Dr Julie Simpson
PhD
Neuroscience, School of Medicine and Population Health
Senior Lecturer in Translational Neuropathology
+44 114 222 2242
Full contact details
Neuroscience, School of Medicine and Population Health
葫芦影业 Institute for Translational Neuroscience (SITraN)
385a Glossop Road
葫芦影业
S10 2HQ
- Profile
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I graduated from the University of 葫芦影业 in 1995 with BSc (Hons) in Neuroscience, and was awarded a PhD in Neuroimmunology from 葫芦影业 Hallam University in 1999. I joined the former Department of Neuroscience (now part of the School of Medicine and Population Health) at the University of 葫芦影业 in 2002 and have been a member of the Neuropathology research group since 2004. I was appointed Lecturer in Translational Neuropathology at SITraN in 2016 and Senior Lecturer in 2020.
- Research interests
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My main research interests are identifying and understanding neuroinflammatory contributions to ageing and dementia. My research primarily focusses on the detailed immunohistological characterisation and gene expression profiling of specific cell populations in the ageing brain.
Current Projects
- Blood brain barrier dysfunction in the ageing brain
- The link between systemic infection and cognitive decline in patients with dementia
- Microglial-mediated mechanisms underlying the pathogenesis of neurodegenerative diseases
- Publications
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Journal articles
- . Brain Communications, 6(2).
- . Neuroscience Research.
- . Transl Stroke Res.
- . Journal of Neurochemistry.
- . Brain Pathology, 31(3).
- . Acta Neuropathologica Communications, 9(1).
- . Alzheimer's & Dementia, 16(S3).
- . Acta Neuropathologica Communications, 8(1).
- . Neuropathology and Applied Neurobiology.
- . Brain, Behavior, & Immunity - Health, 5.
- . Neuropathology.
- . International Journal of Molecular Sciences, 21(1).
- . International Journal of Molecular Sciences, 20(20).
- . International Journal of Molecular Sciences, 20(12).
- . Neuropathology and Applied Neurobiology.
- . NeuroImage Clinical, 23.
- . Data in Brief, 23.
- . Brain Research, 1706, 218-223.
- . Journal of Alzheimer's disease : JAD.
- . PLoS ONE, 14(1).
- . Glia, 66(11), 2316-2323.
- . Neuroscience, 390, 46-59.
- . NeuroImage, 179, 275-287.
- . European Journal of Neuroscience, 47(12), 1444-1456.
- . Alzheimer's & Dementia, 14(7S_Part_31), P1624-P1624.
- . Alzheimer's & Dementia, 14(7S_Part_27), P1455-P1455.
- . Neuropathology and Applied Neurobiology, 44(3), 328-340.
- , 273-284.
- . Neuropathology and Applied Neurobiology, 43(7), 553-570.
- . Neuropathology and Applied Neurobiology, 43(4), 281-298.
- . Neurobiology of Disease.
- . Journal of Neuroimmunology, 299, 139-146.
- . Journal of Neuroscience Methods, 268, 125-130.
- . Neuropathology and Applied Neurobiology, 42(2), 167-179.
- . Molecular Brain, 8(1).
- . Neuroscience Letters, 609, 11-17.
- . Brain Pathology, 25(5), 565-574.
- . Neuropathology and Applied Neurobiology, 41(4), 483-496.
- . Journal of Cerebral Blood Flow & Metabolism, 35(3), 412-423.
- . Brain Pathology, 25(1), 35-43.
- . GLIA.
- . FASEB J, 28(6), 2551-2565.
- . Neuropathol Appl Neurobiol, 40(7), 802-814.
- . Journal of Aging Science, 2(1).
- . Neuropathol Appl Neurobiol, 40(3), 258-269.
- . Neuropathol Appl Neurobiol, 39(7), 788-799.
- . Neurodegenerative Disease Management, 2(5), 471-482.
- . Dement Geriatr Cogn Disord, 34(1), 15-24.
- . J Neurosci Methods, 208(2), 108-113.
- . NEUROBIOL AGING, 32(10), 1795-1807.
- . Neurosci Lett, 505(1), 25-30.
- . Alzheimer's & Dementia, 7, S566-S566.
- . J Alzheimers Dis, 25(2), 359-372.
- . NeuroMolecular Medicine, 13(4), 289-299.
- Brain Iron Dysregulation and the Risk of Ageing White Matter Lesions. NeuroMolecular Medicine, 1-11.
- . Neuroscience Letters, 505(1), 25-30.
- . Neurosci Lett, 486(3), 246-251.
- . Neurobiol Aging, 31(4), 578-590.
- . Neuropathol Appl Neurobiol, 36(1), 25-40.
- . Neuroscience Letters, 486(3), 246-251.
- . Stroke, 40(2), 369-375.
- . Dement Geriatr Cogn Disord, 27(5), 465-473.
- . Neuropathol Appl Neurobiol, 33(6), 670-683.
- . Neuropathol Appl Neurobiol, 33(4), 410-419.
- . Stroke, 37(6), 1391-1398.
- . Neurology, 58(8), 1221-1226.
