Wharton, Stephen B, Professor

Professor Stephen B Wharton

School of Medicine and Population Health

Professor and Honorary Consultant in Neuropathology

s.wharton@sheffield.ac.uk

��«Ӱҵ Institute for Translational Neuroscience (SITraN)

Full contact details

Professor Stephen B Wharton
School of Medicine and Population Health
��«Ӱҵ Institute for Translational Neuroscience (SITraN)
385a Glossop Road
��«Ӱҵ
S10 2HQ

Profile

2014 - present: Professor in Neuropathology, ��«Ӱҵ
2001-2014: Senior Lecturer / Reader in Neuropathology, ��«Ӱҵ
2001 – present: honorary consultant in neuropathology, ��«Ӱҵ Teaching Hospitals
1997 - 2001: Senior lecturer / honorary consultant in Neuropathology, Edinburgh University
1994 – 1997: Senior registrar in Neuropathology, Addenbrookes Hospital, Cambridge

Qualifications

PhD, University of ��«Ӱҵ, 2013
FRCPath awarded 2005
MRCPath in Neuropathology 1997
DipRCPath Histopathology 1995
MSc University of Cambridge 1995
MBBS London University 1988
BSc (Hons) University of London 1985

Research interests

Professor Wharton’s research interest are focused on the cellular and molecular pathology of dementia and brain ageing. His major areas of interest are in:

Lead in neuropathology for the which takes a population-based approach to understanding the pathological basis of late-life dementia.
Investigating the cellular and molecular pathology of astrocytes, neurones and endothelium as components of the neurovascular unit in brain ageing and in the pathogenesis of dementia.
The pathogenesis of white matter pathology in brain ageing and its contribution to dementia.
The pathology of motor neurone diseases and tissue banking.

External collaborations

Prof Fiona Matthews (University of Newcastle) and Prof Carol Brayne (University of Cambridge). The Cognitive Function and Ageing Study.

