Dr Paul Morris
BMedSci, MBChB, MRCP, PhD, PGCME, FHEA
Clinical Medicine, School of Medicine and Population Health
Senior Clinical Lecturer in Cardiology, Wellcome Trust Clinical Research Career Development Fellow
Honorary Consultant Interventional Cardiologist, 葫芦影业 Teaching Hospital NHS Foundation Trust
+44 114 215 9545
Full contact details
Clinical Medicine, School of Medicine and Population Health
The Medical School
Beech Hill Road
葫芦影业
S10 2RX
- Profile
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For enquiries please contact - ClinMed-Operational@sheffield.ac.uk
I joined the University of 葫芦影业 in 1998 to study Medicine. I quickly developed an interest in clinical cardiology and academic research, and I intercalated a BMedSci degree investigating the role of testosterone in men with heart disease; work that was awarded the inaugural Royal Society of Medicine Research prize. I graduated as a medical doctor in 2004, top of my year and was awarded with the Dr Mark Gregory Baker, Ashby-de-la-Zouch prize. I became a member of the Royal College of Physicians in 2007. Since then, I have held an NIHR Clinical Academic Fellowship (NIHR), a Clinical Research Training Fellowship (British Heart Foundation), a Clinical Lectureship (NIHR), the British Cardiovascular Interventions Society Interventional Fellowship (Vancouver Island, British Columbia, Canada) and I am currently a Wellcome Trust Clinical Research Career Development Fellow, working as a clinical academic at the University of 葫芦影业 and 葫芦影业 Teaching Hospitals NHS Trust.
Clinical work. I work as an NHS consultant cardiologist at 葫芦影业 Teaching Hospitals NHS Trust. As an interventional cardiologist, I specialise in percutaneous coronary intervention (PCI, 鈥榮tenting鈥). I have sub-specialty interest and expertise in complex PCI, CTO (chronic total occlusion) PCI and invasive coronary physiological assessment. The latter helps in the care of patients with epicardial and microvascular coronary disease (also known as ANOCA 鈥 angina with no obstructive coronary artery disease).
- Research interests
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My research is focused on computational, physics-based mathematical modelling of cardiovascular physiology and heart disease. I lead the continued development of the suite of cardiovascular physiological simulation methods which is an image-based model that computes fractional flow reserve (FFR), flow and resistance in the coronary arterial circulation. Current work focusses on the integration of x-ray angiography with optical coherence tomography (OCT) to develop detailed and comprehensive 3D models of coronary disease that bring anatomy and physiology together into comprehensive clinical assessment tools. Other projects are focused on the in vivo validation of the virtuQ tool for computing absolute coronary physiology.
I have done significant work on coronary morphometric scaling; i.e. the relationships between arterial size and blood flow, with particular focus on bifurcation physiology. A meta-analysis on various morphometric scaling laws including Murray鈥檚 law, can be found . I am also interested in use of non-invasive imaging (cardiac MRI) can be used to derive metrics of coronary physiology. Published early pilot work on this project can be found . I am also leading the development of zero-dimensional models of cardiovascular physiology, with the aim of understanding the link between ischaemia and cardiac function.
I am also leading a collaboration between the University of 葫芦影业 and the (CAA), where we are seeking to use Zero-dimensional models to predict the response of the ageing and diseased cardiovascular system to the acceleration forces involved in commercial spaceflight. A more detailed description of this work published in Nature Reviews Cardiology, co-authored with NASA, Virgin Galactic, UK CAA and the RAF, can be found
Image from the VIRTUheart鈩 workflow. VIRTUheart predicts pressure and flow dynamics within coronary arteries. These data inform decisions about how to treat coronary artery disease with tablets, PCI (stenting) or bypass surgery.
- Publications
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Show: Featured publications All publications
Featured publications
Journal articles
- . Nature Reviews Cardiology.
- . American Journal of Physiology-Heart and Circulatory Physiology, 327(1), H182-H190.
- . Heart.
- . The Lancet Digital Health, 5(7), E467-E476.
- . European Heart Journal - Digital Health, 4(4), 283-290.
- . Nature Cardiovascular Research, 1(7), 611-616.
- . Heart, 108(21), 1737-1746.
- . Heart.
- . Cardiovascular Research, 117(6), 1567-1577.
- . JACC: Cardiovascular Imaging, 12(5), 865-872.
- . Heart, 102(1), 18-28.
- . JACC Cardiovasc Interv, 6(2), 149-157.
All publications
Journal articles
- . European Heart Journal, 45(Supplement_1), ehae666.1668.
