Professor Nigel Hoggard
MD, MRCP, FRCR
Clinical Medicine, School of Medicine and Population Health
Professor of Neuroradiology
+44 114 215 9607
Full contact details
Clinical Medicine, School of Medicine and Population Health
Floor C
Royal Hallamshire Hospital
Glossop Road
ºù«Ӱҵ
S10 2JF
- Profile
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For enquiries please contact - ClinMed-Operational@sheffield.ac.uk
I joined the University of ºù«Ӱҵ in 2006 with interests in adult diagnostic neuroradiology and novel MR imaging agents. Prior to that I had been an NHS Consultant Neuroradiologist at the Manchester Neurosciences Centre, Hope Hospital Salford from 2003. I have been Professor of Neuroradiology since 2018.
I have published over 90 peer reviewed articles.
- Research interests
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My research interests remain primarily centred on the diagnostic applications of MR imaging in radiology with a particular emphasis on neuroscience and the cerebellum in particular. I work closely with Prof Marios Hadjivassiliou, we are part of the SIGReD group founded by Marios, a multi-disciplinary research group focussed on gluten related diseases. We have published numerous articles on gluten ataxia and brain imaging in gluten sensitivity.
The cerebellum is a small part of the brain that never the less contains over half of the neurons. It represents a highly compact system for combining and analysing information subconsciously for the rest of the brain, it can be thought of as the brain’s own supercomputer. It is designed to compare feedback information such as where is my hand in space to pre-existing models held in the cerebellum and then feed-forward into motor commands to ensure movements coordinated in real time such as would be required for catching a ball.The cerebellum not only helps the brain to control balance and coordination of movement but is now having its role in control of emotion, language and cognition gradually revealed. When it is damaged patients may be affected by falls and feel clumsy. They may lose the ability to walk, speak normally, use utensils or dress themselves and quite frequently may have to use a wheel chair as it becomes more severe.
The cerebellum is affected by a wide range of diseases including genetic conditions, degenerative conditions, alcohol and auto-immunity related diseases. There are new treatments being developed for diseases affecting the cerebellum but trials are hampered by the lack of suitable ways to measure their effectiveness. In dementia and MS many trial outcomes are based on MR imaging techniques as a well as clinical changes in the patients. But because the cerebellum’s activity is subconscious and represents feedback control beneath the surface it is difficult to measure clinically. Our group’s research is focussed on assessment of the cerebellum with advanced MR imaging based techniques. In particular, there is a need for measurements in the autoimmune cerebellar diseases and aggressive degenerative cerebellar disease such as MSA-C.
Gluten sensitivity, as well as causing ataxia, can be associated with accelerated white matter small vessel disease and imaging to assess this and the evaluation the blood brain barrier is an area of great interest to us in SIGReD. We recently published a paper demonstrating cognitive and structural brain changes in patients with coeliac ideas from the UK BioBank study in Gastroenterology. We have been recently funded by the Peter Sowerby Foundation to investigate the potential consequences of gluten possessing antibodies gliadins in the blood, which affects about 10% of the UK population, on brain structure and neuro-cognitive performance.
I have been heavily involved in the UK and European response to the evidence of the accumulation of gadolinium in the brain in patients after routine administration of gadolinium based contrast agents for MR scans.I co-chaired the PRAC which recommended to the Human Medicines agency to restrict the use of linear structure gadolinium based contrast agents in the European Union.
- Publications
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Show: Featured publications All publications
Featured publications
Journal articles
All publications
Journal articles
- . Brain Communications, 6(2).
- . Gastroenterology.
- . BMJ Open, 13(11), e077348-e077348.
- . Quantitative Imaging in Medicine and Surgery, 13(10), 7304-7337.
- . Rheumatology, 61(Supplement_1).
- . Journal of the Neurological Sciences, 429, 119412-119412.
- . Practical Neurology, 21(4), 351-353.
- . Cerebellum Ataxias, 8(1), 16.
- . Clinical Radiology.
- . The Lancet Rheumatology, 3(6), e406-e407.
- . Nutrients, 13(6).
- . Nutrients, 13(4).
- . Nutrients, 13(2), 1-19.
- . Cerebellum and Ataxias, 8(1).
- . The Lancet Rheumatology.
- . BMJ Open, 10(8), e038911-e038911.
