Professor Arshad Majid
Neuroscience, School of Medicine and Population Health
Professor of Cerebrovascular Neurology
Deputy Dean of School of Medicine and Population Health
Consultant Neurologist, Royal Hallamshire Hospital
+44 114 222 2290
Full contact details
Neuroscience, School of Medicine and Population Health
ºù«Ӱҵ Institute for Translational Neuroscience (SITraN)
385a Glossop Road
ºù«Ӱҵ
S10 2HQ
- Profile
-
Professor Arshad Majid’s professional mission is to develop new therapies for patients afflicted with neurological diseases, especially cerebrovascular diseases.
Professor Majid’s training and background is unique in that as well as being a leading translational neuroscientist, he is also an accomplished Vascular and Interventional Neurologist. He graduated in Medicine from the University of Glasgow, Scotland.
After obtaining Membership of the Royal College of Physicians (MRCP) he moved to the USA where he did further training in Neurology at the University of Pennsylvania and Fellowship training in Stroke Research at Washington University in St. Louis.
He did additional Fellowship training in Endovascular Surgical Neuroradiology at the Medical College of Wisconsin. Professor Majid has published extensively in high impact international peer-reviewed journals, and presented at national and international meetings.
After finishing his training, Professor Majid served as the founding Director of the Division of Cerebrovascular Diseases at Michigan State University and was the founding Medical Director of the William and Claire Dart Stroke Center at Sparrow Health System.
Professor Majid is a diplomate of the American Board of Psychiatry and Neurology and is a Fellow of the Royal College of Physicians and Surgeons of Glasgow and also serves as their Regional Advisor.
He joined the University of ºù«Ӱҵ and Royal Hallamshire Hospital in August 2013 as Professor of Cerebrovascular Neurology and Consultant Neurologist.
Professor Majid also serves as a Governor of Rotherham NHS Foundation Trust.
- Research interests
-
Key research areas:
- Neuroprotection and Neuroregeneration
- Electroceuticals
- Stroke Clinical Trials,
- Animal and Cellular Models of Stroke and Neuroinflammation
- Novel Drug Delivery (nanotechnology and exosomes)
- Remote Conditioning, Vagus Nerve Stimulation.
Professor Majid is the Director of the Comprehensive Cerebrovascular Research Unit (CCRU). Professor Majid's focus is translational neuroscience research with special focus on cerebrovascular disease and neuroinflammation.
Stroke models: The models that are used in his research include both in vitro models (cell culture) and in vivo models (focal ischaemia and global ischaemia).
He is interested in understanding the pathogenesis of cerebrovascular diseases with the overall aim of developing new treatment and brain repair strategies. To this end, his lab has been successful in developing two novel treatments which are undergoing further preclinical testing before they are taken to the clinic.
He has a particular interest in ischaemic preconditioning, a fascinating phenomenon whereby animals exposed to sub-lethal or mild insults develop protection against subsequent severe insults. His lab has developed a mouse model of ischaemic preconditioning which is used extensively in their research efforts.
Other interests and areas of collaboration include: large animal (ovine) models of stroke, clinical outcomes research, clinical trials, stroke epidemiology and translational bioengineering.
- Neuroinflammation: In collaboration with Professor Basil Sharrack, Professor Majid’s lab are working on neuroprotection in Multiple Sclerosis (MS) and are developing in vitro and in vivo models of MS such as the Experimental Allergic Encephalomyelitis (EAE). This work involves study of novel carnosine analogues and the use of exosomes to modulate neuroinflammation.
- Vagal nerve stimulation: In collaboration with Dr. Jessica Redgrave and Harvey Leung (PhD student), Professor Majid has been evaluating the mechanisms of action and the feasibility and safety of invasive and non-invasive vagal nerve stimulation in limb and speech recovery after stroke.
- Exercise and stroke: In collaboration with Dr. Ali Ali, ºù«Ӱҵ Teaching Hospitals, the safety and efficacy of post stroke and TIA exercise programmes are being evaluated.
- Stroke vaccine: Professor Majid’s lab has developed a therapeutic vaccine which is in the final stages of preclinical testing. This project is being led by Dr. Saurabh Jain (post-doctoral fellow).
His research has been funded by the NIH, the American Heart Association, MRC (UK), NIHR (UK) and industry.
- Publications
-
Edited books
Journal articles
- . Neurorehabilitation and Neural Repair.
- . Annals of Pharmacotherapy, 56(12), 1386-1387.
- . Toxicological Research, 38(4), 479-486.
- . Stroke, 53(Suppl_1).
