Dr Julie Simpson

PhD

Neuroscience, School of Medicine and Population Health

Senior Lecturer in Translational Neuropathology

Julie Simpson
Profile picture of Julie Simpson
julie.simpson@sheffield.ac.uk
+44 114 222 2242

Full contact details

Dr Julie Simpson
Neuroscience, School of Medicine and Population Health
葫芦影业 Institute for Translational Neuroscience (SITraN)
385a Glossop Road
葫芦影业
S10 2HQ
Profile

I graduated from the University of 葫芦影业 in 1995 with BSc (Hons) in Neuroscience, and was awarded a PhD in Neuroimmunology from 葫芦影业 Hallam University in 1999. I joined the former Department of Neuroscience (now part of the School of Medicine and Population Health) at the University of 葫芦影业 in 2002 and have been a member of the Neuropathology research group since 2004.  I was appointed Lecturer in Translational Neuropathology at SITraN in 2016 and Senior Lecturer in 2020.

Research interests

My main research interests are identifying and understanding neuroinflammatory contributions to ageing and dementia. My research primarily focusses on the detailed immunohistological characterisation and gene expression profiling of specific cell populations in the ageing brain.

Current Projects

  1. Blood brain barrier dysfunction in the ageing brain
  2. The link between systemic infection and cognitive decline in patients with dementia
  3. Microglial-mediated mechanisms underlying the pathogenesis of neurodegenerative diseases
Publications

