Mortiboys, Heather, Professor

Professor Heather Mortiboys

PhD

Neuroscience, School of Medicine and Population Health

Head of Neuroscience

Professor of Cellular Neuroscience and Metabolism

h.mortiboys@sheffield.ac.uk
+44 114 222 2259

+44 114 222 2261 (Administrator: Rebecca Brown)

Room B50, ��«Ӱҵ Institute for Translational Neuroscience (SITraN)

Full contact details

Professor Heather Mortiboys
Neuroscience, School of Medicine and Population Health
Room B50
��«Ӱҵ Institute for Translational Neuroscience (SITraN)
385a Glossop Road
��«Ӱҵ
S10 2HQ

Profile

I was awarded my PhD from the International Max Planck PhD Program in Dresden Germany in 2006 with the grade summa cum laude; this project focused on the ‘Influence of mitochondrial energy metabolism on cellular function: implications for neurometabolic and neurodegenerative diseases.’

After which I worked in the Neurology department at the University Hospital Dresden as a research associate on an EU funded project investigating Co-enzyme Q deficiency in patient tissue.

I joined the Neuroscience department at the University of ��«Ӱҵ in 2006 to set up mitochondrial investigations in models of Parkinson’s Disease working as a postdoctoral research associate with Prof. Oliver Bandmann.

I started my own lab when I became a Parkinson’s UK Senior Research Fellow in September 2013 based within the ��«Ӱҵ Institute for Translational Neuroscience (SITraN).

Research interests

The main focus of my lab is mitochondria in neurodegenerative diseases, primarily focused on Parkinson’s Disease. This encompasses mitochondrial function, DNA, morphology and recycling as well as links with other cellular pathways.

My research focuses on both trying to further the understanding of the causes of mitochondrial problems in neurodegenerative conditions and in vitro drug screening for molecules which rescue mitochondrial function in patient tissue.

The lab has also recently become interested in investigating these mitochondrial abnormalities in Alzheimer’s Disease and Motor Neuron Disease patient derived cells. It is interesting to investigate the differing mitochondrial phenotypes between neurodegenerative diseases and the mechanisms by which they occur and potentially drive neuronal vulnerability.

Current projects

Targeting mitochondrial dysfunction with novel small molecules in Parkinson’s Disease and Alzheimer’s Disease
Repurposing of compounds for the treatment of Parkinson’s Disease
LRRK2 and mitochondria – what is the connection?
Differing types of mitophagy in neurons and astrocytes
Targeting mitophagy with small molecules in Parkinson’s Disease
Mitochondrial morphological abnormalities in patient derived models of Alzheimer’s Disease
What are the metabolic abnormalities in Motor Neuron Disease

