Dr Sophie Whyte
MMath (Warwick), PhD (Birmingham)
Population Health, School of Medicine and Population Health
Senior Research Fellow
+44 114 222 0859
Full contact details
Population Health, School of Medicine and Population Health
Regent Court (ScHARR)
30 Regent Street
葫芦影业
S1 4DA
- Profile
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I joined the HEDS section of ScHARR as a mathematical modeller in September 2007. Previous to this, I obtained a Masters in Mathematics from the University of Warwick and a PhD in Pure Mathematics (Group Theory) from Birmingham University.
- Research interests
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My broad research is focused on mathematical modelling within health economics. I have gained significant expertise and experience in two related areas:
- Bayesian calibration of cancer natural history models: This is my main methodological research theme, please see MDM publication and Example Excel model using the Metropolis Hastings algorithm to calibrate a state transition model available to down load from the Downloads box)
- Early diagnosis of bowel cancer: I have substantial experience in early diagnosis of cancer generally having worked on more than 15 projects in this area of applied research. My main expertise lies in the modelling bowel cancer screening to inform national bowel cancer screening policy.
In addition to these main research themes I have undertaken research to inform policy making: Health Technology Assessment (HTA) for NICE, and research as part of the Policy Research Unit in Economic Evaluation of Health and Care Interventions (EEPRU) for DH ()
- Publications
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Show: Featured publications All publications
Featured publications
Journal articles
- . Value in Health, 25(6), 954-964.
- . Gut, 69(2), 201-223.
- . Cancer Management and Research, 10, 637-645.
- . Health Economics, 24(6), 742-754.
- . British Journal of Cancer, 111(9), 1734-1741.
- . Cancer Causes Control, 25(6), 647-658.
- . Pharmacoeconomics, 30(12), 1119-1132.
- . Colorectal Dis, 14(9), e547-e561.
- . Br J Cancer, 106(5), 805-816.
- . Value Health, 14(6), 953-960.
- . Value Health, 14(4), 465-474.
- . Medical Decision Making, 31(4), 625-641.
- . Health Technol Assess, 14(Suppl. 2), 47-53.
- . Value in Health, 12(7), A395-A395.
Reports
All publications
Journal articles
- . Journal of Thoracic Oncology, 18(11), S134-S134.
- . Value in Health, 25(6), 954-964.
- . Cancer Prevention Research, 14(8), 811-822.
- . BMJ Open, 11(3).
- . Gastroenterology, 158(6), 1529-1533.e4.
- . Gut, 69(2), 201-223.
- . Value in Health, 22(10), 1154-1161.
- . Cancer Management and Research, 10, 637-645.
- . Health Technology Assessment, 21(79), 1-308.
- . PharmacoEconomics.
- . PharmacoEconomics, 35(7), 717-726.
- . Medical Decision Making, 37(2), 148-161.
- . BMC Medicine, 15(1).
- . BMC Medicine, 14(1), 200-200.
- . Trials, 17(1).
- . Value in Health, 19(2), 138-144.
- . British Journal of Cancer, 114(3), 327-333.
- . Medical Decision Making, 36(2), 210-222.
- . British Journal of Cancer, 113(1), 135-141.
- . Health Economics, 24(6), 742-754.
- . British Journal of Cancer, 111(9), 1734-1741.
- . Cancer Causes Control, 25(6), 647-658.
- . VALUE IN HEALTH, 16(7), A426-A426.
- . BMC Health Serv Res, 13, 105.
- . British Journal of Cancer, 108(5), 1211-1212.
- . Pharmacoeconomics, 30(12), 1119-1132.
- . Colorectal Dis, 14(9), e547-e561.
- . Br J Cancer, 106(5), 805-816.
- . European Journal of Health Economics, 13(4), 511-524.
- . Value Health, 14(6), 953-960.
- . Value Health, 14(4), 465-474.
- . BMC Cancer, 11.
- . Medical Decision Making, 31(4), 625-641.
- . Health Technol Assess, 14(Suppl. 2), 47-53.
- . Value in Health, 12(7), A395-A395.
- COST-EFFECTIVENESS OF A POPULATION-BASED COLORECTAL CANCER SCREENING PROGRAMME IN IRELAND. VALUE HEALTH, 12(7), A280-A280.
- Faecal Immunochemical Tests For Patients With Symptoms Suggestive Of Colorectal Cancer: An Updated Systematic Review And Multiple-Threshold Meta-Analysis of Diagnostic Test Accuracy Studies. Colorectal Disease.
- Modelling cost-effective strategies for minimising socioeconomic inequalities in colorectal cancer screening outcomes in England. Preventive Medicine.
- . Cancer Reports.
- . Health Technology Assessment, 14(Suppl 2), 47-53.