Journal articles

  • Floare M-L, Wharton SB, Simpson JE, Aeschlimann D, Hoggard N & Hadjivassiliou M (2024) . Brain Communications, 6(2). RIS download Bibtex download
  • Mistry H, Richardson CD, Higginbottom A, Ashford B, Ahamed SU, Moore Z, Matthews FE, Brayne C, Simpson JE & Wharton SB (2024) . Neuroscience Research. RIS download Bibtex download
  • Waller R, Hase Y, Simpson JE, Heath PR, Wyles M, Kalaria RN & Wharton SB (2022) . Transl Stroke Res. RIS download Bibtex download
  • Matuszyk MM, Garwood CJ, Ferraiuolo L, Simpson JE, Staniforth RA & Wharton SB (2021) . Journal of Neurochemistry. RIS download Bibtex download
  • Waller R, Narramore R, Simpson JE, Heath PR, Verma N, Tinsley M, Barnes J, Haris H, Henderson FE, Matthews FE , Richardson CD et al (2021) . Brain Pathology, 31(3). RIS download Bibtex download
  • Bury JJ, Chambers A, Heath PR, Ince PG, Shaw PJ, Matthews FE, Brayne C, Simpson JE & Wharton SB (2021) . Acta Neuropathologica Communications, 9(1). RIS download Bibtex download
  • Almasnouri TS, Hamilton N, Heath P, van Eeden Van Eeden F & Simpson JE (2020) . Alzheimer's & Dementia, 16(S3). RIS download Bibtex download
  • MacGregor Sharp M, Saito S, Keable A, Gatherer M, Aldea R, Agarwal N, Simpson JE, Wharton SB, Weller RO & Carare RO (2020) . Acta Neuropathologica Communications, 8(1). RIS download Bibtex download
  • Ashford BA, Boche D, Cooper鈥怟nock J, Heath PR, Simpson JE & Highley JR (2020) . Neuropathology and Applied Neurobiology. RIS download Bibtex download
  • Brezzo G, Simpson J, Ameen-Ali KE, Berwick J & Martin C (2020) . Brain, Behavior, & Immunity - Health, 5. RIS download Bibtex download
  • Waller R, Mandeya M, Viney E, Simpson JE & Wharton SB (2020) . Neuropathology. RIS download Bibtex download
  • Fadul MM, Garwood CJ, Waller R, Garrett N, Heath PR, Matthews FE, Brayne C, Wharton SB & Simpson JE (2020) . International Journal of Molecular Sciences, 21(1). RIS download Bibtex download
  • Ajikumar A, Long MB, Heath PR, Wharton SB, Ince PG, Ridger VC & Simpson JE (2019) . International Journal of Molecular Sciences, 20(20). RIS download Bibtex download
  • Goodall EF, Leach V, Wang C, Cooper-Knock J, Heath PR, Baker D, Drew DR, Saffrey MJ, Simpson JE, Romero IA & Wharton SB (2019) . International Journal of Molecular Sciences, 20(12). RIS download Bibtex download
  • Vazquez鈥怴illase帽or I, Garwood CJ, Heath PR, Simpson JE, Ince PG & Wharton SB (2019) . Neuropathology and Applied Neurobiology. RIS download Bibtex download
  • Mozumder M, Pozo JM, Coelho S, Constantini M, Simpson J, Highley JR, Ince PG & Frangi AF (2019) . NeuroImage Clinical, 23. RIS download Bibtex download
  • Coelho S, Pozo JM, Costantini M, Highley JR, Mozumder M, Simpson JE, Ince PG & Frangi AF (2019) . Data in Brief, 23. RIS download Bibtex download
  • L贸pez KLR, Simpson JE, Watson LC, Mortiboys H, Hautbergue GM, Bandmann O & Highley JR (2019) . Brain Research, 1706, 218-223. RIS download Bibtex download
  • Ameen-Ali K, Simpson J, Wharton S, Heath P, Sharp P, Brezzo G & Berwick J (2019) . Journal of Alzheimer's disease : JAD. RIS download Bibtex download
  • Waller R, Baxter L, Fillingham DJ, Coelho S, Pozo JM, Mozumder M, Frangi AF, Ince PG, Simpson JE & Highley JR (2019) . PLoS ONE, 14(1). RIS download Bibtex download
  • Waller R, Murphy M, Garwood C, Jennings L, Heath P, Chambers A, Matthews F, Brayne C, Ince P, Wharton S & Simpson J (2018) . Glia, 66(11), 2316-2323. RIS download Bibtex download
  • Ratcliffe LE, V谩zquez Villase帽or I, Jennings L, Heath PR, Mortiboys H, Schwartzentruber A, Karyka E, Simpson JE, Ince PG, Garwood CJ & Wharton SB (2018) . Neuroscience, 390, 46-59. RIS download Bibtex download
  • Coelho S, Pozo JM, Costantini M, Highley JR, Mozumder M, Simpson JE, Ince PG & Frangi AF (2018) . NeuroImage, 179, 275-287. RIS download Bibtex download