Publications

Journal articles

Au WH, Miller-Fleming L, Sanchez-Martinez A, Lee JAK, Twyning MJ, Prag HA, Raik L, Allen SP, Shaw PJ, Ferraiuolo L , Mortiboys H et al (2024) . Life Science Alliance, 7(9), e202402853-e202402853.
McCarron KR, Elcocks H, Mortiboys H, Urbé S & Clague MJ (2024) . Biochemical Journal, 481(4), 265-278.
Harvey C, Weinreich M, Lee JAK, Shaw AC, Ferraiuolo L, Mortiboys H, Zhang S, Hop PJ, Zwamborn RAJ, van Eijk K , Julian TH et al (2024) . Heliyon, 10(3), e24975-e24975.
Bell SM, Wareing H, Hamshaw A, De S, New E, Shaw P, De Marco M, Venneri A, Blackburn DJ, Ferraiuolo L & Mortiboys H (2023) . Alzheimer's & Dementia, 19(S13).
Payne T, Burgess T, Bradley S, Roscoe S, Sassani M, Dunning MJ, Hernandez D, Scholz S, McNeill A, Taylor R , Su L et al (2023) . Brain, awad364.
Capriglia F, Burgess T, Bandmann O & Mortiboys H (2023) . Journal of Parkinson's Disease, 13(6), 851-864.
Gonzalez-Robles C, Weil RS, van Wamelen D, Bartlett M, Burnell M, Clarke CS, Hu MT, Huxford B, Jha A, Lambert C , Lawton M et al (2023) . Journal of Parkinson's Disease, 13(6), 1011-1033.
Keatinge M, Gegg ME, Watson L, Mortiboys H, Li N, Dunning M, Ailani D, Bui H, van Rens A, Lefeber DJ , Schapira AHV et al (2023) . Disease Models & Mechanisms, 16(6).
Elcocks H, Brazel AJ, McCarron KR, Kaulich M, Husnjak K, Mortiboys H, Clague MJ & Urbé S (2023) . The EMBO Journal.
Morsli S, Henriques CM, Ellis PS, Mortiboys H, Baxendale S, Loynes CA, Renshaw SA & Bellantuono I (2023) . Aging Cell.
Payne T, Burgess T, Sassani M, Bradley S, Roscoe S, Reed E, Wilkinson ID, Mortiboys H, Jenkins TM & Bandmann O (2022) . Journal of Neurology, Neurosurgery & Psychiatry, 93(9), e2.2-e2.2.
Rusilowicz-Jones EV, Barone FG, Martins Lopes F, Stephen E, Mortiboys H, Urbé S & Clague MJ (2022) . Life Science Alliance, 5(2).
Sassani M, Alix J, Mcdermott C, Baster K, Hoggard N, Wild J, Mortiboys H, Shaw P, Wilkinson I & Jenkins T (2021) . Journal of the Neurological Sciences, 429, 119412.
Frison M, Faccenda D, Abeti R, Rigon M, Strobbe D, England-Rendon BS, Cash D, Barnes K, Sadeghian M, Sajic M , Wells LA et al (2021) . Molecular Psychiatry.
Leah T, Vazquez-Villaseñor I, Ferraiuolo L, Wharton S & Mortiboys H (2021) . Bio-protocol, 11(1).
Gatto N, Dos Santos Souza C, Shaw AC, Bell SM, Myszczynska MA, Powers S, Meyer K, Castelli LM, Karyka E, Mortiboys H , Azzouz M et al (2020) . Aging Cell.
Bell SM, De Marco M, Barnes K, Shaw P, Ferraiuolo L, Blackburn DJ, Mortiboys H & Venneri A (2020) . Alzheimer's & Dementia, 16(S6).
Bell SM, Burgess T, Lee J, Blackburn DJ, Allen SP & Mortiboys H (2020) . International Journal of Molecular Sciences, 21(23).
Schwartzentruber A, Boschian C, Lopes FM, Myszczynska MA, New EJ, Beyrath J, Smeitink J, Ferraiuolo L & Mortiboys H (2020) . Scientific Reports, 10(1).
Rusilowicz-Jones EV, Jardine J, Kallinos A, Pinto-Fernandez A, Guenther F, Giurrandino M, Barone FG, McCarron K, Burke CJ, Murad A , Martinez A et al (2020) . Life Science Alliance, 3(8).
Bell SM, De Marco M, Barnes K, Shaw PJ, Ferraiuolo L, Blackburn DJ, Mortiboys H & Venneri A (2020) . Journal of Personalized Medicine, 10(2).
Bell S, De Marco M, Barnes K, Shaw P, Ferraiuolo L, Blackburn D, Mortiboys H & Venneri A (2020) . Neurology, 94(15_supplement).