Publications

Journal articles

Xia Z, Prescott EE, Urbanek A, Wareing HE, King MC, Olerinyova A, Dakin H, Leah T, Barnes KA, Matuszyk MM , Dimou E et al (2024) . Nature Communications, 15.
Floare M-L, Wharton SB, Simpson JE, Aeschlimann D, Hoggard N & Hadjivassiliou M (2024) . Brain Communications, 6(2).
Rajab MD, Taketa T, Wharton SB, Wang D & Cognitive Function and Ageing Neuropathology Study, and for the (2024) . Brain Pathol, e13247.
Mistry H, Richardson CD, Higginbottom A, Ashford B, Ahamed SU, Moore Z, Matthews FE, Brayne C, Simpson JE & Wharton SB (2024) . Neuroscience Research.
Sanders MI, Gatt D, Lee V, Wharton SB & Bagga V (2024) . Brain and Spine, 4, 102819-102819.
Rajab MD, Jammeh E, Taketa T, Brayne C, Matthews FE, Su L, Ince PG, Wharton SB & Wang D (2023) . Alzheimer’s Research & Therapy, 15.
Nichols E, Merrick R, Hay SI, Himali D, Himali JJ, Hunter S, Keage HAD, Latimer CS, Scott MR, Steinmetz JD , Walker JM et al (2023) . The Lancet Healthy Longevity, 4(3), e115-e125.
Nichols E, Merrick R, Wharton S, Matthews FE, Brayne C & Vos T (2022) . Alzheimer's & Dementia, 18(S5).
Williamson D, Schwalbe EC, Hicks D, Aldinger KA, Lindsey JC, Crosier S, Richardson S, Goddard J, Hill RM, Castle J , Grabovska Y et al (2022) . Cell Reports, 40(5), 111162-111162.
Hase Y, Ameen‐Ali KE, Waller R, Simpson JE, Stafford C, Mahesh A, Ryan L, Pickering L, Bodman C, Hase M , Boche D et al (2022) . Brain Pathology.
Nelson PT, Brayne C, Flanagan ME, Abner EL, Agrawal S, Attems J, Castellani RJ, Corrada MM, Cykowski MD, Di J , Dickson DW et al (2022) . Acta Neuropathologica, 144(1), 27-44.
Waller R, Hase Y, Simpson JE, Heath PR, Wyles M, Kalaria RN & Wharton SB (2022) . Translational Stroke Research.
Perez-Nievas BG, Johnson L, Beltran-Lobo P, Hughes MM, Gammallieri L, Tarsitano F, Myszczynska MA, Vazquez-Villasenor I, Jimenez-Sanchez M, Troakes C , Wharton SB et al (2021) . Journal of Neuroinflammation, 18(1).
Matuszyk MM, Garwood CJ, Ferraiuolo L, Simpson JE, Staniforth RA & Wharton SB (2021) . Journal of Neurochemistry.
Ellmerich S, Taylor GW, Richardson CD, Minett T, Schmidt AF, Brayne C, Matthews FE, Ince PG, Wharton SB & Pepys MB (2021) . Brain Communications, 3(4).
Vazquez‐Villasenor I, Garwood CJ, Simpson JE, Heath PR, Mortiboys H & Wharton SB (2021) . European Journal of Neuroscience.
Waller R, Narramore R, Simpson JE, Heath PR, Verma N, Tinsley M, Barnes J, Haris H, Henderson FE, Matthews FE , Richardson CD et al (2021) . Brain Pathology, 31(3).
Crosier S, Hicks D, Schwalbe EC, Williamson D, Nicholson SL, Smith A, Lindsey JC, Michalski A, Pizer B, Bailey S , Bown N et al (2021) . Neuropathol Appl Neurobiol.
Dodds RM, Murray JC, Granic A, Hurst C, Uwimpuhwe G, Richardson S, Brayne C, Matthews FE & Sayer AA (2021) . Journal of Cachexia, Sarcopenia and Muscle, 12(2), 308-318.
Bury JJ, Chambers A, Heath PR, Ince PG, Shaw PJ, Matthews FE, Brayne C, Simpson JE & Wharton SB (2021) . Acta Neuropathologica Communications, 9(1).
Leah T, Vazquez-Villaseñor I, Ferraiuolo L, Wharton S & Mortiboys H (2021) . Bio-protocol, 11(1).
Richardson S, Hill RM, Kui C, Lindsey JC, Grabovska Y, Schwalbe EC, Hicks D, Williamson D, Crosier S, Joshi A , Wharton SB et al (2020) . Neuro-Oncology, 22(Supplement_3), iii408-iii408.
Hill R, Richardson S, Schwalbe E, Hicks D, Lindsey J, Crosier S, Rafiee G, Grabovska Y, Wharton S, Jacques T , Michalski A et al (2020) . Neuro-Oncology, 22(Supplement_3), iii405-iii406.
De Marco M, Manca R, Kirby J, Hautbergue G, Blackburn DJ, Wharton S & Venneri A (2020) . Alzheimer's & Dementia, 16(S4).
Richardson S, Hill RM, Kui C, Lindsey JC, Grabovska Y, Schwalbe EC, Hicks D, Williamson D, Crosier S, Joshi A , Wharton SB et al (2020) MBRS-60. THE ACTIONABLE GENOMIC LANDSCAPE OF RELAPSED MEDULLOBLASTOMA IS DEFINED BY MAINTENANCE AND ACQUISITION OF DRIVER EVENTS. Neuro-oncology, 22(Suppl 3), iii408-iii408.
Hill R, Richardson S, Schwalbe E, Hicks D, Lindsey J, Crosier S, Rafiee G, Grabovska Y, Wharton S, Jacques T , Michalski A et al (2020) MBRS-44. TIME, PATTERN AND OUTCOME OF MEDULLOBLASTOMA RELAPSE ARE ASSOCIATED WITH TUMOUR BIOLOGY AT DIAGNOSIS AND UPFRONT THERAPY: A COHORT STUDY. Neuro-oncology, 22(Suppl 3), iii405-iii406.
Allen SP, Seehra RS, Heath PR, Hall BPC, Bates J, Garwood CJ, Matuszyk MM, Wharton SB & Simpson JE (2020) . International Journal of Molecular Sciences, 21(21).
Fadul MM, Heath PR, Cooper-Knock J, Kurz JM, Al-Azzawi HA, Ali Z, Smith T, Matthews FE, Brayne C, Wharton SB & Simpson JE (2020) . International Journal of Molecular Sciences, 21(21).
Hill RM, Richardson S, Schwalbe EC, Hicks D, Lindsey JC, Crosier S, Rafiee G, Grabovska Y, Wharton SB, Jacques TS , Michalski A et al (2020) . The Lancet Child & Adolescent Health.
De Marco M, Manca R, Kirby J, Hautbergue GM, Blackburn DJ, Wharton SB & Venneri A (2020) . Current Alzheimer Research, 17.
Hicks D, Rafiee G, Schwalbe EC, Howell CI, Lindsey JC, Hill RM, Smith AJ, Adidharma P, Steel C, Richardson S , Pease L et al (2020) . Neuropathology and Applied Neurobiology.
MacGregor Sharp M, Saito S, Keable A, Gatherer M, Aldea R, Agarwal N, Simpson JE, Wharton SB, Weller RO & Carare RO (2020) . Acta Neuropathologica Communications, 8(1).
Chambers A, Bury JJ, Minett T, Richardson CD, Brayne C, Ince PG, Shaw PJ, Garwood CJ, Heath PR, Simpson JE , Matthews FE et al (2020) . Journal of Neuropathology & Experimental Neurology, 79(9), 950-958.
Shabir O, Sharp P, Rebollar MA, Boorman L, Howarth C, Wharton SB, Francis SE & Berwick J (2020) . Scientific Reports, 10(1).
Das J, Gill A, Lo C, Chan-Lam N, Price S, Wharton SB, Jessop H, Sharrack B & Snowden JA (2020) . Frontiers in Immunology, 11.
Das J, Gill A, Lo C, Chan-Lam N, Price S, Wharton S, Jessop H, Sharrack B & Snowden J (2020) . Neurology, 94(15_supplement).
Waller R, Mandeya M, Viney E, Simpson JE & Wharton SB (2020) . Neuropathology.
Richardson K, Wharton SB, Grossi CM, Matthews FE, Fox C, Maidment I, Loke YK, Steel N, Arthur A, Myint PK , Boustani M et al (2020) . Journal of Alzheimer's Disease.
Fadul MM, Garwood CJ, Waller R, Garrett N, Heath PR, Matthews FE, Brayne C, Wharton SB & Simpson JE (2020) . International Journal of Molecular Sciences, 21(1).
Arthur A, Savva GM, Barnes LE, Borjian-Boroojeny A, Dening T, Jagger C, Matthews FE, Robinson L & Brayne C (2020) . The British Journal of Psychiatry, 216(1), 49-54.
Wharton SB, Wang D, Parikh C, Matthews FE, Brayne C & Ince PG (2019) . Acta Neuropathologica Communications, 7(1), 1-12.
Sharp P, Ameen-Ali K, Boorman L, Harris S, Wharton S, Howarth C, Shabir O, Redgrave P & Berwick J (2019) . Journal of Cerebral Blood Flow and Metabolism.
Ajikumar A, Long MB, Heath PR, Wharton SB, Ince PG, Ridger VC & Simpson JE (2019) . International Journal of Molecular Sciences, 20(20).
Fox C, Richardson K, Savva GM, Robinson L, Maidment ID, Loke Y, Brayne C, Mathews F, Ince P, Wharton S , Myint P et al (2019) . Alzheimer's & Dementia, 15, P1232-P1232.
Goodall EF, Leach V, Wang C, Cooper-Knock J, Heath PR, Baker D, Drew DR, Saffrey MJ, Simpson JE, Romero IA & Wharton SB (2019) . International Journal of Molecular Sciences, 20(12).
Vazquez‐Villaseñor I, Garwood CJ, Heath PR, Simpson JE, Ince PG & Wharton SB (2019) . Neuropathology and Applied Neurobiology.
Ameen-Ali K, Simpson J, Wharton S, Heath P, Sharp P, Brezzo G & Berwick J (2019) . Journal of Alzheimer's disease : JAD.
Wharton SB, Verber NS, Wagner BE, Highley JR, Fillingham DJ, Waller R, Strand K, Ince PG & Shaw PJ (2019) . Neuropathology and Applied Neurobiology.
Waller R, Murphy M, Garwood C, Jennings L, Heath P, Chambers A, Matthews F, Brayne C, Ince P, Wharton S & Simpson J (2018) . Glia, 66(11), 2316-2323.
Mills MT, Wharton SB, Connolly DJ, Mirza S & Sinha S (2018) . British Journal of Neurosurgery.
Ratcliffe LE, Vázquez Villaseñor I, Jennings L, Heath PR, Mortiboys H, Schwartzentruber A, Karyka E, Simpson JE, Ince PG, Garwood CJ & Wharton SB (2018) . Neuroscience, 390, 46-59.
Morgan SV, Garwood CJ, Jennings L, Simpson JE, Castelli LM, Heath PR, Mihaylov SR, Vaquéz-Villaseñor I, Minshull TC, Ince PG , Dickman MJ et al (2018) . European Journal of Neuroscience, 47(12), 1444-1456.
Simpson JE, Wharton S, Brayne C, Matthews F, Heath P & Ince P (2018) . Alzheimer's & Dementia, 14(7S_Part_31), P1624-P1624.
Ajikumar A, Ridger V, Heath P, Wharton S, Ince P & Simpson JE (2018) . Alzheimer's & Dementia, 14(7S_Part_27), P1455-P1455.