  • Morgan SV, Garwood CJ, Jennings L, Simpson JE, Castelli LM, Heath PR, Mihaylov SR, Vaqu茅z-Villase帽or I, Minshull TC, Ince PG , Dickman MJ et al (2018) . European Journal of Neuroscience, 47(12), 1444-1456. RIS download Bibtex download
  • Simpson JE, Wharton S, Brayne C, Matthews F, Heath P & Ince P (2018) . Alzheimer's & Dementia, 14(7S_Part_31), P1624-P1624. RIS download Bibtex download
  • Ajikumar A, Ridger V, Heath P, Wharton S, Ince P & Simpson JE (2018) . Alzheimer's & Dementia, 14(7S_Part_27), P1455-P1455. RIS download Bibtex download
  • Goodall EF, Wang C, Simpson JE, Baker DJ, Drew DR, Heath PR, Saffrey MJ, Romero IA & Wharton SB (2018) . Neuropathology and Applied Neurobiology, 44(3), 328-340. RIS download Bibtex download
  • Simpson JE, Wharton SB & Heath PR (2018) , 273-284. RIS download Bibtex download
  • Ameen-Ali KE, Wharton SB, Simpson JE, Heath PR, Sharp P & Berwick J (2017) . Neuropathology and Applied Neurobiology, 43(7), 553-570. RIS download Bibtex download
  • Garwood CJ, Ratcliffe LE, Simpson JE, Heath PR, Ince PG & Wharton SB (2017) . Neuropathology and Applied Neurobiology, 43(4), 281-298. RIS download Bibtex download
  • Tu WY, Simpson JE, Robin Highley J & Heath PR (2017) . Neurobiology of Disease. RIS download Bibtex download
  • Simpson JE, Waller R, Woodroofe MN, Wharton SB, Ince PG, Francese S, Heath PR, Cudzich-Madry A, Thomas R, Rounding N & Sharrack B (2016) . Journal of Neuroimmunology, 299, 139-146. RIS download Bibtex download
  • Appleby-Mallinder C, Wyles MD, Simpson JE, Wharton SB, Ince PG & Heath PR (2016) . Journal of Neuroscience Methods, 268, 125-130. RIS download Bibtex download
  • Simpson JE, Ince PG, Minett T, Matthews FE, Heath PR, Shaw PJ, Goodall E, Garwood CJ, Ratcliffe LE, Brayne C , Rattray M et al (2016) . Neuropathology and Applied Neurobiology, 42(2), 167-179. RIS download Bibtex download
  • Garwood CJ, Ratcliffe LE, Morgan SV, Simpson JE, Owens H, Vazquez-Villase帽or I, Heath PR, Romero IA, Ince PG & Wharton SB (2015) . Molecular Brain, 8(1). RIS download Bibtex download
  • Fluteau A, Ince PG, Minett T, Matthews FE, Brayne C, Garwood CJ, Ratcliffe LE, Morgan S, Heath PR, Shaw PJ , Wharton SB et al (2015) . Neuroscience Letters, 609, 11-17. RIS download Bibtex download
  • Al-Mashhadi S, Simpson JE, Heath PR, Dickman M, Forster G, Matthews FE, Brayne C, Ince PG & Wharton SB (2015) . Brain Pathology, 25(5), 565-574. RIS download Bibtex download
  • Simpson JE, Ince PG, Matthews FE, Shaw PJ, Heath PR, Brayne C, Garwood C, Higginbottom A & Wharton SB (2015) . Neuropathology and Applied Neurobiology, 41(4), 483-496. RIS download Bibtex download
  • Wu D, Cerutti C, Lopez-Ramirez MA, Pryce G, King-Robson J, Simpson JE, van der Pol SMA, Hirst MC, de Vries HE, Sharrack B , Baker D et al (2015) . Journal of Cerebral Blood Flow & Metabolism, 35(3), 412-423. RIS download Bibtex download
  • Wharton SB, Simpson JE, Brayne C & Ince PG (2015) . Brain Pathology, 25(1), 35-43. RIS download Bibtex download
  • Asi YT, Lees AJ, Revesz T, Holton JL, Simpson JE, Heath PR, Wharton SB & Houlden H (2014) . GLIA. RIS download Bibtex download
  • Lopez-Ramirez MA, Wu D, Pryce G, Simpson JE, Reijerkerk A, King-Robson J, Kay O, de Vries HE, Hirst MC, Sharrack B , Baker D et al (2014) . FASEB J, 28(6), 2551-2565. RIS download Bibtex download
  • Garwood CJ, Simpson JE, Al Mashhadi S, Axe C, Wilson S, Heath PR, Shaw PJ, Matthews FE, Brayne C, Ince PG , Wharton SB et al (2014) . Neuropathol Appl Neurobiol, 40(7), 802-814. RIS download Bibtex download
  • Highley JR, Gebril OH, Simpson JE, Wharton SB, Kirby J, O'Brien JT, Barber R, Kalaria RN, Brayne C, Lewis CE , Shaw PJ et al (2014) . Journal of Aging Science, 2(1). RIS download Bibtex download