Carling PJ, Mortiboys H, Green C, Mihaylov S, Sandor C, Schwartzentruber A, Taylor R, Wei W, Hastings C, Wong S , Lo C et al (2020) . Progress in Neurobiology, 187.
Allen SP, Hall B, Woof R, Francis L, Gatto N, Shaw AC, Myszczynska M, Hemingway J, Coldicott I, Willcock A , Job L et al (2019) . Brain, 1-20.
López KLR, Simpson JE, Watson LC, Mortiboys H, Hautbergue GM, Bandmann O & Highley JR (2019) . Brain Research, 1706, 218-223.
Bell SM, Barnes K, Clemmens H, Al-Rafiah AR, Al-ofi EA, Leech V, Bandmann O, Shaw PJ, Blackburn DJ, Ferraiuolo L & Mortiboys H (2018) . Journal of Molecular Biology, 430(21), 3942-3953.
Ratcliffe LE, Vázquez Villaseñor I, Jennings L, Heath PR, Mortiboys H, Schwartzentruber A, Karyka E, Simpson JE, Ince PG, Garwood CJ & Wharton SB (2018) . Neuroscience, 390, 46-59.
Macdonald R, Barnes K, Hastings C & Mortiboys H (2018) . Biochemical Society Transactions, 46(4), 891-909.
Mortiboys H, Macdonald R, Payne T, Sassani M, Jenkins T & Bandmann O (2018) . FEBS Letters, 592(5), 776-792.
Carling P, Mortiboys H, Mihaylov S, Clemmens H, Schwartzenhuber A, Wade-Martins R, Talbot K, Hu M & Bandmann O (2017) . Journal of Neurology, Neurosurgery & Psychiatry, 88(Suppl 1), A31.4-A32.
Bell SM, Clemmens H, Blackburn DJ, Bandmann O, Ferraiuolo L & Mortiboys H (2017) . Alzheimer's & Dementia, 13(7S_Part_26), P1269-P1269.
Dombi E, Mortiboys H & Poulton J (2017) . Curr Med Chem.
Soman S, Keatinge M, Moein M, DaCosta M, Mortiboys H, Skupin A, Sugunan S, Bazala M, Kuznicki J & Bandmann O (2017) . European Journal of Neuroscience, 45(4), 528-535.
Liao C, Ashley N, Diot A, Morten K, Phadwal K, Williams A, Fearnley I, Rosser L, Lowndes J, Fratter C , Ferguson DJ et al (2017) . Neurology, 88(2), 131-142.
Mortiboys H (2016) . Biochemical Society Transactions, 44(6), 1617-1623.
Yealland G, Battaglia G, Bandmann O & Mortiboys H (2016) . Neuroscience Letters, 630, 23-29.
Keatinge M, Bui H, Menke A, Chen Y-C, Sokol AM, Bai Q, Ellett F, Da Costa M, Burke D, Gegg M , Trollope L et al (2015) . Human Molecular Genetics, 24(23), 6640-6652.
Diot A, Hinks-Roberts A, Lodge T, Liao C, Dombi E, Morten K, Brady S, Fratter C, Carver J, Muir R , Davis R et al (2015) . Pharmacological Research, 100, 24-35.
Mortiboys H, Furmston R, Bronstad G, Aasly J, Elliott C & Bandmann O (2015) . Neurology, 85(10), 846-852.
Pogson JH, Ivatt RM, Sanchez-Martinez A, Tufi R, Wilson E, Mortiboys H & Whitworth AJ (2014) . PLoS Genetics, 10(11).
Hickey FB, Corcoran JB, Griffin B, Bhreathnach U, Mortiboys H, Reid HM, Andrews D, Byrne S, Furlong F, Martin F , Godson C et al (2014) . Diabetes, 63(12), 4314-4325.
Bandmann O, Keatinge M, DaCosta M, Mortiboys H & Flinn L (2014) . Neurology, 82(10_supplement).
Bandmann O, Keatinge M, DaCosta M, Mortiboys H & Flinn L (2014) . Neurology, 82(10_supplement).
Hinks-Roberts A, Dombi E, Diot A, Liao C, Morten K, Carver J, Lodge T, Mortiboys H & Poulton J (2014) . Neuromuscular Disorders, 24, S15-S15.
Allen SP, Rajan S, Duffy L, Mortiboys H, Higginbottom A, Grierson AJ & Shaw PJ (2014) . Neurobiol Aging, 35(6), 1499-1509.
Mortiboys H, Aasly J & Bandmann O (2013) . Brain, 136(Pt 10), 3038-3050.
Flinn LJ, Keatinge M, Bretaud S, Mortiboys H, Matsui H, De Felice E, Woodroof HI, Brown L, McTighe A, Soellner R , Allen CE et al (2013) . Ann Neurol, 74(6), 837-847.