- . Medical Engineering and Physics, 130.
- . Nature Reviews Cardiology.
- . Expert Review of Cardiovascular Therapy, 22(7), 339-345.
- . American Journal of Physiology-Heart and Circulatory Physiology, 327(1), H182-H190.
- . Heart.
- . Computers in Biology and Medicine, 173.
- . Journal of Invasive Cardiology.
- . Medical Engineering & Physics, 130, 104204-104204.
- . Frontiers in Cardiovascular Medicine, 10.
- . The Lancet Digital Health, 5(7), E467-E476.
- . Fluids, 8(5).
- . European Heart Journal - Digital Health, 4(4), 283-290.
- . Cardiology Research and Practice, 2023.
- . European Heart Journal: Digital Health, 4(2), 81-89.
- AAG COUNCILLORS FOR 2023-2024. ELEMENTS, 19(2), 118-118.
- . Journal of Mental Health, 31(6), (ii)-(iii).
- . Cardiovascular Research, 118(Supplement_2).
- . European Heart Journal - Digital Health, 3(3), 481-488.
- . PLoS ONE, 17(7).
- . Nature Cardiovascular Research, 1(7), 611-616.
- . Heart, 108(21), 1737-1746.
- . Heart, 108(22), 1754-1755.
- . International Journal of Cardiology, 364, 148-156.
- . Fluids, 7(6).
- . Frontiers in Materials, 13.
- . Journal of the American College of Cardiology, 79(9), 2022.
- . Heart.
- . IEEE Transactions on Visualization and Computer Graphics, 28(1), 901-911.
- . European Heart Journal, 43(16), 1582-1593.
- . Journal of Echocardiography, 20(1), 1-9.
- . Scientific Reports, 11.
- . Frontiers in Cardiovascular Medicine, 8.
- . European Heart Journal - Digital Health, 2(4), 616-625.
- . JACC: Cardiovascular Interventions, 14(15), 1731-1733.
- . Heart, 107(22), 1826-1834.
- . Journal of Engineering and Science in Medical Diagnostics and Therapy, 4(3).
- . Canadian Journal of Cardiology, 37(10), 1530-1538.
- . Cardiovascular Research, 117(6), 1567-1577.
- . Wellcome Open Research, 6.
- . Clinical Medicine, 21(2), e242-e242.
- . European Heart Journal - Digital Health, 2(2), 263-270.
- . ESC Heart Failure, 8(1), 566-576.
- . Heart, 107.
- . Cardiovascular Research, 117(1), 29-42.
- . Cardiovascular Research, 117(8), 1811-1813.
- . Circulation, 142(Suppl_3).
- . Journal of the American College of Cardiology, 76(17), B98-B99.
- . Interventional Cardiology Review, 15.
- . Canadian Journal of Cardiology, 36(6), 852-859.
- . Journal of Biomechanics, 103.
- . Journal of the American Heart Association, 9(6).
- . Heart, 106(3), 240-241.
- . Geochemistry: Exploration, Environment, Analysis, 20(1), 35-49.
- . Heart, 105(Suppl 6), a15-a15.
- . Heart, 105(Suppl 6), a51-a51.
- . Heart, 105(Suppl 6), a14-a14.
- . JACC: Cardiovascular Imaging, 12(5), 865-872.
- . British Journal of Hospital Medicine, 80(2), C28-C31.
- . BMJ Evidence-Based Medicine, 24(4), 162-162.
- . EuroIntervention, 15(8), 707-713.
- . Catheterization and Cardiovascular Interventions, 92(6), E381-E392.
- . Nature Communications, 9(1).
- . EuroIntervention, 14(8), 935-941.
- . Frontiers in Physiology, 9.
- . Frontiers in Physiology, 9, 1107-1107.
- . Evidence-Based Medicine, 23(2), 71-72.
- . Polish Archives of Internal Medicine, 128(2), 74-76.
- . Geochemistry: Exploration, Environment, Analysis, 18(1), 1-11.
- . Circulation: Cardiovascular Interventions, 10(9).
- . European Heart Journal, 38(suppl_1).
- . JACC: Basic to Translational Science, 2(4), 434-446.
- . Internal and Emergency Medicine, 12(2), 147-155.
- . Emergency Medicine Journal, 34.
- . British Journal of Hospital Medicine, 77(7), 427-427.
- . Andrology, 4(3), 486-491.
- . Catheterization and Cardiovascular Interventions, 87(4), E104-E112.
- . Heart, 102(1), 18-28.
- . Canadian Journal of Cardiology, 31(10), S2-S2.