  • Janaway BM, Simpson JE, Hoggard N, Highley JR, Forster G, Drew D, Gebril OH, Matthews FE, Brayne C, Wharton SB , Ince PG et al (2014) . Neuropathol Appl Neurobiol, 40(3), 258-269. RIS download Bibtex download
  • Garwood C, Faizullabhoy A, Wharton SB, Ince PG, Heath PR, Shaw PJ, Baxter L, Gelsthorpe C, Forster G, Matthews FE , Brayne C et al (2013) . Neuropathol Appl Neurobiol, 39(7), 788-799. RIS download Bibtex download
  • Stephan BCM, Wharton SB, Simpson J, Matthews FE, Ince P & Brayne C (2012) . Neurodegenerative Disease Management, 2(5), 471-482. RIS download Bibtex download
  • Lace G, Ince PG, Brayne C, Savva GM, Matthews FE, de Silva R, Simpson JE & Wharton SB (2012) . Dement Geriatr Cogn Disord, 34(1), 15-24. RIS download Bibtex download
  • Waller R, Woodroofe MN, Francese S, Heath PR, Wharton SB, Ince PG, Sharrack B & Simpson JE (2012) . J Neurosci Methods, 208(2), 108-113. RIS download Bibtex download
  • Simpson JE, Ince PG, Shaw PJ, Heath PR, Raman R, Garwood CJ, Gelsthorpe C, Baxter L, Forster G, Matthews FE , Brayne C et al (2011) . NEUROBIOL AGING, 32(10), 1795-1807. RIS download Bibtex download
  • Viggars AP, Wharton SB, Simpson JE, Matthews FE, Brayne C, Savva GM, Garwood C, Drew D, Shaw PJ & Ince PG (2011) . Neurosci Lett, 505(1), 25-30. RIS download Bibtex download
  • Simpson J, Ince P, Heath P, Raman R, Garwood C, Shaw P, Gelstorpe C, Baxter L, Forster G, Fiona M , Savva G et al (2011) . Alzheimer's & Dementia, 7, S566-S566. RIS download Bibtex download
  • Wharton SB, Brayne C, Savva GM, Matthews FE, Forster G, Simpson J, Lace G, Ince PG & Medical Research Council Cognitive Function and Aging Study (2011) . J Alzheimers Dis, 25(2), 359-372. RIS download Bibtex download
  • Gebril OH, Simpson JE, Kirby J, Brayne C & Ince PG (2011) . NeuroMolecular Medicine, 13(4), 289-299. RIS download Bibtex download
  • Gebril OH, Simpson JE, Kirby J, Brayne C & Ince PG (2011) Brain Iron Dysregulation and the Risk of Ageing White Matter Lesions. NeuroMolecular Medicine, 1-11. RIS download Bibtex download
  • Viggars AP, Wharton SB, Simpson JE, Matthews FE, Brayne C, Savva GM, Garwood C, Drew D, Shaw PJ & Ince PG (2011) . Neuroscience Letters, 505(1), 25-30. RIS download Bibtex download
  • Simpson JE, Wharton SB, Cooper J, Gelsthorpe C, Baxter L, Forster G, Shaw PJ, Savva G, Matthews FE, Brayne C & Ince PG (2010) . Neurosci Lett, 486(3), 246-251. RIS download Bibtex download
  • Simpson JE, Ince PG, Lace G, Forster G, Shaw PJ, Matthews F, Savva G, Brayne C, Wharton SB & MRC Cognitive Function and Ageing Neuropathology Study Group (2010) . Neurobiol Aging, 31(4), 578-590. RIS download Bibtex download
  • Simpson JE, Ince PG, Haynes LJ, Theaker R, Gelsthorpe C, Baxter L, Forster G, Lace GL, Shaw PJ, Matthews FE , Savva GM et al (2010) . Neuropathol Appl Neurobiol, 36(1), 25-40. RIS download Bibtex download
  • Simpson JE, Wharton SB, Cooper J, Gelsthorpe C, Baxter L, Forster G, Shaw PJ, Savva G, Matthews FE, Brayne C & Ince PG (2010) . Neuroscience Letters, 486(3), 246-251. RIS download Bibtex download
  • Simpson JE, Hosny O, Wharton SB, Heath PR, Holden H, Fernando MS, Matthews F, Forster G, O'Brien JT, Barber R , Kalaria RN et al (2009) . Stroke, 40(2), 369-375. RIS download Bibtex download
  • Wharton SB, O'Callaghan JP, Savva GM, Nicoll JAR, Matthews F, Simpson JE, Forster G, Shaw PJ, Brayne C, Ince PG & MRC Cognitive Function and Ageing Neuropathology Study Group (2009) . Dement Geriatr Cogn Disord, 27(5), 465-473. RIS download Bibtex download
  • Simpson JE, Ince PG, Higham CE, Gelsthorpe CH, Fernando MS, Matthews F, Forster G, O'Brien JT, Barber R, Kalaria RN , Brayne C et al (2007) . Neuropathol Appl Neurobiol, 33(6), 670-683. RIS download Bibtex download
  • Simpson JE, Fernando MS, Clark L, Ince PG, Matthews F, Forster G, O'Brien JT, Barber R, Kalaria RN, Brayne C , Shaw PJ et al (2007) . Neuropathol Appl Neurobiol, 33(4), 410-419. RIS download Bibtex download