Richardson K, Allen SP, Mortiboys HJ, Grierson AJ, Wharton SB, Ince PG, Shaw PJ & Heath PR (2013) . Plos One, 6(8), e68256-e68256.
Mortiboys H, Johansen KK, Aasly JO & Bandmann O (2010) . Neurology, 75(22), 2017-2020.
Bandmann O, Flinn L & Mortiboys H (2010) . J Neurol Neurosurg Psychiatry, 81(11), e59.
Bandmann O, Flinn L & Mortiboys H (2010) A PINK1 Mutant Zebrafish Model of Early Onset Parkinson's Disease. MOVEMENT DISORD, 25, S631-S631.
Cox LE, Ferraiuolo L, Goodall EF, Heath PR, Higginbottom A, Mortiboys H, Hollinger HC, Hartley JA, Brockington A, Burness CE , Morrison KE et al (2010) . PLoS One, 5(3), e9872.
Tain LS, Mortiboys H, Tao RN, Ziviani E, Bandmann O & Whitworth AJ (2009) . Nature Neuroscience, 12(9), 1129-1135.
Flinn L, Mortiboys H, Volkmann K, Köster RW, Ingham PW & Bandmann O (2009) . Brain, 132(Pt 6), 1613-1623.
Mortiboys H, Thomas KJ, Koopman WJH, Klaffke S, Abou-Sleiman P, Cookson MR & Bandmann O (2009) . Mitochondrion, 9(1), 63-63.
Mortiboys H, Thomas KJ, Koopman WJH, Klaffke S, Abou-Sleiman P, Olpin S, Wood NW, Willems PHGM, Smeitink JAM, Cookson MR & Bandmann O (2008) . Ann Neurol, 64(5), 555-565.
Osborne NN, Li G-Y, Ji D, Mortiboys HJ & Jackson S (2008) . J Neurochem, 105(5), 2013-2028.
Mortiboys HJ, Schaefer J, Reichmann H & Jackson S (2007) Mitochondrial dysfunction in Parkinson's disease--revisited.. Neurol Neurochir Pol, 41(2), 150-159.
Schaefer J, Mortiboys H, Navas P, Weinhold M, Reichmann H & Jackson S (2006) . Aktuelle Neurologie, 33(S 1).
Bell SM, Wareing H, Capriglia F, Hughes R, Barnes K, Hamshaw A, Adair L, Shaw A, Olejnik A, De S , New E et al () . Molecular Psychiatry.
De S () Co-aggregation with Apolipoprotein E modulates the function of Amyloid-β in Alzheimer's disease. Nature Communications.
() . Aging Cell.
Mihaylov SR, Castelli LM, Lin Y-H, Gül A, Soni N, Hastings C, Flynn HR, Păun O, Dickman MJ, Snijders AP , Goldstone R et al () . Nature Communications, 14(1).
Bellantuono I, Mortiboys H, Rocha E, Chamoli M, Chinta SJ, Andersen JK, Wallis R, Bezard E, Goldberg M, Greenamyre T , Hirst W et al () . Aging Biology, 1(1), 20230010-20230010.
Foltynie T, Gandhi S, Gonzalez-Robles C, Zeissler M-L, Mills G, Barker R, Carpenter J, Schrag A, Schapira A, Bandmann O , Mullin S et al () . Brain.
Luxenburger A, Clemmens H, Hastings C, Harris LD, Ure EM, Cameron SA, Aasly J, Bandmann O, Weymouth-Wilson A, Furneaux RH & Mortiboys H () . Biomolecules, 13(1), 76-76.
Stephen E & Mortiboys H () . Cellular Reprogramming.
Vazquez‐Villasenor I, Garwood CJ, Simpson JE, Heath PR, Mortiboys H & Wharton SB () . European Journal of Neuroscience.
Schaefer J, Mortiboys H, Reichmann H & Jackson S () . Aktuelle Neurologie, 32(S 4).
Mortiboys HJ, Cox A, Brock IW & Bandmann O () The common PARK8 mutation LRRK2 G2019S is not a risk factor for breast cancer in the absence of Parkinson's disease.. Journal of Neurology.
Sassani M, Alix J, McDermott C, Baster K, Hoggard N, Wild J, Mortiboys H, Shaw P, Wilkinson I & Jenkins T () Magnetic resonance spectroscopy reveals mitochondrial dysfunction in amyotrophic lateral sclerosis. Brain.
Bell SM, Barnes K, De Marco M, Shaw PJ, Ferraiuolo L, Blackburn DJ, Venneri A & Mortiboys H () . Biomedicines, 9(1), 63-63.