Hicks D, Rafiee G, Schwalbe EC, Lindsey JC, Hill RM, Smith A, Crosier S, Joshi A, Robson K, Wharton S , Jacques T et al (2018) . Neuro-Oncology, 20(suppl_2), i123-i123.
Hicks D, Rafiee G, Schwalbe EC, Lindsey JC, Hill RM, Smith A, Crosier S, Joshi A, Robson K, Wharton S , Jacques T et al (2018) MBCL-30. SUBGROUP-DIRECTED CLINICAL AND MOLECULAR STRATIFICATION OF DISEASE RISK IN INFANT MEDULLOBLASTOMA.. Neuro-oncology, 20(Suppl 2), i123-i123.
Goodall EF, Wang C, Simpson JE, Baker DJ, Drew DR, Heath PR, Saffrey MJ, Romero IA & Wharton SB (2018) . Neuropathology and Applied Neurobiology, 44(3), 328-340.
Eagle D, Merla A, Ushewokunze SO, Jellinek D, Zaki H, Wharton S & Mckevitt F (2018) Genomic Analysis, Surgical Treatment and Outcomes of Lower-Grade Gliomas in a Single Institution.. Neuro-oncology, 20(Suppl 1), i20-i20.
Simpson JE, Wharton SB & Heath PR (2018) , 273-284.
Ameen-Ali KE, Wharton SB, Simpson JE, Heath PR, Sharp P & Berwick J (2017) . Neuropathology and Applied Neurobiology, 43(7), 553-570.
Kingston A, Wohland P, Wittenberg R, Robinson L, Brayne C, Matthews FE, Jagger C, Green E, Gao L, Barnes R , Arthur A et al (2017) . The Lancet.
Schwalbe EC, Lindsey JC, Nakjang S, Crosier S, Smith AJ, Hicks D, Rafiee G, Hill RM, Iliasova A, Stone T , Pizer B et al (2017) . The Lancet Oncology, 18(7), 958-971.
Kovacs GG, Xie SX, Lee EB, Robinson JL, Caswell C, Irwin DJ, Toledo JB, Johnson VE, Smith DH, Alafuzoff I , Attems J et al (2017) . Journal of Neuropathology and Experimental Neurology, 76(7), 605-619.
Garwood CJ, Ratcliffe LE, Simpson JE, Heath PR, Ince PG & Wharton SB (2017) . Neuropathology and Applied Neurobiology, 43(4), 281-298.
Hill R, Richardson S, Lindsey J, Crosier S, Schwalbe E, Hicks D, Rafiee G, Smithh A, Joshi A, Robson K , Wharton S et al (2017) . Neuro-Oncology, 19(suppl_4), iv41-iv41.
Hicks D, Rafiee G, Schwalbe EC, Howell CI, Lindsey JC, Hill RM, Smith A, Crosier S, Joshi A, Robson K , Wharton S et al (2017) . Neuro-Oncology, 19(suppl_4), iv39-iv39.
Schwalbe E, Lindsey J, Nakjang S, Crosier S, Smith A, Hicks D, Rafiee G, Hill R, Iliasova A, Stone T , Pizer B et al (2017) . Neuro-Oncology, 19(suppl_4), iv38-iv38.
Hill R, Richardson S, Lindsey J, Crosier S, Schwalbe E, Hicks D, Rafiee G, Smithh A, Joshi A, Robson K , Wharton S et al (2017) MEDU-16. TIME, PATTERN AND OUTCOME OF MEDULLOBLASTOMA RELAPSE IS BIOLOGY AND THERAPY-DEPENDENT. Neuro-oncology, 19(Suppl 4), iv41-iv41.
Schwalbe E, Lindsey J, Nakjang S, Crosier S, Smith A, Hicks D, Rafiee G, Hill R, Iliasova A, Stone T , Pizer B et al (2017) MEDU-06. NOVEL MOLECULAR SUBGROUPS IMPROVE CLINICAL CLASSIFICATION AND OUTCOME PREDICTION FOR CHILDHOOD MEDULLOBLASTOMA. Neuro-oncology, 19(Suppl 4), iv38-iv38.
Hicks D, Rafiee G, Schwalbe EC, Howell CI, Lindsey JC, Hill RM, Smith A, Crosier S, Joshi A, Robson K , Wharton S et al (2017) MEDU-09. SUBGROUP-DIRECTED STRATIFICATION OF DISEASE RISK IN INFANT MEDULLOBLASTOMA. Neuro-oncology, 19(Suppl 4), iv39-iv39.
Bagga V, Kailaya-Vasan A, Wharton SB & Patel U (2017) . World Neurosurgery.
Larsen J, Wharton SB, Romanowski C, McKevitt FM, Bridgewater C, Zaki H & Hoggard N (2016) . British Journal of Radiology.
Simpson JE, Waller R, Woodroofe MN, Wharton SB, Ince PG, Francese S, Heath PR, Cudzich-Madry A, Thomas R, Rounding N & Sharrack B (2016) . Journal of Neuroimmunology, 299, 139-146.
Ince PG, Minett T, Forster G, Brayne C, Wharton SB & Medical Research Council Cognitive Function Ageing Neuropathology Study (2016) . Neuropathol Appl Neurobiol.
McAleese KE, Alafuzoff I, Charidimou A, De Reuck J, Grinberg LT, Hainsworth AH, Hortobagyi T, Ince P, Jellinger K, Gao J , Kalaria RN et al (2016) . BMC Medicine, 14(1).
Appleby-Mallinder C, Wyles MD, Simpson JE, Wharton SB, Ince PG & Heath PR (2016) . Journal of Neuroscience Methods, 268, 125-130.
Hicks D, Rafiee G, Schwalbe E, Howell C, Lindsey J, Hill R, Smith A, Crosier S, Joshi A, Robson K , Wharton S et al (2016) . Neuro-Oncology, 18(suppl 3), iii111.2-iii111.
Crosier S, Hicks D, Schwalbe E, Williamson D, Nicholson S, Michalski A, Pizer B, Bailey S, Bown N, Robson K , Wharton S et al (2016) . Neuro-Oncology, 18(suppl 3), iii115.1-iii115.
Hicks D, Rafiee G, Schwalbe E, Howell C, Lindsey J, Hill R, Smith A, Crosier S, Joshi A, Robson K , Wharton S et al (2016) MB-63SUBGROUP-DIRECTED STRATIFICATION OF RISK IN INFANT MEDULLOBLASTOMA. Neuro-oncology, 18(Suppl 3), iii111-iii111.
Crosier S, Hicks D, Schwalbe E, Williamson D, Nicholson S, Michalski A, Pizer B, Bailey S, Bown N, Robson K , Wharton S et al (2016) MB-79CENTRALISED MOLECULAR PATHOLOGY FOR RARE TUMOURS: A NATIONAL FEASIBILITY STUDY OF REAL-TIME MEDULLOBLASTOMA DIAGNOSTICS. Neuro-oncology, 18(Suppl 3), iii115-iii115.
Highley JR, Pons AL, Cooper‐Knock J, Wharton SB, Ince PG, Shaw PJ, Wood J & Kirby J (2016) . Neuropathology and Applied Neurobiology, 42(4), 377-389.
Matthews FE, Stephan BCM, Robinson L, Jagger C, Barnes LE, Arthur A, Brayne C, Comas-Herrera A, Wittenberg R, Dening T , McCracken CFM et al (2016) . Nature Communications, 7, 11398-11398.
Lewis R, Jenkins T, Wharton S, Lorenz E, Rao G, Stevens R, Hadjivassiliou M & Blackburn D (2016) . Practical Neurology, 16(2), 153-156.
Wharton SB, Minett T, Drew D, Forster G, Matthews F, Brayne C, Ince PG & on behalf of the MRC Cognitive Function and Ageing Neuropathology Study Group (2016) . Acta Neuropathologica Communications, 4(1).
Simpson JE, Ince PG, Minett T, Matthews FE, Heath PR, Shaw PJ, Goodall E, Garwood CJ, Ratcliffe LE, Brayne C , Rattray M et al (2016) . Neuropathology and Applied Neurobiology, 42(2), 167-179.
Kovacs GG, Ferrer I, Grinberg LT, Alafuzoff I, Attems J, Budka H, Cairns NJ, Crary JF, Duyckaerts C, Ghetti B , Halliday GM et al (2016) . Acta Neuropathologica, 131(1), 87-102.
Bargiela D, Shanmugarajah P, Lo C, Blakely EL, Taylor RW, Horvath R, Wharton S, Chinnery PF & Hadjivassiliou M (2015) . Cerebellum & Ataxias, 2.
Garwood CJ, Ratcliffe LE, Morgan SV, Simpson JE, Owens H, Vazquez-Villaseñor I, Heath PR, Romero IA, Ince PG & Wharton SB (2015) . Molecular Brain, 8(1).
Fluteau A, Ince PG, Minett T, Matthews FE, Brayne C, Garwood CJ, Ratcliffe LE, Morgan S, Heath PR, Shaw PJ , Wharton SB et al (2015) . Neuroscience Letters, 609, 11-17.
Al-Mashhadi S, Simpson JE, Heath PR, Dickman M, Forster G, Matthews FE, Brayne C, Ince PG & Wharton SB (2015) . Brain Pathology, 25(5), 565-574.
Stratmann K, Heinsen H, Korf H-W, Del Turco D, Ghebremedhin E, Seidel K, Bouzrou M, Grinberg LT, Bohl J, Wharton SB , den Dunnen W et al (2015) . Brain Pathology, 26(3), 371-386.
Alafuzoff I, Pikkarainen M, Neumann M, Arzberger T, Al-Sarraj S, Bodi I, Bogdanovic N, Bugiani O, Ferrer I, Gelpi E , Gentleman S et al (2015) . Journal of Neural Transmission, 122(7), 973-974.
Cooper-Knock J, Higginbottom A, Stopford MJ, Highley JR, Ince PG, Wharton SB, Pickering-Brown S, Kirby J, Hautbergue GM & Shaw PJ (2015) . Acta Neuropathologica, 130(1), 63-75.
Alafuzoff I, Pikkarainen M, Neumann M, Arzberger T, Al-Sarraj S, Bodi I, Bogdanovic N, Bugiani O, Ferrer I, Gelpi E , Gentleman S et al (2015) . Journal of Neural Transmission, 122(7), 957-972.
Simpson JE, Ince PG, Matthews FE, Shaw PJ, Heath PR, Brayne C, Garwood C, Higginbottom A & Wharton SB (2015) . Neuropathology and Applied Neurobiology, 41(4), 483-496.
Gopal-Kothandapani JS, Bagga V, Wharton SB, Connolly DJ, Sinha S & Dimitri PJ (2015) . Endocrinology, Diabetes & Metabolism Case Reports, 2015.
Wharton SB, Simpson JE, Brayne C & Ince PG (2015) . Brain Pathology, 25(1), 35-43.
Hill RM, Kuijper S, Lindsey JC, Petrie K, Schwalbe EC, Barker K, Boult JKR, Williamson D, Ahmad Z, Hallsworth A , Ryan SL et al (2015) . Cancer Cell, 27(1), 72-84.
Beer AM, Cooper-Knock J, Higginbottom A, Highley JR, Wharton SB, Ince PG, Milano A, Jones AA, Al-Chalabi A, Kirby J & Shaw PJ (2015) . Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 16(3-4), 249-251.
Highley JR, Kirby J, Jansweijer JA, Webb PS, Hewamadduma CA, Heath PR, Higginbottom A, Raman R, Ferraiuolo L, Cooper-Knock J , McDermott CJ et al (2014) . Neuropathol Appl Neurobiol, 40(6), 670-685.
Cooper-Knock J, Walsh MJ, Higginbottom A, Robin Highley J, Dickman MJ, Edbauer D, Ince PG, Wharton SB, Wilson SA, Kirby J , Hautbergue GM et al (2014) . Brain, 137(Pt 7), 2040-2051.
Asi YT, Lees AJ, Revesz T, Holton JL, Simpson JE, Heath PR, Wharton SB & Houlden H (2014) . GLIA.