  • Fernando MS, Simpson JE, Matthews F, Brayne C, Lewis CE, Barber R, Kalaria RN, Forster G, Esteves F, Wharton SB , Shaw PJ et al (2006) . Stroke, 37(6), 1391-1398. RIS download Bibtex download
  • Hadjivassiliou M, Boscolo S, Davies-Jones GAB, Gr眉newald RA, Not T, Sanders DS, Simpson JE, Tongiorgi E, Williamson CA & Woodroofe NM (2002) . Neurology, 58(8), 1221-1226. RIS download Bibtex download
  • Hadjivassiliou M, Grunewald RA, Davies-Jones GAB, Simpson JE, Williamson CA, Woodroofe MN, Boscolo S, Tongiorgi E & Not T (2001) Humoral response in the pathogenesis of gluten ataxia. ANNALS OF NEUROLOGY, 50(3), S37-S37. RIS download Bibtex download
  • John GR, Simpson JE, Woodroofe MN, Lee SC & Brosnan CF (2001) Extracellular nucleotides differentially regulate interleukin-1 beta signaling in primary human astrocytes: Implications for inflammatory gene expression. J NEUROSCI, 21(12), 4134-4142. RIS download Bibtex download
  • Simpson JE & Woodroofe MN (2001) . Inflammopharmacology, 9(1-2), 23-33. RIS download Bibtex download
  • Simpson J, Rezaie P, Newcombe J, Cuzner ML, Male D & Woodroofe MN (2000) . J Neuroimmunol, 108(1-2), 192-200. RIS download Bibtex download
  • Simpson JE, Newcombe J, Cuzner ML & Woodroofe MN (2000) . Neuropathol Appl Neurobiol, 26(2), 133-142. RIS download Bibtex download
  • Woodroofe N, Cross AK, Harkness K & Simpson JE (1999) . Adv Exp Med Biol, 468, 135-150. RIS download Bibtex download
  • Simpson JE, Hadjivassiliou M, Grunewald R, Smith C, Davies-Jones GAB & Woodroofe MN (1998) . Journal of Neuroimmunology, 90(1), 32-32. RIS download Bibtex download
  • Simpson JE, Newcombe J, Cuzner ML & Woodroofe MN (1998) . J Neuroimmunol, 84(2), 238-249. RIS download Bibtex download
  • Almansouri T, Waller R, Wharton SB, Heath PR, Matthews FE, Brayne C, van Eeden F & Simpson JE () . International Journal of Molecular Sciences, 25(8), 4445-4445. RIS download Bibtex download
  • Wharton SB, Simpson JE, Ince PG, Richardson CD, Merrick R, Matthews FE & Brayne C () . Neuropathology and Applied Neurobiology. RIS download Bibtex download
  • Simpson JE () . International Journal of Molecular Sciences, 24(9), 8184-8184. RIS download Bibtex download
  • Hase Y, Ameen鈥怉li KE, Waller R, Simpson JE, Stafford C, Mahesh A, Ryan L, Pickering L, Bodman C, Hase M , Boche D et al () . Brain Pathology. RIS download Bibtex download
  • V谩zquez-Villase帽or I, Smith CI, Thang YJR, Heath PR, Wharton SB, Blackburn DJ, Ridger VC & Simpson JE () . International Journal of Molecular Sciences, 23(11), 5913-5913. RIS download Bibtex download
  • Vazquez鈥怴illasenor I, Garwood CJ, Simpson JE, Heath PR, Mortiboys H & Wharton SB () . European Journal of Neuroscience. RIS download Bibtex download
  • Allen SP, Seehra RS, Heath PR, Hall BPC, Bates J, Garwood CJ, Matuszyk MM, Wharton SB & Simpson JE () . International Journal of Molecular Sciences, 21(21), 8028-8028. RIS download Bibtex download
  • Chambers A, Bury JJ, Minett T, Richardson CD, Brayne C, Ince PG, Shaw PJ, Garwood CJ, Heath PR, Simpson JE , Matthews FE et al () . Journal of Neuropathology & Experimental Neurology. RIS download Bibtex download
  • Brezzo G, Simpson J, Ameen-Ali KE, Berwick J & Martin C () . RIS download Bibtex download
  • Ameen-Ali KE, Simpson JE, Wharton SB, Heath PR, Sharp P, Brezzo G & Berwick J () . RIS download Bibtex download
  • Mathur R, Ince PG, Minett T, Garwood CJ, Shaw PJ, Matthews FE, Brayne C, Simpson JE & Wharton SB () . PLoS ONE, 10(2). RIS download Bibtex download
  • Fadul MM, Heath PR, Cooper-Knock J, Kurz JM, Al-Azzawi HA, Ali Z, Smith T, Matthews FE, Brayne C, Wharton SB & Simpson JE () . International Journal of Molecular Sciences, 21(21), 7924-7924. RIS download Bibtex download