Chapters

Lee J, Pye N, Ellis L, Vos KD & Mortiboys H (2024) , International Review of Neurobiology Elsevier

Conference proceedings papers

Hartopp N, Thoma A, Mossman E, Ellis L, Hughes R, Bhosale G, Gandini A, Pristera A, Doe C, Allen S , Ferraiuolo L et al (2024) . I: Experimental therapeutics – preclinical (pp A152.1-A152)
Gonzalez-Robles C, Byrom D, Chapman R, Dexter D, Duty S, Ellis-Doyle R, Jabbari E, Mills G, Mortiboys H, Rudiger J , Sammler E et al (2022) Treatment Selection in Multi-Arm Multi-Stage Clinical Trials in Parkinson Disease: The Search for the Ideal Neuroprotective Drug. MOVEMENT DISORDERS, Vol. 37 (pp S329-S329)
Payne T, Burgess T, Sassani M, Roscoe S, Bradley S, Anton A, Reed E, Wilkinson I, Mortiboys H, Jenkins T & Bandmann O (2022) Multimodal mechanistic disease stratification in sporadic Parkinson's disease. MOVEMENT DISORDERS, Vol. 37 (pp S113-S113)
Payne T, Sassani M, Roscoe S, Bradley S, Anton A, Reed E, Wilkinson I, Mortiboys H, Jenkins T & Bandmann O (2021) Developing 31-phosphorus magnetic resonance spectroscopy (31P-MRS) as an imaging biomarker to identify mitochondrial dysfunction in Parkinson's disease. MOVEMENT DISORDERS, Vol. 36 (pp S370-S371)
Payne T, Sassani M, Roscoe S, Bradley S, Anton A, Reed E, Wilkinson ID, Mortiboys H, Jenkins TM & Bandmann O (2021) (31)Phosphorus Magnetic Resonance Spectroscopy as a Tool to Identify Mitochondrial Dysfunction in Parkinson's Disease In-Vivo. ANNALS OF NEUROLOGY, Vol. 90 (pp S152-S153)
Bell S, De Marco M, Barnes K, Shaw P, Ferraiuolo L, Blackburn D, Mortiboys H & Venneri A (2020) Do deficits in Mitochondrial Spare Respiratory Capacity contribute to Neuropsychological changes seen in Alzheimer's disease?. NEUROLOGY, Vol. 94(15)
Keatinge M, Trollope L, Mortiboys H & Bandmann O (2018) Acid sphingomyelinase deficiency rescues mitochondrial dysfunction in gba-/- zebrafish (Danio rerio). MOVEMENT DISORDERS, Vol. 33 (pp S615-S615)
Oliver B, Solman S, Keatinge M, DaCosta M, Mortiboys H, Sugunan S & Kuznicki J (2016) Inhibition of the mitochondrial calcium uniporter (MCU) rescues dopaminergic neurons in pink1-/- zebrafish. MOVEMENT DISORDERS, Vol. 31 (pp S209-S209)
Dombi E, Diot A, Hinks-Roberts A, Lodge T, Liao C, Morten K, Brady S, Fratter C, Carver J, Green CJ , Churchill G et al (2016) Identifying novel pharmacological drugs to eliminate pathogenic heteroplasmic mtDNA by using a novel quantitative assay of mitophagy. NEUROMUSCULAR DISORDERS, Vol. 26 (pp S21-S21)
Liao C, Diot A, Ashley N, Morten K, Fratter C, Moroni I, Bianchi S, Lamperti C, Dombi E, Downes S , Sitarz K et al (2015) . Neuromuscular Disorders, Vol. 25 (pp S185-S186)
Bandmann O, Johansen KK, Aasly JO & Mortiboys H (2010) Mitochondrial Impairment in Manifesting LRRK2-G2019S Carriers. NEUROLOGY, Vol. 74(9) (pp A255-A255)
Flinn L, Mortiboys H, Volkmann K, Koester RW, Ingham PW & Bandmann O (2009) Complex I deficiency and dopaminergic neuronal cell loss in parkin-deficient zebrafish (Danio rerio). MOVEMENT DISORDERS, Vol. 24 (pp S135-S135)
Bandmann O, Klaffke S, Sleiman P, Wood NW & Mortiboys HJ (2008) Abnormal mitochondrial function and morphology in fibroblasts of patients with early onset Parkinson's disease and two parkin mutations. NEUROLOGY, Vol. 70(11) (pp A485-A485)
Mortiboys H, Thomas K, Klaffke S, Koopman W, Cookson M & Bandmann O (2008) Mitochondrial function and morphology in parkin mutant fibroblasts. MOVEMENT DISORDERS, Vol. 23(1) (pp S49-S49)

Datasets

Gatto N, Souza CDS, Bell S, Shaw A, Myszczynska M, Powers S, Meyer K, Heath P, Castelli L, Karyka E , Mortiboys H et al .

