Dr Andrew Grierson
PhD
School of Medicine and Population Health
Senior Lecturer in Neuroscience
+44 114 222 2277
Full contact details
School of Medicine and Population Health
Room B25
葫芦影业 Institute for Translational Neuroscience (SITraN)
385a Glossop Road
葫芦影业
S10 2HQ
- Qualifications
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2009 鈥損resent: Senior Lecturer
2001 - 2008: Lecturer, University of 葫芦影业
1997 - 2001: Postdoctoral Research Associate, Institute of Psychiatry, Kings College London
1994 - 1997: Postdoctoral Research Associate, University of Amsterdam, Netherlands
1991 - 1994: PhD (Molecular Genetics) University of 葫芦影业
1988 - 1991: BSc (Genetics) University of 葫芦影业
- Research interests
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Research in my laboratory concerns identifying the molecular mechanisms underlying the regulation of axonal transport in health and disease. In particular we are investigating the involvement of axonal transport in diseases including motor neurone disease (MND) and hereditary spastic paraplegia (HSP).
In addition we are developing and characterising novel vertebrate models of neurodegeneration in zebrafish and mouse. With support from the NC3Rs we are refining the widely used SOD1G93A model of motor neuron disease.
Current projects
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Preclinical testing of HDAC6 inhibition in a zebrafish model of CMT2A (Hereditary Neuropathy Foundation)Investigating the function of the C9ORF72 protein in motor neuron disease (University Studentship)
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Preclinical assessment of histone deacetylase 6 (HDAC6) inhibition as a therapy for hereditary spastic paraplegia (Spastic Paraplegia Foundation)
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ANIMPACT: An ethical, legal and practical perspective on the impact of a new regulatory framework for the scientific use of animals on research and innovation (European Union) Zebrafish C9orf72 loss of function models of ALS (MND Association)
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Role of C9ORF72 in proteostasis. (De Vos PI) (Thierry Latran Foundation) ROLE OF MITOCHONDRIA IN C9ORF72-RELATED ALS/MND (De Vos is PI) (MND Association)
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Preclinical assessment of spastin gene replacement therapy as a treatment for hereditary spastic paraplegia (Spastic Paraplegia Foundation)
Research collaborations
- Pamela Shaw, Academic Neurology Unit, University of 葫芦影业
- , University of 葫芦影业
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- Publications
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Journal articles
Chapters
Conference proceedings papers
Preprints
- Research group
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- Natalie Rounding (PhD student)
- Khlood Mehdar (PhD student)
- Gary Shaw (Research Technician)
- Katie Adamson (Research Technician)
- Yolanda Gibson (PhD student)
- Grants
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