, Hsu SN, Boatemaa L, Kwasah L, Adusei-Poku M, Odoom JK, Awuku-Larbi Y, Foulkes BH, Oliver-Commey J, Asiedu EK , Parker MD et al (2023) . The Lancet Global Health, 11(7), e1075-e1085.
Panca M, Blackstone J, Stirrup O, Cutino-Moguel M-T, Thomson E, Peters C, Snell LB, Nebbia G, Holmes A, Chawla A , Machin N et al (2023) . Journal of Hospital Infection.
Williams DM, Hornsby HR, Shehata OM, Brown R, Gallis M, Meardon N, Newman TAH, Plowright M, Zafred D, Shun-Shion ASM , Hodder AJ et al (2023) . iScience, 26(7), 107056-107056.
Keeley AJ, Groves D, Armitage EP, Senghore E, Jagne YJ, Sallah HJ, Drammeh S, Angyal A, Hornsby H, de Crombrugghe G , Smeesters PR et al (2023) . The Journal of Infectious Diseases, 228(7), 957-965.
Dijokaite-Guraliuc A, Das R, Zhou D, Ginn HM, Liu C, Duyvesteyn HME, Huo J, Nutalai R, Supasa P, Selvaraj M , de Silva TI et al (2023) . Cell Reports, 42(4).
Goldswain H, Dong X, Penrice-Randal R, Alruwaili M, Shawli GT, Prince T, Williamson MK, Raghwani J, Randle N, Jones B , Donovan-Banfield I et al (2023) . Genome Biology, 24(1).
Moore SC, Kronsteiner B, Longet S, Adele S, Deeks AS, Liu C, Dejnirattisai W, Reyes LS, Meardon N, Faustini S , Al-Taei S et al (2023) . Med, 4(3), 191-215.e9.
Kanteh A, Jallow HS, Manneh J, Sanyang B, Kujabi MA, Ndure SL, Jarju S, Sey AP, Damilare K D, Bah Y , Sambou S et al (2023) . The Lancet Global Health, 11(3), e414-e424.
Turtle L, Thorpe M, Drake TM, Swets M, Palmieri C, Russell CD, Ho A, Aston S, Wootton DG, Richter A , de Silva TI et al (2023) . PLoS Medicine, 20(1).
Armitage EP, Keeley AJ, de Crombrugghe G, Senghore E, Camara FE, Jammeh M, Bittaye A, Ceesay H, Ceesay I, Samateh B , Manneh M et al (2023) . Wellcome Open Research, 8.
Carabelli AM, Peacock TP, Thorne LG, Harvey WT, Hughes J, de Silva TI, Peacock SJ, Barclay WS, Towers GJ & Robertson DL (2023) . Nature Reviews Microbiology, 21(3), 162-177.
Liew F, Talwar S, Cross A, Willett BJ, Scott S, Logan N, Siggins MK, Swieboda D, Sidhu JK, Efstathiou C , Moore SC et al (2023) . eBioMedicine, 87.
Miller PDE, Patel SR, Skinner R, Dignan F, Richter A, Jeffery K, Khan A, Heath PT, Clark A, Orchard K , Snowden JA et al (2023) . Journal of Infection, 86(1), 1-8.
Huo J, Dijokaite-Guraliuc A, Liu C, Zhou D, Ginn HM, Das R, Supasa P, Selvaraj M, Nutalai R, Tuekprakhon A , Duyvesteyn HME et al (2022) . Cell Reports, 111903-111903.
Colton H, Parker MD, Stirrup O, Blackstone J, Loose M, McClure CP, Roy S, Williams C, McLeod J, Smith D , Taha Y et al (2022) . Journal of Hospital Infection.
Stirrup O, Blackstone J, Mapp F, MacNeil A, Panca M, Holmes A, Machin N, Shin GY, Mahungu T, Saeed K , Saluja T et al (2022) . eLife, 11.
Longet S, Hargreaves A, Healy S, Brown R, Hornsby HR, Meardon N, Tipton T, Barnes E, Dunachie S, Duncan CJA , Klenerman P et al (2022) . Frontiers in Immunology, 13.
Boswell MT, Nazziwa J, Kuroki K, Palm A, Karlson S, Månsson F, Biague A, da Silva ZJ, Onyango CO, de Silva TI , Jaye A et al (2022) . Virus Evolution, 8(2).