Garwood CJ, Simpson JE, Al Mashhadi S, Axe C, Wilson S, Heath PR, Shaw PJ, Matthews FE, Brayne C, Ince PG , Wharton SB et al (2014) . Neuropathol Appl Neurobiol, 40(7), 802-814.
Cooper-Knock J, Walsh M, Higginbottom A, Highley JR, Bury J, Dickman M, Rattray M, Heath P, Wyles M, Ince P , Wharton S et al (2014) . Neurology, 82(10_supplement).
Cooper-Knock J, Walsh M, Higginbottom A, Highley JR, Bury J, Dickman M, Rattray M, Heath P, Wyles M, Ince P , Wharton S et al (2014) . Neurology, 82(10_supplement).
Gallagher MD, Suh E, Grossman M, Elman L, McCluskey L, Van Swieten JC, Al-Sarraj S, Neumann M, Gelpi E, Ghetti B , Rohrer JD et al (2014) . Acta Neuropathol, 127(3), 407-418.
Janaway BM, Simpson JE, Hoggard N, Highley JR, Forster G, Drew D, Gebril OH, Matthews FE, Brayne C, Wharton SB , Ince PG et al (2014) . Neuropathol Appl Neurobiol, 40(3), 258-269.
Hickman SJ, Allen JA, Baisre A, Batty R, Lari HB, Melen O, Pepper IM, Sarrigiannis PG, Turbin RE, Wharton SB & McDermott CJ (2013) . Neuro-Ophthalmology, 37(4), 146-156.
Richardson K, Allen SP, Mortiboys HJ, Grierson AJ, Wharton SB, Ince PG, Shaw PJ & Heath PR (2013) . Plos One, 6(8), e68256-e68256.
Garwood C, Faizullabhoy A, Wharton SB, Ince PG, Heath PR, Shaw PJ, Baxter L, Gelsthorpe C, Forster G, Matthews FE , Brayne C et al (2013) . Neuropathol Appl Neurobiol, 39(7), 788-799.
Brayne C, Barker RA, Harold D, Ince PG, Savva GM, Williams J, Williams-Gray CH & Wharton SB (2013) . Journal of Alzheimer's Disease, 33(SUPPL. 1).
Brockington A, Ning K, Heath PR, Wood E, Kirby J, Fusi N, Lawrence N, Wharton SB, Ince PG & Shaw PJ (2013) . Acta Neuropathol, 125(1), 95-109.
Alafuzoff I, Gelpi E, Al-Sarraj S, Arzberger T, Attems J, Bodi I, Bogdanovic N, Budka H, Bugiani O, Englund E , Ferrer I et al (2012) . Experimental Gerontology, 47(11), 825-833.
Stephan BCM, Wharton SB, Simpson J, Matthews FE, Ince P & Brayne C (2012) . Neurodegenerative Disease Management, 2(5), 471-482.
Lace G, Ince PG, Brayne C, Savva GM, Matthews FE, de Silva R, Simpson JE & Wharton SB (2012) . Dement Geriatr Cogn Disord, 34(1), 15-24.
Waller R, Woodroofe MN, Francese S, Heath PR, Wharton SB, Ince PG, Sharrack B & Simpson JE (2012) . J Neurosci Methods, 208(2), 108-113.
Cooper-Knock J, Hewitt C, Highley JR, Brockington A, Milano A, Man S, Martindale J, Hartley J, Walsh T, Gelsthorpe C , Baxter L et al (2012) . Brain, 135(Pt 3), 751-764.
Brayne C, Barker RA, Harold D, Ince PG, Savva GM, Williams J, Williams-Gray CH & Wharton SB (2012) . Advances in Alzheimer's Disease, 3, 385-396.
Keage HAD, Ince PG, Matthews FE, Wharton SB, McKeith IG, Brayne C & CC75C MRCC (2012) . JOURNAL OF ALZHEIMERS DISEASE, 28(2), 485-493.
Ince PG, Highley JR, Kirby J, Wharton SB, Takahashi H, Strong MJ & Shaw PJ (2011) . Acta Neuropathol, 122(6), 657-671.
Simpson JE, Ince PG, Shaw PJ, Heath PR, Raman R, Garwood CJ, Gelsthorpe C, Baxter L, Forster G, Matthews FE , Brayne C et al (2011) . NEUROBIOL AGING, 32(10), 1795-1807.
Viggars AP, Wharton SB, Simpson JE, Matthews FE, Brayne C, Savva GM, Garwood C, Drew D, Shaw PJ & Ince PG (2011) . Neurosci Lett, 505(1), 25-30.
Simpson J, Ince P, Heath P, Raman R, Garwood C, Shaw P, Gelstorpe C, Baxter L, Forster G, Fiona M , Savva G et al (2011) . Alzheimer's & Dementia, 7, S566-S566.
Keage H, Ince P, Matthews F, Wharton S, McKieth I & Brayne C (2011) . Alzheimer's & Dementia, 7, S606-S607.
Langheinrich TC, Romanowski CAJ, Wharton S & Hadjivassiliou M (2011) . NEUROLOGY, 76(16), 1435-1436.
Wharton SB, Brayne C, Savva GM, Matthews FE, Forster G, Simpson J, Lace G, Ince PG & Medical Research Council Cognitive Function and Aging Study (2011) . J Alzheimers Dis, 25(2), 359-372.
Kirby J, Ning K, Ferraiuolo L, Heath PR, Ismail A, Kuo S-W, Valori CF, Cox L, Sharrack B, Wharton SB , Ince PG et al (2011) . Brain, 134(Pt 2), 506-517.
Viggars AP, Wharton SB, Simpson JE, Matthews FE, Brayne C, Savva GM, Garwood C, Drew D, Shaw PJ & Ince PG (2011) . Neuroscience Letters, 505(1), 25-30.
Simpson JE, Wharton SB, Cooper J, Gelsthorpe C, Baxter L, Forster G, Shaw PJ, Savva G, Matthews FE, Brayne C & Ince PG (2010) . Neurosci Lett, 486(3), 246-251.
Hadjivassiliou M, Rao DG, Wharton SB, Sanders DS, Grünewald RA & Davies-Jones AGB (2010) . Neurology, 75(11), 1003-1008.
Rajaram S, Wharton SB, Shackley F, Raghavan A & Connolly DJA (2010) . Pediatr Radiol, 40 Suppl 1, S145-S149.
Kirby J, Goodall EF, Smith W, Highley JR, Masanzu R, Hartley JA, Hibberd R, Hollinger HC, Wharton SB, Morrison KE , Ince PG et al (2010) . Neurogenetics, 11(2), 217-225.
Simpson JE, Ince PG, Lace G, Forster G, Shaw PJ, Matthews F, Savva G, Brayne C, Wharton SB & MRC Cognitive Function and Ageing Neuropathology Study Group (2010) . Neurobiol Aging, 31(4), 578-590.
Simpson JE, Ince PG, Haynes LJ, Theaker R, Gelsthorpe C, Baxter L, Forster G, Lace GL, Shaw PJ, Matthews FE , Savva GM et al (2010) . Neuropathol Appl Neurobiol, 36(1), 25-40.
Simpson JE, Wharton SB, Cooper J, Gelsthorpe C, Baxter L, Forster G, Shaw PJ, Savva G, Matthews FE, Brayne C & Ince PG (2010) . Neuroscience Letters, 486(3), 246-251.
Cox LE, Ferraiuolo L, Goodall EF, Heath PR, Higginbottom A, Mortiboys H, Hollinger HC, Hartley JA, Brockington A, Burness CE , Morrison KE et al (2010) . PLoS One, 5(3), e9872.
Matthews FE, Brayne C, Lowe J, McKeith I, Wharton SB & Ince P (2009) . PLOS MED, 6(11).
Blackburn D, Highley JR, Wharton S, Romanowski C, Bowen J & Sharrack B (2009) . APMIS, 117(10), 768-772.
Savva GM, Wharton SB, Ince PG, Forster G, Matthews FE, Brayne C & Med Res Council Cognitive Function (2009) Age, Neuropathology, and Dementia. NEW ENGL J MED, 360(22), 2302-2309.
Lace G, Savva GM, Forster G, de Silva R, Brayne C, Matthews FE, Barclay JJ, Dakin L, Ince PG, Wharton SB & MRC-CFAS (2009) . Brain, 132(Pt 5), 1324-1334.
Alafuzoff I, Thal DR, Arzberger T, Bogdanovic N, Al-Sarraj S, Bodi I, Boluda S, Bugiani O, Duyckaerts C, Gelpi E , Gentleman S et al (2009) . ACTA NEUROPATHOL, 117(3), 309-320.
Simpson JE, Hosny O, Wharton SB, Heath PR, Holden H, Fernando MS, Matthews F, Forster G, O'Brien JT, Barber R , Kalaria RN et al (2009) . Stroke, 40(2), 369-375.
Keage HAD, Carare RO, Friedland RP, Ince PG, Love S, Nicoll JA, Wharton SB, Weller RO & Brayne C (2009) . BMC NEUROL, 9.
Wharton SB, O'Callaghan JP, Savva GM, Nicoll JAR, Matthews F, Simpson JE, Forster G, Shaw PJ, Brayne C, Ince PG & MRC Cognitive Function and Ageing Neuropathology Study Group (2009) . Dement Geriatr Cogn Disord, 27(5), 465-473.
Kasher PR, De Vos KJ, Wharton SB, Manser C, Bennett EJ, Bingley M, Wood JD, Milner R, McDermott CJ, Miller CCJ , Shaw PJ et al (2009) . J Neurochem, 110(1), 34-44.
Alafuzoff I, Arzberger T, Al-Sarraj S, Bodi I, Bogdanovic N, Braak H, Bugiani O, Del-Tredici K, Ferrer I, Gelpi E , Giaccone G et al (2008) . BRAIN PATHOL, 18(4), 484-496.
Wharton S (2008) . Neuropathology and Applied Neurobiology, 34(1), 1-3.
Romanowski CAJ, Hoggard N, Jellinek DA, Levy D, Wharton SB, Kotsarini C, Batty R & Wilkinson ID (2008) . Neuroradiology Journal, 21(SUPPL. 1), 47-66.
Simpson JE, Ince PG, Higham CE, Gelsthorpe CH, Fernando MS, Matthews F, Forster G, O'Brien JT, Barber R, Kalaria RN , Brayne C et al (2007) . Neuropathol Appl Neurobiol, 33(6), 670-683.
Simpson JE, Fernando MS, Clark L, Ince PG, Matthews F, Forster G, O'Brien JT, Barber R, Kalaria RN, Brayne C , Shaw PJ et al (2007) . Neuropathol Appl Neurobiol, 33(4), 410-419.
Hadjivassiliou M, Chattopadhyay AK, Grünewald RA, Jarratt JA, Kandler RH, Rao DG, Sanders DS, Wharton SB & Davies-Jones GAB (2007) . Muscle Nerve, 35(4), 443-450.
Lace GL, Wharton SB & Ince PG (2007) . Clin Neuropathol, 26(2), 43-58.
Wharton SB, Maltby E, Jellinek DA, Levy D, Atkey N, Hibberd S, Crimmins D, Stoeber K & Williams GH (2007) . Acta Neuropathol, 113(2), 119-127.
Taha M, Patel U, Wharton SB, Cooper PC & Makris M (2007) . J Neurosurg, 106(2 Suppl), 143-146.
Wharton S (2007) . Neuropathology and Applied Neurobiology, 33(1), 1-1.
Hadjivassiliou M, Grünewald RA, Kandler RH, Chattopadhyay AK, Jarratt JA, Sanders DS, Sharrack B, Wharton SB & Davies-Jones GAB (2006) . J Neurol Neurosurg Psychiatry, 77(11), 1262-1266.
Fernando MS, Simpson JE, Matthews F, Brayne C, Lewis CE, Barber R, Kalaria RN, Forster G, Esteves F, Wharton SB , Shaw PJ et al (2006) . Stroke, 37(6), 1391-1398.