- . Nutrients, 12(7).
- . Biochemical Pharmacology, 178, 114109-114109.
- . Gastroenterology.
- . Radiology, 295(1), 171-180.
- . Clinical Radiology, 75(5), 348-350.
- . Journal of Neurology, 267(1), 257-258.
- . Journal of Functional Foods, 64, 103597-103597.
- . The Journal of Nutritional Biochemistry, 78, 108325-108325.
- . Cerebellum & Ataxias, 6(1).
- . Cerebellum & Ataxias, 6(5).
- A population survey of dietary attitudes towards gluten. Nutrients, 11(6).
- . Gastroenterology.
- . NeuroImage, 191, 537-548.
- . Neurology, 92(15_supplement).
- . Clinical Gastroenterology and Hepatology.
- . Journal of Magnetic Resonance Imaging.
- . Clinical Radiology, 74(3), 242-246.
- . Neurology Genetics, 4(6), e300-e300.
- . Neurology Genetics, 4(6), e279-e279.
- . Genes & Nutrition, 13(1).
- . Lupus.
- . Neuroscience Letters, 678(Epilepsia 54 2013), 124-130.
- . The Journal of Laryngology & Otology, 132(06), 550-553.
- . Clinical Neurophysiology, 129(7), 1372-1373.
- . British Journal of Nutrition, 119(5), 496-506.
- . Journal of Neuromuscular Diseases, 5(1), 107-107.
- . Journal of Neurology, Neurosurgery, and Psychiatry, 89, 248-255.
- . Seizure, 56, 26-30.
- . Pract Neurol, 18(1), 27-34.
- . J Neurol.
- . Neurology Genetics, 3(5), e181-e181.
- . NeuroImage, 159, 32-45.
- . Pract Neurol.
- . Neurology, 89(7), 705-709.
- . British Journal of Radiology, 90(1074).
- . Cerebellum Ataxias, 4, 1-1.
- . Cerebellum & Ataxias, 4(1).
- . Journal of Neurology, Neurosurgery, and Psychiatry, 88, 301-309.
- . British Journal of Radiology.
- . British Journal of Radiology, 90(1069).
- . Cerebellum Ataxias, 3, 17-17.
- . European Journal of Gastroenterology & Hepatology, 28(12), 1383-1387.
- . Neuroscience, 324, 377-389.
- . The American Journal of Gastroenterology, 111(4), 561-567.
- . The Lancet Neurology, 15(3), 259-269.
- . Pediatric Radiology, 46(1), 73-81.
- . The Cerebellum, 14(2), 175-196.
- . Cerebellum & Ataxias, 2(1).
- . Brain Stimulation, 8(6), 1230-1233.
- . Cerebellum & Ataxias, 1.
- . AJNR Am J Neuroradiol, 35(9), 1753-1758.
- . Autoimmune Dis, 2014, 237107.
- . British Journal of Radiology, 87(1033).
- . Pract Neurol, 14(4), 258-260.
- . Neuropathol Appl Neurobiol, 40(3), 258-269.
- . J Neurol Neurosurg Psychiatry, 84(11), e2.
- . J Neurol Neurosurg Psychiatry, 84(11), e2.
- . PLoS ONE, 8(10).
- . Journal of Nutritional Science, 2.
- . Amyotroph Lateral Scler Frontotemporal Degener, 14(5-6), 414-423.
- . Pract Neurol, 13(2), 114-119.
- . Pract Neurol, 13(4), 263-267.
- . J Vasc Interv Radiol, 24(4), 528-533.
- . J Neuroradiol, 40(4), 310-312.
- . PLoS One, 8(6), e66186.
- . Neuroradiology, 1-5.
- . Postgrad Med J, 89(1050), 209-223.
- . Postgrad Med J, 89(1048), 94-106.
- . Cerebellum, 12(2), 205-211.
- . Clin Radiol, 68(3), 245-250.
- . British Journal of Nutrition, 109(6), 1040-1051.
- . Cerebellum, 12(2), 245-266.
- . Radiographics, 32(7), 2101-2112.
- . Seizure, 21(10), 820-822.
- . Obesity, 20(6), 1158-1167.
- . J Neurol Neurosurg Psychiatry, 83(12), 1216-1221.
