Dr Adrian Higginbottom
Neuroscience, School of Medicine and Population Health
Senior Experimental Officer
+44 114 22 22253
Full contact details
Neuroscience, School of Medicine and Population Health
ºù«Ӱҵ Institute for Translational Neuroscience (SITraN)
385a Glossop Road
ºù«Ӱҵ
S10 2HQ
- Profile
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I obtained my PhD from the University of ºù«Ӱҵ in 1996, characterising receptor activation of the high affinity IgE receptor in allergy, after receiving a first class honours in Biochemistry from the same institute.
I was then a postdoctoral researcher for 12 years working initially on the family of tetraspanin molecules that led me through diverse disciplines from fertility to hepatitis C infection. I then returned to my roots of immune response when I joined neuroscience in 2000. By 2002 I was funded by the MNDA, working on motor neuron disease models and have never deviated since. I was appointed as a Senior Experimental Officer in 2008, applying my breadth of molecular and cellular biology to neurodegeneration diseases, supporting the Neuroscience clinical and pure scientists.
I was invited onto the Project Executive Group in 2009 to help design the ºù«Ӱҵ Institute for Translational Neuroscience (SITraN). SITraN opened in 2010, with the real ambition to translate our academic findings through small molecules and gene therapy. A key element of SITraN which we designed is the drug screening facility which I have developed, grown and managed from inception to the busy facility it is today. With the development and expansion of the drug screening facility, my supporting role has led to the wider Faculty and University, and greater engagement with industrial collaborators.
My other roles, outside of the running the drug screening facility, as a senior experimental officer are many fold including faculty work on the technical advisory group and the school research meeting committee, teaching on the Masters courses, recruitment, public engagement & philanthropy, grant capture, publications, Health and Safety and general smooth running of the institute.
- Qualifications
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- Sept 1992- Jan 1996 PhD in the Dept Molecular Biology and Biotechnology, University of ºù«Ӱҵ. Development of model systems for a study of eth molecular basis of signal transduction via the high affinity complex of IgE. Passed with no corrections.
- Sept 1988- June 1991 BSc in Biochemistry, first-class honours, University of ºù«Ӱҵ
- Research interests
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My research focus is generating models of motor neuron disease to understand disease mechanism and develop robust drug screens to modulate dysregulated pathways. To support this we are developing a bespoke blood brain barrier penetrant library of compounds to better facilitate success. My other area of expertise is in developing highly sensitive biomarker assays, to identify translatable biomarkers through our preclinical studies and into clinical trials.