Dr Andrew Grierson
PhD
Neuroscience, School of Medicine and Population Health
Senior Lecturer in Neuroscience
+44 114 222 2277
Full contact details
Neuroscience, School of Medicine and Population Health
Room B25
葫芦影业 Institute for Translational Neuroscience (SITraN)
385a Glossop Road
葫芦影业
S10 2HQ
- Qualifications
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2009 鈥損resent: Senior Lecturer
2001 - 2008: Lecturer, University of 葫芦影业
1997 - 2001: Postdoctoral Research Associate, Institute of Psychiatry, Kings College London
1994 - 1997: Postdoctoral Research Associate, University of Amsterdam, Netherlands
1991 - 1994: PhD (Molecular Genetics) University of 葫芦影业
1988 - 1991: BSc (Genetics) University of 葫芦影业
- Research interests
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Research in my laboratory concerns identifying the molecular mechanisms underlying the regulation of axonal transport in health and disease. In particular we are investigating the involvement of axonal transport in diseases including motor neurone disease (MND) and hereditary spastic paraplegia (HSP).
In addition we are developing and characterising novel vertebrate models of neurodegeneration in zebrafish and mouse. With support from the NC3Rs we are refining the widely used SOD1G93A model of motor neuron disease.
Current projects
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Preclinical testing of HDAC6 inhibition in a zebrafish model of CMT2A (Hereditary Neuropathy Foundation)Investigating the function of the C9ORF72 protein in motor neuron disease (University Studentship)
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Preclinical assessment of histone deacetylase 6 (HDAC6) inhibition as a therapy for hereditary spastic paraplegia (Spastic Paraplegia Foundation)
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ANIMPACT: An ethical, legal and practical perspective on the impact of a new regulatory framework for the scientific use of animals on research and innovation (European Union) Zebrafish C9orf72 loss of function models of ALS (MND Association)
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Role of C9ORF72 in proteostasis. (De Vos PI) (Thierry Latran Foundation) ROLE OF MITOCHONDRIA IN C9ORF72-RELATED ALS/MND (De Vos is PI) (MND Association)
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Preclinical assessment of spastin gene replacement therapy as a treatment for hereditary spastic paraplegia (Spastic Paraplegia Foundation)
Research collaborations
- Pamela Shaw, Academic Neurology Unit, University of 葫芦影业
- , University of 葫芦影业
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- Publications
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Journal articles
- . Frontiers in Cellular Neuroscience, 16.
- . Life Science Alliance, 5(9), e202101276-e202101276.
- Loss of TMEM106B exacerbates C9ALS/FTD DPR pathology by disrupting autophagosome maturation. Frontiers in cellular neuroscience, 16.
- . Development.
- . Scientific Reports, 11.
- . Molecular Therapy 鈥 Methods & Clinical Development, 21, 413-433.
- . Autophagy.
- . BMJ Open Science, 3(1).
- . Small GTPases.
- . EMBO Journal, 35(15), 1656-1676.
- . Molecular Therapy - Methods and Clinical Development, 3.
- . Neurobiology of Aging, 36(10), 2893-2903.
- . PLoS ONE, 9(9), e107918-e107918.
- . Behav Brain Res, 259, 274-283.
- . Neurobiol Aging, 35(6), 1499-1509.
- . Plos One, 6(8), e68256-e68256.
- . Free Radic Biol Med, 61, 438-452.
- . Hum Mol Genet, 22(12), 2376-2386.
- . PLoS One, 8(6), e67276.
- . PLoS One, 8(1), e54636.
- . PLoS ONE, 7(7).
- . Nat Rev Neurol, 7(11), 616-630.
- . PLoS One, 6(8), e23244.
- . Neuropathol Appl Neurobiol, 37(4), 336-352.
- . Hum Mol Genet, 20(8), 1574-1584.
- Role of Mitochondrial Dynamics in Neurodegeneration. J NEUROGENET, 24, 64-65.
- . Sci Transl Med, 2(35), 35ra42.
- . PLoS One, 5(3), e9872.
- . Neurogenetics, 10(2), 105-110.
- . J Neurochem, 110(1), 34-44.
- . Eur J Neurosci, 27(7), 1626-1633.
- . Annu Rev Neurosci, 31, 151-173.