- . JACC: Cardiovascular Interventions, 8(8), 1009-1017.
- . Postgraduate Medical Journal, 90(1068), 575-575.
- . Postgraduate Medical Journal, 90(1067), 520-528.
- . British Journal of Hospital Medicine, 74(4), 233-233.
- . Br J Hosp Med (Lond), 74(2), C23-C25.
- . JACC Cardiovasc Interv, 6(2), 149-157.
- . Br J Hosp Med (Lond), 74(2), C26-C30.
- . Thorax, 68(5), 498.
- . Postgrad Med J, 88(1046), 706-712.
- . BMJ, 344(jun13 2), e3992-e3992.
- . Asian Journal of Andrology, 14(3), 428-435.
- . Emergency Medicine Journal.
- . BMJ (Online), 344(7851).
- Smells like a heart attack, but is it?. BMJ Case Reports.
- . Infect Immun, 79(6), 2241-2249.
- . Heart, 96(22), 1821-1825.
- Unnatural beliefs. PSYCHOLOGIST, 23(8), 620-620.
- . Clin Med (Lond), 6(2), 174-177.
- . European Journal of Endocrinology, 151(2), 241-249.
- . Heart, 90(8), 871-876.
- . The American Journal of Cardiology, 92(10), 1241-1243.
- . Clinical Science, 102(s46), 5P-5P.
- . Heart.
- . PLOS ONE, 19(11), e0314392-e0314392.
Chapters
- , Cardiac Pathology (pp. 25-48). Springer International Publishing
- , Practical Interventional Cardiology (pp. 109-123). CRC Press
- , Cardiac Pathology (pp. 19-42). Springer London
Conference proceedings papers
- . Basic science
- . Stable IHD/Prevention/Hypertension/Lipids
- . Acute coronary syndromes & Interventional Cardiology
- . Acute coronary syndromes & Interventional Cardiology
- . Acute coronary syndromes & Interventional Cardiology
- . Acute coronary syndromes & Interventional Cardiology
- CORONARY FLOW RESERVE AND CARDIOVASCULAR OUTCOMES: A SYSTEMATIC REVIEW AND META-ANALYSIS. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol. 79(9) (pp 989-989)
- . European Heart Journal, Vol. 42(Suppl 1) (pp 1074-1074). Digital Congress, 27 August 2021 - 27 August 2021.
- . Acute coronary syndromes & Interventional cardiology
- . Circulation, Vol. 142(Suppl_3) (pp A15636). Virtual conference, 15 November 2020 - 15 November 2020.
- In-Hospital Outcomes of CABG Candidates Undergoing PCI During the ICU Restricted COVID-19 Pandemic: The Multi-Center Prospective UK-REVASC Registry. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol. 76(17) (pp B98-B99)
- . Heart, Vol. 105(Suppl 6) (pp a45-a45). Manchester, UK, 3 June 2019 - 3 June 2019.
- . International Journal of Surgery, Vol. 55 (pp S9-S9)
- . European Heart Journal , Vol. 38, S1 (pp 183-184). Barcelona, Spain, 26 August 2017 - 26 August 2017.
- . European Heart Journal, Vol. 38(Suppl 1) (pp 87-87). Barcelona, Spain, 26 August 2017 - 26 August 2017.