- . Annals of Pharmacotherapy.
- . Life Sciences in Space Research.
- . Autonomic Neuroscience, 237, 102909-102909.
- . International Journal of Peptide Research and Therapeutics, 28(1).
- . International Journal of Molecular Sciences, 22(14).
- . Stroke, 52(7), 2445-2455.
- . Stroke and Vascular Neurology, 6(2).
- . The Lancet, 397(10284), 1545-1553.
- . Frontiers in Human Neuroscience, 14.
- . International Journal of Molecular Sciences, 22(5).
- . Arteriosclerosis, Thrombosis, and Vascular Biology, 41(3), 1127-1145.
- . Scientific Reports, 10(1).
- . Journal of Extracellular Vesicles, 10(1).
- . BMJ Open Sport & Exercise Medicine, 6(1).
- . International Journal of Molecular Sciences, 21(9).
- . Journal of Neurology, Neurosurgery & Psychiatry, 91(4), 396-401.
- . Fluids and Barriers of the CNS, 17(1).
- . Efficacy and Mechanism Evaluation, 7(1).
- . Journal of Pharmaceutical Investigation, 50(4), 373-381.
- . Journal of Stroke and Cerebrovascular Diseases, 28(12).
- . Cerebrovascular Diseases, 48(3-6), 184-192.
- . Safety Science, 118, 881-886.
- . Nutrients, 11(6).
- . Basic Science.
- . The FASEB Journal, 33(S1).
- . Multiple Sclerosis Journal, 25(3), 306-324.
- . The Lancet, 393(10168), 265-274.
- . Frontiers in Cell and Developmental Biology, 6.
- . British Journal of Sports Medicine, 53(24), 1515-1525.
- . Frontiers in Cellular Neuroscience, 12.
- . Brain Stimulation, 11(6), 1225-1238.
- . Journal of Stroke & Cerebrovascular Diseases, 27(7), 1998-2005.
- . Stroke, 49(6), 1571-1579.
- . Journal of Toxicology and Environmental Health, Part A, 81(9), 266-277.
- . Current Opinion in Supportive and Palliative Care, 12(2), 142-147.
- . Topics in Stroke Rehabilitation, 25(3), 214-223.
- . International Journal of Pharmaceutics, 525(1), 92-100.
- . Mol Neurobiol.
- . Journal of Cerebral Blood Flow and Metabolism, 36(10), 1686-1694.
- . Eur J Pharm Biopharm, 108, 187-195.
- . Chemico-Biological Interactions, 256, 102-110.
- . Stroke, 47(suppl_1).
- . Molecular Neurobiology, 53(4), 2579-2593.
- The role of relatives in help-seeking for patients with stroke/TIA: Results from Stroke and TIA Awareness and Response to Symptoms (STARS) study. INTERNATIONAL JOURNAL OF STROKE, 10, 121-121.
- Ethnic minority recruitment into stroke research trials at a university teaching hospital in the UK.. CEREBROVASCULAR DISEASES, 39, 287-287.
- Post stroke cognitive and mood screening: The ºù«Ӱҵ experience. INTERNATIONAL JOURNAL OF STROKE, 9, 42-42.
- . International Journal of Stroke, 9(7), 939-942.
- . Biological and Pharmaceutical Bulletin, 37(8), 1397-1401.
- . Stroke, 45(8), 2438-2443.
- . Stroke, 45(2), 520-526.
- . ISRN Neurology, 2014(2014).
- . International Journal of Networking and Virtual Organisations, 14(4), 377-377.
- . J Neuroimaging, 23(4), 495-501.
- . Brain Res, 1527, 246-254.
- . AJNR Am J Neuroradiol, 34(5), 1049-S1.
- . Stroke, 44(1), 205-212.
- Systematic review and meta-analysis of newly detected atrial fibrillation after ischaemic stroke/TIA using non-invasive and invasive cardiac monitoring. INTERNATIONAL JOURNAL OF STROKE, 7, 17-17.
- . International Journal of Stroke, 7(8).
- . Neurology, 79(13 SUPPL. 1).
- . Stroke, 43(6), 1632-1638.
- . J Neurosci, 32(21), 7278-7286.
- . Stroke, 43(suppl_1).
- . The Neurohospitalist, 2(1), 12-17.
- . Expert Rev Cardiovasc Ther, 9(10), 1315-1330.
- . Neurosci Lett, 500(3), 157-161.
- . Stroke Res Treat, 2011, 172074.
- . Stroke Res Treat, 2010, 245715.