Sanyang B, de Silva TI, Kanteh A, Bojang A, Manneh J, de Steenhuijsen Piters WAA, Peno C, Bogaert D, Sesay AK & Roca A (2022) . eBioMedicine, 83.
Wilkinson SAJ, Richter A, Casey A, Osman H, Mirza JD, Stockton J, Quick J, Ratcliffe L, Sparks N, Cumley N , Poplawski R et al (2022) . Virus Evolution, 8(2).
Smallman-Raynor MR & Cliff AD (2022) . Epidemiology and Infection, 150.
Parker MD, Stewart H, Shehata OM, Lindsey BB, Shah DR, Hsu S, Keeley AJ, Partridge DG, Leary S, Cope A , State A et al (2022) . Commun Biol, 5(1), 666.
Colton H, Hodgson D, Hornsby H, Brown R, Mckenzie J, Bradley KL, James C, Lindsey BB, Birch S, Marsh L , Wood S et al (2022) . Wellcome Open Research, 6, 220.
Relph KA, Russell CD, Fairfield CJ, Turtle L, de Silva TI, Siggins MK, Drake TM, Thwaites RS, Abrams S, Moore SC , Hardwick HE et al (2022) . Open Forum Infectious Diseases, 9(5).
Blackstone J, Stirrup O, Mapp F, Panca M, Copas A, Flowers P, Hockey L, Price J, Partridge D, Peters C , de Silva T et al (2022) . BMJ Open, 12(4), e052514-e052514.
Locke T, Parsons H, Briffa N, Stott M, de Silva TI & Darton TC (2022) . Journal of Hospital Infection.
Tomic A, Skelly DT, Ogbe A, O’Connor D, Pace M, Adland E, Alexander F, Ali M, Allott K, Azim Ansari M , Belij-Rammerstorfer S et al (2022) . Nature Communications, 13(1).
Lindsey BB, Villabona-Arenas CJ, Campbell F, Keeley AJ, Parker MD, Shah DR, Parsons H, Zhang P, Kakkar N, Gallis M , Foulkes BH et al (2022) . Nature Communications, 13(1).
Costa-Martins AG, Mane K, Lindsey BB, Ogava RLT, Castro IC, Jagne YJ, Sallah HJ, Armitage EP, Jarju S, Ahadzie B , Ellis-Watson R et al (2022) . Cell Reports Medicine, 3(2), 100516-100516.
Lindsey BB, Villabona-Arenas CJ, Campbell F, Keeley AJ, Parker MD, Shah DR, Parsons H, Zhang P, Kakkar N, Gallis M , Foulkes BH et al (2022) . Nature Communications, 13(1).
Cencioni MT, Genchi A, Brittain G, de Silva TI, Sharrack B, Snowden JA, Alexander T, Greco R & Muraro PA (2022) . Frontiers in Immunology, 12.
Jagne I, Keeley AJ, Bojang A, Camara B, Jallow E, Senghore E, Oluwalana C, Bah SY, Turner CE, Sesay AK , D’Alessandro U et al (2022) . BMC Infectious Diseases, 22(1).
Angyal A, Longet S, Moore SC, Payne RP, Harding A, Tipton T, Rongkard P, Ali M, Hering LM, Meardon N , Austin J et al (2022) . The Lancet Microbe, 3(1), e21-e31.
Costa-Martins AG, Mane K, Lindsey BB, Ogava RLT, Castro Í, Jagne YJ, Sallah HJ, Armitage EP, Jarju S, Ahadzie B , Ellis-Watson R et al (2021) . Cell Reports Medicine, 2(12).
Payne RP, Longet S, Austin JA, Skelly DT, Dejnirattisai W, Adele S, Meardon N, Faustini S, Al-Taei S, Moore SC , Tipton T et al (2021) . Cell, 184(23), 5699-5714.e11.
Boshier FAT, Venturini C, Stirrup O, Guerra-Assunção JA, Alcolea-Medina A, Becket AH, Byott M, Charalampous T, Filipe ADS, Frampton D , Glaysher S et al (2021) . J Infect.
de Silva TI, Liu G, Lindsey BB, Dong D, Moore SC, Hsu NS, Shah D, Wellington D, Mentzer AJ, Angyal A , Brown R et al (2021) . iScience, 103353-103353.