- . Heart, Vol. 101(Suppl 4) (pp A115.1-A115)
- . Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention, Vol. 2 (pp 619-626)
- Reconstruction of coronary trees from 3DRA using a 3D+t statistical cardiac prior. Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention, Vol. 17 (pp 619-626)
- . IEEE Transactions on Nuclear Science, Vol. 60(4) (pp 2530-2536)
- . Ironmaking and Steelmaking, Vol. 39(4) (pp 236-243)
- . IEEE Transactions on Nuclear Science, Vol. 59(6) (pp 2824-2830)
- . Heart, Vol. 98(Suppl 1) (pp A14.1-A14)
- . IEEE Transactions on Nuclear Science, Vol. 58(6) (pp 2687-2694)
- . IEEE Transactions on Nuclear Science, Vol. 58(3) (pp 952-959)
- Computer-aided Self-assessment and Independent Learning in Higher Education.. CSEDU (2) (pp 139-142)
- A Categorical Semantics for Inductive-Inductive Definitions.. CALCO, Vol. 6859 (pp 70-84)
- Virtual Coronary Physiology and Anatomy Derived From Rotational Angiography: The First Step. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol. 58(20) (pp B189-B189)
- . Ironmaking and Steelmaking, Vol. 37(4) (pp 242-250)
- The gentle art of levitation.. ICFP (pp 3-14)
- . LICS (pp 277-285)
- Discovery of Regulatory Elements in Oomycete Orthologs.. BIOCOMP (pp 34-38)
- Constructing Strictly Positive Families.. CATS, Vol. 65 (pp 111-121)
- A Structural Characterization of Temporal Dynamic Controllability.. CP, Vol. 4204 (pp 375-389)
- . Ironmaking and Steelmaking, Vol. 32(5) (pp 391-396)
- . Ironmaking and Steelmaking, Vol. 31(1) (pp 8-13)
- Exploring the Regular Tree Types.. TYPES, Vol. 3839 (pp 252-267)
- . Journal of the American College of Cardiology, Vol. 41(6) (pp 344-344)
- . Journal of the American College of Cardiology, Vol. 41(6) (pp 344-344)
- . European Heart Journal, Vol. 24(5) (pp 20-20)
- Keynote: Metrics Based Project Governance.. IEEE METRICS
- The Academic Library's Role in Transmitting Cultural Heritage Using 21st Centuri Technology: The University of Arizona Libraries and the Cultural Community Collaboration Model.. ICHIM (1) (pp 375-383)
- Dependable Embedded Systems: The Challenges for Requirements Engineering.. REFSQ (pp 187-192)
- . ICRE (pp 130-137)
- . RE (pp 41-41)
- A Framework for Requirements Analysis Using Automated Reasoning. CAiSE, Vol. 932 (pp 68-81)
- The Breakout Method for Escaping from Local Minima.. AAAI (pp 40-45)
- Formalizing and Validating Complex Security Requirements.. DBSec, Vol. A-21 (pp 113-124)
- On the Density of Solutions in Equilibrium Points for the Queens Problem.. AAAI (pp 428-433)
- The Structure of Permissions: A Normative Framework for Access Rights.. DBSec, Vol. A-6 (pp 77-97)
- Admissible Criteria for Loop Control in Planning.. AAAI (pp 151-157)
- Stable Closures, Defeasible Logic and Contradiction Tolerant Reasoning.. AAAI (pp 506-511)
- Curing Anomalous Extensions.. AAAI (pp 437-442)
- Representing Actions with an Assumption-Based Truth Maintenance System.. AAAI (pp 13-20)
- Don't Be Stupid.. IJCAI (pp 345-347)
- Managing Network Access to a Distributed Database.. Berkeley Workshop (pp 58-67)
Preprints
- Grants
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- UK-CAA Spaceflight. Computational modelling to risk stratify commercial spaceflight. 拢200,000. 2023-2024.
- British Heart Foundation. Translational Award no TG/19/1/34451. How will virtual (computed) fractional flow reserve (vFFR) impact the management of coronary artery disease? (VIRTU-4). 2019. 拢370,679.
- National Institute for Health Research, Invention for Innovation (i4i). A prototype tool to calculate 'virtual' myocardial fractional flow reserve (vFFR) non-invasively (VIRTU-3). II-LB-0216-20006. 拢282,186.
- Wellcome Trust. Clinical Research Career Development Fellowship. Morris PD. Computational modelling to improve the assessment and management of patients with coronary artery disease. 2019. 拢570,000.
- Teaching interests
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I enjoy teaching clinical cardiology to undergraduates and post-graduates. I teach clinical skills to medical students and doctors on the wards and in the clinic.
I have written textbooks and chapters of books focused on clinical and academic aspects of clinical cardiology. I also enjoy teaching about cardiac physiology and fluid dynamics modelling.
I have a Postgraduate Certificate in Medical Education and have recently become a Fellow of the Higher Education Academy.
- Professional activities and memberships
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I am Director for Clinical Translation at the Insigneo Institute. I sit on the Steering Committee. I am phase lead for Cardiology Teaching on the 葫芦影业 Medical (MBChB) and Physician Associate (MMedSci) courses. I am also a member of the British Cardiovascular Society, the British Cardiovascular Interventions Society, the Royal College of Physicians and the European Society of Cardiology.
- Invention and innovation
My research has led to several innovations. In 2012, I led the development of angiography-derived (vFFR), an approach that has translated into routine clinical practice to assess the physiological significance of coronary disease in the cardiac catheter laboratory. Similar image-based CFD modelling methods were used to develop the patented virtuQ method of , microvascular resistance and flow reserve. I also co-led to the development of the patented GuideGlideTM catheter that is designed to improve comfort and safety of radial access procedures during radial coronary intervention.
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