- Humoral response in the pathogenesis of gluten ataxia. ANNALS OF NEUROLOGY, 50(3), S37-S37.
- Extracellular nucleotides differentially regulate interleukin-1 beta signaling in primary human astrocytes: Implications for inflammatory gene expression. J NEUROSCI, 21(12), 4134-4142.
- . Inflammopharmacology, 9(1-2), 23-33.
- . J Neuroimmunol, 108(1-2), 192-200.
- . Neuropathol Appl Neurobiol, 26(2), 133-142.
- . Adv Exp Med Biol, 468, 135-150.
- . Journal of Neuroimmunology, 90(1), 32-32.
- . J Neuroimmunol, 84(2), 238-249.
- . International Journal of Molecular Sciences, 25(8), 4445-4445.
- . Neuropathology and Applied Neurobiology.
- . International Journal of Molecular Sciences, 24(9), 8184-8184.
- . Brain Pathology.
- . International Journal of Molecular Sciences, 23(11), 5913-5913.
- . European Journal of Neuroscience.
- . International Journal of Molecular Sciences, 21(21), 8028-8028.
- . Journal of Neuropathology & Experimental Neurology.
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- . PLoS ONE, 10(2).
- . International Journal of Molecular Sciences, 21(21), 7924-7924.
Conference proceedings papers
- Inflammatory pathology in human motor neuron disease. JOURNAL OF PATHOLOGY, Vol. 261 (pp S5-S5)
- Characterising the astrocyte response to oligomeric and fibrillary A beta 1-42 in Alzheimer's disease. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 48
- The miRNA profile of neutrophil-derived microvesicles may impact blood-brain barrier integrity in Alzheimer's disease. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 48
- Demystifying the gluten brain: Understanding the origin of gluten-related neurological disorders. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 48
- Exploring the neuroinflammatory response of the motor cortex and spinal cord in human motor neurone disease. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 48
- Microarray approach to identifying the role of microglia in the pathogenesis of age-associated deep-subcortical white matter lesions. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 48
- What happens to cells of the brain in people who develop dementia after stroke?. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 47 (pp 8-8)
- Exploring the Neuroinflammatory Response of the Motor Regions in Human Motor Neurone Disease. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 47 (pp 11-11)
- The effect of systemic atherosclerosis on the neurovascular unit. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 47 (pp 21-21)
- . Neuropathology and Applied Neurobiology, Vol. 46 (pp 5-6)
- Transcriptomic profile of the blood-brain barrier in age-associated white matter lesions. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 46 (pp 46-46)
- 121st Meeting of the British Neuropathological Society UCL Great Ormond Street Institute of Child Health, London. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 46 (pp 14-15)
- Identification of miRNA and mRNA regulatory networks in the ageing blood-brain barrier: Comparative gene expression studies in human and mouse. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 45 (pp 31-31)
- Investigating senescence activation in response to oxidative DNA damage in neurones in vitro. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 45 (pp 39-39)
- Cholesterol dysregulation in the neurone-astrocyte unit as an early contributor to neuronal dysfunction in Alzheimer's disease. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 45 (pp 15-16)
- The effect of systemic atherosclerosis in the neurovascular unit. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 45 (pp 31-31)
- . Neuropathology and Applied Neurobiology, Vol. 45(S1) (pp 33-33), 6 March 2019 - 8 March 2019.
- The role of immunity in human motor neuron disease (MND). NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 45 (pp 24-24)
- A microarray analysis approach to identify mechanisms underlying the pathogenesis of age-associated periventricular white matter lesions. GLIA, Vol. 67 (pp E300-E300)
- Hypoxia-induced changes in astrocytes and their role in the formation of age-associated white matter lesions. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 44 (pp 17-18)
- Advanced glycosylated end products in the ageing brain. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 44 (pp 12-12)
- Identification of miRNA and mRNA regulatory networks in the ageing blood-brain barrier: Comparative gene expression studies in human and mouse. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 44 (pp 36-36)
- Local volume fraction distributions of axons, astrocytes, and myelin in deep subcortical white matter lesions and normal white matter in the ageing brain. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 44 (pp 26-26)
- Early cellular changes and cognitive decline in an Alzheimer's mouse model. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 43 (pp 42-43)
- Neuronal senescence as a contributor to neurodegeneration. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 43 (pp 43-43)
- Impairment of IGF1 signalling in human astrocytes and it's effect on astrocyte support for neurons. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 42 (pp 51-52)
- Neuronal senescence as a contributor to neurodegeneration. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 42 (pp 27-28)
- Neuronal senescence as a contributor to neurodegeneration. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 41 (pp 32-32)
- . Journal of Neuroimmunology, Vol. 275(1-2) (pp 128-128)
- Investigating RNA editing in the pathogenesis of amyotrophic lateral sclerosis. FEBS JOURNAL, Vol. 281 (pp 685-686)
- A neuronal DNA damage response is detected at low Braak stages and correlates with cognitive impairment in the ageing brain. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 40 (pp 31-32)