- . Br J Neurosurg, 26(3), 361-366.
- . Br J Radiol, 85(1017), 1236-1242.
- . Acta Neurol Scand, 126(2), 138-143.
- USE OF MR SPECTROSCOPY AND DIFFUSION TO DIFFERENTIATE GBM FROM SOLITARY CEREBRAL METASTASES. NEURO-ONCOLOGY, 13, 141-141.
- CHO/CR RATIO APPEARS TO BE AN INDEPENDENT IMAGING BIOMARKER OF SURVIVAL FOR PATIENTS NOT SUITABLE FOR OPEN RESECTION OF GLIOBLASTOMA. NEURO-ONCOLOGY, 13, 141-142.
- . J NEUROL NEUROSUR PS, 82(9).
- . Journal of Cellular Physiology, 226(8), 2123-2130.
- . Br J Radiol, 84(1000), e79-e82.
- Magnetic resonance imaging of epilepsy at 3 Tesla. Clinical Radiology.
- . Digestive Diseases and Sciences, 56(4), 1028-1036.
- . Neurosurgery, 67(6), 1799-1815.
- . Postgrad Med J, 86(1019), 552-559.
- . Postgrad Med J, 86(1017), 409-418.
- . British Journal of Oral and Maxillofacial Surgery, 48, S28-S28.
- . Clin Gastroenterol Hepatol, 8(5), 433-438.
- . AM J NEURORADIOL, 31(5), 856-861.
- . Br J Radiol, 83(986), 113-117.
- . J Cereb Blood Flow Metab, 29(12), 1975-1982.
- . Epilepsia, 50(12), 2605-2610.
- . J Magn Reson Imaging, 30(5), 981-988.
- . Journal of Molecular Endocrinology, 43(4), 171-177.
- . EUR RADIOL, 19(4), 1025-1025.
- . J Med Ethics, 35(3), 194-199.
- . Phys Med Biol, 53(21), 6055-6063.
- . Neurosurgery, 62(2), 336-344.
- . Neuroradiology Journal, 21(SUPPL. 1), 20-26.
- . Neuroradiology Journal, 21(SUPPL. 1), 47-66.
- . Mechanisms of Ageing and Development, 129(3), 129-137.
- . Journal of Molecular Endocrinology, 39(3), 199-210.
- . Neurosurgery, 61(1 Suppl), 187-196.
- . Int J Radiat Oncol Biol Phys, 68(3), 952-957.
- . Endocrinology, 148(8), 3750-3757.
- . Acta Radiol, 47(10), 1079-1084.
- . Journal of Molecular Endocrinology, 33(3), 693-703.
- . Neurology, 63(7), 1340-1341.
- . Clinical Endocrinology, 61(1), 31-39.
- . Clin Radiol, 59(4), 356-357.
- . Journal of Molecular Endocrinology, 32(1), 145-153.
- Short-term changes in cerebral microhemodynamics after carotid stenting.. AJNR Am J Neuroradiol, 24(8), 1501-1507.
- . DEV MED CHILD NEUROL, 45(2), 139-139.
- . Biochemical and Biophysical Research Communications, 299(3), 432-437.
- . Clin Radiol, 57(11), 957-968.
- . Endocrinology, 143(4), 1166-1173.
- . American Journal of Reproductive Immunology, 47(3), 151-158.
- Comparison of the aging of neonatal and adult blood samples in an in vitro subdural hemorrhage model. RADIOLOGY, 221, 487-487.
- Brain MR perfusion imaging in humans - Advantages of high-molarity gadolinium chelates. ACTA RADIOL, 42(6), 555-559.
- Brain MR perfusion imaging in humans.. Acta Radiol, 42(6), 555-559.
- Multimodality MR imaging depiction of hemodynamic changes and cerebral ischemia in subarachnoid hemorrhage.. AJNR Am J Neuroradiol, 22(9), 1690-1697.
- Research outcomes in British gastroenterology: an audit of the subsequent full publication of abstracts presented at the British Society of Gastroenterology. GUT, 49(1), 154-155.
- Erratum: Brain iron deposition in Parkinson's disease imaged using the PRIME magnetic resonance sequence (Brain (December 2000) 123:12 (2423-2431)). Brain, 124(6), 1258.
- . Journal of Endocrinology, 169(3), 465-476.