Preprints

McCarron KR, Elcocks H, Mortiboys HJ, Urbe S & Clague MJ (2023) , Cold Spring Harbor Laboratory.
Au WH, Miller-Fleming L, Sanchez-Martinez A, Lee JAK, Twyning MJ, Prag HA, Granger S, Roome K, Ferraiuolo L, Mortiboys H & Whitworth AJ (2023) , Cold Spring Harbor Laboratory.
Bell SM, Wareing H, Hamshaw A, De S, New E, Shaw PJ, De Marco M, Venneri A, Blackburn DJ, Ferraiuolo L & Mortiboys H (2023) , Cold Spring Harbor Laboratory.
Xia Z, Prescott E, Wareing H, Matuszyk M, Dakin H, Dimou E, Hidari E, Zhang Y, Lam J, Danial J , Leah T et al (2022) , Research Square Platform LLC.
Elcocks H, Brazel AJ, McCarron KR, Kaulich M, Husnjak K, Mortiboys H, Clague MJ & Urbé S (2022) , Cold Spring Harbor Laboratory.
Morsli S, Henriques C, Ellis PS, Mortiboys HJ, Baxendale S, Loynes CA, Renshaw S & Bellantuono I (2022) , Cold Spring Harbor Laboratory.
Martins RR, Rera M & Henriques CM (2022) , Cold Spring Harbor Laboratory.
Mihaylov SR, Castelli LM, Lin Y-H, Gül A, Soni N, Hastings C, Flynn HR, Dickman MJ, Snijders AP, Bandmann O , Mortiboys H et al () , Cold Spring Harbor Laboratory.
Xia Z, Prescott E, Leah T, Dakin H, Dimou E, Zuo E, Zhang YP, Lam JYL, Danial JSH, Jiang H , Mortiboys H et al () , Cold Spring Harbor Laboratory.
Rusilowicz-Jones EV, Barone FG, Lopes FM, Stephen E, Mortiboys H, Urbé S & Clague MJ () .
Keatinge M, Gegg ME, Watson L, Mortiboys H, Bui H, Lefeber D, Rens AV, MacDonald R, Schapira A & Bandmann O () , Research Square Platform LLC.
Schwartzentruber A, Boschian C, Lopes FM, Myszczynska MA, New EJ, Beyrath J, Smeitink J, Ferraiuolo L & Mortiboys H () , Cold Spring Harbor Laboratory.
Rusilowicz-Jones E, Jardine J, Kallinos A, Pinto-Fernandez A, Guenther F, Giurrandino M, Barone FG, McCarron K, Burke CJ, Murad A , Martinez A et al () , Cold Spring Harbor Laboratory.
Keatinge M, Gegg ME, Watson L, Mortiboys H, Li N, Dunning M, Ailani D, Bui H, van Rens A, Lefeber DJ , MacDonald RB et al () , Cold Spring Harbor Laboratory.
Lucas RM, Bauer CS, Chinnaiya K, Schwartzentruber A, MacDonald R, Collins MO, Aasly JO, Brønstad G, Ferraiuolo L, Mortiboys H & Vos KJD () , Cold Spring Harbor Laboratory.

Research group

Postdoctoral Research Associates

Dr Francesco Capriglia
Dr Naomi Hartopp
Dr Alex Bury
Dr Rachel Hughes
Dr Katy Barnes
Dr Orlaith O'Shaughnessy
Dr Elezebeth Stephen

Research Assistants

Nikolaos Stefanadis
Ella Simmonite

PhD students

James Lee
Toby Burgess
Louise Heywood
Alicja Olejnik
Rhiannon Brown

Grants: My research is currently funded by Parkinson’s UK Virtual Biotech, Cue Parkinson's, several industrial partners including Verge Genomics, NZP UK Ltd and Spark Therapeutics, and the Michael J Fox Foundation.

Teaching activities

I teach on the MSc courses in Translational Neuroscience, Translational Neuropathology, Clinical Neurology and Molecular Medicine focussing on protein assay work and basic cell biology assays, the pathogenetic mechanisms involved in Parkinson’s Disease and critical review of the literature teaching.

I also teach on the undergraduate Biomedical Science course on the module the Biological Basis of Brain Disease.

I enjoy training and supervising MSc and BMedSci students during their research projectsand usually host 2-3 students per year. In addition we host multiple medical students from the MBChB course for short projects per year.

Professional activities and memberships

I am a member of the Parkinson’s UK college of experts as well as the Patient Public Involvement Steering Group. I also sit on the Cure Parkinson’s Trust Review Panel.

I am lead external examiner for MRes courses at University of Newcastle. I regularly review for several funding bodies including MRC, Parkinson’s UK, BBSRC, Motor Neuron Disease Association, EU, ARUK and many others.

Collaborators

Within ��«Ӱҵ: Dr Laura Ferraiuolo, Prof Oliver Bandmann, Prof Kurt De Vos, Dr Suman De and Prof Val Gillet

Outside of ��«Ӱҵ: Prof Sylvie Urbe (University of Liverpool), Prof Mike Clague (University of Liverpool), Dr Liz New (University of Sydney), Prof Joanna Poulton (University of Oxford), Dr Alex Whitworth (University of Cambridge)

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School of Medicine and Population Health