Conference proceedings papers

  • Ashford BA, Appleby-Mallinder CS, Dawson C, Matuszyk MM, Heath PR, Wei W, Dunning MJ, Boche D, Simpson JE & Highley JR (2023) Inflammatory pathology in human motor neuron disease. JOURNAL OF PATHOLOGY, Vol. 261 (pp S5-S5) RIS download Bibtex download
  • Matuszyk M, Ferraiuolo L, Taylor A, Davis P, Staniforth R, Garwood C, Simpson J & Wharton S (2022) Characterising the astrocyte response to oligomeric and fibrillary A beta 1-42 in Alzheimer's disease. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 48 RIS download Bibtex download
  • Thang Y, Vazquez-Villasenor I, Smith C, Blackburn D, Wharton S, Heath P, Ridger V & Simpson J (2022) The miRNA profile of neutrophil-derived microvesicles may impact blood-brain barrier integrity in Alzheimer's disease. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 48 RIS download Bibtex download
  • Floare M, Simpson J, Wharton S, Aeschlimann D & Hadjivassiliou M (2022) Demystifying the gluten brain: Understanding the origin of gluten-related neurological disorders. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 48 RIS download Bibtex download
  • Ashford B, Dunning M, Wei W, Heath P, Boche D, Simpson J & Highley R (2022) Exploring the neuroinflammatory response of the motor cortex and spinal cord in human motor neurone disease. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 48 RIS download Bibtex download
  • Almansouri T, Heath P, Wharton S, Van Eeden F & Simpson J (2022) Microarray approach to identifying the role of microglia in the pathogenesis of age-associated deep-subcortical white matter lesions. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 48 RIS download Bibtex download
  • Waller R, Heath PR, Simpson JE, Hase Y, Kalaria RN & Wharton SB (2021) What happens to cells of the brain in people who develop dementia after stroke?. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 47 (pp 8-8) RIS download Bibtex download
  • Ashford B, Appleby-Mallinder C, Boche D, Wei W, Heath P, Simpson J & Highley R (2021) Exploring the Neuroinflammatory Response of the Motor Regions in Human Motor Neurone Disease. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 47 (pp 11-11) RIS download Bibtex download
  • Guagnelli MAR, Wharton S, Francis S & Simpson J (2021) The effect of systemic atherosclerosis on the neurovascular unit. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 47 (pp 21-21) RIS download Bibtex download
  • (2020) . Neuropathology and Applied Neurobiology, Vol. 46 (pp 5-6) RIS download Bibtex download
  • Jennings O, Ajikumar A, Heath PR, Wharton SB & Simpson JE (2020) Transcriptomic profile of the blood-brain barrier in age-associated white matter lesions. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 46 (pp 46-46) RIS download Bibtex download
  • Hase Y, Foster V, Waller R, Simpson JE, Heath P, Wharton SB & Kalaria RN (2020) 121st Meeting of the British Neuropathological Society UCL Great Ormond Street Institute of Child Health, London. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 46 (pp 14-15) RIS download Bibtex download
  • Leach V, Goodall E, Cooper-Knock J, Wang C, Simpson J, Baker D, Drew D, Saffrey MJ, Romero I, Heath P & Wharton S (2019) Identification of miRNA and mRNA regulatory networks in the ageing blood-brain barrier: Comparative gene expression studies in human and mouse. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 45 (pp 31-31) RIS download Bibtex download
  • Vazquez-Villasenor I, Garwood CJ, Heath PR, Simpson JE & Wharton SB (2019) Investigating senescence activation in response to oxidative DNA damage in neurones in vitro. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 45 (pp 39-39) RIS download Bibtex download
  • Mistry H, Simpson J, Chambers A, Garwood C, Ince P, Heath P & Wharton S (2019) Cholesterol dysregulation in the neurone-astrocyte unit as an early contributor to neuronal dysfunction in Alzheimer's disease. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 45 (pp 15-16) RIS download Bibtex download
  • Rebollar MA, Wharton S, Francis S & Simpson J (2019) The effect of systemic atherosclerosis in the neurovascular unit. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 45 (pp 31-31) RIS download Bibtex download
  • Waller S, Baxter L, Fillingham D, Coelho S, Pozo JM, Mozumder M, Frangi A, Ince PG, Simpson JE & Highley JR (2019) . Neuropathology and Applied Neurobiology, Vol. 45(S1) (pp 33-33), 6 March 2019 - 8 March 2019. RIS download Bibtex download
  • Ashford BA, Appleby-Mallinder CS, Heath P, Simpson JE & Highley R (2019) The role of immunity in human motor neuron disease (MND). NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 45 (pp 24-24) RIS download Bibtex download
  • Fadul MM, Heath P, Cooper-Knock J, Brayne C, Matthews F, Wharton S & Simpson J (2019) A microarray analysis approach to identify mechanisms underlying the pathogenesis of age-associated periventricular white matter lesions. GLIA, Vol. 67 (pp E300-E300) RIS download Bibtex download
  • Seehra RS, Wharton S, Heath P, Ince P, Muthana M, Garwood C & Simpson J (2018) Hypoxia-induced changes in astrocytes and their role in the formation of age-associated white matter lesions. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 44 (pp 17-18) RIS download Bibtex download
  • Chambers A, Minett T, Matthews F, Brayne C, Ince P, Shaw P, Heath P, Simpson J & Wharton S (2018) Advanced glycosylated end products in the ageing brain. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 44 (pp 12-12) RIS download Bibtex download
  • Leach V, Goodall E, Cooper-Knock J, Wang J, Simpson J, Baker D, Drew D, Saffrey J, Romero I, Heath P & Wharton S (2018) Identification of miRNA and mRNA regulatory networks in the ageing blood-brain barrier: Comparative gene expression studies in human and mouse. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 44 (pp 36-36) RIS download Bibtex download
  • Coelho S, Highley R, Pozo J, Costantini M, Mozumder M, Simpson J, Ince P & Frangi A (2018) Local volume fraction distributions of axons, astrocytes, and myelin in deep subcortical white matter lesions and normal white matter in the ageing brain. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 44 (pp 26-26) RIS download Bibtex download
  • Ameen-Ali KE, Simpson JE, Wharton SB, Heath PR, Sharp P & Berwick J (2017) Early cellular changes and cognitive decline in an Alzheimer's mouse model. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 43 (pp 42-43) RIS download Bibtex download
  • Vazquez-Villasenor I, Simpson JE, Garwood CJ, Ince PG, Heath PR & Wharton SB (2017) Neuronal senescence as a contributor to neurodegeneration. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 43 (pp 43-43) RIS download Bibtex download
  • Ratcliffe L, Garwood CJ, Heath P, Villasenor I, Simpson J, Ince PG & Wharton SB (2016) Impairment of IGF1 signalling in human astrocytes and it's effect on astrocyte support for neurons. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 42 (pp 51-52) RIS download Bibtex download