Brockington A, Wharton SB, Fernando M, Gelsthorpe CH, Baxter L, Ince PG, Lewis CE & Shaw PJ (2006) . J Neuropathol Exp Neurol, 65(1), 26-36.
Baron P, Bussini S, Cardin V, Corbo M, Conti G, Galimberti D, Scarpini E, Bresolin N, Wharton SB, Shaw PJ & Silani V (2005) . MUSCLE NERVE, 32(4), 541-544.
Taha M, Ahmad A, Wharton S & Jellinek D (2005) . Br J Neurosurg, 19(4), 348-351.
Wharton SB, Williams GH, Stoeber K, Gelsthorpe CH, Baxter L, Johnson AL, Ince PG & MRC-CFAS (2005) . Neurosci Lett, 383(1-2), 33-38.
Bell HS, Whittle IR, Bader SA & Wharton SB (2005) . NEUROPATH APPL NEURO, 31(2), 191-202.
Newbery HJ, Gillingwater TH, Dharmasaroja P, Peters J, Wharton SB, Thomson D, Ribchester RR & Abbott CM (2005) Progressive loss of motor neuron function in wasted mice: Effects of a spontaneous null mutation in the gene for the eEF1A2 translation factor. J NEUROPATH EXP NEUR, 64(4), 295-303.
Henson JD, Hannay JA, McCarthy SW, Royds JA, Yeager TR, Robinson RA, Wharton SB, Jellinek DA, Arbuckle SM, Yoo JY , Robinson BG et al (2005) A robust assay for alternative lengthening of telomeres in tumors shows the significance of alternative lengthening of telomeres in sarcomas and astrocytomas. CLIN CANCER RES, 11(1), 217-225.
Ince PG & Wharton SB (2004) , 149-167.
Brockington A, Lewis C, Wharton S & Shaw PJ (2004) . Neuropathol Appl Neurobiol, 30(5), 427-446.
Wharton SB, Hibberd S, Eward KL, Crimmins D, Jellinek DA, Levy D, Stoeber K & Williams GH (2004) . Br J Cancer, 91(2), 262-269.
Goel S, Wharton SB, Brett LP & Whittle IR (2003) Morphological changes and stress responses in neurons in cerebral cortex infiltrated by diffuse astrocytoma. NEUROPATHOLOGY, 23(4), 262-270.
McDermott CJ, Grierson AJ, Wood JD, Bingley M, Wharton SB, Bushby KMD & Shaw PJ (2003) . Ann Neurol, 54(6), 748-759.
Wharton SB, McDermott CJ, Grierson AJ, Wood JD, Gelsthorpe C, Ince PG & Shaw PJ (2003) . J Neuropathol Exp Neurol, 62(11), 1166-1177.
Wharton SB, Wardle C, Ironside JW, Wallace WH, Royds JA & Hammond DW (2003) . Neuropathol Appl Neurobiol, 29(3), 254-261.
Ince PG, Evans J, Knopp M, Forster G, Hamdalla HHM, Wharton SB & Shaw PJ (2003) . Neurology, 60(8), 1252-1258.
Allen S, Heath PR, Kirby J, Wharton SB, Cookson MR, Menzies FM, Banks RE & Shaw PJ (2003) . J Biol Chem, 278(8), 6371-6383.
Wharton SB (2003) . The Journal of Pathology, 199(2), 271-271.
Miller MW, Peter A, Wharton SB & Wyllie AH (2003) . Brain Research, 965(1-2), 57-66.
Yamaguchi S, Bell HS, Shinoda J, Holmes MC, Wharton SB & Whittle IR (2002) Glioma tumourgenicity is decreased by iNOS knockout: experimental studies using the C6 striatal implantation glioma model. BRIT J NEUROSURG, 16(6), 567-572.
Leaver HA, Wharton SB, Bell HS, Leaver-Yap IMM & Whittle IR (2002) . PROSTAG LEUKOTR ESS, 67(5), 283-292.
Horsburgh MJ, Wharton SJ, Karavolos M & Foster SJ (2002) . Trends in Microbiology, 10(11), 496-501.
Ramaesh K, Bhagat S, Wharton SB & Singh J (2002) . EYE, 16(5), 670-673.
Whittle IR, Mitchener A, Atkinson HD & Wharton SB (2002) . ACTA NEUROPATHOL, 104(2), 215-215.
Wharton SB, Whittle IR, Collie DA, Bell HS & Ironside JW (2002) Gliosarcoma with areas of primitive neuroepithelial differentiation and extracranial metastasis - Reply. CLIN NEUROPATHOL, 21(4), 195-196.
Wharton SB, Chan KK & Whittle IR (2002) . J CLIN NEUROSCI, 9(2), 165-169.
Taguri AH, Dhillon B, Wharton SB & Kamal A (2002) . Am J Ophthalmol, 133(1), 147-149.
Leaver HA, Bell HS, Rizzo MT, Ironside JW, Gregor A, Wharton SB & Whittle IR (2002) . Prostaglandins Leukot Essent Fatty Acids, 66(1), 19-29.
Kepes JJ, Wharton SB, Whittle IR, Collie DA, Bell HS & Ironside JW (2002) Gliosarcoma with areas of primitive neuroepithelial differentiation and extracranial metastasis [2] (multiple letters). Clinical Neuropathology, 21(4), 193-196.
Lo S, Bell HS, Yamaguchi S, Wharton SB & Whittle IR (2001) . Br J Neurosurg, 15(5), 416-418.
Wharton SB, Whittle IR, Collie DA, Bell HS & Ironside JW (2001) Gliosarcoma with areas of primitive neuroepithelial differentiation and extracranial metastasis.. Clin Neuropathol, 20(5), 212-218.
Bell HS, Whittle IR, Walker M, Leaver HA & Wharton SB (2001) . Neuropathol Appl Neurobiol, 27(4), 291-304.
Wharton SB, Chan KK, Anderson JR, Stoeber K & Williams GH (2001) . Neuropathol Appl Neurobiol, 27(4), 305-313.
Ramaesh K, Wharton SB & Dhillon B (2001) . Eye (Lond), 15(Pt 3), 309-312.
Singh J, Ramaesh K, Wharton SB, Cormack G & Chawla HB (2001) . Retina, 21(3), 247-251.
Wharton SB, Lammie GA, Collie DA & Whittle IR (2000) . Acta Neuropathol, 100(6), 695-700.
Wharton SB, McNelis U, Bell HS & Whittle IR (2000) . Neuropathol Appl Neurobiol, 26(6), 528-535.
Brewis C, Bottrill ID, Wharton SB, Path & Moffat (2000) . The Journal of Laryngology & Otology, 114(1), 17-23.
Brewis C, Bottrill ID, Wharton SB & Moffat DA (2000) . The Journal of Laryngology & Otology, 114(1), 67-69.
Bhagat S, Ramaesh K, Wharton SB & Dhillon B (1999) Spontaneous acute scleritis and scleral necrosis in choroidal malignant melanoma. EYE, 13, 793-795.
Bell HS, Wharton SB, Leaver HA & Whittle IR (1999) . J Neurosurg, 91(6), 989-996.
Waring WS, Wharton SB, Grant R & McIntyre M (1999) . Clin Neurol Neurosurg, 101(4), 275-279.
Delgado MB, Anderson JR, Whittle IR & Wharton SB (1999) . Neuropathol Appl Neurobiol, 25(5), 400-407.
Ramaesh K, Bhagat S, Wharton SB & Singh J (1999) . Arch Ophthalmol, 117(10), 1411-1413.
Ramaesh K, Marshall JW, Wharton SB & Dhillon B (1999) . Eye (Lond), 13 ( Pt 2), 247-250.
Hutchinson PJ, O'Connell MT, Al-Rawi PG, Maskell LB, Gupta AK, Hutchinson DB, Pickard JD, Kirkpatrick PJ & Wharton SB (1999) Neuropathological findings after intracerebral implantation of microdialysis catheters in sheep forebrain.. Neuroreport, 10(3).
Waite KJ, Wharton SB, Old SE & Burnet NG (1999) Systemic metastases of glioblastoma multiforme. CLIN ONCOL-UK, 11(3), 205-207.
Leaver HA, Whittle IR, Wharton SB & Ironside JW (1998) . Br J Neurosurg, 12(6), 539-546.
Robertson NP, Wharton S, Anderson J & Scolding NJ (1998) . Journal of Neurology, Neurosurgery & Psychiatry, 65(5), 788-790.
Wharton SB, Chan KK, Hamilton FA & Anderson JR (1998) . Neuropathol Appl Neurobiol, 24(4), 302-308.
Wharton SB, Hamilton FA, Chan WK, Chan KK & Anderson JR (1998) Proliferation and cell death in oligodendrogliomas. NEUROPATH APPL NEURO, 24(1), 21-28.
Wharton SB, Antoun NM, Macfarlane R & Anderson JR (1998) The natural history of a recurrent central neurocytoma-like tumor.. Clin Neuropathol, 17(3), 136-140.
Lau DPC, Wharton SB, Antoun NM, Bottrill ID & Moffat DA (1997) . The Journal of Laryngology & Otology, 111(4), 368-371.
Wharton SB, Chan KK, Pickard JD & Anderson JR (1996) . Journal of Neurology, Neurosurgery & Psychiatry, 61(5), 461-465.
Wharton SB, Meyers NL & Nash AA (1995) . Neuropathology and Applied Neurobiology, 21(3), 228-237.
Wharton SB & Nash AA (1993) . Current Opinion in Neurobiology, 3(5), 768-772.
Almansouri T, Waller R, Wharton SB, Heath PR, Matthews FE, Brayne C, van Eeden F & Simpson JE () . International Journal of Molecular Sciences, 25(8), 4445-4445.
Wharton SB, Simpson JE, Ince PG, Richardson CD, Merrick R, Matthews FE & Brayne C () . Neuropathology and Applied Neurobiology.
Cooper‐Knock J, Julian TH, Feneberg E, Highley JR, Sidra M, Turner MR, Talbot K, Ansorge O, Allen SP, Moll T , Shelkovnikova T et al () . Brain Pathology.
Vázquez-Villaseñor I, Smith CI, Thang YJR, Heath PR, Wharton SB, Blackburn DJ, Ridger VC & Simpson JE () . International Journal of Molecular Sciences, 23(11), 5913-5913.
Richardson S, Hill RM, Kui C, Lindsey JC, Grabovksa Y, Keeling C, Pease L, Bashton M, Crosier S, Vinci M , André N et al () . Neuro-Oncology.
Shabir O, Pendry B, Lee L, Eyre B, Sharp P, Rebollar MA, Howarth C, Heath PR, Wharton SB, Francis SE & Berwick J () .
Shabir O, Pendry B, Heath PR, Rebollar MA, Howarth C, Wharton SB, Berwick J & Francis SE () .
Ameen-Ali KE, Simpson JE, Wharton SB, Heath PR, Sharp P, Brezzo G & Berwick J () .
Sharp PS, Ameen-Ali K, Boorman L, Harris S, Wharton S, Howarth C, Redgrave P & Berwick J () .
Gopal-Kothandapani JS, Bagga V, Wharton SB, Connolly DJ, Sinha S & Dimitri P () . Endocrine Abstracts.
Mathur R, Ince PG, Minett T, Garwood CJ, Shaw PJ, Matthews FE, Brayne C, Simpson JE & Wharton SB () . PLoS ONE, 10(2).
Shabir O, Pendry B, Lee L, Eyre B, Sharp P, Rebollar M, Drew D, Howarth C, Heath P, Wharton S , Francis S et al () . eLife.