Peno C, Armitage EP, Clerc M, Balcazar Lopez C, Jagne YJ, Drammeh S, Jarju S, Sallah H, Senghore E, Lindsey BB , Camara J et al (2021) . The Lancet Microbe, 2(12), e656-e665.
Stirrup O, Boshier F, Venturini C, Guerra-Assunção JA, Alcolea-Medina A, Beckett A, Charalampous T, da Silva Filipe A, Glaysher S, Khan T , Kulasegaran Shylini R et al (2021) . BMJ Open Respiratory Research, 8(1), e001029-e001029.
Boshier FAT, Pang J, Penner J, Parker M, Alders N, Bamford A, Grandjean L, Grunewald S, Hatcher J, Best T , Dalton C et al (2021) . J Med Virol.
Abatan B, Agboghoroma O, Akemoke F, Antonio M, Awokola B, Bittaye M, Bojang A, Bojang K, Brotherton H, Cerami C , Clarke E et al (2021) . Emerging Infectious Diseases, 27(8), 2064-2072.
Colton H, Greenfield DM, Snowden JA, Miller PDE, Morley NJ, Wright J, Darton TC, Evans CM & de Silva TI (2021) . Vaccine, 39(34), 4778-4783.
Lindsey BB, Villabona-Arenas CJ, Campbell F, Keeley AJ, Parker MD, Shah DR, Parsons H, Zhang P, Kakkar N, Gallis M , Foulkes BH et al (2021) .
Drake TM, Riad AM, Fairfield CJ, Egan C, Knight SR, Pius R, Hardwick HE, Norman L, Shaw CA, McLean KA , Thompson AAR et al (2021) . The Lancet, 398(10296), 223-237.
De Silva TI & Malavige GN (2021) . Sri Lanka Journal of Medicine, 30(1), 4-8.
Stirrup O, Hughes J, Parker M, Partridge DG, Shepherd JG, Blackstone J, Coll F, Keeley A, Lindsey BB, Marek A , Peters C et al (2021) . eLife, 10.
Russell CD, Fairfield CJ, Drake TM, Turtle L, Seaton RA, Wootton DG, Sigfrid L, Harrison EM, Docherty AB, de Silva TI , Egan C et al (2021) . The Lancet Microbe.
Peacock T, Sheppard C, Brown J, Goonawardane N, Zhou J, Whiteley M, de Silva T, Barclay W & PHE Virology Consortium (2021) .
Peto L, Rodger G, Carter DP, Osman KL, Yavuz M, Johnson K, Raza M, Parker MD, Wyles MD, Andersson M , Justice A et al (2021) . Journal of Clinical Microbiology, 59(6).
de Silva T, Liu G, B Lindsey B, Dong D, Shah D, J. Mentzer A, Angyal A, Brown R, D. Parker M, Ying Z , Yao X et al (2021) .
Ogbe A, Kronsteiner B, Skelly DT, Pace M, Brown A, Adland E, Adair K, Akhter HD, Ali M, Ali SE , Angyal A et al (2021) . Nature Communications, 12(1).
ten-Caten F, Gonzalez-Dias P, Castro Í, Ogava RLT, Giddaluru J, Silva JCS, Martins F, Gonçalves ANA, Costa-Martins AG, Araujo JD , Viegas AC et al (2021) . International Journal of Infectious Diseases, 105, 579-587.
Angyal A, Longet S, Moore S, Payne R, Harding A, Tipton T, Rongkard P, Ali M, Hering L, Meardon N , Austin J et al (2021) .
Parker MD, Lindsey BB, Leary S, Gaudieri S, Chopra A, Wyles M, Angyal A, Green LR, Parsons P, Tucker RM , Brown R et al (2021) . Genome Research.
Thomson EC, Rosen LE, Shepherd JG, Spreafico R, da Silva Filipe A, Wojcechowskyj JA, Davis C, Piccoli L, Pascall DJ, Dillen J , Lytras S et al (2021) . Cell, 184(5), 1171-1187.e20.
Williams EJ, Mair L, de Silva TI, Green DJ, House P, Cawthron K, Gillies C, Wigfull J, Parsons H & Partridge DG (2021) . Journal of Hospital Infection.