  • Vazquez-Villasenor I, Simpson JE, Garwood C, Ince PG, Heath P & Wharton SB (2016) Neuronal senescence as a contributor to neurodegeneration. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 42 (pp 27-28) RIS download Bibtex download
  • Vazquez-Villasenor I, Simpson JE, Garwood C, Ince PG, Heath P & Wharton SB (2015) Neuronal senescence as a contributor to neurodegeneration. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 41 (pp 32-32) RIS download Bibtex download
  • Ramos I, Walter R, Simpson J, Woodroofe N & Lyng F (2014) . Journal of Neuroimmunology, Vol. 275(1-2) (pp 128-128) RIS download Bibtex download
  • Alsomali KY, Simpson J & Heath PR (2014) Investigating RNA editing in the pathogenesis of amyotrophic lateral sclerosis. FEBS JOURNAL, Vol. 281 (pp 685-686) RIS download Bibtex download
  • Simpson JE, Ince PG, Matthews F, Shaw PJ, Heath PR, Brayne C, Garwood C, Abdalla H, Higginbottom A & Wharton SB (2014) A neuronal DNA damage response is detected at low Braak stages and correlates with cognitive impairment in the ageing brain. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 40 (pp 31-32) RIS download Bibtex download
  • Al-Mashhadi SA, Simpson JE, Heath PR, Dickman MJ, Ince PG & Wharton SB (2014) Oxidative stress and DNA damage in cerebral white matter lesions of the ageing human brain. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 40 (pp 33-34) RIS download Bibtex download
  • Al-Mashhadi SA, Simpson JE, Heath PR, Dickman MJ, Ince PG & Wharton SB (2013) Oxidative stress and DNA damage in cerebral white matter lesions of the ageing human brain. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 39 (pp 36-37) RIS download Bibtex download
  • Ince PG, Janaway B, Wharton SB, Simpson JE, Highley JR, Matthews FE, Forster G & Brayne C (2013) Evidence for an ischemic origin of deep brain 'microbleeds'. CEREBROVASCULAR DISEASES, Vol. 35 (pp 42-42) RIS download Bibtex download
  • Lopez-Ramirez MA, Wu D, Pryce G, Simpson JE, Reijerkerk A, King-Robson J, de Vries HE, Hirst MC, Sharrack B, Baker D , Michael GJ et al (2012) Endothelial miR-155 promotes blood brain barrier dysfunction in neuroinflammation. JOURNAL OF NEUROIMMUNOLOGY, Vol. 253(1-2) (pp 3-4) RIS download Bibtex download
  • Waller R, Heath PR, Woodroofe MN, Francese S, Wharton SB, Ince PG, Sharrack B & Simpson JE (2012) Microarray analysis of the astrocyte transcriptome in normal appearing white matter in multiple sclerosis. JOURNAL OF NEUROIMMUNOLOGY, Vol. 253(1-2) (pp 54-54) RIS download Bibtex download
  • Simpson J, Richardson K, Heath P & Wharton S (2011) Oxidative nucleic acid damage in motor neuron disease. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 37 (pp 36-36) RIS download Bibtex download
  • Simpson JE, Ince PG, Heath PR, Raman R, Shaw PJ, Gelsthorpe C, Baxter L, Forster G, Matthews F, Savva G , Brayne C et al (2011) Microarray analysis of the astrocyte transcriptome in the ageing brain: relationship to Alzheimer's pathology and ApoE genotype. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 37 (pp 33-33) RIS download Bibtex download
  • Simpson J, Ince P, Heath P, Raman R, Shaw P, Gelsthorpe C, Baxter L, Forster G, Matthews F, Savva G , Brayne C et al (2010) Microarray analysis of the astrocyte transcriptome in the ageing brain: relationship to Alzheimer's pathology and ApoE genotype. BRAIN PATHOLOGY, Vol. 20 (pp 46-46) RIS download Bibtex download
  • Simpson JE, Ince PG, Theaker R, Haynes L, Forster G, Shaw PJ, Matthews F, Savva G, Brayne C, Wharton SB & MRC Cognitive Function & Ageing Ne (2009) Evidence of an astrocytic DNA damage response to oxidative stress in the ageing brain. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 35 (pp 18-19) RIS download Bibtex download
  • Simpson J, Ince P, Theaker R, Haynes L, Forster G, Shaw P, Matthews F, Savva G, Brayne C & Wharton S (2008) DNA oxidative damage and repair mechanisms in astrocytes, and their relationship to Alzheimer-type pathology in the ageing brain. JOURNAL OF NEURAL TRANSMISSION, Vol. 115(12) (pp 1727-1727) RIS download Bibtex download
  • Hosny O, Kirby J, Simpson J & Ince P (2008) Iron metabolism pathways in white matter lesions in the elderly. JOURNAL OF NEURAL TRANSMISSION, Vol. 115(12) (pp 1717-1718) RIS download Bibtex download
  • Simpson JE, Ince PG, Lace G, Forster G, Shaw PJ, Matthews F, Brayne C, Wharton SB & MRC Cognitive Function Ageing (2008) Characterisation of astrocytes in relation to Alzheimer-type pathology in the ageing brain using a population-based neuropathology cohort. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 34 (pp 31-31) RIS download Bibtex download
  • Simpson JE, El-Sayed OH, Wharton SB, Heath P, Holden H, Forster G, Fernando MS, Matthews F, Brayne C, Lewis CE , Barber R et al (2008) Microarray gene expression analysis of deep subcortical lesions in the ageing brain reveals changes in multiple functional pathways. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 34 (pp 30-31) RIS download Bibtex download
  • Simpson JE, El-Sayed OH, Wharton SB, Heath P, Holden H, Forster G, Fernando MS, Matthews F, Brayne C, Lewis CE , Barber R et al (2007) Microarray gene expression profiling of deep subcortical lesions in the ageing brain. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 33(2) (pp 254-255) RIS download Bibtex download
  • Simpson JE, Higham CE, Gelsthorpe CH, Fernando MS, Matthews F, Forster G, O'Brien JT, Barber R, Kalaria RN, Brayne C , Shaw PJ et al (2007) Microglial activation in white matter of the ageing brain. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 33(2) (pp 255-255) RIS download Bibtex download
  • Hosny O, Highley JR, Simpson JE, Forster G, Wharton SB & Ince PG (2007) Axonal number and myelin sheath degeneration in MRI hyperintense white matter lesions in the aging brain. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 33(2) (pp 266-267) RIS download Bibtex download
  • Ince PG, Fernando MS, Matthews F, Brayne C, Wharton SB, O'Brien JT, Lewis C, Kalaria RN, Shaw PJ & Simpson J (2006) Molecular markers of tissue hypoxia and glial pathology associated with incidental white matter lesions in the ageing brain. BRAIN PATHOLOGY, Vol. 16 (pp S92-S92) RIS download Bibtex download
  • Simpson JE, Fernando MS, Matthews F, Brayne C, Lewis CE, Barber R, Kalaria RN, Forster G, Esteves F, Wharton SB , Shaw PJ et al (2006) Molecular markers of tissue hypoxia are associated with deep subcortical white matter lesions in the ageing brain. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 32(2) (pp 224-224) RIS download Bibtex download
  • Simpson JE, Fernando MS, Clark L, Ince PG, Matthews F, Forster G, O'Brien JT, Barber R, Kalaria RN, Brayne C , Shaw PJ et al (2006) Glial cell pathology of periventricular and deep white matter lesions in the ageing brain. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 32(2) (pp 224-225) RIS download Bibtex download
  • Owasil R, O鈥橬eill R, Keable A, Nimmo J, MacGregor Sharp M, Kelly L, Saito S, Simpson JE, Weller RO, Smith C , Attems J et al () . International Journal of Molecular Sciences, Vol. 21(4) (pp 1225-1225) RIS download Bibtex download