Chapters

Highley JR & Wharton SB (2024) , Greenfield's Neuropathology 10e Set (pp. 875-906). CRC Press
Wharton SB & Sharp AK (2024) , Atlas of Adult Autopsy (pp. 297-330). Springer Nature Switzerland
Ince PG, Highley JR & Wharton SB (2015) Motor neuron disorders In Love S, Budka H, Ironside JW & Perry A (Ed.), Greenfield's Neuropathology (pp. 817-848). Boca Raton: CRC Press.
Ince PG & Wharton SB (2007) (pp. 89-119).
Wharton S & Ince PG (2003) , Motor Neuron Disorders (pp. 17-49). Elsevier

Conference proceedings papers

Floare M-L, Simpson JE, Wharton SB, Aeschlimann D & Hadjivassiliou M (2025) Defining TG6 Autoimmunity in Gluten Ataxia. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 51
Darwin L, Fernando M, McKevitt F, Martin A & Wharton S (2025) CNS Involvement as a Presenting Clinical Feature of Lymphoplasmacytic Lymphoma in the Context of Waldenstrom's Macroglobulinaemia (Bing-Neel Syndrome). NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 51
Moore Z, Wharton S & Simpson J (2025) Characterisation of the Astrocyte Phenotype in Response to Systemic Infection in Alzheimer's Disease. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 51
Thang Y, Vazquez-Villasenor I, Smith C, Blackburn D, Wharton S, Heath P, Ridger V & Simpson J (2022) The miRNA profile of neutrophil-derived microvesicles may impact blood-brain barrier integrity in Alzheimer's disease. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 48
Matuszyk M, Ferraiuolo L, Taylor A, Davis P, Staniforth R, Garwood C, Simpson J & Wharton S (2022) Characterising the astrocyte response to oligomeric and fibrillary A beta 1-42 in Alzheimer's disease. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 48
Floare M, Simpson J, Wharton S, Aeschlimann D & Hadjivassiliou M (2022) Demystifying the gluten brain: Understanding the origin of gluten-related neurological disorders. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 48
Almansouri T, Heath P, Wharton S, Van Eeden F & Simpson J (2022) Microarray approach to identifying the role of microglia in the pathogenesis of age-associated deep-subcortical white matter lesions. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 48
Waller R, Heath PR, Simpson JE, Hase Y, Kalaria RN & Wharton SB (2021) What happens to cells of the brain in people who develop dementia after stroke?. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 47 (pp 8-8)
Guagnelli MAR, Wharton S, Francis S & Simpson J (2021) The effect of systemic atherosclerosis on the neurovascular unit. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 47 (pp 21-21)
Bury J, Chambers A, Heath P, Ince P, Shaw P, Matthew F, Brayne C & Wharton S (2021) Effects of Type 2 Diabetes on Neuronal and Associated Neurovascular Unit Transcriptomes. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 47 (pp 8-8)
Matuszyk M, Ferraiuolo L, Taylor A, Davies P, Staniforth R, Garwood C & Wharton S (2021) Characterising the varying astrocyte response to oligomeric and fibrillar A beta(1-42). NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 47 (pp 18-19)
Jennings O, Ajikumar A, Heath PR, Wharton SB & Simpson JE (2020) Transcriptomic profile of the blood-brain barrier in age-associated white matter lesions. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 46 (pp 46-46)
Hase Y, Foster V, Waller R, Simpson JE, Heath P, Wharton SB & Kalaria RN (2020) 121st Meeting of the British Neuropathological Society UCL Great Ormond Street Institute of Child Health, London. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 46 (pp 14-15)
Matuszyk MM, Ferraiuolo L, Taylor A, Davis P, Staniforth R, Garwood CJ & Wharton SB (2020) Characterising the varying astrocyte response to oligomeric and fibrillar A beta. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 46 (pp 25-25)
Das J, Gill A, Lo C, Chan-Lam N, Price S, Wharton S, Jessop H, Sharrack B & Snowden J (2020) Multiple sclerosis-like CNS inflammation following allogeneic haematopoietic stem cell transplantation treated with a 'domino' autologous haematopoietic stem cell transplantation. NEUROLOGY, Vol. 94(15)
Hill R, Richardson S, Schwalbe E, Hicks D, Lindsey J, Crosier S, Rafiee G, Grabovska Y, Wharton S, Jacques T , Michalski A et al (2020) TIME, PATTERN AND OUTCOME OF MEDULLOBLASTOMA RELAPSE ARE ASSOCIATED WITH TUMOUR BIOLOGY AT DIAGNOSIS AND UPFRONT THERAPY: A COHORT STUDY. NEURO-ONCOLOGY, Vol. 22 (pp 405-406)
Richardson S, Hill RM, Kui C, Lindsey JC, Grabovska Y, Schwalbe EC, Hicks D, Williamson D, Crosier S, Joshi A , Wharton SB et al (2020) THE ACTIONABLE GENOMIC LANDSCAPE OF RELAPSED MEDULLOBLASTOMA IS DEFINED BY MAINTENANCE AND ACQUISITION OF DRIVER EVENTS. NEURO-ONCOLOGY, Vol. 22 (pp 408-408)
Hicks D, Rafiee G, Schwalbe E, Howell C, Lindsey J, Hill R, Smith A, Adidharma P, Steel C, Pease L , Crosier S et al (2019) The Molecular Landscape and Clinical Experience in Infant Medulloblastoma. PEDIATRIC BLOOD & CANCER, Vol. 66 (pp S4-S4)
Fadul MM, Heath P, Cooper-Knock J, Brayne C, Matthews F, Wharton S & Simpson J (2019) A microarray analysis approach to identify mechanisms underlying the pathogenesis of age-associated periventricular white matter lesions. GLIA, Vol. 67 (pp E300-E300)
Hicks D, Rafiee G, Schwalbe EC, Lindsey JC, Hill RM, Smith A, Crosier S, Joshi A, Robson K, Wharton S , Jacques T et al (2018) SUBGROUP-DIRECTED CLINICAL AND MOLECULAR STRATIFICATION OF DISEASE RISK IN INFANT MEDULLOBLASTOMA. NEURO-ONCOLOGY, Vol. 20 (pp 123-123)
Seehra RS, Wharton S, Heath P, Ince P, Muthana M, Garwood C & Simpson J (2018) Hypoxia-induced changes in astrocytes and their role in the formation of age-associated white matter lesions. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 44 (pp 17-18)
Chambers A, Minett T, Matthews F, Brayne C, Ince P, Shaw P, Heath P, Simpson J & Wharton S (2018) Advanced glycosylated end products in the ageing brain. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 44 (pp 12-12)
Leach V, Goodall E, Cooper-Knock J, Wang J, Simpson J, Baker D, Drew D, Saffrey J, Romero I, Heath P & Wharton S (2018) Identification of miRNA and mRNA regulatory networks in the ageing blood-brain barrier: Comparative gene expression studies in human and mouse. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 44 (pp 36-36)
Eagle D, Merla A, Ushewokunze SO, Jellinek D, Zaki H, Wharton S & Mckevitt F (2018) . Neuro-Oncology, Vol. 20(suppl_1) (pp i20-i20)
Eagle D, Merla A, McKevitt F, Clenton S, Bridgewater C, Wharton S, Zaki H, Jellinek D & Ushewokunze S (2017) GENOMIC ANALYSIS, SURGICAL TREATMENT AND OUTCOMES OF LOWER-GRADE GLIOMAS IN A SINGLE INSTITUTION. NEURO-ONCOLOGY, Vol. 19 (pp 238-238)
Hill R, Richardson S, Lindsey J, Crosier S, Schwalbe E, Hicks D, Rafiee G, Smith A, Joshi A, Robson K , Wharton S et al (2017) Time, Pattern and Outcome of Medulloblastoma Relapse is Biology and Therapy-Dependent. PEDIATRIC BLOOD & CANCER, Vol. 64 (pp S13-S14)
Hicks D, Rafiee G, Schwalbe EC, Howell CI, Lindsey JC, Hill RM, Smith A, Crosier S, Joshi A, Robson K , Wharton S et al (2017) SUBGROUP-DIRECTED STRATIFICATION OF DISEASE RISK IN INFANT MEDULLOBLASTOMA. NEURO-ONCOLOGY, Vol. 19 (pp 39-39)
Hill R, Richardson S, Lindsey J, Crosier S, Schwalbe E, Hicks D, Rafiee G, Smithh A, Joshi A, Robson K , Wharton S et al (2017) TIME, PATTERN AND OUTCOME OF MEDULLOBLASTOMA RELAPSE IS BIOLOGY AND THERAPY-DEPENDENT. NEURO-ONCOLOGY, Vol. 19 (pp 41-41)
Vazquez-Villasenor I, Simpson JE, Garwood CJ, Ince PG, Heath PR & Wharton SB (2017) Neuronal senescence as a contributor to neurodegeneration. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 43 (pp 43-43)
Ameen-Ali KE, Simpson JE, Wharton SB, Heath PR, Sharp P & Berwick J (2017) Early cellular changes and cognitive decline in an Alzheimer's mouse model. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 43 (pp 42-43)
Crosier S, Hicks D, Schwalbe E, Williamson D, Nicholson S, Michalski A, Pizer B, Bailey S, Bown N, Robson K , Wharton S et al (2016) CENTRALISED MOLECULAR PATHOLOGY FOR RARE TUMOURS: A NATIONAL FEASIBILITY STUDY OF REAL-TIME MEDULLOBLASTOMA DIAGNOSTICS. NEURO-ONCOLOGY, Vol. 18 (pp 115-115)
Hicks D, Rafiee G, Schwalbe E, Howell C, Lindsey J, Hill R, Smith A, Crosier S, Joshi A, Robson K , Wharton S et al (2016) SUBGROUP-DIRECTED STRATIFICATION OF RISK IN INFANT MEDULLOBLASTOMA. NEURO-ONCOLOGY, Vol. 18 (pp 111-111)
Ratcliffe L, Garwood CJ, Heath P, Villasenor I, Simpson J, Ince PG & Wharton SB (2016) Impairment of IGF1 signalling in human astrocytes and it's effect on astrocyte support for neurons. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 42 (pp 51-52)
Vazquez-Villasenor I, Simpson JE, Garwood C, Ince PG, Heath P & Wharton SB (2016) Neuronal senescence as a contributor to neurodegeneration. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 42 (pp 27-28)
Clifford SC, Crosier S, Hicks D, Nicholson S, Robson K, Jacques TS, Wharton S, Bown N, Michalski A & Pizer B (2016) Establishment of national real-time central pathology review (CPR) and molecular diagnostics for medulloblastoma (MB). NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 42 (pp 19-20)
Ince PG, Minett T, Forster G & Wharton SB (2015) Microinfarcts, Small Vessel Disease and Dementia in the population-representative CFAS brain donor cohort. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 41 (pp 22-23)
Vazquez-Villasenor I, Simpson JE, Garwood C, Ince PG, Heath P & Wharton SB (2015) Neuronal senescence as a contributor to neurodegeneration. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 41 (pp 32-32)
Hill RM, Kuijper S, Lindsey J, Schwalbe EC, Barker K, Boult J, Williamson D, Ahmad Z, Hallsworth A, Ryan S , Poon E et al (2014) . Tumor Biology
Beer A, Cooper-Knock J, Higginbottom A, Robin Highley J, Wharton SP, Milano A, Jones A, Al-Chalabi A, Kirby J & Shaw PJ (2014) . Journal of Neurology, Neurosurgery & Psychiatry, Vol. 85(10) (pp e4.130-e4)
Al-Mashhadi SA, Simpson JE, Heath PR, Dickman MJ, Ince PG & Wharton SB (2014) Oxidative stress and DNA damage in cerebral white matter lesions of the ageing human brain. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 40 (pp 33-34)