Leary S, Gaudieri S, Parker MD, Chopra A, James I, Pakala S, Alves E, John M, Lindsey BB, Keeley AJ , Rowland-Jones SL et al (2021) . Pathogens and Immunity, 6(2), 27-49.
Weissman D, Alameh M-G, de Silva T, Collini P, Hornsby H, Brown R, LaBranche CC, Edwards RJ, Sutherland L, Santra S , Mansouri K et al (2020) . Cell Host & Microbe.
Remmington A, Haywood S, Edgar J, Green LR, de Silva T & Turner CE (2020) . Microbial Genomics.
Boshier FAT, Pang J, Penner J, Hughes J, Parker M, Shepherd J, Alders N, Bamford A, Grandjean L, Grunewald S , Hatcher J et al (2020) .
Peng Y, Mentzer AJ, Liu G, Yao X, Yin Z, Dong D, Dejnirattisai W, Rostron T, Supasa P, Liu C , López-Camacho C et al (2020) . Nature Immunology, 21(11), 1336-1345.
Minter A, Hoschler K, Jagne YJ, Sallah H, Armitage E, Lindsey B, Hay JA, Riley S, de Silva TI & Kucharski A (2020) . The Journal of Infectious Diseases.
Korber B, Fischer WM, Gnanakaran S, Yoon H, Theiler J, Abfalterer W, Hengartner N, Giorgi EE, Bhattacharya T, Foley B , Hastie KM et al (2020) . Cell.
The COVID-19 Genomics UK (COG-UK) consortium , Wang D, Angyal A, Brown RL, Carrilero L, de Silva TI, Green LR, Groves DC, Keeley AJ, Lindsey BB , Parker MD et al (2020) . The Lancet Microbe, 1(3), e99-e100.
Keeley AJ, Evans CM & de Silva TI (2020) . Thorax, 75(8), 621-622.
Adams ER, Ainsworth M, Anand R, Andersson MI, Auckland K, Baillie JK, Barnes E, Beer S, Bell JI, Berry T , Bibi S et al (2020) . Wellcome Open Research, 5.
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de Lima DS, Cardozo LE, Maracaja-Coutinho V, Suhrbier A, Mane K, Jeffries D, Silveira ELV, Amaral PP, Rappuoli R, de Silva TI & Nakaya HI (2019) . Proceedings of the National Academy of Sciences, 116(34), 17121-17126.
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Sabbah S, Jagne YJ, Zuo J, de Silva T, Ahasan MM, Brander C, Rowland-Jones S, Flanagan KL & Hislop AD (2012) . Blood, 119(9), 2083-2092.
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de Silva T & Weiss RA (2010) HIV-2 goes global: An unaddressed issue in Indian anti-retroviral programmes. Indian Journal of Medical Research, 132(12), 660-662.
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de Silva TI, Post FA, Griffin MD & Dockrell DH (2007) . Mayo Clinic Proceedings, 82(9), 1103-1116.
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Jarju S, Wenlock R, Danso M, Jobe D, Jagne YJ, Darboe A, Kumado M, Jallow Y, Touray M, Ceesay EA , Gaye H et al () SARS-CoV-2 Incidence and Re-Infection During Delta and Omicron Ba.1 Waves in the Gambia: Results from a Prospective Household Cohort Study in a Population with Low SARS-CoV-2 Vaccine Coverage.
Goodyear CS, Patel A, Barnes E, willicombe M, Siebert S, de Silva TI, Snowden JA, Lim S, Bowden S, Billingham LJ , Richter AG et al () Immunogenicity of SARSCoV2 Third Dose Vaccine Strategies in Immunocompromised Patients with Suboptimal Immunity Following Two Doses (OCTAVE-DUO): An Open-Label, Multi-Centre, Randomised, Controlled Phase III Trial.
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Chapters