- . Hum Mol Genet, 16(22), 2720-2728.
- . Neuropathol Appl Neurobiol, 31(5), 467-485.
- . Brain Res Mol Brain Res, 137(1-2), 104-109.
- . Curr Biol, 15(7), 678-683.
- . Mol Cell Neurosci, 26(2), 354-364.
- . J Cell Sci, 117(Pt 7), 1017-1024.
- . Ann Neurol, 54(6), 748-759.
- . J Neuropathol Exp Neurol, 62(11), 1166-1177.
- . J Cell Biol, 161(3), 489-495.
- . Blue Books of Practical Neurology, 28(C), 237-257.
- . Hum Mol Genet, 11(23), 2837-2844.
- . J Neurochem, 82(5), 1118-1128.
- Comparision of tau protein expression in AD, FTDP-17, PSP and Pick's disease. NEUROBIOL AGING, 23(1), S505-S505.
- . Cell Mol Life Sci, 59(2), 323-330.
- . Biochim Biophys Acta, 1536(1), 13-20.
- . Neurosci Lett, 298(1), 9-12.
- . J Neurochem, 76(1), 316-320.
- . J Cell Biol, 150(1), 165-176.
- . Neurobiology of Aging, 21, 113-113.
- . Neurosci Lett, 277(1), 9-12.
- Corrigendum: An integrated map of chromosome 18 CAG trinucleotide repeat loci (European Journal of Human Genetics (1999) 7 (12-19)). European Journal of Human Genetics, 7(8), 944.
- . Eur J Hum Genet, 7(1), 12-19.
- . Eur J Biochem, 254(2), 297-303.
- . J Neurochem, 70(1), 335-340.
- . Leuk Lymphoma, 23(3-4), 353-363.
- . Cancer Lett, 104(1), 27-30.
- . Psychiatric Genetics, 6(3), 148-148.
- . Ann Oncol, 5 Suppl 1, 47-50.
- . Public Administration, 6(3), 211-220.
- . Acta Neuropathologica.
- . Frontiers in Cell and Developmental Biology, 9.
- . PLoS ONE, 7(8).
- Spastin recovery in hereditary spastic paraplegia by preventing neddylation-dependent degradation. Life Science Alliance.
Chapters
Conference proceedings papers
- Arfaptin-2 as a therapeutic target for amyotrophic lateral sclerosis (ALS). HUMAN GENE THERAPY, Vol. 30(8) (pp A19-A20)
- . Journal of the Neurological Sciences, Vol. 357 (pp e49-e49)
- FISH ON DRUGS: A ZEBRAFISH PRECLINICAL MODEL FOR CMT2A. JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM, Vol. 20(2) (pp 92-93)
- Regulation of protein aggregation by Arfaptin2 in amyotrophic lateral sclerosis. HUMAN GENE THERAPY, Vol. 25(5) (pp A14-A14)
- A novel alternative splicing event rescues the mutant tardbp phenotype in a zebrafish model of TDP-43 related Amyotrophic Lateral Sclerosis (ALS). NEUROLOGY, Vol. 78
- A novel alternative splicing event rescues the mutant tardbp phenotype in a zebrafish model of TDP-43 related Amyotrophic Lateral Sclerosis (ALS). NEUROLOGY, Vol. 78
- . JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol. 83(3)
- Impact of Olesoxime on disease related mitochondrial membrane properties in mouse models of neurodegenerative diseases. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, Vol. 383 (pp 51-51)
- Systemic delivery of scAAV9 expressing SMN prolongs survival in a mouse model of SMA. HUMAN GENE THERAPY, Vol. 21(10) (pp 1424-1425)
- . JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol. 81 (pp A5-A5)
- Alterations of the Bcl-2 family oncoprotein members in a cell culture model of familial SOD1-related motor neurone disease. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol. 76(1) (pp 157-157)
- Hereditary spastic paraparesis associated with mutation in spastin (SPG4): A disorder of axonal transport?. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol. 74(10) (pp 1453-1453)
Preprints
- Research group
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- Natalie Rounding (PhD student)
- Khlood Mehdar (PhD student)
- Gary Shaw (Research Technician)
- Katie Adamson (Research Technician)
- Yolanda Gibson (PhD student)
- Grants
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