- . Front Neurol, 1, 160.
- . AJNR Am J Neuroradiol, 31(8), 1395-1402.
- . Stroke, 41(8), 1630-1635.
- Peripheral neuropathy: differential diagnosis and management.. Am Fam Physician, 81(7), 887-892.
- . J Neuroimaging, 20(1), 74-77.
- . Stroke, 40(12).
- . Epilepsy Res, 87(2-3), 268-271.
- . Int J Stroke, 4(5), 381-389.
- . J Neurosci Res, 87(11), 2541-2550.
- . Stroke, 40(7), 2594-2600.
- . Stroke, 40(7), 2560-2563.
- . Cell Tissue Res, 337(1), 45-61.
- . Stroke, 40(6), 2244-2250.
- . Neurol Sci, 30(3), 241-245.
- Hypothermia Decreases The Fibrinolytic Activity Of Tissue Plasminogen Activator. STROKE, 40(4), E243-E243.
- . Am J Health Syst Pharm, 66(6), 541-561.
- . Nat Clin Pract Neurol, 5(3), 163-169.
- . VASCULAR MEDICINE, 14(1), 63-71.
- . J Neuroimaging, 19(1), 68-71.
- . Cerebrovasc Dis, 28(1), 45-48.
- . Neurocritical Care, 9(3), 412.
- . Stroke, 39(11).
- . Clin Neuropharmacol, 31(6), 353-362.
- . Neurosurgery, 63(5), 874-878.
- The WHO STEPwise Approach to Stroke Surveillance. JCPSP-JOURNAL OF THE COLLEGE OF PHYSICIANS AND SURGEONS PAKISTAN, 18(10), 665-665.
- . J Neurosci Res, 86(13), 2984-2991.
- . J Neuroimaging, 18(3), 336-339.
- . Stroke, 39(6), 1779-1785.
- . Cerebrovasc Dis, 25(1-2), 12-20.
- . Cerebrovasc Dis, 25(1-2), 107-110.
- . Neurocrit Care, 9(3), 357-360.
- Periodic lateralized epileptiform discharges: an initial electrographic pattern in reversible posterior leukoencephalopathy syndrome.. Neurol Neurochir Pol, 42(1), 55-59.
- . Stroke, 38(11), 3023-3031.
- . ACADEMIC EMERGENCY MEDICINE, 14(11), 1114-1119.
- . Drug News Perspect, 20(8), 495-499.
- . J Headache Pain, 8(5), 289-293.
- . Stroke, 38(9).
- . Journal of Headache and Pain, 8(2), 143-144.
- . Neurocrit Care, 7(1), 36-39.
- . J Am Board Fam Med, 20(1), 65-71.
- . VASCULAR MEDICINE, 12(3), 243-249.
- . CURRENT MEDICINAL CHEMISTRY, 14(1), 103-112.
- . Neurology, 66(3), 306-312.
- . STROKE, 36(12), 2705-2711.
- . Stroke, 36(12), 2705-2711.
- . Journal of Cerebral Blood Flow & Metabolism, 25(1_suppl), S313-S313.
- . ANNALS OF PHARMACOTHERAPY, 39(2), 387-388.
- . Neurotoxicology, 25(6), 895-904.
- . Clin Neuropharmacol, 27(6), 293-298.
- . Vasc Med, 9(3), 225-226.
- . Brain, 125(1), 159-165.
- . Stroke, 31(11), 2707-2714.
- . Journal of Clinical Pathology, 49(12), 1019-1020.
- . Seizure, 5(3), 229-234.
- Involvement of alpha 1-adrenoceptors in the depolarizing but not the hyperpolarizing responses of motorneurones in the neonate rat to noradrenaline. Neuropharmacology, 1399-404.
- . Advances in Clinical Neuroscience & Rehabilitation.
- . International Journal of Molecular Sciences, 16(10), 24048-24058.
- . International Journal of Environmental Research and Public Health, 18(15), 8059-8059.