- CALIBRATING NATURAL HISTORY OF CANCER MODELS IN THE PRESENCE OF DATA INCOMPATIBILITY; PROBLEMS AND SOLUTIONS. PharmacoEconomics.
Conference proceedings papers
- Model-based Evaluations of the Cost-effectiveness of Interventions for Lung Cancer: A Systematic Review. JOURNAL OF THORACIC ONCOLOGY, Vol. 18(11) (pp S134-S134)
- Flexible parametric survival models and time-series analysis for extrapolating time-varying treatment effects in health technology assessment. Flexible parametric survival models and time-series analysis for extrapolating time-varying treatment effects in health technology assessment, 5 September 2016 - 8 September 2016.
- The value of implementation: how to invest in getting cost-effective technologies into practice. Framework and application to novel oral anticoagulants in the prevention of stroke and systemic embolism. HESG. Leeds
- WORKSHOP 2999: From evaluation to implementation: how to ensure efficient investment in implementation of cost-effective technologies in clinical practice?. ISPOR. Amsterdam, 9 November 2014 - 12 November 2014.
- Rowen D, Brazier J, Mukuria C, Whyte S, Keetharuth A, Risa Hole A, Tsuchiya A, Shackley P. Eliciting societal preferences for burden of illness, therapeutic improvement and end of life for value based pricing.. HESG. 葫芦影业, UK, 8 January 2014.
- A framework for the cost-equality analysis of health care programmes. ISPOR. Dublin
- Economic evaluation of an electrical impedance spectroscopy (EIS) device used as an adjunct to colposcopy. VALUE IN HEALTH, Vol. 16(7) (pp A407-A407)
- Cost effectiveness analysis of an early awareness campaign for colorectal cancer. Cancer Outcomes Conference. Brighton
- Effectiveness and cost effectiveness of an awareness campaign for colorectal cancer: A mathematical modelling study. Cancer Research UK NAEDI conference. Cambridge, UK
- The cost effectiveness of an early awareness campaign for colorectal cancer. SMDM. Oslo, Norway, 10 June 2012 - 12 June 2012.
- The cost effectiveness of an early awareness campaign for colorectal cancer. SMDM. Oslo, Norway
- Using a natural history model in combination with screening data to estimate the test characteristics of the FOB test in the English bowel cancer screening programme. Methods for evaluating medical tests and biomarkers. Birmingham, UK
- Bayesian calibration of a natural history model for colorectal cancer. ISPOR. Paris
Reports
- ECASS health economic feasibility study
- Optimising Bowel Cancer Screening Phase 1: Optimising the cost effectiveness of repeated FIT screening and screening strategies combining bowel scope and FIT screening
- Generic Cancer Screen - Economic modelling report
- Degarelix for treating advanced hormone-dependent Prostate cancer [ID590] Spinal cord compression associated with hormonal therapy in men with hormone-dependent metastatic prostate cancer: a systematic review and economic assessment
- Getting cost-effective technologies into practice: the value of implementation An application to novel anticoagulants in the prevention of stroke and systemic embolism
- Getting cost-effective technologies into practice: the value of implementation. An application to B-type natriuretic peptide (BNP) testing in diagnosing chronic heart failure
- Getting cost-effective technologies into practice: the value of implementation. Report on framework for valuing implementation initiatives
- Update: Eliciting societal preferences for weighting QALY's according to burden of illness, size of gain and end of life
- Eliciting societal preferences for burden of illness, therapeutic improvement and end of life for value based pricing: a report of the main survey
- Modelling the cost-effectiveness of early awareness interventions for the early detection of lung cancer
- Early awareness interventions for cancer: Colorectal cancer
- Cost-effectiveness of granulocyte colony-stimulating factor prophylaxis for febrile neutropenia in breast cancer in the United Kingdom
- Cost-effectiveness of granulocyte colony-stimulating factor prophylaxis for febrile neutropenia in patients with non-Hodgkin's lymphoma in the United Kingdom (UK)
- Reappraisal of the options for colorectal cancer screening
- Consistency between direct trial evidence and Bayesian Mixed Treatment Comparison: Is head-to-head evidence always more reliable?
- Granulocyte colony-stimulating factors for prevention of febrile neutropenia following chemotherapy: systematic review and meta-analysis
- Options for a population-based colorectal cancer screening programme in Ireland: a health technology assessment
- Health economics of Colonix: A new diagnostic test in colorectal cancer
Posters
- The value of investing in implementation activities: A case study in natriuretic peptide testing for diagnosing suspected heart failure (SMDM 15th Biennial European Meeting 8-10 June 2015).
Preprints
- Research group
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If you are interested in pursuing a PhD which may fit with my research areas described above please contact me regarding PhD supervision.
- Teaching interests
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I am module lead for the Dissertation on the MSc in Health Economics and Decision Modelling.
Links