Abrahamian FM, Aldape MJ, Aldasoro E, Allen UD, Al-Sum H, Anadkat MJ, Anders K, Angelakis E, Angus BJ, Antoniadou A , Arena F et al (2017) , Infectious Diseases (pp. xv-xxxvi). Elsevier
De Silva TI & Green ST (2017) , Infectious Diseases (pp. 133-135.e1). Elsevier
Moysi E, de Silva T & Rowland-Jones S (2012) , Models of Protection Against HIV/SIV (pp. 293-315). Elsevier
Ball TB, Barré-Sinoussi F, Biasin M, Blankson JN, Broliden K, Buckheit RW, Card CM, Clerici M, de Silva T, Fellay J , Fowke KR et al (2012) , Models of Protection Against HIV/SIV (pp. xi-xii). Elsevier

Conference proceedings papers

Miller PDE, de Silva T, Leonard H, Goddard K, Anthias C, Hoschler K, Peggs K, Madrigal A & Snowden JA (2017) Viral microneutralization assay to determine seasonal influenza vaccine immunogenicity in the first year post reduced intensity conditioning allogeneic HSCT. BONE MARROW TRANSPLANTATION, Vol. 52 (pp S269-S270)
Miller PDE, de Silva T, Skinner R, Gilleece M, Peniket A, Hamblin A, Greenfield D, Anthias C, Peggs K, Madrigal A , Snowden JA et al (2016) Routine Vaccination Programme (RVP) Practice after Adult and Paediatric Allogeneic Haematopoietic Stem Cell Transplant (HSCT): A British Society of Blood and Marrow Transplantation (BSBMT) Survey of UK NHS-Based Programmes. BONE MARROW TRANSPLANTATION, Vol. 51 (pp S400-S401)
Meiring J, De Silva T & Snowden J (2015) A study of adherence to a vaccination schedule following adult allogenic haematopoietic stem cell transplants in UK transplant centre. BONE MARROW TRANSPLANTATION, Vol. 50 (pp S203-S204)

Preprints

Keeley AJ, Camara FE, Armitage E, de Crombrugghe G, Sillah J, Fofana ML, Rollinson V, Senghore E, Jammeh M, Whitcombe AL , Bittaye A et al (2025) , Cold Spring Harbor Laboratory.
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Hall JN, Armitage EP, Senghore E, Darboe S, Barry M, Camara J, Bah S, Keeley AJ, McCarthy JS, Smeesters P , Turner CE et al (2024) , Cold Spring Harbor Laboratory.
Brudenell EL, Pohare MB, Zafred D, Phipps J, Hornsby HR, Darby J, Dai J, Liggett E, Cain K, Barran PE , de Silva TI et al (2024) , Cold Spring Harbor Laboratory.
Openshaw P, Liew F, Efstathiou C, Fontanella S, Richardson M, Saunders R, Swieboda D, Sidhu J, Ascough S, Moore S , Mohamed N et al (2023) , Research Square Platform LLC.
Ali M, Longet S, Neale I, Rongkard P, Chowdhury FUH, Hill J, Brown A, Laidlaw S, Tipton T, Hoque A , Hassan N et al (2023) , Cold Spring Harbor Laboratory.
Liew F, Efstathiou C, Fontanella S, Richardson M, Saunders R, Swieboda D, Sidhu JK, Ascough S, Moore SC, Mohamed N , Nunag J et al (2023) , Cold Spring Harbor Laboratory.
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Hornsby H, Nicols AR, Longet S, Liu C, Tomic A, Angyal A, Kronsteiner B, Tyerman JK, Tipton T, Zhang P , Gallis Ramalho M et al (2023) , Cold Spring Harbor Laboratory.
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Liew F, Talwar S, Cross A, Willett BJ, Scott S, Logan N, Siggins MK, Swieboda D, Sidhu JK, Efstathiou C , Moore SC et al (2022) , Cold Spring Harbor Laboratory.
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Leary S, Gaudieri S, Parker MD, Chopra A, James I, Pakala S, Alves E, John M, Lindsey BB, Keeley AJ , Rowland-Jones SL et al (2020) , Cold Spring Harbor Laboratory.
Armitage EP, Senghore E, Darboe S, Barry M, Camara J, Bah S, Marks M, Cerami C, Roca A, Antonio M , Turner CE et al (2019) , Cold Spring Harbor Laboratory.
Jarju S, Senghore E, Brotherton H, Saidykhan A, Jallow S, Krubally E, Sinjanka E, Ndene MN, Bajo F, Sanyang M , Saidy B et al () , Cold Spring Harbor Laboratory.
Turtle L, Thorpe M, Drake TM, Swets M, Palmieri C, Russell CD, Ho A, Aston S, Wootton DG, Richter A , de Silva TI et al () , Cold Spring Harbor Laboratory.
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Moore SC, Kronsteiner B, Longet S, Adele S, Deeks AS, Liu C, Dejnirattisai W, Silva Reyes L, Meardon N, Faustini S , Al-Taei S et al () , Cold Spring Harbor Laboratory.
Stirrup O, Blackstone J, Mapp F, MacNeil A, Panca M, Holmes A, Machin N, Shin GY, Mahungu T, Saeed K , Saluja T et al () , Cold Spring Harbor Laboratory.
Phillips E, Adele S, Malone T, Deeks A, Stafford L, Dobson SL, Amini A, Skelly D, Eyre D, Jeffery K , Conlon CP et al () , Cold Spring Harbor Laboratory.
Smallman-Raynor MR & Cliff AD () , Cold Spring Harbor Laboratory.
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Teaching interests: I am involved in delivering the undergraduate (MBChB) Infectious Diseases, Tropical Medicine and Microbiology curriculum at the University of ��«Ӱҵ. I also lecture on the MSc in Antimicrobial Resistance (MED404), Molecular Medicine MSc (MED6006) and Pharmacology of Respiratory Disease (CDL302, Biomedical Science).