- . Neurosurgery, 48(5), 973-983.
- Cerebral arteriovenous malformations: comparison of novel magnetic resonance angiographic techniques and conventional catheter angiography.. Neurosurgery, 48(5), 973-982.
- . Clin Radiol, 56(3), 171-183.
- . J Neurol Neurosurg Psychiatry, 70(2), 205-211.
- . Imaging Decisions MRI, 5(1), 2-10.
- In vivo measurement of cerebral blood flow: a review of methods and applications.. Vasc Med, 6(1), 51-60.
- . Placenta, 22(4), 347-352.
- . Endocrinology, 142(7), 2888-2897.
- . CNS Drugs, 14(6), 413-424.
- . British Journal of Nutrition, 83(3), 317-326.
- . Brain, 123 Pt 12, 2423-2431.
- Brain arteriovenous malformations: assessment with dynamic MR digital subtraction angiography.. AJNR Am J Neuroradiol, 21(10), 1892-1899.
- . Stroke, 31(9), 2266-2278.
- . Stroke, 31(9), 2266-2278.
- Leptomeningeal enhancement and extravasation of contrast medium into the CSF space? Response. STROKE, 31(9), 2276-2277.
- . Molecular Human Reproduction, 6(8), 763-769.
- Full publication of abstracts presented at the British Society of Gastroenterology.. GASTROENTEROLOGY, 118(4), A217-A217.
- Full publication of abstracts presented at the British Society of Gastroenterology. GUT, 46, A18-A18.
- . Stroke, 31(4), 848-851.
- . Reviews of Reproduction, 5(1), 18-24.
- . American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 278(1), R271-R281.
- . Journal of Neuroendocrinology, 11(3), 165-169.
- . International Journal of Obesity, 23(S1), S22-S28.
- . Archiv für Tierernaehrung, 51(2-3), 177-185.
- . Proceedings of the Nutrition Society, 57(3), 421-427.
- . Proceedings of the Nutrition Society, 57(3), 413-419.
- . Regulatory Peptides, 75-76, 271-278.
- . Biochemical and Biophysical Research Communications, 247(3), 654-658.
- . Endocrinology, 139(1), 29-34.
- . Physiology & Behavior, 64(2), 191-195.
- . FEBS Letters, 415(2), 134-138.
- . FEBS Letters, 402(2-3), 185-188.
- . American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 273(1), R446-R450.
- . Biochemical and Biophysical Research Communications, 232(2), 383-387.
- . Biochemical and Biophysical Research Communications, 230(2), 360-364.
- . Journal of Neuroendocrinology, 8(10), 733-735.
- . FEBS Letters, 387(2-3), 113-116.
- . American Journal of Gastroenterology.
- . Nutrients, 16(8), 1209-1209.
- . The Cerebellum.
- . Journal of Neurology, Neurosurgery & Psychiatry.
- . Practical Neurology.
- . Frontiers in Nutrition, 10.
- . Journal of Neurology.
- . The British Journal of Radiology.
- . Nutrients, 13(5), 1692-1692.
- . The Cerebellum.
- . The Cerebellum.
- . Journal of Neurology.
- . PLOS ONE, 15(8), e0238283-e0238283.
- . Nutrients, 10(10), 1444-1444.
- . Neuroradiologie Scan, 03(04), 285-298.
- . Frontiers in Genetics, 3.
- . Br J Radiol.
- . International Journal of General Medicine, 403-403.
- . Journal of Neuroendocrinology, ja(ja), 070927052250001-070927052250001.
- . Journal of Neuroendocrinology, 12(7), 649-655.
- . The Cerebellum.
- . The Cerebellum.
- . Journal of Neurology.
- Magnetic resonance spectroscopy reveals mitochondrial dysfunction in amyotrophic lateral sclerosis. Brain.
- . Journal of Magnetic Resonance Imaging.
Conference proceedings papers
- . 2023 IEEE Nuclear Science Symposium, Medical Imaging Conference and International Symposium on Room-Temperature Semiconductor Detectors (NSS MIC RTSD), 4 November 2023 - 11 November 2023.