- Oxidative stress and DNA damage in cerebral white matter lesions of the ageing human brain. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 40 (pp 33-34)
- Oxidative stress and DNA damage in cerebral white matter lesions of the ageing human brain. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 39 (pp 36-37)
- Evidence for an ischemic origin of deep brain 'microbleeds'. CEREBROVASCULAR DISEASES, Vol. 35 (pp 42-42)
- Endothelial miR-155 promotes blood brain barrier dysfunction in neuroinflammation. JOURNAL OF NEUROIMMUNOLOGY, Vol. 253(1-2) (pp 3-4)
- Microarray analysis of the astrocyte transcriptome in normal appearing white matter in multiple sclerosis. JOURNAL OF NEUROIMMUNOLOGY, Vol. 253(1-2) (pp 54-54)
- Oxidative nucleic acid damage in motor neuron disease. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 37 (pp 36-36)
- Microarray analysis of the astrocyte transcriptome in the ageing brain: relationship to Alzheimer's pathology and ApoE genotype. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 37 (pp 33-33)
- Microarray analysis of the astrocyte transcriptome in the ageing brain: relationship to Alzheimer's pathology and ApoE genotype. BRAIN PATHOLOGY, Vol. 20 (pp 46-46)
- Evidence of an astrocytic DNA damage response to oxidative stress in the ageing brain. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 35 (pp 18-19)
- DNA oxidative damage and repair mechanisms in astrocytes, and their relationship to Alzheimer-type pathology in the ageing brain. JOURNAL OF NEURAL TRANSMISSION, Vol. 115(12) (pp 1727-1727)
- Iron metabolism pathways in white matter lesions in the elderly. JOURNAL OF NEURAL TRANSMISSION, Vol. 115(12) (pp 1717-1718)
- Characterisation of astrocytes in relation to Alzheimer-type pathology in the ageing brain using a population-based neuropathology cohort. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 34 (pp 31-31)
- Microarray gene expression analysis of deep subcortical lesions in the ageing brain reveals changes in multiple functional pathways. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 34 (pp 30-31)
- Microarray gene expression profiling of deep subcortical lesions in the ageing brain. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 33(2) (pp 254-255)
- Microglial activation in white matter of the ageing brain. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 33(2) (pp 255-255)
- Axonal number and myelin sheath degeneration in MRI hyperintense white matter lesions in the aging brain. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 33(2) (pp 266-267)
- Molecular markers of tissue hypoxia and glial pathology associated with incidental white matter lesions in the ageing brain. BRAIN PATHOLOGY, Vol. 16 (pp S92-S92)
- Molecular markers of tissue hypoxia are associated with deep subcortical white matter lesions in the ageing brain. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 32(2) (pp 224-224)
- Glial cell pathology of periventricular and deep white matter lesions in the ageing brain. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 32(2) (pp 224-225)
- . International Journal of Molecular Sciences, Vol. 21(4) (pp 1225-1225)
Preprints
- Research group
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PhD students
- Mara Floare. Supervisors: Julie Simpson, Marios Hadjivassilou 鈥TG6 autoimmunity and the development of neurological dysfunction in gluten sensitivity related disorders鈥
- Zoe Moore. Supervisors: Julie Simpson, Steve Wharton 鈥淒oes systemic infection modulate astrocyte function in Alzheimer鈥檚 disease?鈥
- Teaching interests
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I am involved in teaching on all MSc courses within the Division of Neuroscience. I am Course Lead of the MSc Translational Neuroscience, a course which is designed for students interested in gaining the practical, lab-based skills necessary to understand neurological diseases at the molecular and cellular level, and how to apply this knowledge to benefit patients.
I was awarded a Postgraduate Certificate in Learning and Teaching in Higher Education from 葫芦影业 Hallam University in 1999, became a Fellow of the Higher Education Academy in 2011, and a Senior Fellow of the HEA in 2019.
- Teaching activities
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I am involved in teaching on all MSc courses within the Department of Neuroscience. I am Course Lead of the MSc Translational Neuropathology, a course which combines core teaching of the fundamental aspects of the major neuropathological diseases with significant emphasis on the development of practical laboratory skills, and Course Lead of the MSc Translational Neuroscience, a course which is focused on the molecular basis of neurodegeneration, and looks at how laboratory research relating to brain structure and function informs the development of new therapies for diseases of the nervous system.
I was awarded a Postgraduate Certificate in Learning and Teaching in Higher Education from 葫芦影业 Hallam University in 1999, became a Fellow of the Higher Education Academy in 2011, and a Senior Fellow of the HEA in 2019.
- Professional activities and memberships
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- Alzheimer鈥檚 Research UK Yorkshire Network Co-ordinator
- Peer review of submitted papers for journals including Acta Neuropathologica, Brain Behaviour & Immunity, Glia, Journal of Neuroimmunology, Neuropathology and Applied Neurobiology, Neuroscience Letters, FASEB and PLOS One.
- Peer review of grant applications for funding bodies including the Alzheimer鈥檚 Society, MRC, BBSRC and NC3Rs.
- Ethics reviewer for the School of Medicine
Membership of Associations and Societies
- British Neuropathological Society
- British Neuroscience Association
- Pathological Society