Professional activities and memberships

National and International

British Infection Association Scientific and Research Secretary (2023 - )
Wellcome Trust Early Career Award Interview Committee, Infection and Immunobiology (2022 - )
Africa Research Excellence Fund () College of Experts (2022 - )
Chair, Vaccines Subcommittee, British Society of Blood and Marrow Transplantation and cellular therapy (BSBMTCt), vaccination subcommittee (2023 - )
Associate Editor, Journal of Infection (2019 - )

Local

Co-Director, Florey Institute of Infection (2023 - )
Director of CL3 suite, Medical School, University of ��«Ӱҵ (2022 - )
UREC Ethics reviewer for Medical School (2022 -)
University of ��«Ӱҵ Biosafety Committee (2019 -)

Research themes and key projects

Mucosal and systemic immunity to respiratory viruses

Hybrid immunity to SARS-CoV-2 in Zimbabwean adults with HIV and other chronic diseases (Bill and Melinda Gates Foundation, 2023 – 2026). Key collaborators: Professor Sarah Rowland-Jones, , .
Study of SARS-CoV-2 systemic and mucosal immunity within a household transmission study in The Gambia (UKRI). Key collaborators: , .
Study of SARS-CoV-2 T-cell and antibody responses as part of the , and consortium (2024 – 2028).
Part of a consortium to establish a (Chan Zuckerberg Initiative, 2021 – 2025).
Supervisor for Dr. Ben Lindsey, Wellcome Trust 4ward North Clinical PhD fellowship on inflammatory memory in the upper respiratory tract following respiratory viral infections (2023 – 2026).

Epidemiology of respiratory viruses

Surveillance for SARS-CoV-2 and other respiratory viruses by establishment of a sentinel surveillance platform for influenza-like illness in The Gambia, along with a household transmission cohort (TransVir) with , , Dr. Abdul Karim Sesay.
University of ��«Ӱҵ lead for the COVID-19 Genomics Consortium UK (COG-UK), using Oxford Nanopore Technology (ONT) to sequence SARS-CoV-2 isolates in South Yorkshire. Building on our group’s sequencing expertise gained during this project, we are now focusing on optimising ONT-based assays with direct utility in NHS diagnostic microbiology and virology laboratories. This aligns work with key deliverables our group are leading within the Infection and Immunity Theme of .

The epidemiology and immune responses to Streptococcus pyogenes

Several clinical and molecular epidemiology studies forming part of the MRC Unit The Gambia Strep A research portfolio, with Dr. Claire Turner (School of Biosciences), (LSHTM) and (MRC Gambia).

Co-supervisor for three Wellcome Trust Clinical PhD Training Fellows in Global Health (Dr. Edwin Armitage, Dr. Alex Keeley, Dr Ed Monk) who are using the platform of a household and school transmission studies to explore transmission and natural immunity to S. pyogenes.
Co-lead at the MRC Gambia in a global network of scientists seeking to define correlates of immune protection in natural infection with Streptococcus pyogenes (iSpy Network, 2023 - 2027).
Lead for immunology studies across UoS and MRC Gambia in a Wellcome Trust funded S. pyogenes human challenge study to establish correlates of protection (2025 – 2027).