Chapters
- , Electroceuticals (pp. 55-73). Springer International Publishing
- , Food and Nutritional Components in Focus (pp. 412-431). Royal Society of Chemistry
- , Acute Brain Impairment (pp. 82-104). Royal Society of Chemistry
Conference proceedings papers
- . Journal of Neurology, Neurosurgery & Psychiatry, Vol. 93(9) (pp e2.160-e2.160)
- . Basic science
- INTERVENTIONS TO PREVENT AND TREAT POST STROKE FATIGUE: A SYSTEMATIC REVIEW AND META-ANALYSIS. INTERNATIONAL JOURNAL OF STROKE, Vol. 15(1_SUPPL) (pp 660-660)
- EFFECT OF EXERCISE INTERVENTIONS ON HEALTH-RELATED QUALITY OF LIFE AFTER STROKE AND TRANSIENT ISCHAEMIC ATTACK: A SYSTEMATIC REVIEW AND META-ANALYSIS.. INTERNATIONAL JOURNAL OF STROKE, Vol. 15(1_SUPPL) (pp 657-657)
- A COMMUNITY-BASED EXERCISE REFERRAL PROGRAMME TO PROMOTE CARDIOVASCULAR HEALTH IN STROKE AND TIA PATIENTS: A PILOT FEASIBILITY STUDY. INTERNATIONAL JOURNAL OF STROKE, Vol. 15(1_SUPPL) (pp 142-142)
- UNDERSTANDING THE FACILITATORS AND BARRIERS TO EXERCISE AFTER STROKE AMONG PATIENTS, EXERCISE PROFESSIONALS AND CLINICIANS.. INTERNATIONAL JOURNAL OF STROKE, Vol. 15(1_SUPPL) (pp 260-260)
- PHYSIOLOGICAL RESPONSE AND PERCEIVED EXERTION DURING RECUMBENT AEROBIC CYCLING FOLLOWING ACUTE STROKE. INTERNATIONAL JOURNAL OF STROKE, Vol. 15(1_SUPPL) (pp 212-212)
- Stroke and TIA awareness and response to symptoms study (STARSS): assessing the relationship between stroke knowledge and help-seeking behaviour. INTERNATIONAL JOURNAL OF STROKE, Vol. 13 (pp 21-21)
- . Cardiovascular Research, Vol. 114(suppl_2) (pp S5-S6)
- . Basic Science
- Microglial activation in recent ischemic stroke: comparison of two TSPO tracers. JOURNAL OF NUCLEAR MEDICINE, Vol. 58
- Difference in Acute Ischemic Post Thrombolytic Stroke Outcomes in Pre Comprehensive and Post Comprehensive Status: Single Center Experience. STROKE, Vol. 47
- Inter-rater Reliability of Transient Ischemic Attack Diagnosis in the Emergency Department. STROKE, Vol. 41(4) (pp E203-E203)
- Stroke Symptoms and Risk Factor Awareness Amongst High School Children in Pakistan. STROKE, Vol. 41(4) (pp E291-E291)
- Concordance Between Patient Bedside Dysphagia Assessment Results Obtained From Neurological Nurses and Speech Pathologists. STROKE, Vol. 41(4) (pp E230-E230)
- Predictors of discharge disposition for TIA cases presenting to community-based emergency departments. STROKE, Vol. 39(2) (pp 704-704)
- Ability of the ABCD2 clinical prediction rule to identify low-risk TIA cases in community-based emergency departments. STROKE, Vol. 39(2) (pp 558-558)
- BLOOD PRESSURE CHANGES AFTER INTRAVENOUS LOADING WITH FOSPHENYTOIN AND LEVETIRACETAM IN PATIENTS WITH ACUTE CEREBRAL INSULTS. EPILEPSIA, Vol. 49 (pp 430-431)
- . ANNALS OF EMERGENCY MEDICINE, Vol. 50(3) (pp S102-S102)
- Effect of pre-existing statin use on in-hospital mortality and functional status at discharge in stroke patients: A propensity-based analysis. CIRCULATION, Vol. 115(21) (pp E581-E582)
- The effect of hypoxic preconditioning on the mTOR pathway. STROKE, Vol. 37(2) (pp 682-682)
- Inhibition of brain GTP cyclohydrolase I and tetrahydrobiopterin attenuates cerebral infarction via reducing iNOS and peroxynitrite in ischemic stroke. JOURNAL OF THE NEUROLOGICAL SCIENCES, Vol. 238 (pp S388-S389)
- Factors associated with IV tPA use in eligible acute stroke patients in Michigan. STROKE, Vol. 35(1) (pp 335-335)
- Research group
-
Doctoral Students
Professor Majid welcomes enquiries from students interested in pursuing a doctorate in translational and clinical research. Several projects, preclinical (translational) and clinical are available. These include development of vaccines for neurological diseases, remote conditioning, development of exosome technologies for therapeutics and development of novel neurotherapeutics.
Post-Doctoral Scientists (short and long-term):
Several preclinical and clinical projects are available.
- Teaching activities
-
Professor Majid is the Phase 3a Neurology Lead for ºù«Ӱҵ Medical school.