Simpson JE, Ince PG, Matthews F, Shaw PJ, Heath PR, Brayne C, Garwood C, Abdalla H, Higginbottom A & Wharton SB (2014) A neuronal DNA damage response is detected at low Braak stages and correlates with cognitive impairment in the ageing brain. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 40 (pp 31-32)
Highley JR, Cooper-Knock J, Frolov A, Charlesworth G, Kirby J, Wharton SB, Ince PG, Shaw PJ, Wood N & Bandman O (2013) A pathological basis for the association of parkinsonism and amyotrophic lateral sclerosis. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 39 (pp 51-51)
Clifford S, Crosier S, Nicholson S, Robson K, Jacques T, Wharton S, Bown N, Michalski A & Pizer B (2013) A national feasibility study of real-time central pathology review (CPR) and molecular diagnostics for medulloblastoma. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 39 (pp 20-20)
Al-Mashhadi SA, Simpson JE, Heath PR, Dickman MJ, Ince PG & Wharton SB (2013) Oxidative stress and DNA damage in cerebral white matter lesions of the ageing human brain. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 39 (pp 36-37)
Ince PG, Janaway B, Wharton SB, Simpson JE, Highley JR, Matthews FE, Forster G & Brayne C (2013) Evidence for an ischemic origin of deep brain 'microbleeds'. CEREBROVASCULAR DISEASES, Vol. 35 (pp 42-42)
Waller R, Heath PR, Woodroofe MN, Francese S, Wharton SB, Ince PG, Sharrack B & Simpson JE (2012) Microarray analysis of the astrocyte transcriptome in normal appearing white matter in multiple sclerosis. JOURNAL OF NEUROIMMUNOLOGY, Vol. 253(1-2) (pp 54-54)
Crosier S, Nicholson SL, Robson K, Jacques T, Wharton S, Bown N, Michalski A, Pizer B & Clifford S (2012) A NATIONAL FEASIBILITY STUDY OF REAL-TIME CENTRAL PATHOLOGY REVIEW AND MOLECULAR DIAGNOSTICS FOR MEDULLOBLASTOMA. NEURO-ONCOLOGY, Vol. 14 (pp 44-44)
Brockington A, Ning K, Heath P, Wood E, Malik K, Fusi N, Wharton S, Ince PG & Shaw PJ (2012) . JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol. 83(3)
Romanowski CA, Hoggard N, Jellinek DA, Clenton S, McKevitt F, Wharton S, Craven I, Buller A, Waddle C, Bigley J , Wilkinson ID et al (2011) SEMI-AUTOMATED VOLUMETRIC ANALYSIS OF LOW-GRADE GLIOMAS. NEURO-ONCOLOGY, Vol. 13 (pp 140-140)
Simpson J, Richardson K, Heath P & Wharton S (2011) Oxidative nucleic acid damage in motor neuron disease. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 37 (pp 36-36)
Nicholson SL, Robson DK, Wharton SB, Jacques TS, Michalski AM, Pizer B, Bown NP & Clifford SC (2011) A feasibility study of real-time central pathology review (CPR) and molecular diagnostics for medulloblastoma in the United Kingdom. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 37 (pp 18-19)
Simpson JE, Ince PG, Heath PR, Raman R, Shaw PJ, Gelsthorpe C, Baxter L, Forster G, Matthews F, Savva G , Brayne C et al (2011) Microarray analysis of the astrocyte transcriptome in the ageing brain: relationship to Alzheimer's pathology and ApoE genotype. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 37 (pp 33-33)
Rashbass J, Collins VP & Wharton SB (2011) The development of the National Brain and CNS Tumour Registry. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 37 (pp 19-19)
Simpson J, Ince P, Heath P, Raman R, Shaw P, Gelsthorpe C, Baxter L, Forster G, Matthews F, Savva G , Brayne C et al (2010) Microarray analysis of the astrocyte transcriptome in the ageing brain: relationship to Alzheimer's pathology and ApoE genotype. BRAIN PATHOLOGY, Vol. 20 (pp 46-46)
Nicholson S, Robson D, Jacques T, Wharton S, Michalski A, Pizer B, Bown N & Clifford S (2010) ESTABLISHMENT OF REAL-TIME CENTRALISED PATHOLOGY REVIEW (CPR) AND MOLECULAR DIAGNOSTICS FOR MEDULLOBLASTOMA IN THE UNITED KINGDOM. NEURO-ONCOLOGY, Vol. 12 (pp 6-6)
Nicholson SL, Robson K, Jaques T, Wharton SB, Michalski A, Pizer B, Bown N & Clifford SC (2010) ESTABLISHMENT OF REAL-TIME CENTRALISED PATHOLOGY REVIEW (CPR) AND MOLECULAR DIAGNOSTICS FOR MEDULLOBLASTOMA IN THE UNITED KINGDOM. NEURO-ONCOLOGY, Vol. 12(6) (pp II58-II58)
Langheinrich T, Romanowski C, Wharton S & Hadjivassiliou M (2010) Presenilin 1 S170P Mutation with a Limbic Encephalitis like Presentation. NEUROLOGY, Vol. 74(9) (pp A244-A244)
Langheinrich TC, Wharton S, Romanowski CAJ & Hadjivassiliou M (2009) . JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol. 80(11)
Simpson JE, Ince PG, Theaker R, Haynes L, Forster G, Shaw PJ, Matthews F, Savva G, Brayne C, Wharton SB & MRC Cognitive Function & Ageing Ne (2009) Evidence of an astrocytic DNA damage response to oxidative stress in the ageing brain. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 35 (pp 18-19)
Lace G, Forster G, Savva G, Matthews F, Brayne C, De Silva R, Strong MJ, Ince PG & Wharton SB (2009) Variation in 4R and 3R tau isoforms in the ageing population. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 35 (pp 19-19)
Alafuzoff I, Al-Sarraj S, Arzberger T, Bodi I, Bogdanovic N, Budka H, Bugiani O, Boluda S, Duyckaerts C, Ferrer I , Gelpi E et al (2009) Reproducibility in the assessment of Alzheimer's disease and Lewy body disease-related pathologies: a study by Brain Net Europe. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 35 (pp 12-13)
Simpson J, Ince P, Theaker R, Haynes L, Forster G, Shaw P, Matthews F, Savva G, Brayne C & Wharton S (2008) DNA oxidative damage and repair mechanisms in astrocytes, and their relationship to Alzheimer-type pathology in the ageing brain. JOURNAL OF NEURAL TRANSMISSION, Vol. 115(12) (pp 1727-1727)
Lace GL, Savva G, Strong M, Ince PG, Forster G, Matthews F, Brayne C & Wharton SB (2008) Variation in 4R and 3R Tau isoforms in the ageing population. JOURNAL OF NEURAL TRANSMISSION, Vol. 115(12) (pp 1725-1726)
Harkness KAC, Langeinrich T & Wharton SB (2008) Optic neuropathy and cerebellar degeneration. JOURNAL OF NEUROIMMUNOLOGY, Vol. 197(2) (pp 175-175)
Simpson JE, Ince PG, Lace G, Forster G, Shaw PJ, Matthews F, Brayne C, Wharton SB & MRC Cognitive Function Ageing (2008) Characterisation of astrocytes in relation to Alzheimer-type pathology in the ageing brain using a population-based neuropathology cohort. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 34 (pp 31-31)
Wharton SB, Savva G, Ince PG, Matthews F, Brayne C & MRC-CFAS (2008) Age effects on the relationship between pathology and cognitive impairment in a population cohort. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 34 (pp 10-10)
Lace G, Forster G, Savva G, Barclay JJ, Dakin L, Matthews F, Brayne C, De Silva R, Ince PG, Wharton SB & MRC-CFAS (2008) Population variation in tau pathology in the MRC-CFAS neuropathology cohort. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 34 (pp 10-11)
Simpson JE, El-Sayed OH, Wharton SB, Heath P, Holden H, Forster G, Fernando MS, Matthews F, Brayne C, Lewis CE , Barber R et al (2008) Microarray gene expression analysis of deep subcortical lesions in the ageing brain reveals changes in multiple functional pathways. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 34 (pp 30-31)
Lace G, Ince PG, Matthews F, Brayne C, De Silva R & Wharton SB (2007) Population variation in tau pathology in the aged hippocampus in the MRC-CFAS neuropathology cohort. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 33(2) (pp 263-263)
Highley JR, Smith O, Brockington A, Kirby J, Wharton SB, Spillantini M, Lowe JS, Layfield R, Shaw PJ & Ince PG (2007) Extra-motor manifestations of motor neurone disease and the role of TDP43 in ALS variants. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 33(2) (pp 264-265)
Hosny O, Highley JR, Simpson JE, Forster G, Wharton SB & Ince PG (2007) Axonal number and myelin sheath degeneration in MRI hyperintense white matter lesions in the aging brain. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 33(2) (pp 266-267)
Simpson JE, El-Sayed OH, Wharton SB, Heath P, Holden H, Forster G, Fernando MS, Matthews F, Brayne C, Lewis CE , Barber R et al (2007) Microarray gene expression profiling of deep subcortical lesions in the ageing brain. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 33(2) (pp 254-255)
Simpson JE, Higham CE, Gelsthorpe CH, Fernando MS, Matthews F, Forster G, O'Brien JT, Barber R, Kalaria RN, Brayne C , Shaw PJ et al (2007) Microglial activation in white matter of the ageing brain. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 33(2) (pp 255-255)
Jellinek DA, Levy D, Maltby E, Atkey N, Hibberd S, Crimmins D, Stoeber K, Williams GH & Wharton SB (2006) Cytogenetic subtypes of oligodendroglioma differ in their apoptotic index, while the population of replication-licensed, non-proliferating cells is higher in anaplastic tumors but does not differ according to 1p,19q status. NEURO-ONCOLOGY, Vol. 8(4) (pp 459-459)
Atkey N, Wharton SB, Jellinek D & Maltby EL (2006) FISH for the detection of 1p and 19q deletions in oligodendrogioma paraffin wax sections - A retrospective study of 55 cases. JOURNAL OF MEDICAL GENETICS, Vol. 43 (pp S101-S101)
Ince PG, Fernando MS, Matthews F, Brayne C, Wharton SB, O'Brien JT, Lewis C, Kalaria RN, Shaw PJ & Simpson J (2006) Molecular markers of tissue hypoxia and glial pathology associated with incidental white matter lesions in the ageing brain. BRAIN PATHOLOGY, Vol. 16 (pp S92-S92)
Ince PG, Brayne C, Matthews F, Chatfield M, Esiri MM, Lowe JS & Wharton SB (2006) New pathological findings from the MRC-cognitive function and ageing study (CFAS) neuropathology cohort. BRAIN PATHOLOGY, Vol. 16 (pp S127-S127)
Simpson JE, Fernando MS, Matthews F, Brayne C, Lewis CE, Barber R, Kalaria RN, Forster G, Esteves F, Wharton SB , Shaw PJ et al (2006) Molecular markers of tissue hypoxia are associated with deep subcortical white matter lesions in the ageing brain. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 32(2) (pp 224-224)
Simpson JE, Fernando MS, Clark L, Ince PG, Matthews F, Forster G, O'Brien JT, Barber R, Kalaria RN, Brayne C , Shaw PJ et al (2006) Glial cell pathology of periventricular and deep white matter lesions in the ageing brain. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 32(2) (pp 224-225)
Owasil R, O’Neill R, Keable A, Nimmo J, MacGregor Sharp M, Kelly L, Saito S, Simpson JE, Weller RO, Smith C , Attems J et al () . International Journal of Molecular Sciences, Vol. 21(4) (pp 1225-1225)