Preprints

  • Brezzo G, Simpson J, Ameen-Ali KE, Berwick J & Martin C () , Research Square Platform LLC. RIS download Bibtex download
Research group

PhD students

  • Mara Floare.  Supervisors: Julie Simpson, Marios Hadjivassilou  TG6 autoimmunity and the development of neurological dysfunction in gluten sensitivity related disorders鈥
  • Zoe Moore.  Supervisors: Julie Simpson, Steve Wharton 鈥淒oes systemic infection modulate astrocyte function in Alzheimer鈥檚 disease?鈥
Teaching interests

I am involved in teaching on all MSc courses within the Division of Neuroscience.  I am Course Lead of the MSc Translational Neuroscience, a course which is designed for students interested in gaining the practical, lab-based skills necessary to understand neurological diseases at the molecular and cellular level, and how to apply this knowledge to benefit patients.   

I was awarded a Postgraduate Certificate in Learning and Teaching in Higher Education from 葫芦影业 Hallam University in 1999, became a Fellow of the Higher Education Academy in 2011, and a Senior Fellow of the HEA in 2019.

Teaching activities

I am involved in teaching on all MSc courses within the Department of Neuroscience.  I am Course Lead of the MSc Translational Neuropathology, a course which combines core teaching of the fundamental aspects of the major neuropathological diseases with significant emphasis on the development of practical laboratory skills, and Course Lead of the MSc Translational Neuroscience, a course which is focused on the molecular basis of neurodegeneration, and looks at how laboratory research relating to brain structure and function informs the development of new therapies for diseases of the nervous system.  

I was awarded a Postgraduate Certificate in Learning and Teaching in Higher Education from 葫芦影业 Hallam University in 1999, became a Fellow of the Higher Education Academy in 2011, and a Senior Fellow of the HEA in 2019.

Professional activities and memberships
  • Alzheimer鈥檚 Research UK Yorkshire Network Co-ordinator
  • Peer review of submitted papers for journals including Acta Neuropathologica, Brain Behaviour & Immunity, Glia, Journal of Neuroimmunology, Neuropathology and Applied Neurobiology, Neuroscience Letters, FASEB and PLOS One.
  • Peer review of grant applications for funding bodies including the Alzheimer鈥檚 Society, MRC, BBSRC and NC3Rs.
  • Ethics reviewer for the School of Medicine

Membership of Associations and Societies

  • British Neuropathological Society
  • British Neuroscience Association
  • Pathological Society