- CEREBELLAR ATAXIA IN PRIMARY SJOGREN'S SYNDROME: IS GLUTEN SENSITIVITY THE ANSWER?. RHEUMATOLOGY, Vol. 61
- Cerebellar Ataxia in Primary Sjogren's Syndrome, Is Gluten Sensitivity the Answer?. ARTHRITIS & RHEUMATOLOGY, Vol. 73 (pp 624-625)
- Balo's concentric sclerosis successfully treated with alemtuzumab. MULTIPLE SCLEROSIS JOURNAL, Vol. 26(3_SUPPL) (pp 264-264)
- . Journal of Neurology Neurosurgery & Psychiatry, Vol. 90(12) (pp e55)
- Investigating Directionality of Neurodegeneration in vivo in ALS using Multimodal MRI. NEUROLOGY, Vol. 92(15)
- . Journal of Neurology, Neurosurgery & Psychiatry, Vol. 89(10) (pp A29.1-A29)
- Imaging denervation in amyotrophic lateral sclerosis for future clinical trials: 12-month follow-up from a longitudinal cohort study. EUROPEAN JOURNAL OF NEUROLOGY, Vol. 25 (pp 302-302)
- . Journal of the Neurological Sciences, Vol. 381 (pp 102-102)
- . Journal of the Neurological Sciences, Vol. 381 (pp 304-305)
- . Gut, Vol. 65(Suppl 1) (pp A165.2-A166)
- . Heart, Vol. 102(Suppl 6) (pp A123.2-A124), 6 June 2016 - 8 June 2016.
- Prognostic Factors Associated with Axonal Loss after Optic Neuritis. NEUROLOGY, Vol. 86
- Prognostic Factors Associated with Axonal Loss after Optic Neuritis. NEUROLOGY, Vol. 86
- . Gut, Vol. 64(Suppl 1) (pp A144.1-A144)
- TRANSFORMATION OF LOW-GRADE GLIOMA ASSESSED BY VOLUMETRIC 3T MRI. NEURO-ONCOLOGY, Vol. 14 (pp 4-4)
- Alcoholic Cerebellar Degeneration: Not All Due to Alcohol. ANNALS OF NEUROLOGY, Vol. 72 (pp S96-S96)
- SEMI-AUTOMATED VOLUMETRIC ANALYSIS OF LOW-GRADE GLIOMAS. NEURO-ONCOLOGY, Vol. 13 (pp 140-140)
- Can hyperpolarized He-3 MRI detect radiation induced lung damage?. LUNG CANCER, Vol. 60 (pp S28-S28)
- Dexamethasone and enhancing gliomas: Alterations in perfusion and blood-tumor barrier kinetics shown by magnetic resonace imaging. NEURO-ONCOLOGY, Vol. 9(4) (pp 578-578)
- Improved image registration of hyperpolarized helium-3 MRI and CT for NSCLC planning. RADIOTHERAPY AND ONCOLOGY, Vol. 84 (pp S173-S173)
- . Clinical Oncology, Vol. 19(3) (pp S5-S5)
- . Biochemical Society Transactions, Vol. 29(2) (pp 57-63)
- . Biochemical Society Transactions, Vol. 26(2) (pp S98-S98)
Preprints
- Teaching interests
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I am the lead for the ºù«Ӱҵ academic clinical radiology training scheme and Deputy Lead for the ºù«Ӱҵ academic training programme. The ºù«Ӱҵ radiology training scheme continues to show strong success developing academic radiologists all the way from thesis to tenured full time academic posts. I teach on the Neurology MSc course, the ºù«Ӱҵ Fundamentals of Neuroradiology course and the National ENT radiology Masterclass.
- Professional activities and memberships
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- Editor-in-Chief British Journal of Radiology 2013-2016.
- Expert Advisory Panel member, Commission for Human Medicines/MHRA 2009-present.
- Expert Advisory Panel member, European Medicines Agency 2016.
- Cancer Peer reviewer 2012-2013.
- Member of the Royal College of Radiologists FRCR part I examination committee 2011-2014.
- NIHR doctoral research fellowship selection panel member 2011 and 2013-present.
- NIHR IAT panel for competitive bids for ACF and ACL posts 2015-present.
- ºù«Ӱҵ Teaching Hospitals NHS Foundation Trust, Research Lead for the Directorate of Radiology 2008-present.
- Member of the ºù«Ӱҵ Regional Ethics committee 2006-2012.