Datasets

Appleby-Mallinder C, Schaber E, Kirby J, Shaw P, Cooper-Knock J, Wharton S, Heath P & Highley JR .

Preprints

Xia Z, Prescott E, Wareing H, Matuszyk M, Dakin H, Dimou E, Hidari E, Zhang Y, Lam J, Danial J , Leah T et al (2022) , Research Square Platform LLC.
Rajab MD, Jammeh E, Taketa T, Brayne C, Matthews FE, Su L, Ince PG, Wharton SB & Wang D (2022) , Research Square.
Rajab M, Jammeh E, Taketa T, Brayne C, Matthews F, Su L, Ince P, Wharton S & Wang D (2022) , medRxiv.
Xia Z, Prescott EE, Wareing HE, Matuszyk MM, Dakin H, Dimou E, Zuo E, Zhang YP, Lam JYL, Danial JSH , Leah T et al (2021) , Cold Spring Harbor Laboratory.
Williamson D, Schwalbe EC, Hicks D, Aldinger KA, Lindsey JC, Crosier S, Richardson S, Goddard J, Hill RM, Castle J , Grabovska Y et al () , Cold Spring Harbor Laboratory.
Perez-Nievas BG, Johnson L, Beltran-Lobo P, Hughes MM, Gammallieri L, Tarsitano F, Myszczynska MA, Vazquez-Villasenor I, Jimenez-Sanchez M, Troakes C , Wharton SB et al () , Cold Spring Harbor Laboratory.
Shabir O, Sharp P, Rebollar MA, Boorman L, Howarth C, Wharton SB, Francis SE & Berwick J () , Cold Spring Harbor Laboratory.

Research group

Current PhD students:

Harriet Brooke

Research team:

Dr Bridget Ashford
Dr Bridget Benson
Mr Saif Ahamed

Grants

Current funding sources

Alzheimer’s Society
Alzheimer’s Research UK
British Heart Foundation

Teaching interests

Module leader: Neurodegeneration module, MSc Translational Neuroscience
MSc lectures – Translational Neuroscience
MBBS lectures – Preclinical neurosciences
Neuroanatomy dissection teaching
Supervisor SSC research projects
Supervisor MSc research projects
Seminars to postgraduate trainees in histopathology and clinical neurosciences

Professional activities and memberships

Editorial activities

Consulting editor, Neuropathology and Applied Neurobiology (2014-7)
Editor-in-Chief, Neuropathology and Applied Neurobiology (2007-13)

External professional activities – current and recent

President of the British Neuropathological Society (2022 – 2024)
Vice-president of the British Neuropathological Society (2020-2022)
Member of the annual review panel for Brains for Dementia Research (2022 – present)
Member of the Alzheimer’s Research UK Grant Review Board 2016- 2022
Chair of the specialist advisory committee in neuropathology, Royal College of Pathologists, 2020-2022
Chief of panel of examiners in neuropathology for the Royal College of Pathologists (2018-21)
Examiner in neuropathology for the Royal College of Pathologists (2005-21)

Membership of associations and societies - current

International Society for Neuropathology
British Neuropathological Society

Current projects

Neuronal Senescence as a Contributory Mechanism to Dementia

Funded by Alzheimer's Research UK, this project aims to study the contribution of neuronal senescence to dementia. Markers of dementia, such as tangles and plaques that characterise Alzheimer’s, do not explain all dementia, and treatments aimed at them have been unsuccessful. This suggests other processes contribute to dementia.

Senescent cells, sometimes called zombie cells, are persistently damaged cells, often because of damage to their DNA, which carries all the instructions for the cell. These cells remain alive, but they do not carry out their normal functions. Additionally, they produce factors that damage nearby cells and cause inflammation. Zombie cells are described in other tissues and diseases and there are drug treatments aimed at them. However, their role in dementia is not understood. Using brain tissue samples from the Cognitive Function and Ageing Study, we plan to identify senescent nerve cells in the brain and determine how they relate to dementia.

To determine how senescence causes damage, we will isolate nerve cells with and without markers of senescence from the same cases, and investigate effects on the cells by determining differences in the gene messages present. This will provide greater understanding of how senescence contributes to dementia and identify specific ways in which senescence affects nerve cells, which may lead us to new approaches to target zombie cells.

How does brain microvascular disease, especially pathological changes to capillaries, contribute to dementia?

Studies of blood vessel diseases, the second commonest cause of dementia, have focused mainly on large or small arteries. However, the contribution of pathology affecting the smallest vessels, the capillaries, is not understood. Brain capillaries are specialised to ensure that substances entering the brain from the blood are tightly-regulated and that blood supply is matched to the needs of nerve cells. This study, funded by the British Heart Foundation, will investigate the contribution of microvascular disease (MVD), affecting the capillaries, to dementia. Using donated human brain tissue, we will first characterise MVD using immunohistochemistry, a method that allows us to identify whether and where particular molecules are expressed and to measure them using a computer. Secondly, we will determine how these new MVD measures compare to other, existing measures of dementia-related pathologies. Thirdly, we will extend the assessment of the most informative MVD measures to all 550 donations, then determine how MVD contributes to dementia using advanced statistical methods. Lastly, we will identify potential new mechanisms of capillary damage by examining the expression of all the messages (mRNA) that code for protein production in the capillaries. Computer-based approaches will allow us to analyse this data to identify changes in cell processes that contribute to disease.

What is the Contribution of Basal Ganglia Pathology to Late-life Dementia and Frailty?

Most studies of dementia focused on the cerebral cortex, but other brain regions are also important. This PhD studentship, funded by the Alzheimer’s Society, aims to investigate how pathology in the basal ganglia contributes to dementia and frailty in late-life. The basal ganglia have many connections to the cortex and are involved in cognition as well as in motor control. They are affected by vascular disease and in the progression of Alzheimer’s disease. We plan to use human autopsy brain tissue samples donated as part of the Cognitive Function and Ageing Study. We will characterised vascular pathology and neurodegenerative pathology in basal ganglia using microscopy and immunohistochemistry. We will then determine the contribution that pathology in the basal ganglia makes to dementia and also to frailty. Finally, we will use gene expression analysis to determine new pathways by which pathology in basal ganglia might damage the function of this tissue.

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School of Medicine and Population Health

School of Medicine and Population Health

Professor Stephen B Wharton

External collaborations

Journal articles

Chapters

Conference proceedings papers

Datasets

Preprints

Current PhD students:

Research team:

Current funding sources

Links